David Gewirtz

Summary

Affiliation: Virginia Commonwealth University
Country: USA

Publications

  1. ncbi request reprint A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin
    D A Gewirtz
    Department of Pharmacology Toxicology, and Medical College of Virginia, Virginia Commonwealth University, Richmond 23298, USA
    Biochem Pharmacol 57:727-41. 1999
  2. ncbi request reprint Autophagy as a mechanism of radiation sensitization in breast tumor cells
    David A Gewirtz
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Massey Cancer Center, Virginia 23298, USA
    Autophagy 3:249-50. 2007
  3. ncbi request reprint Erythropoietin fails to interfere with the antiproliferative and cytotoxic effects of antitumor drugs
    David A Gewirtz
    Department of Pharmacology and Toxicology, Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia, USA
    Clin Cancer Res 12:2232-8. 2006
  4. ncbi request reprint Potentiation of radiation sensitivity in breast tumor cells by the vitamin D3 analogue, EB 1089, through promotion of autophagy and interference with proliferative recovery
    Gerald DeMasters
    Massey Cancer Center, Virginia Commonwealth University, P O Box 980035, Richmond, VA 23298, USA
    Mol Cancer Ther 5:2786-97. 2006
  5. ncbi request reprint Vitamin D3 and vitamin D3 analogues as an adjunct to cancer chemo-therapy and radiotherapy
    David A Gewirtz
    Department of Pharmacology, Virginia Commonwealth University Medical College of Virginia, Richmond, VA 23298, USA
    Curr Med Chem Anticancer Agents 2:683-90. 2002
  6. ncbi request reprint Growth arrest and cell death in the breast tumor cell in response to ionizing radiation and chemotherapeutic agents which induce DNA damage
    D A Gewirtz
    Department of Pharmacology, Virginia Commonwealth University Medical College of Virginia, Richmond 23298, USA
    Breast Cancer Res Treat 62:223-35. 2000
  7. ncbi request reprint Rb dephosphorylation and suppression of E2F activity in human breast tumor cells exposed to a pharmacological concentration of estradiol
    D A Gewirtz
    Department of Pharmacology, Toxicology and Medicine, Medical College of Virginia, Virginia Commonwealth University, Richmond, USA
    Arch Biochem Biophys 388:243-52. 2001
  8. ncbi request reprint A chemotherapy-associated senescence bystander effect in breast cancer cells
    Xu Di
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Cancer Biol Ther 7:864-72. 2008
  9. ncbi request reprint Cytotoxicity, DNA strand breakage and DNA-protein crosslinking by a novel transplatinum compound in human A2780 ovarian and MCF-7 breast carcinoma cells
    Nicholas Farrell
    Department of Chemistry, Virginia Commonwealth University, P O Box 23284, 1001 W Main St Richmond, VA 23284 2006, USA
    Biochem Pharmacol 68:857-66. 2004
  10. ncbi request reprint Evasion of a single-step, chemotherapy-induced senescence in breast cancer cells: implications for treatment response
    Lynne W Elmore
    Department of Pathology, Medical College of Virginia at Virginia Commonwealth University, Richmond, Virginia 23298 230, USA
    Clin Cancer Res 11:2637-43. 2005

Research Grants

  1. Development of Vascular Disrupting Agents
    David Gewirtz; Fiscal Year: 2009

Collaborators

Detail Information

Publications30

  1. ncbi request reprint A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin
    D A Gewirtz
    Department of Pharmacology Toxicology, and Medical College of Virginia, Virginia Commonwealth University, Richmond 23298, USA
    Biochem Pharmacol 57:727-41. 1999
    ..The role of free radicals in anthracycline cardiotoxicity is also discussed...
  2. ncbi request reprint Autophagy as a mechanism of radiation sensitization in breast tumor cells
    David A Gewirtz
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Massey Cancer Center, Virginia 23298, USA
    Autophagy 3:249-50. 2007
    ..How and why the cell chooses a particular growth arrest and/or cell death pathway remains a puzzle to be solved...
  3. ncbi request reprint Erythropoietin fails to interfere with the antiproliferative and cytotoxic effects of antitumor drugs
    David A Gewirtz
    Department of Pharmacology and Toxicology, Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia, USA
    Clin Cancer Res 12:2232-8. 2006
    ....
  4. ncbi request reprint Potentiation of radiation sensitivity in breast tumor cells by the vitamin D3 analogue, EB 1089, through promotion of autophagy and interference with proliferative recovery
    Gerald DeMasters
    Massey Cancer Center, Virginia Commonwealth University, P O Box 980035, Richmond, VA 23298, USA
    Mol Cancer Ther 5:2786-97. 2006
    ....
  5. ncbi request reprint Vitamin D3 and vitamin D3 analogues as an adjunct to cancer chemo-therapy and radiotherapy
    David A Gewirtz
    Department of Pharmacology, Virginia Commonwealth University Medical College of Virginia, Richmond, VA 23298, USA
    Curr Med Chem Anticancer Agents 2:683-90. 2002
    ..Consequently, Vitamin D(3) and Vitamin D(3) analogues, utilized at concentrations which produce limited hypercalcemia, are likely to prove effective as adjuncts to conventional chemotherapy and radiotherapy...
  6. ncbi request reprint Growth arrest and cell death in the breast tumor cell in response to ionizing radiation and chemotherapeutic agents which induce DNA damage
    D A Gewirtz
    Department of Pharmacology, Virginia Commonwealth University Medical College of Virginia, Richmond 23298, USA
    Breast Cancer Res Treat 62:223-35. 2000
    ....
  7. ncbi request reprint Rb dephosphorylation and suppression of E2F activity in human breast tumor cells exposed to a pharmacological concentration of estradiol
    D A Gewirtz
    Department of Pharmacology, Toxicology and Medicine, Medical College of Virginia, Virginia Commonwealth University, Richmond, USA
    Arch Biochem Biophys 388:243-52. 2001
    ....
  8. ncbi request reprint A chemotherapy-associated senescence bystander effect in breast cancer cells
    Xu Di
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Cancer Biol Ther 7:864-72. 2008
    ..Our study reveals a novel action of Adriamycin, which may contribute to its potent anti-breast cancer activity and lead to the discovery of additional therapeutic targets for the exploitation of a senescence bystander effect...
  9. ncbi request reprint Cytotoxicity, DNA strand breakage and DNA-protein crosslinking by a novel transplatinum compound in human A2780 ovarian and MCF-7 breast carcinoma cells
    Nicholas Farrell
    Department of Chemistry, Virginia Commonwealth University, P O Box 23284, 1001 W Main St Richmond, VA 23284 2006, USA
    Biochem Pharmacol 68:857-66. 2004
    ..These studies suggest that ATZ has the capacity to interfere with topoisomerase I in the tumor cell, a function not evident in cis-platinum-based drugs...
  10. ncbi request reprint Evasion of a single-step, chemotherapy-induced senescence in breast cancer cells: implications for treatment response
    Lynne W Elmore
    Department of Pathology, Medical College of Virginia at Virginia Commonwealth University, Richmond, Virginia 23298 230, USA
    Clin Cancer Res 11:2637-43. 2005
    ..Here, we test the hypothesis that evasion of senescence confers resistance to chemotherapeutic drugs and ionizing radiation...
  11. ncbi request reprint Autophagy, senescence and tumor dormancy in cancer therapy
    David A Gewirtz
    Department of Pharmacology and Toxicology and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA
    Autophagy 5:1232-4. 2009
    ....
  12. doi request reprint Accelerated senescence: an emerging role in tumor cell response to chemotherapy and radiation
    David A Gewirtz
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298, USA
    Biochem Pharmacol 76:947-57. 2008
    ....
  13. doi request reprint Apoptosis, autophagy, accelerated senescence and reactive oxygen in the response of human breast tumor cells to adriamycin
    Xu Di
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, United States
    Biochem Pharmacol 77:1139-50. 2009
    ..Furthermore, accelerated senescence, autophagy and apoptosis all appear to be effective in suppressing self-renewal capacity in breast tumor cells exposed to Adriamycin...
  14. ncbi request reprint Adriamycin-induced senescence in breast tumor cells involves functional p53 and telomere dysfunction
    Lynne W Elmore
    Department of Pathology, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298 0662, USA
    J Biol Chem 277:35509-15. 2002
    ..To our knowledge, these data are the first to demonstrate that the mechanism of adriamycin-induced senescence is dependent on both functional p53 and telomere dysfunction rather than overall shortening...
  15. doi request reprint Promotion of autophagy as a mechanism for radiation sensitization of breast tumor cells
    David A Gewirtz
    Department of Pharmacology and Toxicology and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA
    Radiother Oncol 92:323-8. 2009
    ..In addition, promotion of autophagic cell death by a vitamin D analog in irradiated breast tumor cells delays and attenuates the proliferative recovery that may be a preclinical indicator of disease recurrence...
  16. ncbi request reprint Influence of p53 and caspase 3 activity on cell death and senescence in response to methotrexate in the breast tumor cell
    Deepali K Hattangadi
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298, USA
    Biochem Pharmacol 68:1699-708. 2004
    ..Furthermore, the senescence phenotype may occur in the absence of direct DNA damage...
  17. pmc Autophagic cell death, polyploidy and senescence induced in breast tumor cells by the substituted pyrrole JG-03-14, a novel microtubule poison
    Christopher R Arthur
    Department of Pharmacology and Toxicology and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA
    Biochem Pharmacol 74:981-91. 2007
    ....
  18. ncbi request reprint Enhancement of radiation sensitivity, delay of proliferative recovery after radiation and abrogation of MAPK (p44/42) signaling by imatinib in glioblastoma cells
    Quincy A Quick
    Department of Pharmacology and Toxicology and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA
    Int J Oncol 29:407-12. 2006
    ..Imatinib may prove to have clinical utility as a neoadjuvant and adjuvant in the treatment of glioblastomas that receive radiation therapy...
  19. ncbi request reprint Potentiation of cell killing by fractionated radiation and suppression of proliferative recovery in MCF-7 breast tumor cells by the Vitamin D3 analog EB 1089
    Gerald A DeMasters
    Department of Pharmacology Toxicology and Medicine, Virginia Commonwealth University, Medical College of Virginia, P O Box 980230, Richmond, VA 23298, USA
    J Steroid Biochem Mol Biol 92:365-74. 2004
    ....
  20. ncbi request reprint An accelerated senescence response to radiation in wild-type p53 glioblastoma multiforme cells
    Quincy A Quick
    Department of Pharmacology and Toxicology and Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    J Neurosurg 105:111-8. 2006
    ..The present study was designed to explore the nature of the response to ionizing radiation in GBM cells to gain insight into the basis for the general failure of radiotherapy in the treatment of this disease...
  21. ncbi request reprint Effect of the vitamin D3 analog ILX 23-7553 on apoptosis and sensitivity to fractionated radiation in breast tumor cells and normal human fibroblasts
    Mark K Polar
    Department of Pharmacology Toxicology, Medical College of Virginia, Virginia Commonwealth University, P O Box 980230, Richmond, VA, USA
    Cancer Chemother Pharmacol 51:415-21. 2003
    ..The potential toxicity to normal tissue of the combination of ILX 23-7553 and fractionated radiation was assessed in a model of BJ human fibroblasts in culture...
  22. pmc Promotion of DNA strand breaks, interstrand cross-links and apoptotic cell death in A2780 human ovarian cancer cells by transplatinum planar amine complexes
    Sheena M Aris
    Department of Chemistry, Virginia Commonwealth University, Richmond, VA, USA
    Biochem Pharmacol 73:1749-57. 2007
    ....
  23. ncbi request reprint Radiosensitization of MDA-MB-231 breast tumor cells by adenovirus-mediated overexpression of a fragment of the XRCC4 protein
    Kara R Jones
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, P O Box 980230, Richmond, VA 23298, USA
    Mol Cancer Ther 4:1541-7. 2005
    ..These studies support the potential clinical utility of combining radiation therapy with agents that inhibit DNA double-strand break repair...
  24. pmc Anibamine, a natural product CCR5 antagonist, as a novel lead for the development of anti-prostate cancer agents
    Xueping Zhang
    Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, VA 23298, USA
    Bioorg Med Chem Lett 20:4627-30. 2010
    ..Preliminary in vivo studies indicate that anibamine also inhibits prostate tumor growth in mice. These findings indicate that anibamine may prove to be a novel lead compound for the development of prostate cancer therapeutic agents...
  25. pmc Docking and hydropathic scoring of polysubstituted pyrrole compounds with antitubulin activity
    Ashutosh Tripathi
    Department of Medicinal Chemistry and Institute for Structural Biology and Drug Discovery, Virginia Commonwealth University, Richmond, VA 23298 0540, USA
    Bioorg Med Chem 16:2235-42. 2008
    ..These results illuminate the binding process and should be valuable in the design of new pyrrole-based colchicine site inhibitors as these compounds have very accessible syntheses...
  26. ncbi request reprint Caveolin and STAT-5 signaling: potential overlap in lactation and breast tumor promotion
    David A Gewirtz
    Department of Pharmacology, Toxicology and Medicine, Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Cancer Biol Ther 5:298-9. 2006
  27. ncbi request reprint The role of senescence in the action of antitumor drugs
    David A Gewirtz
    Curr Opin Investig Drugs 9:562-4. 2008
  28. ncbi request reprint The combination of a potent vitamin D3 analog, EB 1089, with ionizing radiation reduces tumor growth and induces apoptosis of MCF-7 breast tumor xenografts in nude mice
    Sujatha Sundaram
    Departments of Surgery, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Clin Cancer Res 9:2350-6. 2003
    ..The purpose of this research was to evaluate theinfluence of the combination of the vitamin D(3) analogue EB 1089 with fractionated radiation on growth and apoptosis of MCF-7 tumor xenografts in athymic mice...
  29. ncbi request reprint QW-1624F2-2, a synthetic analogue of 1,25-dihydroxyvitamin D3, enhances the response to other deltanoids and suppresses the invasiveness of human metastatic breast tumor cells
    Sujatha Sundaram
    Department of Surgery, Dartmouth Medical School, One Medical Center Drive, HB 7850, Lebanon, NH 03756, USA
    Mol Cancer Ther 5:2806-14. 2006
    ..QW also blocked the sustained induction of CYP24 expression by 1,25(OH)(2)D(3) and EB 1089, increased the potency of 1,25(OH)(2)D(3) and EB 1089, and inhibited breast tumor cell proliferation and invasion...
  30. ncbi request reprint Apoptosis as the predominant tumor cell response to chemotherapy and irradiation: a case of TUNEL vision?
    David A Gewirtz
    Curr Opin Investig Drugs 6:1199. 2005

Research Grants1

  1. Development of Vascular Disrupting Agents
    David Gewirtz; Fiscal Year: 2009
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