Chris Gennings

Summary

Affiliation: Virginia Commonwealth University
Country: USA

Publications

  1. pmc A cohort study evaluation of maternal PCB exposure related to time to pregnancy in daughters
    Chris Gennings
    Department of Biostatistics, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA
    Environ Health 12:66. 2013
  2. pmc Linking empirical estimates of body burden of environmental chemicals and wellness using NHANES data
    Chris Gennings
    Department of Biostatistics, Virginia Commonwealth University, Richmond, VA 23298 0032, USA
    Environ Int 39:56-65. 2012
  3. doi Identifying subsets of complex mixtures most associated with complex diseases: polychlorinated biphenyls and endometriosis as a case study
    Chris Gennings
    Department of Biostatistics, Virginia Commonwealth University, Richmond, VA 23298 0032, USA
    Epidemiology 21:S77-84. 2010
  4. doi Use of desirability functions to evaluate health status in patients with cirrhosis
    Chris Gennings
    Department of Biostatistics, Virginia Commonwealth University, Theatre Row, Rm 3026, 730 East Broad Street, Richmond, VA 23298 0032, USA
    J Hepatol 52:665-71. 2010
  5. doi Hypotheses and fundamental study design characteristics for evaluating potential reduced-risk tobacco products. Part I: Heuristic
    Lenn Murrelle
    Altria Client Services, Research Development and Engineering, Richmond, VA, USA
    Regul Toxicol Pharmacol 57:1-10. 2010
  6. ncbi Ineffective triggering predicts increased duration of mechanical ventilation
    Marjolein de Wit
    Division of Pulmonary Disease and Critical Care Medicine, Virginia Commonwealth University, Richmond, VA, USA
    Crit Care Med 37:2740-5. 2009
  7. doi Drug withdrawal, cocaine and sedative use disorders increase the need for mechanical ventilation in medical patients
    Marjolein de Wit
    Division of Pulmonary Disease and Critical Care Medicine, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USA
    Addiction 103:1500-8. 2008
  8. pmc Who's doing the math? Are we really compensating research participants?
    ELIZABETH RIPLEY
    Division of Nephrology, Virginia Commonwealth University, USA
    J Empir Res Hum Res Ethics 5:57-65. 2010
  9. pmc Randomized trial comparing daily interruption of sedation and nursing-implemented sedation algorithm in medical intensive care unit patients
    Marjolein de Wit
    Pulmonary and Critical Care Division, Department of Internal Medicine, School of Medicine, Virginia Commonwealth University, PO Box 980050, Richmond, VA 23298 0050, USA
    Crit Care 12:R70. 2008
  10. ncbi Physiological effects of enteral and parenteral feeding on pancreaticobiliary secretion in humans
    Stephen J D O'Keefe
    Medical College of Virginia and Virginia Commonwealth University and McGuire Veterans Administration Hospital, Richmond 23298, USA
    Am J Physiol Gastrointest Liver Physiol 284:G27-36. 2003

Collaborators

Detail Information

Publications34

  1. pmc A cohort study evaluation of maternal PCB exposure related to time to pregnancy in daughters
    Chris Gennings
    Department of Biostatistics, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA
    Environ Health 12:66. 2013
    ....
  2. pmc Linking empirical estimates of body burden of environmental chemicals and wellness using NHANES data
    Chris Gennings
    Department of Biostatistics, Virginia Commonwealth University, Richmond, VA 23298 0032, USA
    Environ Int 39:56-65. 2012
    ..Use of a holistic index on both sides of the exposure-health equation is a novel and promising empirical "systems biology" approach to risk evaluation of complex environmental exposures...
  3. doi Identifying subsets of complex mixtures most associated with complex diseases: polychlorinated biphenyls and endometriosis as a case study
    Chris Gennings
    Department of Biostatistics, Virginia Commonwealth University, Richmond, VA 23298 0032, USA
    Epidemiology 21:S77-84. 2010
    ..681) with the sum of 12 estrogenic PCBs. This finding was inconsistent with the widely held notion that endometriosis is an estrogen-dependent disease, prompting further statistical analyses to explore these associations in more detail...
  4. doi Use of desirability functions to evaluate health status in patients with cirrhosis
    Chris Gennings
    Department of Biostatistics, Virginia Commonwealth University, Theatre Row, Rm 3026, 730 East Broad Street, Richmond, VA 23298 0032, USA
    J Hepatol 52:665-71. 2010
    ....
  5. doi Hypotheses and fundamental study design characteristics for evaluating potential reduced-risk tobacco products. Part I: Heuristic
    Lenn Murrelle
    Altria Client Services, Research Development and Engineering, Richmond, VA, USA
    Regul Toxicol Pharmacol 57:1-10. 2010
    ..To assess non-inferiority to quitting, the required sample size tends to be about 10 times greater, again depending on the effectiveness of the PRRP...
  6. ncbi Ineffective triggering predicts increased duration of mechanical ventilation
    Marjolein de Wit
    Division of Pulmonary Disease and Critical Care Medicine, Virginia Commonwealth University, Richmond, VA, USA
    Crit Care Med 37:2740-5. 2009
    ..To determine whether high rates of ineffective triggering within the first 24 hrs of mechanical ventilation (MV) are associated with longer MV duration and shorter ventilator-free survival (VFS)...
  7. doi Drug withdrawal, cocaine and sedative use disorders increase the need for mechanical ventilation in medical patients
    Marjolein de Wit
    Division of Pulmonary Disease and Critical Care Medicine, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USA
    Addiction 103:1500-8. 2008
    ..The objective of this study is to determine if the presence of DUD and drug withdrawal syndromes are associated with increased need for MV in medical patients...
  8. pmc Who's doing the math? Are we really compensating research participants?
    ELIZABETH RIPLEY
    Division of Nephrology, Virginia Commonwealth University, USA
    J Empir Res Hum Res Ethics 5:57-65. 2010
    ..Results suggest that compensation and reimbursement as the primary reasons for paying research participants may not match actual practice...
  9. pmc Randomized trial comparing daily interruption of sedation and nursing-implemented sedation algorithm in medical intensive care unit patients
    Marjolein de Wit
    Pulmonary and Critical Care Division, Department of Internal Medicine, School of Medicine, Virginia Commonwealth University, PO Box 980050, Richmond, VA 23298 0050, USA
    Crit Care 12:R70. 2008
    ..Daily interruption of sedation (DIS) and sedation algorithms (SAs) have been shown to decrease mechanical ventilation (MV) duration. We conducted a randomized study comparing these strategies...
  10. ncbi Physiological effects of enteral and parenteral feeding on pancreaticobiliary secretion in humans
    Stephen J D O'Keefe
    Medical College of Virginia and Virginia Commonwealth University and McGuire Veterans Administration Hospital, Richmond 23298, USA
    Am J Physiol Gastrointest Liver Physiol 284:G27-36. 2003
    ..Enteral "elemental" formulae diminish, but only intravenous feeding avoids pancreatic stimulation. Intravenous administration impairs metabolic clearance...
  11. doi Further considerations on the evaluation of potential reduced-risk tobacco products. Part II: Re-assessment of a heuristic using the CPS-II database
    Lenn Murrelle
    Altria Client Services, Research Development and Engineering, Richmond, VA, USA
    Regul Toxicol Pharmacol 57:11-7. 2010
    ..Altogether, these estimates indicate that it is feasible, in terms of study duration and sample size, to clinically assess the LC risk-reducing potential of a PRRP...
  12. ncbi The simultaneous analysis of discrete and continuous outcomes in a dose-response study: using desirability functions
    Todd Coffey
    Department of Biostatistics, Virginia Commonwealth University, PO Box 980032, Richmond, VA 23298, USA
    Regul Toxicol Pharmacol 48:51-8. 2007
    ....
  13. ncbi The utility of microvascular perfusion assessment in heart failure: a pilot study
    Christopher J Hogan
    Department of Emergency Medicine, VCU Reanimation Engineering Shock Center VCURES, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298 0401, USA
    J Card Fail 11:713-9. 2005
    ..We propose the noninvasive evaluation of microvascular and global perfusion can objectify heart failure severity and provide additional prognostic information...
  14. doi Influence of the phosphodiesterase-5 inhibitor, sildenafil, on sensitivity to chemotherapy in breast tumor cells
    Xu Di
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Massey Cancer Center, 401 College St, Richmond, VA 23298, USA
    Breast Cancer Res Treat 124:349-60. 2010
    ....
  15. ncbi Effects of different macronutrient consumption following a resistance-training session on fat and carbohydrate metabolism
    Kara J Bosher
    Division of Health, Physical Education, and Recreation, Virginia Commonwealth University, Richmond, Virginia 23284, USA
    J Strength Cond Res 18:212-9. 2004
    ..Different macronutrient consumption does influence insulin, glucose, and triacylglycerol concentrations after resistance exercise...
  16. ncbi Short course of omeprazole: a better first diagnostic approach to noncardiac chest pain than endoscopy, manometry, or 24-hour esophageal pH monitoring
    William M Pandak
    Division of Gastroenterology and Department of Biostatistics, Virginia Commonweath University, Richmond, Virginia 23249, USA
    J Clin Gastroenterol 35:307-14. 2002
    ..Noncardiac chest pain (NCCP) presents as a frequent diagnostic challenge, with patients tending to use a disproportionate level of health care resources. Gastroesophageal reflux disease (GERD) is the most frequent cause of NCCP...
  17. ncbi Impact of HbA1c measurement on hospital readmission rates: analysis of 70,000 clinical database patient records
    Beata Strack
    Department of Computer Science, Virginia Commonwealth University, Richmond, VA 23284, USA
    Biomed Res Int 2014:781670. 2014
    ..The data suggest further that the greater attention to diabetes reflected in HbA1c determination may improve patient outcomes and lower cost of inpatient care. ..
  18. pmc Testing for departures from additivity in mixtures of perfluoroalkyl acids (PFAAs)
    Caroline K Carr
    Department of Biostatistics, Virginia Commonwealth University, Richmond, VA 23298 0032, USA
    Toxicology 306:169-75. 2013
    ..The most conservative interpretation for our data would be an assumption of additivity (and lack of a greater than additive interaction), with a potential for antagonistic interactions...
  19. ncbi Alcohol use disorders increase the risk for mechanical ventilation in medical patients
    Marjolein de Wit
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Virginia Commonwealth University, Richmond, VA 23298 0050, USA
    Alcohol Clin Exp Res 31:1224-30. 2007
    ....
  20. ncbi A novel flexible approach for evaluating fixed ratio mixtures of full and partial agonists
    Chris Gennings
    Department of Biostatistics, Virginia Commonwealth University, Richmond, Virginia 23298 0032, USA
    Toxicol Sci 80:134-50. 2004
    ..g., mixtures of full and partial agonists). The methods are illustrated with a combination of six chemicals in an estrogen receptor-alpha (ER-alpha) reporter gene assay...
  21. ncbi Potentiation of cell killing by fractionated radiation and suppression of proliferative recovery in MCF-7 breast tumor cells by the Vitamin D3 analog EB 1089
    Gerald A DeMasters
    Department of Pharmacology Toxicology and Medicine, Virginia Commonwealth University, Medical College of Virginia, P O Box 980230, Richmond, VA 23298, USA
    J Steroid Biochem Mol Biol 92:365-74. 2004
    ....
  22. pmc Why do we pay? A national survey of investigators and IRB chairpersons
    ELIZABETH RIPLEY
    Division of Nephrology, Virginia Commonwealth University, USA
    J Empir Res Hum Res Ethics 5:43-56. 2010
    ..Payment models varied by type of study. Ranges for recommended payments by both groups for different types of procedures and studies are presented...
  23. ncbi Bloodstream infections due to Candida species in the intensive care unit: identifying especially high-risk patients to determine prevention strategies
    Richard P Wenzel
    Department of Internal Medicine, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, USA
    Clin Infect Dis 41:S389-93. 2005
    ..Use of defined risk factors to select patients who are at high risk for candidemia and treatment with effective antibiotics would be an efficient way to reduce infection-related deaths...
  24. ncbi D-optimal experimental designs to test for departure from additivity in a fixed-ratio mixture ray
    Todd Coffey
    Department of Biostatistics, Virginia Commonwealth University, Richmond, 23298, USA
    Toxicol Sci 88:467-76. 2005
    ..Use of a D-optimal criterion produces experimental designs with increased power, whereas standard nonoptimal designs with equally spaced dose groups may result in low power if the active range or threshold is missed...
  25. ncbi Aerobic exercise alters postprandial lipemia in African American versus White women
    Keith A Shannon
    Dept of Exercise Science, Virginia Commonwealth University, Richmond, VA 23298, USA
    Int J Sport Nutr Exerc Metab 18:37-48. 2008
    ..To determine whether ethnicity influences postprandial lipemia after a bout of aerobic exercise...
  26. doi The moderating role of sensory Overresponsivity in HPA activity: a pilot study with children diagnosed with ADHD
    Stacey Reynolds
    Virginia Commonwealth University, USA
    J Atten Disord 13:468-78. 2010
    ..To determine if sensory overresponsivity (SOR) is a moderating condition impacting the activity of the Hypothalamic Pituitary Adrenal (HPA) Axis in children with ADHD...
  27. ncbi Synergistic affective analgesic interaction between delta-9-tetrahydrocannabinol and morphine
    John D Roberts
    Massey Cancer Center and the Department of Internal Medicine, Virginia Commonwealth University, Richmond, 23298, USA
    Eur J Pharmacol 530:54-8. 2006
    ..Future studies of Delta(9)-THC or other cannabinoids in combination with opiates should focus upon clinical rather than experimental pain...
  28. ncbi Titrating and evaluating multi-drug regimens within subjects
    Margaret Shih
    Department of Biostatistics, Virginia Commonwealth University, Richmond, VA 23298 0032, USA
    Stat Med 22:2257-79. 2003
    ..The advantages of this approach include affording every patient the potential to benefit from the combination under study and permitting the consideration of multiple endpoints simultaneously...
  29. ncbi Analysis of the interaction of phytoestrogens and synthetic chemicals: an in vitro/in vivo comparison
    Grantley D Charles
    Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Midland, MI 48674, USA
    Toxicol Appl Pharmacol 218:280-8. 2007
    ..However, these data suggest that extrapolation from in vitro assays to in vivo mixture effects should be approached with caution...
  30. ncbi Response-surface modeling of the effect of 5alpha-dihydrotestosterone and androgen receptor levels on the response to the androgen antagonist vinclozolin
    Susan Y Euling
    National Center for Environmental Assessment, U S Environmental Protection Agency 8623 D, Ariel Rios Building, 1200 Pennsylvania Avenue NW, Washington, DC 20460, USA
    Toxicol Sci 69:332-43. 2002
    ..Thus, two components of the developmental stage, androgen and androgen receptor concentrations, are critical for sensitivity to the inhibitory effects of an androgen antagonist...
  31. ncbi Testing for additivity at select mixture groups of interest based on statistical equivalence testing methods
    Leanna G Stork
    Monsanto Company, St Louis, MO 63167, USA
    Risk Anal 26:1601-12. 2006
    ..The proposed method tests for additivity of the whole mixture and does not take into account subset interactions (e.g., synergistic, antagonistic) that may have occurred and cancelled each other out...
  32. ncbi Analysis of an interaction threshold in a mixture of drugs and/or chemicals
    Adam K Hamm
    Rho, Inc, Chapel Hill, NC 27514, USA
    Stat Med 24:2493-507. 2005
    ..We propose generalized linear models that permit the estimation of interaction threshold boundaries. The methods developed are applied to the combination of ethanol and chloral hydrate...
  33. pmc Thyroid-hormone-disrupting chemicals: evidence for dose-dependent additivity or synergism
    Kevin M Crofton
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Health Perspect 113:1549-54. 2005
    ..The results imply that cumulative risk approaches be considered when assessing the risk of exposure to chemical mixtures that contain TDCs...
  34. ncbi Thermoregulatory response to an organophosphate and carbamate insecticide mixture: testing the assumption of dose-additivity
    Christopher J Gordon
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, B105 04, U S Environmental Protection Agency, 109 S T W Alexander Drive, Research Triangle Park, NC 27711, USA
    Toxicology 217:1-13. 2006
    ..e., ChE inhibition) endpoints for the 2:1 and 1:1 mixtures studies did not coincide as expected. An interaction between CHP and CAR appears to depend on the ratio of compounds in the mixture as well as the biological endpoint...

Research Grants5

  1. Integration of Mixtures Toxicology, Toxicogenomics, and Statistics
    Chris Gennings; Fiscal Year: 2007
    ..The proposed program incorporates a new and additional emphasis on toxicogenomics of mixtures. The proposal also adds a postdoctoral position to the program, supplementing the current five pre-doctoral trainees. ..
  2. Empirical Determination of Sufficiently Similiar Complex Mixtures
    Chris Gennings; Fiscal Year: 2007
    ..The funded project will further develop/characterize a method of determining sufficient similarity in dose-responsiveness for mixtures with many components. ..
  3. Empirical Determination of Sufficiently Similiar Complex Mixtures
    Chris Gennings; Fiscal Year: 2009
    ..The funded project will further develop/characterize a method of determining sufficient similarity in dose-responsiveness for mixtures with many components. ..