KENNETH SEEDMAN KENDLER

Summary

Affiliation: Virginia Commonwealth University
Country: USA

Publications

  1. doi request reprint Genetic and environmental influences on multiple dimensions of religiosity: a twin study
    Todd Vance
    Department of Psychology, Virginia Commonwealth University, Richmond, VA, USA
    J Nerv Ment Dis 198:755-61. 2010
  2. pmc The relationship between the genetic and environmental influences on common externalizing psychopathology and mental wellbeing
    Kenneth S Kendler
    Virginia Institute of Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA 23298 0126, USA
    Twin Res Hum Genet 14:516-23. 2011
  3. doi request reprint What kinds of things are psychiatric disorders?
    K S Kendler
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, VA, USA
    Psychol Med 41:1143-50. 2011
  4. pmc Genetic and familial environmental influences on the risk for drug abuse: a national Swedish adoption study
    Kenneth S Kendler
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, 23219, USA
    Arch Gen Psychiatry 69:690-7. 2012
  5. ncbi request reprint Toward a comprehensive developmental model for major depression in men
    Kenneth S Kendler
    Virginia Institute for Psychiatry and Behavioral Genetics and the Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Am J Psychiatry 163:115-24. 2006
  6. ncbi request reprint The interrelationship of neuroticism, sex, and stressful life events in the prediction of episodes of major depression
    Kenneth S Kendler
    Virginia Institute for Psychiatry and Behavioral Genetics and Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond, 23298 0126, USA
    Am J Psychiatry 161:631-6. 2004
  7. pmc Borderline personality disorder traits and their relationship with dimensions of normative personality: a web-based cohort and twin study
    K S Kendler
    Virginia Institute of Psychiatric and Behavioral Genetics, Medical College of Virginia Virginia Commonwealth University, Richmond, VA, USA
    Acta Psychiatr Scand 123:349-59. 2011
  8. pmc Predicting alcohol consumption in adolescence from alcohol-specific and general externalizing genetic risk factors, key environmental exposures and their interaction
    K S Kendler
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA, USA
    Psychol Med 41:1507-16. 2011
  9. ncbi request reprint Age at onset and familial risk for major depression in a Swedish national twin sample
    Kenneth S Kendler
    Department of Psychiatry, Medical College of Virginia Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Psychol Med 35:1573-9. 2005
  10. doi request reprint Alternative futures for the DSM revision process: iteration v. paradigm shift
    Kenneth S Kendler
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University Medical School, Box 980126, 800 E Leigh Street, Room 1 123, Richmond, VA 23298 0126, USA
    Br J Psychiatry 197:263-5. 2010

Research Grants

Collaborators

Detail Information

Publications104 found, 100 shown here

  1. doi request reprint Genetic and environmental influences on multiple dimensions of religiosity: a twin study
    Todd Vance
    Department of Psychology, Virginia Commonwealth University, Richmond, VA, USA
    J Nerv Ment Dis 198:755-61. 2010
    ..The results suggest that for the population studied, additive genetic and unique environmental effects largely account for the variance across the religiosity construct...
  2. pmc The relationship between the genetic and environmental influences on common externalizing psychopathology and mental wellbeing
    Kenneth S Kendler
    Virginia Institute of Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA 23298 0126, USA
    Twin Res Hum Genet 14:516-23. 2011
    ..In this model, genetic risk factors for externalizing psychopathology predict, albeit weakly, higher levels of mental wellbeing...
  3. doi request reprint What kinds of things are psychiatric disorders?
    K S Kendler
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, VA, USA
    Psychol Med 41:1143-50. 2011
    ..Like species, psychiatric disorders are populations with central paradigmatic and more marginal members. The MPC view is the best current answer to 'What kinds of things are psychiatric disorders?'..
  4. pmc Genetic and familial environmental influences on the risk for drug abuse: a national Swedish adoption study
    Kenneth S Kendler
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, 23219, USA
    Arch Gen Psychiatry 69:690-7. 2012
    ..Prior research suggests that drug abuse (DA) is strongly influenced by both genetic and familial environmental factors. No large-scale adoption study has previously attempted to verify and integrate these findings...
  5. ncbi request reprint Toward a comprehensive developmental model for major depression in men
    Kenneth S Kendler
    Virginia Institute for Psychiatry and Behavioral Genetics and the Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Am J Psychiatry 163:115-24. 2006
    ..In 2002, the authors presented a developmental model for major depression in women. Based on similar methods, they here present an analogous model for men...
  6. ncbi request reprint The interrelationship of neuroticism, sex, and stressful life events in the prediction of episodes of major depression
    Kenneth S Kendler
    Virginia Institute for Psychiatry and Behavioral Genetics and Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond, 23298 0126, USA
    Am J Psychiatry 161:631-6. 2004
    ..Little is known about how they interrelate in the etiology of depressive illness...
  7. pmc Borderline personality disorder traits and their relationship with dimensions of normative personality: a web-based cohort and twin study
    K S Kendler
    Virginia Institute of Psychiatric and Behavioral Genetics, Medical College of Virginia Virginia Commonwealth University, Richmond, VA, USA
    Acta Psychiatr Scand 123:349-59. 2011
    ..To describe the structure of genetic and environmental risk factors for four dimensions of borderline personality disorder (BPD) and to understand the source of resemblance of these dimensions and normal personality...
  8. pmc Predicting alcohol consumption in adolescence from alcohol-specific and general externalizing genetic risk factors, key environmental exposures and their interaction
    K S Kendler
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA, USA
    Psychol Med 41:1507-16. 2011
    ..We have limited knowledge of how these risk factors inter-relate through development...
  9. ncbi request reprint Age at onset and familial risk for major depression in a Swedish national twin sample
    Kenneth S Kendler
    Department of Psychiatry, Medical College of Virginia Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Psychol Med 35:1573-9. 2005
    ..In many biomedical disorders, early age at onset (AAO) is an index of high liability to illness which is manifest by an increased risk of illness in relatives. Most but not all prior studies report such a pattern for major depression (MD)...
  10. doi request reprint Alternative futures for the DSM revision process: iteration v. paradigm shift
    Kenneth S Kendler
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University Medical School, Box 980126, 800 E Leigh Street, Room 1 123, Richmond, VA 23298 0126, USA
    Br J Psychiatry 197:263-5. 2010
    ..We explore each of these two approaches and conclude that although they both have strengths and limitations, our field is not currently ready for a paradigm shift...
  11. ncbi request reprint Psychiatric genetics: a methodologic critique
    Kenneth S Kendler
    Virginia Institute for Psychiatry and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA
    Am J Psychiatry 162:3-11. 2005
    ..This integration can be best done within an overall framework of explanatory pluralism that values a range of reductive explanations across varying levels of biological and psychological complexity...
  12. ncbi request reprint A joint genomewide linkage analysis of symptoms of alcohol dependence and conduct disorder
    Kenneth S Kendler
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Alcohol Clin Exp Res 30:1972-7. 2006
    ..Are the susceptibility genes underlying this peak specific for AD or do they increase risk for externalizing disorders more generally? Can we, in the IASPSAD, replicate prior evidence for linkage to conduct disorder (CD)?..
  13. ncbi request reprint Toward a philosophical structure for psychiatry
    Kenneth S Kendler
    Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, USA
    Am J Psychiatry 162:433-40. 2005
    ....
  14. ncbi request reprint Reflections on the relationship between psychiatric genetics and psychiatric nosology
    Kenneth S Kendler
    Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University, P O Box 980126, Richmond, VA 23298 0126, USA
    Am J Psychiatry 163:1138-46. 2006
    ....
  15. ncbi request reprint The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression: a replication
    Kenneth S Kendler
    Virginia Institute for Psychiatry and Behavioral Genetics, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA 23298, USA
    Arch Gen Psychiatry 62:529-35. 2005
    ..Prior evidence from twin studies suggested genetic moderation of the depressogenic effects of stressful life events (SLEs). Can the specific genes involved in this effect be identified?..
  16. ncbi request reprint "A gene for...": the nature of gene action in psychiatric disorders
    Kenneth S Kendler
    Department of Psychiatry, Virginia Institute for Psychiatry and Behavioral Genetics, Medical College of Virginia Virginia Commonwealth University, P O Box 980126, Richmond, VA 23298 0126, USA
    Am J Psychiatry 162:1243-52. 2005
    ..The phrase "a gene for..." and the preformationist concept of gene action that underlies it are inappropriate for psychiatric disorders...
  17. ncbi request reprint A Swedish national twin study of lifetime major depression
    Kenneth S Kendler
    Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Am J Psychiatry 163:109-14. 2006
    ..It is not known whether genetic effects on major depression are constant across historical cohorts...
  18. pmc The relationship between the genetic and environmental influences on common internalizing psychiatric disorders and mental well-being
    Kenneth S Kendler
    Virginia Institute of Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, P O Box 980126, 800 E Leigh Street, Room 1 123, Richmond, VA 23298 0126, USA
    Behav Genet 41:641-50. 2011
    ..The overlap of environmental risk factors is more modest. Although low levels of IP on average reflect a high genetic propensity for MWB, other independent genetic influences play an important role in producing good mental health...
  19. ncbi request reprint Specificity of genetic and environmental risk factors for use and abuse/dependence of cannabis, cocaine, hallucinogens, sedatives, stimulants, and opiates in male twins
    Kenneth S Kendler
    Virginia Institute for Psychiatric and Behavioral Genetics, USA
    Am J Psychiatry 160:687-95. 2003
    ..Data on use and misuse of six classes of illicit substances by male twin pairs were used to examine whether genetic and shared environmental risk factors for substance use disorders are substance-specific or -nonspecific in their effect...
  20. ncbi request reprint Tobacco consumption in Swedish twins reared apart and reared together
    K S Kendler
    Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, PO Box 980126, Richmond, VA 23298 0126
    Arch Gen Psychiatry 57:886-92. 2000
    ..Prior studies of twins reared together suggest that regular tobacco use (RTU) is substantially heritable. However, strong social influences on RTU might have biased these results...
  21. ncbi request reprint Toward a comprehensive developmental model for major depression in women
    Kenneth S Kendler
    Department of Psychiatry, PO Box 980126, Medical College of Virginia, Richmond, VA 23298 0126, USA
    Am J Psychiatry 159:1133-45. 2002
    ..The authors used structural equation modeling to generate a developmental model for the etiology of major depression in women...
  22. ncbi request reprint Clinical features of schizophrenia and linkage to chromosomes 5q, 6p, 8p, and 10p in the Irish Study of High-Density Schizophrenia Families
    K S Kendler
    Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA 23298 0710, USA
    Am J Psychiatry 157:402-8. 2000
    ..Recent linkage studies suggest that multiple genes are important in the etiology of schizophrenia. The authors examined the hypothesis of whether the clinical variability in schizophrenia is due to genetic heterogeneity...
  23. ncbi request reprint Dimensions of religiosity and their relationship to lifetime psychiatric and substance use disorders
    Kenneth S Kendler
    Virginia Institute for Psychiatry and Behavioral Genetics and Department of Psychiatry and Human Genetics, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298 0126, USA
    Am J Psychiatry 160:496-503. 2003
    ..This study used data from a general population sample to clarify the dimensions of religiosity and the relationships of these dimensions to risk for lifetime psychiatric and substance use disorders...
  24. ncbi request reprint Marker-to-marker linkage disequilibrium on chromosomes 5q, 6p, and 8p in Irish high-density schizophrenia pedigrees
    K S Kendler
    Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298 0126, USA
    Am J Med Genet 88:29-33. 1999
    ..Thus, in Irish families selected for a high density of schizophrenia, M-M LD may be very common within 0.5 cM and frequent up to distances of 2 cM...
  25. ncbi request reprint Caffeine intake, tolerance, and withdrawal in women: a population-based twin study
    K S Kendler
    Department of Psychiatry, Medical College of Virginia Virginia Commonwealth University, and the Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, USA
    Am J Psychiatry 156:223-8. 1999
    ..However, the impact of genetic factors on caffeine consumption, heavy use, intoxication, tolerance, and withdrawal is largely unknown...
  26. ncbi request reprint Longitudinal population-based twin study of retrospectively reported premenstrual symptoms and lifetime major depression
    K S Kendler
    Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298 0126, USA
    Am J Psychiatry 155:1234-40. 1998
    ..In addition, we know little about the relationship of the familial risk factors for premenstrual symptoms and major depression...
  27. ncbi request reprint Boundaries of major depression: an evaluation of DSM-IV criteria
    K S Kendler
    Virginia Institute for Psychiatric and Behavioral Genetics, Medical College of Virginia of Virginia Commonwealth University, Richmond, USA
    Am J Psychiatry 155:172-7. 1998
    ..Little is known about the boundaries between major depression and milder subsyndromal depressive states. With respect to depressive symptoms, does DSM-IV "carve nature at its joints"?..
  28. pmc Is the histidine triad nucleotide-binding protein 1 (HINT1) gene a candidate for schizophrenia?
    Qi Chen
    Department of Psychiatry and Virginia Institute for Psychiatric and Behavior Genetics, Virginia Commonwealth University, 800 E Leigh Street, Richmond, VA 23298, United States
    Schizophr Res 106:200-7. 2008
    ..It was also found to be associated with the dysregulation of postsynaptic dopamine transmission, thus suggesting a potential role in several neuropsychiatric diseases...
  29. ncbi request reprint Association of different adverse life events with distinct patterns of depressive symptoms
    Matthew C Keller
    Department of Psychiatry, Virginia Commonwealth University School of Medicine, Richmond, VA 23219, USA
    Am J Psychiatry 164:1521-9; quiz 1622. 2007
    ..The authors sought to determine whether, in a general population sample, different categories of adverse life events were associated with different patterns of depressive symptoms...
  30. ncbi request reprint The structure of genetic and environmental risk factors for common psychiatric and substance use disorders in men and women
    Kenneth S Kendler
    Virginia Institute for Psychiatry and Behavioral Genetics and the Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298 0126, USA
    Arch Gen Psychiatry 60:929-37. 2003
    ..We do not know how genetic and environmental risk factors contribute to this pattern of comorbidity or whether the etiologic structure of these groups differ in men and women...
  31. pmc Polymorphisms in SLC6A4, PAH, GABRB3, and MAOB and modification of psychotic disorder features
    Sarah E Bergen
    Virginia Commonwealth University, Department of Human and Molecular Genetics, Richmond, Virginia 23219, USA
    Schizophr Res 109:94-7. 2009
    ..031) and QPDTPHASE (chi-square=12.54, p=.028). Also, a significant association between the GABRB3 191 bp allele and the hallucinations factor was detected using QPDTPHASE (chi-square=15.51, p=.030), but not QTDT (chi-square=2.07, p=.560)...
  32. pmc Association study between GABA receptor genes and anxiety spectrum disorders
    Xuan Pham
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298 0126, USA
    Depress Anxiety 26:998-1003. 2009
    ..In this investigation, we explored four GABA receptor genes for their possible associations with genetic risk for anxiety disorders and depression...
  33. pmc No association of dysbindin with symptom factors of schizophrenia in an Irish case-control sample
    Sarah E Bergen
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23219, USA
    Am J Med Genet B Neuropsychiatr Genet 153:700-5. 2010
    ..Several possibilities, such as differing risk haplotypes, may explain this finding...
  34. ncbi request reprint Life event dimensions of loss, humiliation, entrapment, and danger in the prediction of onsets of major depression and generalized anxiety
    Kenneth S Kendler
    Virginia Institute for Psychiatry and Behavioral Genetics, Medical College of Virginia of Virginia Commonwealth University, Richmond, USA
    Arch Gen Psychiatry 60:789-96. 2003
    ..Although substantial evidence suggests that stressful life events predispose to the onset of episodes of depression and anxiety, the essential features of these events that are depressogenic and anxiogenic remain uncertain...
  35. pmc Genetic variation in the serotonin 2A receptor and suicidal ideation in a sample of 270 Irish high-density schizophrenia families
    Ayman H Fanous
    Washington VA Medical Center, Virginia Commonwealth University, Richmond, Virginia, USA
    Am J Med Genet B Neuropsychiatr Genet 150:411-7. 2009
    ..Because of multiple testing, these results do not provide support for HTR2A as a susceptibility gene for psychotic illness, or for suicidal ideation within psychotic illness...
  36. ncbi request reprint Creating a social world: a developmental twin study of peer-group deviance
    Kenneth S Kendler
    Virginia Institute of Psychiatric and Behavioral Genetics, Virginia Commonwealth University Medical School, VA 23298 0126, USA
    Arch Gen Psychiatry 64:958-65. 2007
    ..Peer-group deviance is strongly associated with externalizing behaviors. We have limited knowledge of the sources of individual differences in peer-group deviance...
  37. ncbi request reprint Sex differences in the relationship between social support and risk for major depression: a longitudinal study of opposite-sex twin pairs
    Kenneth S Kendler
    Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Am J Psychiatry 162:250-6. 2005
    ..Prior studies have suggested that women are more sensitive to the depressogenic effects of low social support, but most of these studies had substantial methodologic limitations...
  38. ncbi request reprint Association of the phosphatase and tensin homolog gene (PTEN) with smoking initiation and nicotine dependence
    Lan Zhang
    Department of Psychiatry, Virginia Institute of Psychiatric and Behavioral Genetics, Virginia Commonwealth University, 800 Leigh Street, Suite 1 110, Richmond, VA 23298, USA
    Am J Med Genet B Neuropsychiatr Genet 141:10-4. 2006
    ..These results suggest that the PTEN gene may be involved in the etiology of both smoking initiation and nicotine dependence...
  39. pmc Genetic variation in the 6p22.3 gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia
    Richard E Straub
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA
    Am J Hum Genet 71:337-48. 2002
    ..We conclude that further investigation of dysbindin is warranted...
  40. ncbi request reprint The differential impact of risk factors on illicit drug involvement in females
    Arpana Agrawal
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Dept of Human Genetics, Richmond, VA, USA
    Soc Psychiatry Psychiatr Epidemiol 40:454-66. 2005
    ..Are there risk factors that associate with illicit drug use or illicit drug abuse/dependence? Is the magnitude of the association the same for use and abuse/dependence? Does this pattern of association differ across categories of drugs?..
  41. ncbi request reprint Level of family dysfunction and genetic influences on smoking in women
    Kenneth S Kendler
    Department of Psychiatry, Medical College of Virginia Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Psychol Med 34:1263-9. 2004
    ..An adoption study of alcoholism suggests that in women, the impact of genetic risk factors become greater in the presence of conflict in the family of origin. Is the same true for cigarette smoking (CS)?..
  42. pmc Socioeconomic status and social support following illicit drug use: causal pathways or common liability?
    Sarah E Bergen
    Department of Human Genetics, Medical College of Virginia, Virginia Commonwealth University, Box 980126, Richmond, VA 23219, USA
    Twin Res Hum Genet 11:266-74. 2008
    ..Drug use and social discord also appear to have shared genetic factors, but increased levels of drug involvement seem to causally influence social interactions...
  43. doi request reprint Interleukin 3 and schizophrenia
    Xiangning Chen
    UT Southwestern Medical Center, Department of Psychiatry, 5323 Harry Hines Blvd, NE5 110, Dallas, TX 75390 9070, USA
    Am J Psychiatry 165:13-4. 2008
  44. ncbi request reprint Age-related changes in heritability of behavioral phenotypes over adolescence and young adulthood: a meta-analysis
    Sarah E Bergen
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Human Genetics, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298 0126, United States of America
    Twin Res Hum Genet 10:423-33. 2007
    ..Further studies exploring heritability changes beyond young adulthood would also benefit our understanding of factors influencing heritability of behavioral traits over the lifespan...
  45. ncbi request reprint A multivariate analysis of neuroanatomic relationships in a genetically informative pediatric sample
    J Eric Schmitt
    Virginia Institute for Psychiatric and Behavioral Genetics and Departments of Psychiatry and Human Genetics, Virginia Commonwealth University, Richmond, VA 23298, USA
    Neuroimage 35:70-82. 2007
    ..These findings are concordant with prior volumetric twin studies and support radial models of brain evolution...
  46. pmc Illicit psychoactive substance use, abuse and dependence in a population-based sample of Norwegian twins
    Kenneth S Kendler
    Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA, USA
    Psychol Med 36:955-62. 2006
    ..Would these results replicate in Norway, a Nordic country with a low prevalence of illicit drug use?..
  47. ncbi request reprint The etiology of phobias: an evaluation of the stress-diathesis model
    Kenneth S Kendler
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, 800 E Leigh St, Box 980126, Richmond, VA 23298 0126, USA
    Arch Gen Psychiatry 59:242-8. 2002
    ..We evaluated for phobias the prediction of the stress-diathesis model that the magnitude of stress at onset is inversely proportional to the level of underlying diathesis...
  48. ncbi request reprint Childhood sexual abuse, stressful life events and risk for major depression in women
    Kenneth S Kendler
    Department of Psychiatry, Medical College of Virginia, Richmond, VA 23298 0126, USA
    Psychol Med 34:1475-82. 2004
    ..To explore whether similar processes occur in humans, we examine whether childhood sexual abuse (CSA) in women alters sensitivity in adulthood to the depressogenic effects of stressful life events (SLEs)...
  49. ncbi request reprint No major schizophrenia locus detected on chromosome 1q in a large multicenter sample
    Douglas F Levinson
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 296:739-41. 2002
    ..If schizophrenia susceptibility genes are present on chromosome 1q, their population-wide genetic effects are likely to be small...
  50. pmc Nature and nurture in neuropsychiatric genetics: where do we stand?
    Danielle M Dick
    Department of Psychiatry, Virginia Institute of Psychiatric and Behavioral Genetics, Richmond 23298, USA
    Dialogues Clin Neurosci 12:7-23. 2010
    ..We will review the fields of genetic epidemiology and molecular genetics, providing examples from the literature to illustrate the key concepts emerging from this work...
  51. pmc Measurement non-invariance of DSM-IV narcissistic personality disorder criteria across age and sex in a population-based sample of Norwegian twins
    Thomas S Kubarych
    Department of Psychiatry, Virginia Commonwealth University, P O Box 980126, Richmond, VA 23298 0126, USA
    Int J Methods Psychiatr Res 19:156-66. 2010
    ..The results indicate that DSM-IV NPD criteria perform differently in males and females and across age. Differences in diagnostic rates across groups may not be valid without correcting for measurement non-invariance...
  52. doi request reprint Candidate genes for schizophrenia: a survey of association studies and gene ranking
    Jingchun Sun
    Department of Psychiatry and Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1173-81. 2008
    ..The evaluation of this candidate gene set against sets selected by other methods suggested its utility in follow-up association studies and in further bioinformatics analysis. We also examined the functional biases of the selected genes...
  53. ncbi request reprint Major depression and associated impairment: same or different genetic and environmental risk factors?
    Debra L Foley
    Virginia Institute for Psychiatric and Behavioral Genetics, Departments of Human Genetics and Psychiatry, Virginia Commonwealth University, USA
    Am J Psychiatry 160:2128-33. 2003
    ..Impairment was added as a diagnostic criterion for many psychiatric disorders in DSM-IV. Does the addition of impairment influence only prevalence rates, or does it also introduce new etiological factors into psychiatric diagnoses?..
  54. ncbi request reprint Is bereavement-related depression different than non-bereavement-related depression?
    Sidney Zisook
    Department of Psychiatry, University of California, San Diego, CA 92093, USA
    Psychol Med 37:779-94. 2007
    ....
  55. pmc The relationship between genetic influences on alcohol dependence and on patterns of alcohol consumption
    Kenneth S Kendler
    Virginia Institute of Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298 0126, USA
    Alcohol Clin Exp Res 34:1058-65. 2010
    ..Genetic factors impact substantially both on alcohol consumption (AC) and on the risk for alcohol dependence (AD). However, we know little about the degree to which measures of AC index the genetic risk for AD...
  56. pmc Cannabinoid receptor 1 gene association with nicotine dependence
    Xiangning Chen
    Virginia Institute for Psychiatric and Behavioral Genetics and Department of Psychiatry, Virginia Commonwealth University, 800 Leigh St, Ste 1 110, Richmond, VA 23298, USA
    Arch Gen Psychiatry 65:816-24. 2008
    ..The cannabinoid receptor 1 (CNR1) gene is 1 of the 2 receptors expressed in the brain. It has been reported to be associated with alcoholism and multiple drug abuse and dependence...
  57. pmc ERGR: An ethanol-related gene resource
    An Yuan Guo
    Department of Psychiatry and Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298, USA
    Nucleic Acids Res 37:D840-5. 2009
    ..More functions will also be added. ERGR has a user-friendly web interface with browse and search functions at multiple levels. It is freely available at http://bioinfo.vipbg.vcu.edu/ERGR/...
  58. doi request reprint Allelic heterogeneity in genetic association meta-analysis: an application to DTNBP1 and schizophrenia
    Brion S Maher
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Hum Hered 69:71-9. 2010
    ..We contend that current approaches may obscure interesting phenomena in genetic association data. However, an appropriate approach to examining heterogeneity across studies is lacking...
  59. pmc The structure of genetic and environmental risk factors for DSM-IV personality disorders: a multivariate twin study
    Kenneth S Kendler
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, PO Box 980126, Richmond, VA 23298 0126, USA
    Arch Gen Psychiatry 65:1438-46. 2008
    ....
  60. pmc Apoptotic engulfment pathway and schizophrenia
    Xiangning Chen
    Department of Psychiatry and Virginia Institute for Psychiatric and Behavior Genetics, Virginia Commonwealth University, Richmond, Virginia, USA
    PLoS ONE 4:e6875. 2009
    ..In this study, we followed the apoptotic engulfment pathway involving the MEGF10, GULP1, ABCA1 and ABCA7 genes and tested their association with the disease...
  61. doi request reprint A web-based study of personality, psychopathology and substance use in twin, other relative and relationship pairs
    Kenneth S Kendler
    Virginia Institute of Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, Richmond, VA 23298 012, USA
    Twin Res Hum Genet 12:137-41. 2009
    ..The sample is diverse and pair resemblance is generally similar to that obtained using interviews or mailed questionnaires...
  62. pmc Variants in nicotinic acetylcholine receptors alpha5 and alpha3 increase risks to nicotine dependence
    Xiangning Chen
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia, USA
    Am J Med Genet B Neuropsychiatr Genet 150:926-33. 2009
    ..However, the opposite effects with nicotine dependence and alcohol abuse/dependence were puzzling and future studies are necessary to resolve this issue...
  63. ncbi request reprint Sex differences in the genetic and environmental influences on the development of antisocial behavior
    Kristen C Jacobson
    Virginia Institute for Psychiatric and Behavioral Genetics, USA
    Dev Psychopathol 14:395-416. 2002
    ..We speculate that sex differences in timing of puberty may account for the earlier presence of genetic effects among females...
  64. ncbi request reprint DSM criteria for major depression: evaluating symptom patterns using latent-trait item response models
    Steven H Aggen
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Medical College of Virginia and Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Psychol Med 35:475-87. 2005
    ..The DSM-III-R criteria for major depression (MD) are examined to determine the degree to which latent trait item response models can extract additional useful information...
  65. ncbi request reprint The Irish Affected Sib Pair Study of Alcohol Dependence: study methodology and validation of diagnosis by interview and family history
    Carol A Prescott
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23298, USA
    Alcohol Clin Exp Res 29:417-29. 2005
    ....
  66. ncbi request reprint The sources of co-morbidity between major depression and generalized anxiety disorder in a Swedish national twin sample
    Kenneth S Kendler
    Department of Psychiatry Medical College of Virginia Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Psychol Med 37:453-62. 2007
    ..The personality trait of neuroticism (N) is substantially correlated with risk for MD and GAD...
  67. pmc A twin study of intracerebral volumetric relationships
    J Eric Schmitt
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, 800 East Leigh Street, Suite 100, PO Box 980003, Richmond, VA, 23298 0003, USA
    Behav Genet 40:114-24. 2010
    ..Reanalysis including total brain volume as a covariate dramatically reduced the total residual variance and disproportionately influenced the additive genetic variance in all regions of interest...
  68. ncbi request reprint A twin study of early cannabis use and subsequent use and abuse/dependence of other illicit drugs
    Arpana Agrawal
    Virginia Commonwealth University, Virginia Institute for Psychiatric and Behavioral Genetics, Department of Human Genetics, Richmond, VA 23298 0003, USA
    Psychol Med 34:1227-37. 2004
    ..Gateway and common liabilities models have been employed to explain this relationship. We sought to examine this association using a combination of the discordant twin design and modeling methods...
  69. ncbi request reprint Genetic and environmental contributions to obesity and binge eating
    Cynthia M Bulik
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, PO Box 980126, Richmond, VA 23298 0126, USA
    Int J Eat Disord 33:293-8. 2003
    ..The purpose of this article was to determine the extent of overlap between genetic and environmental factors that contribute to the liability to obesity and binge eating...
  70. ncbi request reprint Review of twin and family studies on neuroanatomic phenotypes and typical neurodevelopment
    J Eric Schmitt
    Virginia Institute for Psychiatric and Behavioral Genetics, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia, USA
    Twin Res Hum Genet 10:683-94. 2007
    ....
  71. ncbi request reprint Is risk for alcoholism mediated by individual differences in drinking motivations?
    Carol A Prescott
    Virginia Institute of Psychiatric and Behavioral Genetics, Departments of Psychiatry and Psychology, Virginia Commonwealth University, Richmond, Virginia, USA
    Alcohol Clin Exp Res 28:29-39. 2004
    ....
  72. ncbi request reprint A population based twin study of sex differences in depressive symptoms
    Arpana Agrawal
    Department of Human Genetics, Virginia Commonwealth University, Virginia Institute for Psychiatric and Behavioral Genetics, Richmond 23298, USA
    Twin Res 7:176-81. 2004
    ..Our analyses suggest that while there may be mean differences in the levels of depressive symptoms across sexes, the genetic and environmental factors that predispose males and females to depressive symptoms are not different...
  73. ncbi request reprint Forms of cannabis and cocaine: a twin study
    Arpana Agrawal
    Department of Human Genetics, Virginia Institute of Psychiatric and Behavioral Genetics, Medical College of Virginia at Virginia Commonwealth University, Richmond, Virginia 23298 0003, USA
    Am J Med Genet B Neuropsychiatr Genet 129:125-8. 2004
    ..These findings also reinforce the validity of composite variables in epidemiological and genetic research...
  74. ncbi request reprint Association study of the Epac gene and tobacco smoking and nicotine dependence
    Xiangning Chen
    Virginia Institute for Psychiatric and Behavior Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Am J Med Genet B Neuropsychiatr Genet 129:116-9. 2004
    ....
  75. ncbi request reprint The structure of genetic and environmental risk factors for anxiety disorders in men and women
    John M Hettema
    Virginia Institute for Psychiatry and Behavioral Genetics and Department of Psychiatry, Virginia Commonwealth University, Richmond, USA
    Arch Gen Psychiatry 62:182-9. 2005
    ..The anxiety disorders exhibit high levels of lifetime comorbidity with one another. Understanding the underlying causes of this comorbidity can provide insight into the etiology of the disorders and inform classification and treatment...
  76. ncbi request reprint The nature of genetic influences on behavior: lessons from "simpler" organisms
    Kenneth S Kendler
    Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University, P O Box 980126, Richmond, 23298 0126, USA
    Am J Psychiatry 163:1683-94. 2006
    ..For some behaviors, the pathway from genes to behavior differs meaningfully in males and females. With respect to the broad patterns of genetic influences on behavior, Homo sapiens appears to be typical of other animal species...
  77. ncbi request reprint The subtypes of major depression in a twin registry
    Patrick F Sullivan
    Virginia Commonwealth University, Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, P O Box 980126, Richmond VA 23298 0126, USA
    J Affect Disord 68:273-84. 2002
    ..The subtypes of major depression (MD) remain incompletely understood. While there is consensus about the existence of MD with 'typical' vegetative features, further data are required to evaluate the existence of MD with atypical features...
  78. ncbi request reprint The heritability of cluster A personality disorders assessed by both personal interview and questionnaire
    Kenneth S Kendler
    Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Psychol Med 37:655-65. 2007
    ..We wish to know whether the same set of PD vulnerability factors are assessed by these two methods...
  79. doi request reprint Lack of association between the amiloride-sensitive cation channel 2 (ACCN2) gene and anxiety spectrum disorders
    John M Hettema
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298 0126, USA
    Psychiatr Genet 18:73-9. 2008
    ..In this study, we examined, for the first time, the human analog of ASIC1, the amiloride-sensitive cation channel 2 (ACCN2) gene, for its association with genetic risk across a range of anxiety spectrum phenotypes...
  80. pmc A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts
    Gursharan Kalsi
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, 800 E Leigh Street, Richmond, VA 23298, USA
    Hum Mol Genet 19:2497-506. 2010
    ..Haplotype-specific expression measurements in post-mortem tissue samples suggested a functional role for DKK2. This evidence notwithstanding, replication is needed before confidence can be placed in these findings...
  81. ncbi request reprint A twin study of genetic and environmental influences on tobacco initiation, regular tobacco use and nicotine dependence
    Hermine H Maes
    Departments of Human Genetics and Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298 0003, USA
    Psychol Med 34:1251-61. 2004
    ..As the development of ND requires regular tobacco use (RTU) which in turn requires TI, a conditional approach is necessary...
  82. pmc Eating disorder symptomatology and substance use disorders: prevalence and shared risk in a population based twin sample
    Jessica H Baker
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University, Richmond, Virginia 23284, USA
    Int J Eat Disord 43:648-58. 2010
    ..The objective of this study is to examine the prevalence, chronology, and possibility of shared familial risk between SUD and ED symptomatology...
  83. ncbi request reprint Characteristics of men with persistent thinness
    Suzanne E Mazzeo
    Department of Psychology, Virginia Commonwealth University, P O Box 842018, Richmond, VA 23284 2018, USA
    Obes Res 12:1367-9. 2004
    ..Although Western society is increasingly obesogenic, some individuals maintain low weights. Thin women manifest fewer eating disorders and higher self-esteem. However, little is known about persistently thin men...
  84. ncbi request reprint Genetic and environmental sources of covariation between generalized anxiety disorder and neuroticism
    John M Hettema
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, P O Box 980126, Richmond, VA 23298 0126, USA
    Am J Psychiatry 161:1581-7. 2004
    ..Because women have higher levels of neuroticism and twice the risk of lifetime generalized anxiety disorder of men, gender-specific effects were also explored...
  85. ncbi request reprint Endorsement frequencies and factor structure of DSM-III-R and DSM-IV Generalized Anxiety Disorder symptoms in women: implications for future research, classification, clinical practice and comorbidity
    Thomas S Kubarych
    Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia 23298 1026, USA
    Int J Methods Psychiatr Res 14:69-81. 2005
    ....
  86. doi request reprint Genetic risk factors for disordered eating in adolescent males and females
    Jessica H Baker
    Department of Psychology, Virginia Commonwealth University, Richmond, VA 23284, USA
    J Abnorm Psychol 118:576-86. 2009
    ..However, only 50% of the genetic risk for this factor is shared between the sexes...
  87. pmc Major depression and coronary artery disease in the Swedish twin registry: phenotypic, genetic, and environmental sources of comorbidity
    Kenneth S Kendler
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298 0126, USA
    Arch Gen Psychiatry 66:857-63. 2009
    ..Major depresssion (MD) and coronary artery disease (CAD) frequently co-occur. The mechanisms of comorbidity are uncertain...
  88. ncbi request reprint Specificity of genetic and environmental risk factors for symptoms of cannabis, cocaine, alcohol, caffeine, and nicotine dependence
    Kenneth S Kendler
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University Medical School, Richmond, VA 23298 0126, USA
    Arch Gen Psychiatry 64:1313-20. 2007
    ..Although genetic risk factors have been found to contribute to dependence on both licit and illicit psychoactive substances, we know little of how these risk factors interrelate...
  89. pmc An investigation of a measure of twins' equal environments
    Karen S Mitchell
    Department of Psychology, Virginia Commonwealth University, Richmond, VA 23284 2018, USA
    Twin Res Hum Genet 10:840-7. 2007
    ..Measurement invariance issues, as well as distributions of equal environments traits, should be considered when evaluating the equal environments assumption, in order to produce accurate parameter estimates in twin models...
  90. pmc MEGF10 association with schizophrenia
    Xiangning Chen
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavior Genetics, Virginia Commonwealth University, Richmond, VA 23298, USA
    Biol Psychiatry 63:441-8. 2008
    ..In this study, we carried out independent replication and expression studies of the MEGF10 gene...
  91. ncbi request reprint Association between broadly defined bulimia nervosa and drug use disorders: common genetic and environmental influences
    Jessica H Baker
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia, USA
    Int J Eat Disord 40:673-8. 2007
    ..Previous research has shown an association between bulimia (BN) and drug use disorders (DUD). The purpose of the present study was to investigate possible influences on the comorbidity between BN and DUD...
  92. pmc A longitudinal twin study of fears from middle childhood to early adulthood: evidence for a developmentally dynamic genome
    Kenneth S Kendler
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University Medical School, Box 980126, 800 E Leigh St, Room 1 123, Richmond, VA 23298 0126, USA
    Arch Gen Psychiatry 65:421-9. 2008
    ..While the nature of common fears changes over development, we do not know whether genetic effects on fear-proneness are developmentally stable or developmentally dynamic...
  93. pmc FBXL21 association with schizophrenia in Irish family and case-control samples
    Xiangning Chen
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavior Genetics, Virginia Commonwealth University, Richmond, Virginia
    Am J Med Genet B Neuropsychiatr Genet 147:1231-7. 2008
    ..0437) and was overrepresented in the ICCSS (P = 0.0177). For both samples, the associated alleles and haplotypes were identical. These data suggested that FBXL21 may be associated with schizophrenia in the Irish samples...
  94. pmc AKT1 is associated with schizophrenia across multiple symptom dimensions in the Irish study of high density schizophrenia families
    Dawn L Thiselton
    Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia 23298 0424, USA
    Biol Psychiatry 63:449-57. 2008
    ..The AKT1 gene has also been implicated in schizophrenia by association studies and decreased protein expression in the brains of schizophrenic patients...
  95. pmc Genetic and environmental influences on alcohol, caffeine, cannabis, and nicotine use from early adolescence to middle adulthood
    Kenneth S Kendler
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Medical School of Virginia Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Arch Gen Psychiatry 65:674-82. 2008
    ..While both environmental and genetic factors are important in the etiology of psychoactive substance use (PSU), we know little of how these influences differ through development...
  96. ncbi request reprint Factor and item-response analysis DSM-IV criteria for abuse of and dependence on cannabis, cocaine, hallucinogens, sedatives, stimulants and opioids
    Nathan A Gillespie
    Department of Psychiatry, Virginia Institute of Psychiatric and Behavioral Genetics, Virginia Commonwealth University, VA 23219 1534, USA
    Addiction 102:920-30. 2007
    ....
  97. pmc Longitudinal modeling of genetic and environmental influences on self-reported availability of psychoactive substances: alcohol, cigarettes, marijuana, cocaine and stimulants
    Nathan A Gillespie
    Department of Psychiatry, Virginia Institute of Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23219 1534, USA
    Psychol Med 37:947-59. 2007
    ..Although an obvious environmental factor influencing drug use, the sources of individual differences in drug availability (DA) are unknown...
  98. ncbi request reprint Identification of susceptibility loci for alcohol-related traits in the Irish Affected Sib Pair Study of Alcohol Dependence
    Po Hsiu Kuo
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23298, USA
    Alcohol Clin Exp Res 30:1807-16. 2006
    ..The goal of this study was to identify genomic regions containing susceptibility loci for alcohol-related traits...
  99. pmc Modeling the genetic and environmental association between peer group deviance and cannabis use in male twins
    Nathan A Gillespie
    Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23219 1534, USA
    Addiction 104:420-9. 2009
    ..Peer group deviance (PGD) is linked strongly to liability to drug use, including cannabis. Our aim was to model the genetic and environmental association, including direction of causation, between PGD and cannabis use (CU)...
  100. pmc Pathways to cannabis abuse: a multi-stage model from cannabis availability, cannabis initiation and progression to abuse
    Nathan A Gillespie
    Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23219 1534, USA
    Addiction 104:430-8. 2009
    ..Our aim is to determine whether the genetic and environmental risk factors for cannabis availability also generate variation in cannabis initiation and/or progression to DSM-IV symptoms of abuse...
  101. ncbi request reprint Caffeine intake, toxicity and dependence and lifetime risk for psychiatric and substance use disorders: an epidemiologic and co-twin control analysis
    Kenneth S Kendler
    Virginia Institute of Psychiatric and Behavioral Genetics, Medical College of Virginia Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Psychol Med 36:1717-25. 2006
    ....

Research Grants54

  1. TWIN-FAMILY STUDY OF DRUG USE, ABUSE, AND DEPENDENCE
    Kenneth Kendler; Fiscal Year: 2002
    ....
  2. GENETIC EPIDEMIOLOGY OF SCHIZOPHRENIA IN IRELAND
    Kenneth Kendler; Fiscal Year: 2002
    ..5 to 1.0 centiMorgans and a cooperative, stable population make Ireland ideal for linkage disequilibrium studies of schizophrenia. ..
  3. IRISH AFFECTED SIB PAIR STUDY OF ALCOHOL DEPENDENCE
    Kenneth Kendler; Fiscal Year: 2001
    ..Phenotypic analyses of the data will focus on detecting familial resemblance for symptoms, factors and typologies of AD to be used to define putative etiologic subtypes of AD for future linkage analyses. ..
  4. The Epidemiology of Mood, Anxiety and Alcohol Disorder
    Kenneth Kendler; Fiscal Year: 2004
    ....
  5. A Twin-Family Study of Drug Use, Abuse, and Dependence
    Kenneth Kendler; Fiscal Year: 2007
    ..abstract_text> ..
  6. THE GENETIC EPIDEMIOLOGY OF SCHIZOPHRENIA IN IRELAND
    Kenneth Kendler; Fiscal Year: 2007
    ..In this competitive renewal, we request 5 further years of support with the primary goals of identifying these pathogenic variant(s) and relating them to the biology of the gene, gene product and disease. ..
  7. Axis I & Axis II Psychiatric Disorders in Norwegian Twin
    Kenneth Kendler; Fiscal Year: 2007
    ..This study has the capacity to address several key and largely unanswered empirical questions about PDs, the answers to which will be critical for proposed revisions in DSM-V. ..
  8. An Irish Affected Sib Pair Study of Alcohol Dependence
    Kenneth Kendler; Fiscal Year: 2005
    ..To conduct this project we have assembled a team of experts in clinical assessment, statistical genetics and molecular genetics...
  9. EPIDEMIOLOGY OF MOOD, ANXIETY AND ALCOHOL DISORDERS
    Kenneth Kendler; Fiscal Year: 1999
    ..We will develop multivariate genetic models including specified environmental risk factors that will provide realistic etiologic models for these disorders that incorporate all major risk factor domains. ..
  10. THE EPIDEMIOLOGY OF MOOD, ANXIETY AND ALCOHOL DISORDERS
    Kenneth Kendler; Fiscal Year: 1993
    ..We will develop multivariate genetic models including specified environmental risk factors that will provide realistic etiologic models for these disorders that incorporate all major risk factor domains...
  11. THE GENETIC EPIDEMIOLOGY OF SCHIZOPHRENIA IN IRELAND
    Kenneth Kendler; Fiscal Year: 1993
    ....
  12. THE GENETIC EPIDEMIOLOGY OF SCHIZOPHRENIA IN IRELAND
    Kenneth Kendler; Fiscal Year: 1991
    ....