K S Kendler

Summary

Affiliation: Virginia Commonwealth University
Country: USA

Publications

  1. ncbi request reprint The diagnostic validity of melancholic major depression in a population-based sample of female twins
    K S Kendler
    Department of Psychiatry and Human Genetics, Medical College of Virginia, Virginia Commonwealth University, Richmond, USA
    Arch Gen Psychiatry 54:299-304. 1997
  2. ncbi request reprint Resemblance of psychotic symptoms and syndromes in affected sibling pairs from the Irish Study of High-Density Schizophrenia Families: evidence for possible etiologic heterogeneity
    K S Kendler
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Richmond 23298 0126, USA
    Am J Psychiatry 154:191-8. 1997
  3. ncbi request reprint Social support: a genetic-epidemiologic analysis
    K S Kendler
    Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, USA
    Am J Psychiatry 154:1398-404. 1997
  4. ncbi request reprint Susceptibility genes for nicotine dependence: a genome scan and followup in an independent sample suggest that regions on chromosomes 2, 4, 10, 16, 17 and 18 merit further study
    R E Straub
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298 1534, USA
    Mol Psychiatry 4:129-44. 1999
  5. ncbi request reprint Genome-wide scans of three independent sets of 90 Irish multiplex schizophrenia families and follow-up of selected regions in all families provides evidence for multiple susceptibility genes
    R E Straub
    Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA
    Mol Psychiatry 7:542-59. 2002
  6. ncbi request reprint A population-based twin study of generalized anxiety disorder in men and women
    J M Hettema
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University, Richmond 23298-0126, USA
    J Nerv Ment Dis 189:413-20. 2001
  7. ncbi request reprint Longitudinal population-based twin study of retrospectively reported premenstrual symptoms and lifetime major depression
    K S Kendler
    Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298 0126, USA
    Am J Psychiatry 155:1234-40. 1998
  8. ncbi request reprint Alcohol dependence is associated with the ZNF699 gene, a human locus related to Drosophila hangover, in the Irish Affected Sib Pair Study of Alcohol Dependence (IASPSAD) sample
    B P Riley
    Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23298 0424, USA
    Mol Psychiatry 11:1025-31. 2006
  9. ncbi request reprint Tobacco consumption in Swedish twins reared apart and reared together
    K S Kendler
    Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, PO Box 980126, Richmond, VA 23298 0126
    Arch Gen Psychiatry 57:886-92. 2000
  10. pmc Replication of association between schizophrenia and ZNF804A in the Irish Case-Control Study of Schizophrenia sample
    B Riley
    Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23298 0424, USA
    Mol Psychiatry 15:29-37. 2010

Collaborators

Detail Information

Publications95

  1. ncbi request reprint The diagnostic validity of melancholic major depression in a population-based sample of female twins
    K S Kendler
    Department of Psychiatry and Human Genetics, Medical College of Virginia, Virginia Commonwealth University, Richmond, USA
    Arch Gen Psychiatry 54:299-304. 1997
    ..If melancholia is a valid subtype of depression, is it quantitatively more severe than or qualitatively distinct from nonmelancholic depression?..
  2. ncbi request reprint Resemblance of psychotic symptoms and syndromes in affected sibling pairs from the Irish Study of High-Density Schizophrenia Families: evidence for possible etiologic heterogeneity
    K S Kendler
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Richmond 23298 0126, USA
    Am J Psychiatry 154:191-8. 1997
    ..The authors sought to determine whether the clinical manifestations of schizophrenia and other psychotic disorders are correlated in affected sibling pairs...
  3. ncbi request reprint Social support: a genetic-epidemiologic analysis
    K S Kendler
    Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, USA
    Am J Psychiatry 154:1398-404. 1997
    ..In this study a longitudinal twin design was used to clarify the etiology of social support...
  4. ncbi request reprint Susceptibility genes for nicotine dependence: a genome scan and followup in an independent sample suggest that regions on chromosomes 2, 4, 10, 16, 17 and 18 merit further study
    R E Straub
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298 1534, USA
    Mol Psychiatry 4:129-44. 1999
    ....
  5. ncbi request reprint Genome-wide scans of three independent sets of 90 Irish multiplex schizophrenia families and follow-up of selected regions in all families provides evidence for multiple susceptibility genes
    R E Straub
    Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA
    Mol Psychiatry 7:542-59. 2002
    ..However, our internal replications, when considered along with the positive results obtained in multiple other samples, suggests that most of these six regions are likely to contain genes that influence liability to schizophrenia...
  6. ncbi request reprint A population-based twin study of generalized anxiety disorder in men and women
    J M Hettema
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University, Richmond 23298-0126, USA
    J Nerv Ment Dis 189:413-20. 2001
    ..The familial aggregation of GAD in this sample was only modest. In the best-fitting models, the heritability of GAD was the same in men and women, estimated at about 15% to 20%, with no effects of gender-specific genes detected...
  7. ncbi request reprint Longitudinal population-based twin study of retrospectively reported premenstrual symptoms and lifetime major depression
    K S Kendler
    Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298 0126, USA
    Am J Psychiatry 155:1234-40. 1998
    ..In addition, we know little about the relationship of the familial risk factors for premenstrual symptoms and major depression...
  8. ncbi request reprint Alcohol dependence is associated with the ZNF699 gene, a human locus related to Drosophila hangover, in the Irish Affected Sib Pair Study of Alcohol Dependence (IASPSAD) sample
    B P Riley
    Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23298 0424, USA
    Mol Psychiatry 11:1025-31. 2006
    ....
  9. ncbi request reprint Tobacco consumption in Swedish twins reared apart and reared together
    K S Kendler
    Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, PO Box 980126, Richmond, VA 23298 0126
    Arch Gen Psychiatry 57:886-92. 2000
    ..Prior studies of twins reared together suggest that regular tobacco use (RTU) is substantially heritable. However, strong social influences on RTU might have biased these results...
  10. pmc Replication of association between schizophrenia and ZNF804A in the Irish Case-Control Study of Schizophrenia sample
    B Riley
    Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23298 0424, USA
    Mol Psychiatry 15:29-37. 2010
    ..This study replicates the original reported association of ZNF804A with schizophrenia and suggests that there is a consistent link between the A allele of rs1344706, increased expression of ZNF804A and risk for schizophrenia...
  11. ncbi request reprint An association study of DRD5 with smoking initiation and progression to nicotine dependence
    P F Sullivan
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Am J Med Genet 105:259-65. 2001
    ..These data are not consistent with a strong etiological role for DRD5 in the etiology of these complex smoking behaviors...
  12. doi request reprint Gambling, disordered gambling and their association with major depression and substance use: a web-based cohort and twin-sibling study
    C Blanco
    Department of Psychiatry, New York State Psychiatric Institute Columbia University, NY, USA
    Psychol Med 42:497-508. 2012
    ..Relatively little is known about the environmental and genetic contributions to gambling frequency and disordered gambling (DG), the full continuum of gambling-related problems that includes pathological gambling (PG)...
  13. ncbi request reprint Catechol-O-methyltransferase and the clinical features of psychosis
    J L McClay
    Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University, Richmond, Virginia 23298 0126, USA
    Am J Med Genet B Neuropsychiatr Genet 141:935-8. 2006
    ..4). These results suggest a modest affective vulnerability conferred by this allele in psychosis, but will require replication...
  14. pmc The trimmed-haplotype test for linkage disequilibrium
    C J MacLean
    Virginia Institute for Psychiatric and Behavioral Genetics, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, 23298, USA
    Am J Hum Genet 66:1062-75. 2000
    ..We present a method for summarizing the LD evidence, in any pedigree, that can be employed in trimmed-haplotype analysis as well as in other methods...
  15. pmc Association study of CSF2RB with schizophrenia in Irish family and case - control samples
    Q Chen
    Department of Psychiatry and Virginia Institute for Psychiatric and Behavior Genetics, Virginia Commonwealth University, Richmond, VA 23298 0424, USA
    Mol Psychiatry 13:930-8. 2008
    ..Since CSF2RB is essential for IL3 signaling, the findings that both IL3 and CSF2RB showed sex-specific and FH-dependent associations suggest that the IL3 pathway is involved in schizophrenia...
  16. ncbi request reprint Clinical features of schizophrenia and linkage to chromosomes 5q, 6p, 8p, and 10p in the Irish Study of High-Density Schizophrenia Families
    K S Kendler
    Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA 23298 0710, USA
    Am J Psychiatry 157:402-8. 2000
    ..Recent linkage studies suggest that multiple genes are important in the etiology of schizophrenia. The authors examined the hypothesis of whether the clinical variability in schizophrenia is due to genetic heterogeneity...
  17. ncbi request reprint The Roscommon Family Study. III. Schizophrenia-related personality disorders in relatives
    K S Kendler
    Department of Psychiatry, Medical College of Virginia Virginia Commonwealth University, Richmond
    Arch Gen Psychiatry 50:781-8. 1993
    ....
  18. ncbi request reprint Variants in the catechol-o-methyltransferase (COMT) gene are associated with schizophrenia in Irish high-density families
    X Chen
    Department of Psychiatry and Virginia Institute for Psychiatric and Behavior Genetics, Virginia Commonwealth University, 800 E Leigh Street, Richmond, VA 23298, USA
    Mol Psychiatry 9:962-7. 2004
    ..We concluded that COMT gene is associated with schizophrenia and carries a small but significant risk to the susceptibility in the Irish subjects...
  19. ncbi request reprint Sibling correlation of deficit syndrome in the Irish study of high-density schizophrenia families
    D E Ross
    Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298 0710, USA
    Am J Psychiatry 157:1071-6. 2000
    ..Little is known about the familial or genetic aspects of the deficit syndrome. The purpose of this study was to determine whether deficit versus nondeficit subtypes are correlated in sibling pairs affected with schizophrenia...
  20. ncbi request reprint Association between glutamic acid decarboxylase genes and anxiety disorders, major depression, and neuroticism
    J M Hettema
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Mol Psychiatry 11:752-62. 2006
    ..Subject to confirmation in an independent sample, our study suggests that variations in the GAD1 gene may contribute to individual differences in N and impact susceptibility across a range of anxiety disorders and major depression...
  21. pmc A psychometric evaluation of the DSM-IV borderline personality disorder criteria: age and sex moderation of criterion functioning
    S H Aggen
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Psychol Med 39:1967-78. 2009
    ....
  22. ncbi request reprint Identification of a high-risk haplotype for the dystrobrevin binding protein 1 (DTNBP1) gene in the Irish study of high-density schizophrenia families
    E J C G van den Oord
    Department of Psychiatry and Virginia Institute for Psychiatric and Behavioral Genetics, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Mol Psychiatry 8:499-510. 2003
    ..Implications of these findings for follow-up and replication studies are discussed...
  23. ncbi request reprint Marker-to-marker linkage disequilibrium on chromosomes 5q, 6p, and 8p in Irish high-density schizophrenia pedigrees
    K S Kendler
    Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298 0126, USA
    Am J Med Genet 88:29-33. 1999
    ..Thus, in Irish families selected for a high density of schizophrenia, M-M LD may be very common within 0.5 cM and frequent up to distances of 2 cM...
  24. ncbi request reprint Gender differences in the rates of exposure to stressful life events and sensitivity to their depressogenic effects
    K S Kendler
    Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, USA
    Am J Psychiatry 158:587-93. 2001
    ..The results suggest that the greater prevalence of major depression in women versus men is due neither to differences in the rates of reported stressful life events nor to differential sensitivity to their pathogenic effect...
  25. pmc Association study between the serotonin 1A receptor (HTR1A) gene and neuroticism, major depression, and anxiety disorders
    J M Hettema
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298 0126, USA
    Am J Med Genet B Neuropsychiatr Genet 147:661-6. 2008
    ..Our data suggests that the HTR1A gene may not play a major role in the genetic susceptibility underlying depressive and anxiety-related phenotypes...
  26. pmc GWA study data mining and independent replication identify cardiomyopathy-associated 5 (CMYA5) as a risk gene for schizophrenia
    X Chen
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298 0424, USA
    Mol Psychiatry 16:1117-29. 2011
    ..On the basis of these results, we concluded that CMYA5 is associated with schizophrenia and further investigation of the gene is warranted...
  27. ncbi request reprint Pregnancy and perinatal complications associated with risks for common psychiatric disorders in a population-based sample of female twins
    D L Foley
    Department of Human Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298-0003, USA
    Am J Med Genet 105:426-31. 2001
    ..Pregnancy and perinatal complications may be associated with an increased risk for eating disorders in women...
  28. ncbi request reprint Interleukin 3 and schizophrenia: the impact of sex and family history
    X Chen
    Department of Psychiatry and Virginia Institute for Psychiatric and Behavior Genetics, Virginia Commonwealth University, Richmond, VA 23298, USA
    Mol Psychiatry 12:273-82. 2007
    ..They may explain the sex-specific associations and be functional for the expression of IL3 gene...
  29. ncbi request reprint Evidence for a schizophrenia vulnerability locus on chromosome 8p in the Irish Study of High-Density Schizophrenia Families
    K S Kendler
    Departments of Psychiatry and Human Genetics, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298 0126, USA
    Am J Psychiatry 153:1534-40. 1996
    ..This study was an attempt to replicate evidence for a vulnerability locus for schizophrenia and associated disorders in the 8p22-21 region reported by Pulver and colleagues...
  30. ncbi request reprint Latent class analysis of lifetime depressive symptoms in the national comorbidity survey
    P F Sullivan
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond 23298 0126, USA
    Am J Psychiatry 155:1398-406. 1998
    ..In a prior report, the authors used latent class analysis (LCA) to identify a distinctive atypical depressive subtype; they sought to replicate that finding in the current study...
  31. ncbi request reprint A multivariate genetic analysis of the use of tobacco, alcohol, and caffeine in a population based sample of male and female twins
    J M Hettema
    Virginia Institute for Psychiatric and Behavioral Genetics, and Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298 0126, USA
    Drug Alcohol Depend 57:69-78. 1999
    ..Underlying genetic and individual environmental risk factors produce liability to (poly)substance use in general; substance specific factors also play an important etiologic role...
  32. ncbi request reprint Evaluating the spectrum concept of schizophrenia in the Roscommon Family Study
    K S Kendler
    Department of Psychiatry, Medical College of Virginia, Richmond 23298 0710, USA
    Am J Psychiatry 152:749-54. 1995
    ..The authors sought to evaluate whether the pattern of schizophrenia and related disorders in probands and their relatives can be explained by a single underlying continuum of liability to the "schizophrenia spectrum."..
  33. ncbi request reprint The effects of anxiety, substance use and conduct disorders on risk of major depressive disorder
    J M Hettema
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Medical College of Virginia Campus of Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Psychol Med 33:1423-32. 2003
    ..Major depressive disorder (MDD) is highly co-morbid with other Axis I disorders, which commonly precede its onset. We sought to determine the level and periods of risk for MDD posed by prior or co-occurring psychiatric disorders...
  34. pmc Association of the histidine-triad nucleotide-binding protein-1 (HINT1) gene variants with nicotine dependence
    K J Jackson
    Department of Psychiatry and Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298, USA
    Pharmacogenomics J 11:251-7. 2011
    ..These results indicate a genetic association between HINT1 variants and ND, and indicate that nicotine-induced modulation of HINT1 level may be involved in mechanisms of excess smoking...
  35. ncbi request reprint The genetic epidemiology of irrational fears and phobias in men
    K S Kendler
    Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University, 800 E Leigh St, PO Box 980126, Richmond, VA 23298-0126, USA
    Arch Gen Psychiatry 58:257-65. 2001
    ..Family environment probably has an impact on risk for agoraphobia and social phobia. The genetic liability to blood/injury phobias is not distinct from those of the more typical phobias...
  36. pmc Multicenter linkage study of schizophrenia candidate regions on chromosomes 5q, 6q, 10p, and 13q: schizophrenia linkage collaborative group III
    D F Levinson
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, 19104, USA
    Am J Hum Genet 67:652-63. 2000
    ..0038). More-modest support for linkage was observed for chromosome 10p, with logistic-regression analysis of linkage producing an empirical P=. 045 and with significant evidence for intersample heterogeneity (empirical P=.0096)...
  37. ncbi request reprint Sex-specific genetic influences on the comorbidity of alcoholism and major depression in a population-based sample of US twins
    C A Prescott
    Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298 0126, USA
    Arch Gen Psychiatry 57:803-11. 2000
    ..We studied the importance of genetic influences on risk for lifetime comorbidity of major depression and alcoholism by means of a population-based twin sample...
  38. ncbi request reprint A region of 35 kb containing the trace amine associate receptor 6 (TAAR6) gene is associated with schizophrenia in the Irish study of high-density schizophrenia families
    V Vladimirov
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298 0424, USA
    Mol Psychiatry 12:842-53. 2007
    ..004) and hallucinations (P<0.0004), supporting the family-based association with schizophrenia...
  39. ncbi request reprint A genetically informative developmental study of the relationship between conduct disorder and peer deviance in males
    K S Kendler
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University Medical School, Richmond, VA 23298 0126, USA
    Psychol Med 38:1001-11. 2008
    ..Although levels of CD and PD are strongly correlated, the causal relationship between them has remained controversial and has not been examined by a genetically informative study...
  40. pmc Association analysis of the PIP4K2A gene on chromosome 10p12 and schizophrenia in the Irish study of high density schizophrenia families (ISHDSF) and the Irish case-control study of schizophrenia (ICCSS)
    D L Thiselton
    Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia 23298 0424, USA
    Am J Med Genet B Neuropsychiatr Genet 153:323-31. 2010
    ..This study supports a minor role for PIP4K2A in schizophrenia etiology in the Irish population...
  41. ncbi request reprint Relationship between positive and negative symptoms of schizophrenia and schizotypal symptoms in nonpsychotic relatives
    A Fanous
    Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, USA
    Arch Gen Psychiatry 58:669-73. 2001
    ..We therefore sought to clarify the relationship between positive and negative symptoms of schizophrenic probands and dimensions of schizotypy in their first-degree relatives...
  42. ncbi request reprint Family characteristics of deficit and nondeficit schizophrenia in the Roscommon Family Study
    B Kirkpatrick
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland, Baltimore, MD 21228, USA
    Schizophr Res 45:57-64. 2000
    ..The deficit syndrome may be a useful phenotype in genetic linkage studies...
  43. pmc A latent class approach to the external validation of respiratory and non-respiratory panic subtypes
    R Roberson-Nay
    Department of Psychiatry, Virginia Commonwealth University, Virginia Institute for Psychiatric and Behavioral Genetics, P O Box 980489, Richmond, VA 23298, USA
    Psychol Med 42:461-74. 2012
    ..e. severity) dimension only; or (3) qualitatively from one another...
  44. ncbi request reprint Does the level of family dysfunction moderate the impact of genetic factors on the personality trait of neuroticism?
    K S Kendler
    Department of Psychiatry, Medical College of Virginia Virginia Commonwealth University and Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, VA, USA
    Psychol Med 33:817-25. 2003
    ..Can a similar pattern be seen for the personality trait of Neuroticism (N)-which is a risk factor for many psychiatric conditions?..
  45. ncbi request reprint Boundaries of major depression: an evaluation of DSM-IV criteria
    K S Kendler
    Virginia Institute for Psychiatric and Behavioral Genetics, Medical College of Virginia of Virginia Commonwealth University, Richmond, USA
    Am J Psychiatry 155:172-7. 1998
    ..Little is known about the boundaries between major depression and milder subsyndromal depressive states. With respect to depressive symptoms, does DSM-IV "carve nature at its joints"?..
  46. pmc A developmental twin study of symptoms of anxiety and depression: evidence for genetic innovation and attenuation
    K S Kendler
    Virginia Institute of Psychiatric and Behavioral Genetics, Medical College of Virginia Virginia Commonwealth University, Richmond, VA, USA
    Psychol Med 38:1567-75. 2008
    ..Analysis conducted using the Mx program included SxAnxDep by parental and self-report...
  47. doi request reprint The genetic and environmental relationship between major depression and the five-factor model of personality
    K S Kendler
    Departments of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Psychol Med 40:801-6. 2010
    ....
  48. ncbi request reprint Twin studies of psychiatric illness: an update
    K S Kendler
    Department of Psychiatry, Medical College of Virginia Hospitals at Virginia Commonwealth University, Box 980126, Richmond, VA 23298-0126, USA
    Arch Gen Psychiatry 58:1005-14. 2001
    ..Twin studies remain a vibrant part of the field of psychiatric genetics and an important complement to and context for current efforts to localize individual susceptibility genes...
  49. ncbi request reprint A review and meta-analysis of the genetic epidemiology of anxiety disorders
    J M Hettema
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Pychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond, 23298-0126, USA
    Am J Psychiatry 158:1568-78. 2001
    ..The role of nonshared environmental experience is significant, underscoring the importance of identifying putative environmental risk factors that predispose individuals to anxiety...
  50. pmc Should the diagnosis of major depression be made independent of or dependent upon the psychosocial context?
    K S Kendler
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA 23298 0126, USA
    Psychol Med 40:771-80. 2010
    ..For other syndromes (e.g. schizophrenia), the context is generally irrelevant. Should the diagnosis of major depression (MD) be made dependent upon or independent of the psychosocial context in which it occurs?..
  51. ncbi request reprint Association of the tryptophan hydroxylase gene with smoking initiation but not progression to nicotine dependence
    P F Sullivan
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Am J Med Genet 105:479-84. 2001
    ..If these results replicate in other samples, the serotonergic system may be involved in the etiology of smoking initiation given the rate-limiting role of TPH in the biosynthesis of serotonin...
  52. ncbi request reprint Analysis of epistasis in linked regions in the Irish study of high-density schizophrenia families
    P F Sullivan
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Am J Med Genet 105:266-70. 2001
    ..No correlation reached our a priori level of statistical significance. Using this statistical approach, we did not find evidence of important epistatic effects among these six regions in the ISHDSF...
  53. ncbi request reprint The joint analysis of personal interview and family history diagnoses: evidence for validity of diagnosis and increased heritability estimates
    K S Kendler
    Virginia Institute for Psychiatric and Behavioral Genetics and Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University, Richmond 23298 0126, USA
    Psychol Med 32:829-42. 2002
    ..Reports by family members provide additional information but may be biased. It is unclear how best to combine these two sources of diagnostic data...
  54. pmc A twin study of specific bulimia nervosa symptoms
    S E Mazzeo
    Department of Psychology, Virginia Commonwealth University, Richmond, VA 23284 2018, USA
    Psychol Med 40:1203-13. 2010
    ..The validity of the equal environment assumption (EEA) for BN was also tested...
  55. ncbi request reprint No evidence for linkage or association of neuregulin-1 (NRG1) with disease in the Irish study of high-density schizophrenia families (ISHDSF)
    D L Thiselton
    Department of Psychiatry, Virginia Institute of Psychiatric and Behavioural Genetics, Virginia Commonwealth University, Richmond, VA, USA
    Mol Psychiatry 9:777-83; image 729. 2004
    ..We therefore conclude that if NRG1 does contain susceptibility alleles for schizophrenia, they impact quite weakly on risk in the ISHDSF...
  56. pmc Assessing the heritability of anorexia nervosa symptoms using a marginal maximal likelihood approach
    S E Mazzeo
    Department of Psychology, Virginia Commonwealth University, Richmond, VA 23284 2018, USA
    Psychol Med 39:463-73. 2009
    ..We examined genetic and environmental contributions to liability to anorexia nervosa (AN) symptoms in a population-based twin sample using a genetic common pathway model...
  57. pmc Predicting alcohol consumption in adolescence from alcohol-specific and general externalizing genetic risk factors, key environmental exposures and their interaction
    K S Kendler
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA, USA
    Psychol Med 41:1507-16. 2011
    ..We have limited knowledge of how these risk factors inter-relate through development...
  58. ncbi request reprint Caffeine intake, tolerance, and withdrawal in women: a population-based twin study
    K S Kendler
    Department of Psychiatry, Medical College of Virginia Virginia Commonwealth University, and the Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, USA
    Am J Psychiatry 156:223-8. 1999
    ..However, the impact of genetic factors on caffeine consumption, heavy use, intoxication, tolerance, and withdrawal is largely unknown...
  59. pmc Borderline personality disorder traits and their relationship with dimensions of normative personality: a web-based cohort and twin study
    K S Kendler
    Virginia Institute of Psychiatric and Behavioral Genetics, Medical College of Virginia Virginia Commonwealth University, Richmond, VA, USA
    Acta Psychiatr Scand 123:349-59. 2011
    ..To describe the structure of genetic and environmental risk factors for four dimensions of borderline personality disorder (BPD) and to understand the source of resemblance of these dimensions and normal personality...
  60. ncbi request reprint Clinical features of psychotic disorders and polymorphisms in HT2A, DRD2, DRD4, SLC6A3 (DAT1), and BDNF: a family based association study
    Ayman H Fanous
    Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia, USA
    Am J Med Genet B Neuropsychiatr Genet 125:69-78. 2004
    ..However, given prior evidence of involvement of the proteins encoded by these genes in psychopathology, our results suggest that more attention should be focused on the impact of these alleles on clinical features of schizophrenia...
  61. ncbi request reprint A schizophrenia locus may be located in region 10p15-p11
    R E Straub
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Medical College of Virginia Virginia Commonwealth University, Richmond 23219 1534, USA
    Am J Med Genet 81:296-301. 1998
    ..When evaluated in the context of our genome scan results, the evidence suggests the possibility of a fourth vulnerability locus for schizophrenia in these Irish families, in region 10p15-p11...
  62. ncbi request reprint Sex differences in the sources of genetic liability to alcohol abuse and dependence in a population-based sample of U.S. twins
    C A Prescott
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University, Richmond 23298 0126, USA
    Alcohol Clin Exp Res 23:1136-44. 1999
    ..S. adults. The goal of this study was to test whether the magnitude and sources of genetic and environmental influences on liability for alcohol abuse and dependence differ for men and women...
  63. ncbi request reprint Personality and the experience of environmental adversity
    K S Kendler
    Virginia Institute for Psychiatry and Behavioral Genetics, Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Psychol Med 33:1193-202. 2003
    ..g. environment to person), individuals probably make important contributions to the quality of their environments (person to environment)...
  64. ncbi request reprint Neuroticism, major depression and gender: a population-based twin study
    A Fanous
    Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University and Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, USA
    Psychol Med 32:719-28. 2002
    ..Females have both higher levels of N and higher rates of MD than males, suggesting that these traits may be more genetically correlated in females...
  65. ncbi request reprint Genetic risk, number of previous depressive episodes, and stressful life events in predicting onset of major depression
    K S Kendler
    Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, USA
    Am J Psychiatry 158:582-6. 2001
    ..How do genetic risk factors for major depression impact on this "kindling" phenomenon? In particular, do those at high genetic risk exhibit an increase in the speed of kindling, or are they "prekindled"?..
  66. ncbi request reprint Monozygotic twins discordant for major depression: a preliminary exploration of the role of environmental experiences in the aetiology and course of illness
    K S Kendler
    Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University and Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, USA
    Psychol Med 31:411-23. 2001
    ..Genetic effects upon behaviour are pervasive. To what extent are the many correlates of major depression (MD) due to individual-specific environmental experiences versus genetic factors correlated with risk for MD?..
  67. ncbi request reprint Cannabis use in the last year in a US national sample of twin and sibling pairs
    K S Kendler
    Department of Psychiatry, Medical College of Virginia Virginia Commonwealth University and Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, USA
    Psychol Med 32:551-4. 2002
    ..We seek to replicate these results in a US national probability sample of twin and sibling pairs examining only last year cannabis use...
  68. pmc A whole genome association study of neuroticism using DNA pooling
    S Shifman
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Mol Psychiatry 13:302-12. 2008
    ..Our findings argue the need for much larger samples than anticipated in genetic association studies and that the biological basis of emotional disorders is extremely complex...
  69. ncbi request reprint Clinical indices of familial depression in the Swedish Twin Registry
    K S Kendler
    Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, USA
    Acta Psychiatr Scand 115:214-20. 2007
    ..Although familial factors certainly contribute to the etiology of major depression (MD), further information is needed about which clinical features of depressive illness index the familial vulnerability in MD...
  70. ncbi request reprint Sex differences in genetic and environmental risk factors for irrational fears and phobias
    K S Kendler
    Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, USA
    Psychol Med 32:209-17. 2002
    ..How does sex impact on the familial transmission of liability to fears and phobias?..
  71. ncbi request reprint Genetic and environmental risk factors for depression assessed by subject-rated symptom check list versus structured clinical interview
    D L Foley
    Virginia Commonwealth University, Virginia Institute for Psychiatric and Behavioral Genetics, Department of Human Genetics, Richmond 23298-0003, USA
    Psychol Med 31:1413-23. 2001
    ..SCL depression scores may therefore be a useful screening measure for many of the genetic risk factors which influence liability to major depression...
  72. ncbi request reprint Panic syndromes in a population-based sample of male and female twins
    K S Kendler
    Virginia Institute for Psychiatric and Behavioral Genetics and the Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University, Richmond 23298-0126, USA
    Psychol Med 31:989-1000. 2001
    ..to a similar degree, on the liability to PD in males and females...
  73. ncbi request reprint Genetic and environemental factors in conduct problems and adult antisocial behavior among adult female twins
    R B Goldstein
    ROW Sciences, Inc, Rockville, Maryland, USA
    J Nerv Ment Dis 189:201-9. 2001
    ....
  74. ncbi request reprint Haplotypes of four novel single nucleotide polymorphisms in the nicotinic acetylcholine receptor beta2-subunit (CHRNB2) gene show no association with smoking initiation or nicotine dependence
    M A Silverman
    Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia 23219 1534, USA
    Am J Med Genet 96:646-53. 2000
    ..None of the four polymorphisms we tested, nor their estimated haplotypes, were associated with smoking initiation or progression to nicotine dependence...
  75. ncbi request reprint Evidence for genetic influences on sleep disturbance and sleep pattern in twins
    A C Heath
    Department of Human Genetics, Medical College of Virginia, Richmond
    Sleep 13:318-35. 1990
    ..Short-term environmental fluctuations accounted for as much as 30% of the variance, and more stable nonfamilial environmental effects accounted for the remainder. No effect of shared family environment on sleep characteristics was found...
  76. pmc LRRTM1 on chromosome 2p12 is a maternally suppressed gene that is associated paternally with handedness and schizophrenia
    C Francks
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Mol Psychiatry 12:1129-39, 1057. 2007
    ..LRRTM1 is a candidate gene for involvement in several common neurodevelopmental disorders, and may have played a role in human cognitive and behavioral evolution...
  77. ncbi request reprint Genetic heterogeneity, modifier genes, and quantitative phenotypes in psychiatric illness: searching for a framework
    A H Fanous
    Washington VA Medical Center, Georgetown University Medical Center Schizophrenia Research Program, Washington DC 20008, USA
    Mol Psychiatry 10:6-13. 2005
    ..We describe five classes of genes and their predictions of the outcomes of family, twin, and several types of linkage studies. We go on to explore how these predictions can in turn be used to aid in the design of linkage studies...
  78. ncbi request reprint Illicit drug use and abuse/dependence: modeling of two-stage variables using the CCC approach
    A Agrawal
    Department of Human Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Box 980003 Suite 1 154, Richmond, VA 23298 0003, USA
    Addict Behav 30:1043-8. 2005
    ..Finally, sexes could be equated for all illicit drugs. The findings of this study emphasize the need for models that can partition the sources of individual differences into common and stage-specific influences...
  79. ncbi request reprint Genomewide linkage study in the Irish affected sib pair study of alcohol dependence: evidence for a susceptibility region for symptoms of alcohol dependence on chromosome 4
    C A Prescott
    Department of Psychology, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, USA
    Mol Psychiatry 11:603-11. 2006
    ..The results of this study suggest the importance of genetic variation in chromosome 4 in the etiology and severity of alcoholism in Caucasian populations...
  80. ncbi request reprint Gender differences in binge-eating: a population-based twin study
    T Reichborn-Kjennerud
    Department of Epidemiology, The Norwegian Institute of Public Health, Oslo, Norway
    Acta Psychiatr Scand 108:196-202. 2003
    ..To assess whether genetic and environmental effects on liability to binge-eating (BE) are of equal importance for males and females and whether the same genetic risk factors predispose to BE in the two sexes...
  81. ncbi request reprint Linkage analysis of smoking initiation and quantity in Dutch sibling pairs
    J M Vink
    Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands
    Pharmacogenomics J 4:274-82. 2004
    ..66) for SI and on chromosome 3 (LOD=1.98) for NC. Strikingly, on chromosome 10 a peak was found in the same region for both SI (LOD=1.92) and for NC (LOD=2.29) which may partly explain the overlapping etiological factors for SI and NC...
  82. ncbi request reprint Time, memory and the heritability of major depression
    K S Kendler
    Department of Psychiatry, Medical College of Virginia, of Virginia Commonwealth University, Richmond, USA
    Psychol Med 31:923-8. 2001
    ..Could the estimates of heritability of MD be biased by the well-demonstrated genetic influences on memory?..
  83. ncbi request reprint Interpersonal dependence and major depression: aetiological inter-relationship and gender differences
    V A Sanathara
    Virginia Institute for Psychiatry and Behavioral Genetics and Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA, USA
    Psychol Med 33:927-31. 2003
    ....
  84. ncbi request reprint FP-TDI SNP scoring by manual and statistical procedures: a study of error rates and types
    E J C G van den Oord
    Department of Psychiatry, Virginia Commonwealth University, P O Box 980126, Richmond, VA 23298 0126, USA
    Biotechniques 34:610-6, 618-20, 622 passim. 2003
    ..There were 3.3% more missing genotypes in the manual scoring due to errors in data manipulation (1.7%) and conservative scoring (1.6%)...
  85. ncbi request reprint Multicenter linkage study of schizophrenia loci on chromosome 22q
    B J Mowry
    Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, Queensland, Australia
    Mol Psychiatry 9:784-95. 2004
    ..We interpret these findings to mean that the population-wide effects of putative 22q schizophrenia susceptibility loci are too weak to detect with linkage analysis even in large samples...
  86. ncbi request reprint Fatigue in a community sample of twins
    P F Sullivan
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Psychol Med 33:263-81. 2003
    ..Fatigue is a complex symptom associated with many physiological, psychological and pathological processes. Its correlates and typology remain inadequately understood...
  87. ncbi request reprint RhoA, encoding a Rho GTPase, is associated with smoking initiation
    X Chen
    Virginia Institute for Psychiatric and Behavioral Genetics and Department of Psychiatry, Richmond, VA, USA
    Genes Brain Behav 6:689-97. 2007
    ..Our results indicated that the RhoA gene is likely involved in initiation of tobacco smoking and ND. Replication and future model system studies will be needed to validate the role of RhoA gene in SI and ND...
  88. ncbi request reprint Childhood parental loss and risk for first-onset of major depression and alcohol dependence: the time-decay of risk and sex differences
    K S Kendler
    Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, USA
    Psychol Med 32:1187-94. 2002
    ....
  89. pmc Avoidant personality disorder is a separable schizophrenia-spectrum personality disorder even when controlling for the presence of paranoid and schizotypal personality disorders The UCLA family study
    D L Fogelson
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, USA
    Schizophr Res 91:192-9. 2007
    ..This indicates that APD is a separate Sz-spectrum disorder, and not merely a sub-clinical form of SPD or PPD...
  90. ncbi request reprint Significant correlation in linkage signals from genome-wide scans of schizophrenia and schizotypy
    A H Fanous
    Mental Health Service Line, Washington VA Medical Center, Washington, DC 20422, USA
    Mol Psychiatry 12:958-65. 2007
    ..Power may therefore be increased in molecular genetic studies of schizophrenia if they incorporate measures of schizotypy in non-psychotic relatives...
  91. ncbi request reprint A twin study of sex differences in social support
    A Agrawal
    Medical College of Virginia of Virginia Commonwealth University, Virginia Institute for Psychiatric and Behavioral Genetics, Department of Human Genetics, Richmond 23298, USA
    Psychol Med 32:1155-64. 2002
    ..A relationship between social roles and personality with social support suggests possible sex effects on the sources of individual differences in social support...
  92. ncbi request reprint Genetic risk factors for major depression in men and women: similar or different heritabilities and same or partly distinct genes?
    K S Kendler
    Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University and Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, USA
    Psychol Med 31:605-16. 2001
    ..Is the heritability of MD different in men and women? Do the same genetic risk factors predispose to MD in the two sexes?..
  93. ncbi request reprint Are there sex differences in the reliability of a lifetime history of major depression and its predictors?
    K S Kendler
    Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University and Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, USA
    Psychol Med 31:617-25. 2001
    ..Given the large impact of sex on risk for LTMD, it is of interest to know if there are sex differences in the reliability of LTMD and its predictors...
  94. ncbi request reprint Family history information in biomedical research
    K S Kendler
    Departments of Psychiatry and Human Genetics, Medical College of Virginia/Virginia Commonwealth University, Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, Virginia, USA
    J Contin Educ Health Prof 21:215-23. 2001
    ..Adding special restrictions for the collection of family history information on psychiatric and drug abuse disorders may reinforce stigma and substantially burden researchers examining these vital public health problems...
  95. ncbi request reprint The prediction of thoughts of death or self-harm in a population-based sample of female twins
    A H Fanous
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA
    Psychol Med 34:301-12. 2004
    ..Although suicide is a leading cause of death, few studies have attempted to predict suicidal ideation prospectively using epidemiological samples or multivariate methods...