Guimin Gao

Summary

Affiliation: Virginia Commonwealth University
Country: USA

Publications

  1. pmc A generalized sequential Bonferroni procedure using smoothed weights for genome-wide association studies incorporating information on Hardy-Weinberg disequilibrium among cases
    Guimin Gao
    Department of Biostatistics, Virginia Commonwealth University, Richmond, VA 23298 0032, USA
    Hum Hered 73:1-13. 2012
  2. pmc A rapid association test procedure robust under different genetic models accounting for population stratification
    Wenan Chen
    Department of Biostatistics, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298 0032, USA
    Hum Hered 75:23-33. 2013
  3. pmc Haplotyping methods for pedigrees
    Guimin Gao
    Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, Ala, USA
    Hum Hered 67:248-66. 2009
  4. pmc Similarity-based multimarker association tests for continuous traits
    Wan Yu Lin
    Department of Biostatistics, University of Alabama at Birmingham, USA
    Ann Hum Genet 76:246-60. 2012
  5. pmc Genome-wide association studies of rheumatoid arthritis data via multiple hypothesis testing methods for correlated tests
    Guolian Kang
    Section on Statistical Genetics, Department of Biostatistics, The University of Alabama at Birmingham, 1665 University Boulevard, Birmingham, Alabama 35294, USA
    BMC Proc 3:S38. 2009
  6. pmc MethylPCA: a toolkit to control for confounders in methylome-wide association studies
    Wenan Chen
    Department of Biostatistics, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA
    BMC Bioinformatics 14:74. 2013
  7. pmc Evaluation of pooled association tests for rare variant identification
    Wan Yu Lin
    Department of Biostatistics, University of Alabama at Birmingham, 1665 University Boulevard, Birmingham, AL 35294, USA
    BMC Proc 5:S118. 2011
  8. pmc Double genomic control is not effective to correct for population stratification in meta-analysis for genome-wide association studies
    Shudong Wang
    Department of Biostatistics, School of Medicine, Virginia Commonwealth University Richmond, VA, USA College of Information Science and Engineering, Shandong University of Science and Technology Qingdao, China
    Front Genet 3:300. 2012
  9. pmc Application of imputation methods to the analysis of rheumatoid arthritis data in genome-wide association studies
    Douglas K Childers
    Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    BMC Proc 3:S24. 2009
  10. pmc A rapid conditional enumeration haplotyping method in pedigrees
    Guimin Gao
    Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Genet Sel Evol 40:25-36. 2008

Detail Information

Publications11

  1. pmc A generalized sequential Bonferroni procedure using smoothed weights for genome-wide association studies incorporating information on Hardy-Weinberg disequilibrium among cases
    Guimin Gao
    Department of Biostatistics, Virginia Commonwealth University, Richmond, VA 23298 0032, USA
    Hum Hered 73:1-13. 2012
    ....
  2. pmc A rapid association test procedure robust under different genetic models accounting for population stratification
    Wenan Chen
    Department of Biostatistics, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298 0032, USA
    Hum Hered 75:23-33. 2013
    ....
  3. pmc Haplotyping methods for pedigrees
    Guimin Gao
    Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, Ala, USA
    Hum Hered 67:248-66. 2009
    ..We explore the connections among these methods, and describe the challenges that remain to be addressed...
  4. pmc Similarity-based multimarker association tests for continuous traits
    Wan Yu Lin
    Department of Biostatistics, University of Alabama at Birmingham, USA
    Ann Hum Genet 76:246-60. 2012
    ..3). Our SIMp test outperforms other tests when the causal variant was introduced at common haplotypes (the maximum frequency of risk haplotypes >0.4). We also applied our two tests to an adiposity data set to show their utility...
  5. pmc Genome-wide association studies of rheumatoid arthritis data via multiple hypothesis testing methods for correlated tests
    Guolian Kang
    Section on Statistical Genetics, Department of Biostatistics, The University of Alabama at Birmingham, 1665 University Boulevard, Birmingham, Alabama 35294, USA
    BMC Proc 3:S38. 2009
    ..Simulation studies demonstrate that the MC method may have slightly higher power than the p-values adjusted for correlated tests method...
  6. pmc MethylPCA: a toolkit to control for confounders in methylome-wide association studies
    Wenan Chen
    Department of Biostatistics, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA
    BMC Bioinformatics 14:74. 2013
    ..This approach is, however, computationally very challenging due to the extremely large number of methylation sites in the human genome...
  7. pmc Evaluation of pooled association tests for rare variant identification
    Wan Yu Lin
    Department of Biostatistics, University of Alabama at Birmingham, 1665 University Boulevard, Birmingham, AL 35294, USA
    BMC Proc 5:S118. 2011
    ....
  8. pmc Double genomic control is not effective to correct for population stratification in meta-analysis for genome-wide association studies
    Shudong Wang
    Department of Biostatistics, School of Medicine, Virginia Commonwealth University Richmond, VA, USA College of Information Science and Engineering, Shandong University of Science and Technology Qingdao, China
    Front Genet 3:300. 2012
    ..The results also suggest that PCA correction is more effective than the double GC correction in meta-analysis...
  9. pmc Application of imputation methods to the analysis of rheumatoid arthritis data in genome-wide association studies
    Douglas K Childers
    Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    BMC Proc 3:S24. 2009
    ..We found some untyped SNP that showed significant association with rheumatoid arthritis. Among them, a few of these were not located near any typed SNP that was found to be significant and thus may be worth further investigation...
  10. pmc A rapid conditional enumeration haplotyping method in pedigrees
    Guimin Gao
    Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Genet Sel Evol 40:25-36. 2008
    ..The new algorithm is much more efficient than our previous method and the widely used software SimWalk2...
  11. pmc Testing for differences in distribution tails to test for differences in 'maximum' lifespan
    Guimin Gao
    Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, Alabama, USA
    BMC Med Res Methodol 8:49. 2008
    ..However, a limitation of these tests is that they do not consider how much above the threshold any particular observation is...

Research Grants4

  1. Haplotyping and QTL Mapping in Pedigrees with Missing Data
    Guimin Gao; Fiscal Year: 2010
    ..The methodologies developed in this research will enhance our ability to map QTL and complex disease genes in human and animal populations. ..
  2. Haplotyping and QTL Mapping in Pedigrees with Missing Data
    Guimin Gao; Fiscal Year: 2009
    ..The methodologies developed in this research will enhance our ability to map QTL and complex disease genes in human and animal populations. ..