J M Hettema

Summary

Affiliation: Virginia Commonwealth University
Country: USA

Publications

  1. pmc Pilot multimodal twin imaging study of generalized anxiety disorder
    John M Hettema
    Departments of Psychiatry, State University of New York Upstate Medical University, Syracuse, New York, USA
    Depress Anxiety 29:202-9. 2012
  2. pmc Association study between the serotonin 1A receptor (HTR1A) gene and neuroticism, major depression, and anxiety disorders
    J M Hettema
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298 0126, USA
    Am J Med Genet B Neuropsychiatr Genet 147:661-6. 2008
  3. pmc The genetic covariation between fear conditioning and self-report fears
    John M Hettema
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia 23298 0126, USA
    Biol Psychiatry 63:587-93. 2008
  4. doi The nosologic relationship between generalized anxiety disorder and major depression
    John M Hettema
    Virginia Institute for Psychiatry and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia
    Depress Anxiety 25:300-16. 2008
  5. doi What is the genetic relationship between anxiety and depression?
    John M Hettema
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Am J Med Genet C Semin Med Genet 148:140-6. 2008
  6. pmc Catechol-O-methyltransferase contributes to genetic susceptibility shared among anxiety spectrum phenotypes
    John M Hettema
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, 23298 0126, USA
    Biol Psychiatry 64:302-10. 2008
  7. pmc Association study of CREB1 with Major Depressive Disorder and related phenotypes
    John M Hettema
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, 23298 0126, USA
    Am J Med Genet B Neuropsychiatr Genet 150:1128-32. 2009
  8. pmc Prioritization and association analysis of murine-derived candidate genes in anxiety-spectrum disorders
    John M Hettema
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298 0126, USA
    Biol Psychiatry 70:888-96. 2011
  9. ncbi Association between glutamic acid decarboxylase genes and anxiety disorders, major depression, and neuroticism
    J M Hettema
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Mol Psychiatry 11:752-62. 2006
  10. ncbi A population-based twin study of generalized anxiety disorder in men and women
    J M Hettema
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University, Richmond 23298-0126, USA
    J Nerv Ment Dis 189:413-20. 2001

Research Grants

Detail Information

Publications32

  1. pmc Pilot multimodal twin imaging study of generalized anxiety disorder
    John M Hettema
    Departments of Psychiatry, State University of New York Upstate Medical University, Syracuse, New York, USA
    Depress Anxiety 29:202-9. 2012
    ..Neuroimaging studies have begun to implicate particular neural structures and circuitry in its pathophysiology; however, no genetically informative research has examined the potential sources of reported brain differences...
  2. pmc Association study between the serotonin 1A receptor (HTR1A) gene and neuroticism, major depression, and anxiety disorders
    J M Hettema
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298 0126, USA
    Am J Med Genet B Neuropsychiatr Genet 147:661-6. 2008
    ..Our data suggests that the HTR1A gene may not play a major role in the genetic susceptibility underlying depressive and anxiety-related phenotypes...
  3. pmc The genetic covariation between fear conditioning and self-report fears
    John M Hettema
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia 23298 0126, USA
    Biol Psychiatry 63:587-93. 2008
    ..Although prior studies have demonstrated that fear conditioning and self-report fears are heritable, no studies have determined whether they share a common genetic basis...
  4. doi The nosologic relationship between generalized anxiety disorder and major depression
    John M Hettema
    Virginia Institute for Psychiatry and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia
    Depress Anxiety 25:300-16. 2008
    ....
  5. doi What is the genetic relationship between anxiety and depression?
    John M Hettema
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Am J Med Genet C Semin Med Genet 148:140-6. 2008
    ..Molecular genetic studies of these conditions, though too early to draw firm conclusions, thus far provide tentative support for specific genetic loci that may generally influence susceptibility across the anxiety-depressive spectrum...
  6. pmc Catechol-O-methyltransferase contributes to genetic susceptibility shared among anxiety spectrum phenotypes
    John M Hettema
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, 23298 0126, USA
    Biol Psychiatry 64:302-10. 2008
    ..Catechol-O-methyltransferase (COMT) has been investigated for its possible role in a wide range of psychiatric phenotypes. In particular, several studies support association of this gene with panic disorder and other anxiety-related traits...
  7. pmc Association study of CREB1 with Major Depressive Disorder and related phenotypes
    John M Hettema
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, 23298 0126, USA
    Am J Med Genet B Neuropsychiatr Genet 150:1128-32. 2009
    ..However, none of these markers were significant in stage 2 in either sex individually or combined. Our data suggests that common variations in the CREB1 gene do not appear to increase susceptibility for MDD or related phenotypes...
  8. pmc Prioritization and association analysis of murine-derived candidate genes in anxiety-spectrum disorders
    John M Hettema
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298 0126, USA
    Biol Psychiatry 70:888-96. 2011
    ....
  9. ncbi Association between glutamic acid decarboxylase genes and anxiety disorders, major depression, and neuroticism
    J M Hettema
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Mol Psychiatry 11:752-62. 2006
    ..Subject to confirmation in an independent sample, our study suggests that variations in the GAD1 gene may contribute to individual differences in N and impact susceptibility across a range of anxiety disorders and major depression...
  10. ncbi A population-based twin study of generalized anxiety disorder in men and women
    J M Hettema
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University, Richmond 23298-0126, USA
    J Nerv Ment Dis 189:413-20. 2001
    ..The familial aggregation of GAD in this sample was only modest. In the best-fitting models, the heritability of GAD was the same in men and women, estimated at about 15% to 20%, with no effects of gender-specific genes detected...
  11. pmc Genome-wide pharmacogenomic study of citalopram-induced side effects in STAR*D
    D E Adkins
    Center for Biomarker Research and Personalized Medicine, Virginia Commonwealth University, School of Pharmacy, Richmond, VA 23298 0581, USA
    Transl Psychiatry 2:e129. 2012
    ..Although our findings require replication and functional validation, this study demonstrates the potential of GWAS to discover genes and pathways that potentially mediate adverse effects of antidepressant medications...
  12. pmc Association study between GABA receptor genes and anxiety spectrum disorders
    Xuan Pham
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298 0126, USA
    Depress Anxiety 26:998-1003. 2009
    ..In this investigation, we explored four GABA receptor genes for their possible associations with genetic risk for anxiety disorders and depression...
  13. ncbi A review and meta-analysis of the genetic epidemiology of anxiety disorders
    J M Hettema
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Pychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond, 23298-0126, USA
    Am J Psychiatry 158:1568-78. 2001
    ..The role of nonshared environmental experience is significant, underscoring the importance of identifying putative environmental risk factors that predispose individuals to anxiety...
  14. ncbi The effects of anxiety, substance use and conduct disorders on risk of major depressive disorder
    J M Hettema
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Medical College of Virginia Campus of Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Psychol Med 33:1423-32. 2003
    ..Major depressive disorder (MDD) is highly co-morbid with other Axis I disorders, which commonly precede its onset. We sought to determine the level and periods of risk for MDD posed by prior or co-occurring psychiatric disorders...
  15. ncbi A multivariate genetic analysis of the use of tobacco, alcohol, and caffeine in a population based sample of male and female twins
    J M Hettema
    Virginia Institute for Psychiatric and Behavioral Genetics, and Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298 0126, USA
    Drug Alcohol Depend 57:69-78. 1999
    ..Underlying genetic and individual environmental risk factors produce liability to (poly)substance use in general; substance specific factors also play an important etiologic role...
  16. ncbi Life event dimensions of loss, humiliation, entrapment, and danger in the prediction of onsets of major depression and generalized anxiety
    Kenneth S Kendler
    Virginia Institute for Psychiatry and Behavioral Genetics, Medical College of Virginia of Virginia Commonwealth University, Richmond, USA
    Arch Gen Psychiatry 60:789-96. 2003
    ..Although substantial evidence suggests that stressful life events predispose to the onset of episodes of depression and anxiety, the essential features of these events that are depressogenic and anxiogenic remain uncertain...
  17. pmc Pharmacogenomic study of side-effects for antidepressant treatment options in STAR*D
    S L Clark
    Center for Biomarker Research and Personalized Medicine, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298 0581, USA
    Psychol Med 42:1151-62. 2012
    ..Understanding individual differences in susceptibility to antidepressant therapy side-effects is essential to optimize the treatment of depression...
  18. doi Genomewide association analysis followed by a replication study implicates a novel candidate gene for neuroticism
    Edwin J C G van den Oord
    Center for Biomarker Research and Personalized Medicine, Medical College of Virginia, Virginia Commonwealth University, PO Box 980533, Richmond, VA 23298 0533, USA
    Arch Gen Psychiatry 65:1062-71. 2008
    ..It has long been linked to internalizing psychiatric conditions, such as anxiety and depression, and it accounts for much of the substantial comorbidity seen between these disorders...
  19. pmc Variants in nicotinic acetylcholine receptors alpha5 and alpha3 increase risks to nicotine dependence
    Xiangning Chen
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia, USA
    Am J Med Genet B Neuropsychiatr Genet 150:926-33. 2009
    ..However, the opposite effects with nicotine dependence and alcohol abuse/dependence were puzzling and future studies are necessary to resolve this issue...
  20. pmc Assessment of generalized anxiety disorder diagnostic criteria in the National Comorbidity Survey and Virginia Adult Twin Study of Psychiatric and Substance Use Disorders
    Thomas S Kubarych
    Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23298 1026, USA
    Psychol Assess 20:206-16. 2008
    ....
  21. ncbi A twin study of the genetics of fear conditioning
    John M Hettema
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Medical College of Virginia Campus of Virginia Commonwealth University, Richmond, 23298, USA
    Arch Gen Psychiatry 60:702-8. 2003
    ..The objective of this study was to determine the genetic and environmental sources of individual differences in fear conditioning by means of a twin sample...
  22. pmc Cannabinoid receptor 1 gene association with nicotine dependence
    Xiangning Chen
    Virginia Institute for Psychiatric and Behavioral Genetics and Department of Psychiatry, Virginia Commonwealth University, 800 Leigh St, Ste 1 110, Richmond, VA 23298, USA
    Arch Gen Psychiatry 65:816-24. 2008
    ..The cannabinoid receptor 1 (CNR1) gene is 1 of the 2 receptors expressed in the brain. It has been reported to be associated with alcoholism and multiple drug abuse and dependence...
  23. ncbi A population-based twin study of the relationship between neuroticism and internalizing disorders
    John M Hettema
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, P O Box 980126, Richmond, VA 23298 0126, USA
    Am J Psychiatry 163:857-64. 2006
    ..The authors examined how genetic and environmental factors shared by the personality trait neuroticism and seven internalizing disorders may help explain this comorbidity...
  24. ncbi Genetic and environmental sources of covariation between generalized anxiety disorder and neuroticism
    John M Hettema
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, P O Box 980126, Richmond, VA 23298 0126, USA
    Am J Psychiatry 161:1581-7. 2004
    ..Because women have higher levels of neuroticism and twice the risk of lifetime generalized anxiety disorder of men, gender-specific effects were also explored...
  25. ncbi The structure of genetic and environmental risk factors for anxiety disorders in men and women
    John M Hettema
    Virginia Institute for Psychiatry and Behavioral Genetics and Department of Psychiatry, Virginia Commonwealth University, Richmond, USA
    Arch Gen Psychiatry 62:182-9. 2005
    ..The anxiety disorders exhibit high levels of lifetime comorbidity with one another. Understanding the underlying causes of this comorbidity can provide insight into the etiology of the disorders and inform classification and treatment...
  26. doi Lack of association between the amiloride-sensitive cation channel 2 (ACCN2) gene and anxiety spectrum disorders
    John M Hettema
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298 0126, USA
    Psychiatr Genet 18:73-9. 2008
    ..In this study, we examined, for the first time, the human analog of ASIC1, the amiloride-sensitive cation channel 2 (ACCN2) gene, for its association with genetic risk across a range of anxiety spectrum phenotypes...
  27. ncbi Endorsement frequencies and factor structure of DSM-III-R and DSM-IV Generalized Anxiety Disorder symptoms in women: implications for future research, classification, clinical practice and comorbidity
    Thomas S Kubarych
    Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia 23298 1026, USA
    Int J Methods Psychiatr Res 14:69-81. 2005
    ....
  28. ncbi The impact of generalized anxiety disorder and stressful life events on risk for major depressive episodes
    John M Hettema
    Virginia Institute for Psychiatry and Behavioral Genetics and Department of Psychiatry, Virginia of Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Psychol Med 36:789-95. 2006
    ..In this study, we sought to analyze the joint effects of prior history of GAD and recent SLEs on risk for major depressive episodes, comparing these in men and women...
  29. ncbi Posttraumatic stress disorder: clinical features, pathophysiology, and treatment
    W Victor R Vieweg
    Psychiatry, Hunter Holmes McGuire Veterans Affairs Medical Center, Richmond, VA, USA
    Am J Med 119:383-90. 2006
    ..This review of PTSD will provide the reader with a clearer understanding of this condition, an increased capacity to recognize and treat this syndrome, and a greater appreciation for the role of the internist in PTSD...
  30. ncbi Low extraversion and high neuroticism as indices of genetic and environmental risk for social phobia, agoraphobia, and animal phobia
    O Joseph Bienvenu
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Meyer 115, 600 North Wolfe St, Baltimore, MD 21287, USA
    Am J Psychiatry 164:1714-21. 2007
    ....
  31. ncbi Heritability of obsessive-compulsive symptom dimensions
    Daniel S van Grootheest
    Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
    Am J Med Genet B Neuropsychiatr Genet 147:473-8. 2008
    ..Use of the Contamination dimension could therefore provide a powerful approach for the detection of genetic susceptibility loci that contribute to OCS...
  32. doi The risk of overweight in children and adolescents with major mental illness
    Mehrul Hasnain
    Department of Psychiatry, Western Regional Integrated Health Authority, Sir Thomas Roddick Hospital, Newfoundland, Canada
    South Med J 101:367-72. 2008
    ..To survey the charts of youths with major mental illness who may constitute a high-risk group (HRG) for overweight...

Research Grants4

  1. Genetics of Fear and Anxiety Disorders
    JOHN HETTEMA; Fiscal Year: 2006
    ..abstract_text> ..
  2. Identification of Susceptibility Genes for the Anxiety Disorders
    JOHN HETTEMA; Fiscal Year: 2007
    ....
  3. The role of genes and environment in anxiety spectrum disorders
    John M Hettema; Fiscal Year: 2010
    ..The identification of the genes that play a role in their susceptibility will provide new clues to their causes and, hopefully, new directions for prevention and treatment research. ..