Post-transcriptional regulation of noise in protein distributions during gene expressionTao Jia
Department of Physics, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA
Phys Rev Lett 105:018101. 2010
..The results obtained also demonstrate how different sources of intrinsic noise in gene expression can be discriminated based on observations of regulated protein distributions...
Intrinsic noise in stochastic models of gene expression with molecular memory and burstingTao Jia
Department of Physics, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA
Phys Rev Lett 106:058102. 2011
..The analytical expressions obtained provide insight into the role of transcriptional, post-transcriptional, and post-translational mechanisms in controlling the noise in gene expression...
Connecting protein and mRNA burst distributions for stochastic models of gene expressionVlad Elgart
Department of Physics, Virginia Tech, Blacksburg, VA 24061, USA
Phys Biol 8:046001. 2011
..The analytical results obtained in this work can thus serve as useful inputs for a broad range of studies focusing on stochasticity in gene expression...
Regulation by small RNAs via coupled degradation: mean-field and variational approachesThierry Platini
Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA
Phys Rev E Stat Nonlin Soft Matter Phys 84:021928. 2011
..The proposed approach can be applied for quantitative modeling of stochastic gene expression in complex regulatory networks...
Quantifying mRNA synthesis and decay rates using small RNAsVlad Elgart
Department of Physics, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA
Biophys J 98:2780-4. 2010
..Our analysis suggests experimental protocols for determining parameters controlling the efficiency of stoichiometric regulation by small RNAs and for analyzing factors and processes regulating changes in mRNA transcription and decay...
Applications of Little's Law to stochastic models of gene expressionVlad Elgart
Department of Physics, Virginia Polytechnic Institute and State University, Blacksburg, 24060, USA
Phys Rev E Stat Nonlin Soft Matter Phys 82:021901. 2010
..The results obtained show that the degree of transcriptional bursting can, in principle, be determined from changes in mean steady-state protein levels for general stochastic models of gene expression...
Stochastic modeling of regulation of gene expression by multiple small RNAsCHARLES BAKER
Department of Physics, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA
Phys Rev E Stat Nonlin Soft Matter Phys 85:061915. 2012
..In particular, we show that, in contrast to regulation by a single sRNA, multiple sRNAs provide a mechanism for independently controlling the mean and variance of the regulated protein distribution...