Tai L Guo

Summary

Affiliation: Virginia Commonwealth University
Country: USA

Publications

  1. ncbi request reprint Genistein modulates splenic natural killer cell activity, antibody-forming cell response, and phenotypic marker expression in F(0) and F(1) generations of Sprague-Dawley rats
    T L Guo
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond 23298 0613, USA
    Toxicol Appl Pharmacol 181:219-27. 2002
  2. ncbi request reprint Myelotoxicity in genistein-, nonylphenol-, methoxychlor-, vinclozolin- or ethinyl estradiol-exposed F1 generations of Sprague-Dawley rats following developmental and adult exposures
    T L Guo
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, P O Box 980613, Richmond, VA 23298 0613, USA
    Toxicology 211:207-19. 2005
  3. pmc Genistein enhancement of respiratory allergen trimellitic anhydride-induced IgE production by adult B6C3F1 mice following in utero and postnatal exposure
    Tai L Guo
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, 23298 0613, USA
    Toxicol Sci 87:399-408. 2005
  4. ncbi request reprint Modulation of immune response following dietary genistein exposure in F0 and F1 generations of C57BL/6 mice: evidence of thymic regulation
    T L Guo
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, 23298 0613, USA
    Food Chem Toxicol 44:316-25. 2006
  5. pmc Stimulation of the immune response in B6C3F1 mice by genistein is affected by exposure duration, gender, and litter order
    Tai L Guo
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298 0613, USA
    J Nutr 135:2449-56. 2005
  6. ncbi request reprint Thalidomide enhances both primary and secondary host resistances to Listeria monocytogenes infection by a neutrophil-related mechanism in female B6C3F1 mice
    Tai L Guo
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, PO Box 980613, Richmond, Virginia 23298 6013, USA
    Toxicol Appl Pharmacol 209:244-54. 2005
  7. ncbi request reprint Differential STAT5 activation and phenotypic marker expression by immune cells following low levels of ethanol consumption in mice
    Tai L Guo
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond 23298 0613, USA
    Immunopharmacol Immunotoxicol 24:121-38. 2002
  8. ncbi request reprint Genistein and methoxychlor modulate the activity of natural killer cells and the expression of phenotypic markers by thymocytes and splenocytes in F0 and F1 generations of Sprague-Dawley rats
    T L Guo
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, P O Box 980613, Richmond, VA 23298 0613, USA
    Toxicology 172:205-15. 2002
  9. ncbi request reprint Genistein modulates immune responses and increases host resistance to B16F10 tumor in adult female B6C3F1 mice
    T L Guo
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298 0613, USA
    J Nutr 131:3251-8. 2001
  10. doi request reprint Immunotoxicological profile of chloramine in female B6C3F1 mice when administered in the drinking water for 28 days
    Tai L Guo
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA
    J Immunotoxicol 8:381-8. 2011

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Genistein modulates splenic natural killer cell activity, antibody-forming cell response, and phenotypic marker expression in F(0) and F(1) generations of Sprague-Dawley rats
    T L Guo
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond 23298 0613, USA
    Toxicol Appl Pharmacol 181:219-27. 2002
    ..Furthermore, the sexual dimorphic effects of GEN in F(1) male and female rats suggest that there may be interactions between GEN and the responses modulated by sex hormones...
  2. ncbi request reprint Myelotoxicity in genistein-, nonylphenol-, methoxychlor-, vinclozolin- or ethinyl estradiol-exposed F1 generations of Sprague-Dawley rats following developmental and adult exposures
    T L Guo
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, P O Box 980613, Richmond, VA 23298 0613, USA
    Toxicology 211:207-19. 2005
    ..Furthermore, the sex-specific effects of these chemicals in F1 male and female rats suggest that there may be interactions between these compounds and sex hormone in modulating these responses...
  3. pmc Genistein enhancement of respiratory allergen trimellitic anhydride-induced IgE production by adult B6C3F1 mice following in utero and postnatal exposure
    Tai L Guo
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, 23298 0613, USA
    Toxicol Sci 87:399-408. 2005
    ..Overall, the results demonstrated that GEN differentially modulated the developing immune system in male and female mice, and that more IgE was produced upon exposure to TMA in the adult...
  4. ncbi request reprint Modulation of immune response following dietary genistein exposure in F0 and F1 generations of C57BL/6 mice: evidence of thymic regulation
    T L Guo
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, 23298 0613, USA
    Food Chem Toxicol 44:316-25. 2006
    ..The differential effects of GEN on thymocytes in F(1) male and female mice indicate that GEN immunomodulation might be related to its effect on thymus...
  5. pmc Stimulation of the immune response in B6C3F1 mice by genistein is affected by exposure duration, gender, and litter order
    Tai L Guo
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298 0613, USA
    J Nutr 135:2449-56. 2005
    ..Overall, the results demonstrated that GEN could enhance the immune responses in mice from the 1st and 2nd litters; however, the effects varied depending on the exposure duration, gender, and litter order...
  6. ncbi request reprint Thalidomide enhances both primary and secondary host resistances to Listeria monocytogenes infection by a neutrophil-related mechanism in female B6C3F1 mice
    Tai L Guo
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, PO Box 980613, Richmond, Virginia 23298 6013, USA
    Toxicol Appl Pharmacol 209:244-54. 2005
    ..In conclusion, thalidomide enhanced host resistance to both primary and secondary L. monocytogenes infections by a neutrophil-related mechanism in female B6C3F1 mice...
  7. ncbi request reprint Differential STAT5 activation and phenotypic marker expression by immune cells following low levels of ethanol consumption in mice
    Tai L Guo
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond 23298 0613, USA
    Immunopharmacol Immunotoxicol 24:121-38. 2002
    ..Taken together, these findings suggest that low levels of ethanol consumption can differentially modulate immune cells in thymus, spleen, bone marrow and liver, which may be due to differential regulation of STAT5 activation by ethanol...
  8. ncbi request reprint Genistein and methoxychlor modulate the activity of natural killer cells and the expression of phenotypic markers by thymocytes and splenocytes in F0 and F1 generations of Sprague-Dawley rats
    T L Guo
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, P O Box 980613, Richmond, VA 23298 0613, USA
    Toxicology 172:205-15. 2002
    ..A lack of interaction between these two estrogenic chemicals in modulating these immune parameters indicates that their effects on the immune system might involve other mechanisms in addition to the estrogen receptors...
  9. ncbi request reprint Genistein modulates immune responses and increases host resistance to B16F10 tumor in adult female B6C3F1 mice
    T L Guo
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298 0613, USA
    J Nutr 131:3251-8. 2001
    ..In conclusion, genistein enhanced host resistance as evaluated in the B16F10 tumor model, which may be related to the increases in the activities of cytotoxic T cells and NK cells...
  10. doi request reprint Immunotoxicological profile of chloramine in female B6C3F1 mice when administered in the drinking water for 28 days
    Tai L Guo
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA
    J Immunotoxicol 8:381-8. 2011
    ..In conclusion, chloramine produced no toxicological and immunotoxic effects in female B(6)C(3)F(1) mice when administered for 28 days in the drinking water at concentrations ranging from 2-200 ppm...
  11. doi request reprint Immunotoxicological profile of chloroform in female B6C3F1 mice when administered in drinking water
    Wimolnut Auttachoat
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia 23298 0613, USA
    Drug Chem Toxicol 32:77-87. 2009
    ....
  12. pmc Decreased 7,12-dimethylbenz[a]anthracene-induced carcinogenesis coincides with the induction of antitumor immunities in adult female B6C3F1 mice pretreated with genistein
    Tai L Guo
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298 0613, USA
    Carcinogenesis 28:2560-6. 2007
    ....
  13. pmc Biological characterization of 3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione (K145) as a selective sphingosine kinase-2 inhibitor and anticancer agent
    Kai Liu
    Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, Virginia, USA
    PLoS ONE 8:e56471. 2013
    ..Collectively, these results strongly encourage further optimization of K145 as a novel lead compound for development of more potent and selective SphK2 inhibitors...
  14. pmc Differential surface expression of CD18 and CD44 by neutrophils in bone marrow and spleen contributed to the neutrophilia in thalidomide-treated female B6C3F1 mice
    Wimolnut Auttachoat
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, PO Box 980613, Richmond, VA 23298 6013, USA
    Toxicol Appl Pharmacol 218:227-37. 2007
    ..Taken together, Thd treatment increased neutrophils in female B6C3F1 mice, at least partially, through differentially modulating the surface expression of CD18 and CD44 by the neutrophils in the bone marrow and spleen...
  15. doi request reprint Contact sensitizing potential of annatto extract and its two primary color components, cis-bixin and norbixin, in female BALB/c mice
    Wimolnut Auttachoat
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298 6013, USA
    Food Chem Toxicol 49:2638-44. 2011
    ..1-0.5%. These results have demonstrated that cis-bixin, but not norbixin, is likely a contact sensitizer and contributes to the contact hypersensitivity effects observed following dermal exposure to ANT in mice...
  16. doi request reprint Immunotoxicity of dibromoacetic acid administered via drinking water to female B₆C₃F₁ mice
    Matthew J Smith
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298, USA
    J Immunotoxicol 7:333-43. 2010
    ..With the exception of changes in thymus weight, these results indicate that DBA exposure resulted in no immunotoxic effects at concentrations much larger than those considered acceptable in human drinking water...
  17. ncbi request reprint Nonylphenol alters the activity of splenic NK cells and the numbers of leukocyte subpopulations in Sprague-Dawley rats: a two-generation feeding study
    N A Karrow
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298 6013, USA
    Toxicology 196:237-45. 2004
    ..The immunological changes that were observed in the F(1) generation also appeared to be gender-specific...
  18. doi request reprint Immunomodulation in female B₆C₃F₁ mice following treatment with the HIV protease inhibitor saquinavir for 28 days by gavage
    Tai L Guo
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    J Immunotoxicol 7:289-97. 2010
    ..In addition, exposure to SQV did not affect host resistance in the B16F10 melanoma model. In conclusion, SQV produced an enhancement of the humoral immune response, possibly through modulating T-cell function in female B₆C₃F₁ mice...
  19. ncbi request reprint Immunotoxicity of sodium bromate in female B6C3F1 mice: a 28-day drinking water study
    T L Guo
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, PO Box 980613, Richmond, VA 23298-0613, USA
    Drug Chem Toxicol 24:129-49. 2001
    ..In conclusion, SB, when administered in the drinking water at doses from 80 mg/l to 800 mg/l, produced minimal toxicological and immunotoxic effects in female B6C3F1 mice...
  20. ncbi request reprint Dietary methoxychlor exposure modulates splenic natural killer cell activity, antibody-forming cell response and phenotypic marker expression in F0 and F1 generations of Sprague Dawley rats
    K L White
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298 0613, USA
    Toxicology 207:271-81. 2005
    ..Increases in antibody-forming cell response and NK cell activity, and altered spleen cell subpopulation numbers were observed in the F1 generation male rats, without similar changes to the F1 generation females...
  21. ncbi request reprint Evaluation of the immunomodulatory effects of the disinfection by-product, sodium chlorite, in female B6C3F1 mice: a drinking water study
    N A Karrow
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298-6013, USA
    Drug Chem Toxicol 24:239-58. 2001
    ..These results suggest that sodium chlorite, within the range 0.1-30 mg/L, produces minimal immunotoxicity in mice...
  22. doi request reprint 3,5-Disubstituted-thiazolidine-2,4-dione analogs as anticancer agents: design, synthesis and biological characterization
    Kai Liu
    Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, VA 23298 0540, USA
    Eur J Med Chem 47:125-37. 2012
    ..Collectively, these results strongly encourage further optimization of 15 as a new lead with multi-target properties to develop more potent compounds as anticancer agents...
  23. pmc Regulation of inflammatory pain by inhibition of fatty acid amide hydrolase
    Pattipati S Naidu
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298, USA
    J Pharmacol Exp Ther 334:182-90. 2010
    ....
  24. ncbi request reprint Oral exposure to atrazine modulates cell-mediated immune function and decreases host resistance to the B16F10 tumor model in female B6C3F1 mice
    N A Karrow
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298 6013, USA
    Toxicology 209:15-28. 2005
    ..These results demonstrate that oral ATZ exposure is sufficient to alter cell-mediated immune function and disease resistance in female B6C3F1 mice...
  25. pmc Molecular chaperoning by glucose-regulated protein 170 in the extracellular milieu promotes macrophage-mediated pathogen sensing and innate immunity
    Daming Zuo
    Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
    FASEB J 26:1493-505. 2012
    ....
  26. doi request reprint (Xeno)estrogen regulation of food allergy
    Tai L Guo
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia 23298 0613, USA
    J Immunotoxicol 5:259-70. 2008
    ..Further clinical and animal studies are needed to determine the causal relationship between the exposure of (xeno)estrogens and incidence of food allergy, and the underlying mechanisms...
  27. ncbi request reprint Sodium metasilicate hypersensitivity in BALB/c mice
    N A Karrow
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298, USA
    Am J Contact Dermat 13:133-9. 2002
    ..Although little is known about potential for this chemical to cause allergic reactions, a similar silicate compound, sodium silicate, was reported to elicit IgE-mediated contact urticaria...
  28. ncbi request reprint Dermal exposure to cinnamaldehyde alters lymphocyte subpopulations, number of interferon-gamma-producing cells, and expression of B7 costimulatory molecules and cytokine messenger RNAs in auricular lymph nodes of B6C3F1 mice
    N A Karrow
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298 6013, USA
    Am J Contact Dermat 12:6-17. 2001
    ..However, they may help identify compounds inappropriately classified as sensitizers or nonsensitizers by the LLNA and MEST...
  29. ncbi request reprint Phthalate treatment does not influence levels of IgE or Th2 cytokines in B6C3F1 mice
    John H Butala
    Toxicology Consultants, Gibsonia, PA, USA
    Toxicology 201:77-85. 2004
    ..In summary, treatment with DEHP, DINP, DIHP, and BBP did not result in significant elevations in total serum IgE, IL-4, or IL-13. As such it is unlikely that these substances would produce antibody-mediated respiratory allergy...
  30. ncbi request reprint Immunomodulation by Dok Din Daeng (Aeginetia indica Roxb.) extracts in female B6C3F1 mice: (I): stimulation of T cells
    Wimolnut Auttachoat
    Department of Environmental Biology, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand
    Int Immunopharmacol 4:1367-79. 2004
    ..Overall, this study demonstrated that the extracts from A. indica Roxbert had a T cell stimulatory activity...
  31. ncbi request reprint Immunomodulation by Dok Din Daeng (Aeginetia indica Roxb.) extracts in female B6C3F1 mice: II. Humoral immunity, innate immunity and hematology
    Wimolnut Auttachoat
    Department of Environmental Biology, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand
    Int Immunopharmacol 4:1381-90. 2004
    ..Taken together, the enhancing effect of DDD extracts on T cells may be primarily responsible for the successful and long-time use of this traditional herbal medicine in Thailand...