Paulo A Garcia

Summary

Affiliation: Virginia Polytechnic Institute and State University
Country: USA

Publications

  1. pmc A parametric study delineating irreversible electroporation from thermal damage based on a minimally invasive intracranial procedure
    Paulo A Garcia
    Bioelectromechanical Systems Laboratory, School of Biomedical Engineering and Sciences, Virginia Tech Wake Forest University, Blacksburg, VA, USA
    Biomed Eng Online 10:34. 2011
  2. pmc 7.0-T magnetic resonance imaging characterization of acute blood-brain-barrier disruption achieved with intracranial irreversible electroporation
    Paulo A Garcia
    Bioelectromechanical Systems Lab, School of Biomedical Engineering and Sciences, Virginia Tech Wake Forest University, Blacksburg, Virginia, United States of America
    PLoS ONE 7:e50482. 2012
  3. doi request reprint Electrical conductivity changes during irreversible electroporation treatment of brain cancer
    Paulo A Garcia
    Virginia Tech Wake Forest University School of Biomedical Engineering and Sciences, Blacksburg, VA 24061, USA
    Conf Proc IEEE Eng Med Biol Soc 2011:739-42. 2011
  4. doi request reprint Non-thermal irreversible electroporation for deep intracranial disorders
    Paulo A Garcia
    Virginia Tech Wake Forest University School of Biomedical Engineering and Sciences, Blacksburg, VA 24061, USA
    Conf Proc IEEE Eng Med Biol Soc 2010:2743-6. 2010
  5. doi request reprint Pilot study of irreversible electroporation for intracranial surgery
    Paulo A Garcia
    Virginia Tech Wake Forest University School of Biomedical Engineering and Sciences, Blacksburg, VA 24061, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:6513-6. 2009
  6. doi request reprint Experimental characterization and numerical modeling of tissue electrical conductivity during pulsed electric fields for irreversible electroporation treatment planning
    Robert E Neal
    Bioelectromechanical Systems Laboratory, Virginia Tech Wake Forest School of Biomedical Engineering and Sciences, Virginia Tech, Blacksburg, VA 24060, USA
    IEEE Trans Biomed Eng 59:1076-85. 2012
  7. doi request reprint Intracranial nonthermal irreversible electroporation: in vivo analysis
    Paulo A Garcia
    Bioelectromechanical Systems BEMS Laboratory, School of Biomedical Engineering and Sciences SBES, Virginia Tech Wake Forest University, Virginia Tech, 329 ICTAS Building, Stanger Street MC 0298, Blacksburg, VA 24061, USA
    J Membr Biol 236:127-36. 2010
  8. doi request reprint Experimental characterization of intrapulse tissue conductivity changes for electroporation
    Robert E Neal
    Bioelectromechanical Systems Laboratory, Virginia Tech Wake Forest School of Biomedical Engineering and Sciences, Virginia Tech, Blacksburg, VA 24060, USA
    Conf Proc IEEE Eng Med Biol Soc 2011:5581-4. 2011
  9. doi request reprint A study using irreversible electroporation to treat large, irregular tumors in a canine patient
    Robert E Neal
    Bioelectromechanical Systems Lab in the Virginia Tech Wake Forest School of Biomedical Engineering and Sciences at Virginia Tech, Blacksburg, VA 24060, USA
    Conf Proc IEEE Eng Med Biol Soc 2010:2747-50. 2010
  10. pmc A three-dimensional in vitro tumor platform for modeling therapeutic irreversible electroporation
    Christopher B Arena
    School of Biomedical Engineering and Sciences, Virginia Tech Wake Forest University, Blacksburg, Virginia, USA
    Biophys J 103:2033-42. 2012

Detail Information

Publications16

  1. pmc A parametric study delineating irreversible electroporation from thermal damage based on a minimally invasive intracranial procedure
    Paulo A Garcia
    Bioelectromechanical Systems Laboratory, School of Biomedical Engineering and Sciences, Virginia Tech Wake Forest University, Blacksburg, VA, USA
    Biomed Eng Online 10:34. 2011
    ....
  2. pmc 7.0-T magnetic resonance imaging characterization of acute blood-brain-barrier disruption achieved with intracranial irreversible electroporation
    Paulo A Garcia
    Bioelectromechanical Systems Lab, School of Biomedical Engineering and Sciences, Virginia Tech Wake Forest University, Blacksburg, Virginia, United States of America
    PLoS ONE 7:e50482. 2012
    ....
  3. doi request reprint Electrical conductivity changes during irreversible electroporation treatment of brain cancer
    Paulo A Garcia
    Virginia Tech Wake Forest University School of Biomedical Engineering and Sciences, Blacksburg, VA 24061, USA
    Conf Proc IEEE Eng Med Biol Soc 2011:739-42. 2011
    ..42-3.67 times the baseline conductivity, confirming the physical phenomenon that has been detected in other tissues undergoing similar electroporation-based treatments...
  4. doi request reprint Non-thermal irreversible electroporation for deep intracranial disorders
    Paulo A Garcia
    Virginia Tech Wake Forest University School of Biomedical Engineering and Sciences, Blacksburg, VA 24061, USA
    Conf Proc IEEE Eng Med Biol Soc 2010:2743-6. 2010
    ..We also confirm the non-thermal aspect of the technique with real time temperature data measured at the electrode-tissue interface...
  5. doi request reprint Pilot study of irreversible electroporation for intracranial surgery
    Paulo A Garcia
    Virginia Tech Wake Forest University School of Biomedical Engineering and Sciences, Blacksburg, VA 24061, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:6513-6. 2009
    ..This preliminary study is the first step towards using irreversible electroporation as a brain cancer treatment...
  6. doi request reprint Experimental characterization and numerical modeling of tissue electrical conductivity during pulsed electric fields for irreversible electroporation treatment planning
    Robert E Neal
    Bioelectromechanical Systems Laboratory, Virginia Tech Wake Forest School of Biomedical Engineering and Sciences, Virginia Tech, Blacksburg, VA 24060, USA
    IEEE Trans Biomed Eng 59:1076-85. 2012
    ..We conclude that significant changes in predicted outcomes will occur when the experimental results are applied to the numerical model, where the direction and degree of change varies with the electric field considered...
  7. doi request reprint Intracranial nonthermal irreversible electroporation: in vivo analysis
    Paulo A Garcia
    Bioelectromechanical Systems BEMS Laboratory, School of Biomedical Engineering and Sciences SBES, Virginia Tech Wake Forest University, Virginia Tech, 329 ICTAS Building, Stanger Street MC 0298, Blacksburg, VA 24061, USA
    J Membr Biol 236:127-36. 2010
    ..Knowledge of the dynamic electrical conductivity of the tissue and electric field that correlates to lesion volume is crucial to ensure predictable complete NTIRE treatment while minimizing damage to surrounding healthy tissue...
  8. doi request reprint Experimental characterization of intrapulse tissue conductivity changes for electroporation
    Robert E Neal
    Bioelectromechanical Systems Laboratory, Virginia Tech Wake Forest School of Biomedical Engineering and Sciences, Virginia Tech, Blacksburg, VA 24060, USA
    Conf Proc IEEE Eng Med Biol Soc 2011:5581-4. 2011
    ..This conductivity curve was used in a numerical model to demonstrate the impact of accounting for these changes when modeling electric field distributions to develop treatment plans...
  9. doi request reprint A study using irreversible electroporation to treat large, irregular tumors in a canine patient
    Robert E Neal
    Bioelectromechanical Systems Lab in the Virginia Tech Wake Forest School of Biomedical Engineering and Sciences at Virginia Tech, Blacksburg, VA 24060, USA
    Conf Proc IEEE Eng Med Biol Soc 2010:2747-50. 2010
    ..The executed plan was able to alleviate the patient's clinical symptoms without damaging any of the nearby sensitive tissues in a complex heterogeneous environment...
  10. pmc A three-dimensional in vitro tumor platform for modeling therapeutic irreversible electroporation
    Christopher B Arena
    School of Biomedical Engineering and Sciences, Virginia Tech Wake Forest University, Blacksburg, Virginia, USA
    Biophys J 103:2033-42. 2012
    ..Overall, these results illustrate the advantages of using 3D cancer cell culture models to improve IRE-treatment planning and facilitate widespread clinical use of the technology...
  11. doi request reprint Towards a predictive model of electroporation-based therapies using pre-pulse electrical measurements
    Paulo A Garcia
    Virginia Tech Wake Forest University School of Biomedical Engineering and Sciences, Blacksburg, VA 24061, USA
    Conf Proc IEEE Eng Med Biol Soc 2012:2575-8. 2012
    ....
  12. pmc High-frequency irreversible electroporation (H-FIRE) for non-thermal ablation without muscle contraction
    Christopher B Arena
    Bioelectromechanical Systems Lab, Virginia Tech Wake Forest University School of Biomedical Engineering and Sciences, 330 ICTAS Building MC0298, Blacksburg, VA 24061, USA
    Biomed Eng Online 10:102. 2011
    ..This study shows that by applying high-frequency, bipolar bursts, muscle contractions can be eliminated during IRE without compromising the non-thermal mechanism of cell death...
  13. pmc Towards the creation of decellularized organ constructs using irreversible electroporation and active mechanical perfusion
    Michael B Sano
    School of Biomedical Engineering and Sciences, Virginia Tech Wake Forest University, Blacksburg, VA, USA
    Biomed Eng Online 9:83. 2010
    ..This work outlines a method of organ decellularization using non-thermal irreversible electroporation (N-TIRE) which, in combination with reseeding, may help supplement the supply of organs for transplant...
  14. pmc Pathology of non-thermal irreversible electroporation (N-TIRE)-induced ablation of the canine brain
    John H Rossmeisl
    Department of Small Animal Clinical Sciences, Virginia Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061, USA
    J Vet Sci 14:433-40. 2013
    ..This study identified N-TIRE pulse parameters that can be used to safely create circumscribed foci of brain necrosis while selectively preserving major vascular structures. ..
  15. doi request reprint A preliminary study to delineate irreversible electroporation from thermal damage using the arrhenius equation
    Hadi Shafiee
    Bioelectromechanical Systems Laboratory, Department of Engineering Science and Mechanics, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    J Biomech Eng 131:074509. 2009
    ..These results confirm that the region to induce IRE without thermal damage is substantial. We believe that our new theoretical analysis will allow researchers to optimize IRE parameters without inducing deleterious thermal effects...
  16. doi request reprint Invited review--neuroimaging response assessment criteria for brain tumors in veterinary patients
    John H Rossmeisl
    Department of Small Animal Clinical Sciences, Virginia Maryland Regional College of Veterinary Medicine, VA, 24061 Biomechanical Systems and Veterinary and Comparative Neuro oncology Laboratories, Department of Biomedical Engineering, Virginia Tech Wake Forest University School of Biomedical Engineering and Sciences, VA, 24061
    Vet Radiol Ultrasound 55:115-32. 2014
    ....