Research Topics
Species | Kimberly Forsten-WilliamsSummaryAffiliation: Virginia Polytechnic Institute and State University Country: USA Publications
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Detail Information
Publications
Ligand rebinding: self-consistent mean-field theory and numerical simulations applied to surface plasmon resonance studiesManoj Gopalakrishnan
Department of Physics, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
Eur Biophys J 34:943-58. 2005..Our results provide a means for analyzing SPR biosensor data where rebinding is problematic and a methodology to do so is presented...- Sucrose octasulfate regulates fibroblast growth factor-2 binding, transport, and activity: potential for regulation of tumor growthMichael Fannon
Department of Ophthalmology and Visual Science, University of Kentucky, Lexington, Kentucky, USA
J Cell Physiol 215:434-41. 2008..Our results suggest that molecules such as SOS have the potential to remove growth factors from tumor microenvironments and the approach offers an attractive area for further study... - Self-consistent theory of reversible ligand binding to a spherical cellShivam Ghosh
Harish Chandra Research Institute, Jhunsi, Allahabad 211 019, India
Phys Biol 4:344-54. 2007..Implications of our results for binding experiments and numerical simulations of ligand-receptor systems are also discussed... - Complex receptor-ligand dynamics control the response of the VEGF system to protease injuryKimberly Forsten-Williams
Department of Chemical Engineering, Virginia Polytechnic Institute and State University Blacksburg, VA 24061, USA
BMC Syst Biol 5:170. 2011..abstract:.. - Control of growth factor networks by heparan sulfate proteoglycansKimberly Forsten-Williams
Department of Chemical Engineering, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
Ann Biomed Eng 36:2134-48. 2008..Exogenous manipulation of cellular responses to growth factors in complex living systems will require understanding the HSPG-controlled network... - Enhanced insulin-like growth factor-I (IGF-I) cell association at reduced pH is dependent on IGF binding protein-3 (IGFBP-3) interactionKimberly Forsten-Williams
Department of Chemical Engineering, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA
J Cell Physiol 210:298-308. 2007..Identifying the pH-dependent binding partner(s) for IGFBP-3 is a necessary next step in deciphering this process... - Regulation of insulin-like growth factor-I (IGF-I) delivery by IGF binding proteins and receptorsJulie M D Paye
Department of Chemical Engineering, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA
Ann Biomed Eng 34:618-32. 2006.... - The kinetics of FGF-2 binding to heparan sulfate proteoglycans and MAP kinase signalingKimberly Forsten-Williams
Department of Chemical Engineering and Virginia Tech Wake Forest University School of Biomedical Engineering and Sciences, Virginia Polytechnic Institute and State University, 141 Randolph Hall, Blacksburg, VA 24061, USA
J Theor Biol 233:483-99. 2005.... - Autocrine production of insulin-like growth factor-I (IGF-I) affects paracellular transport across epithelial cells in vitroJulie M D Paye
Department of Chemical Engineering, Virginia Polytechnic Institute and State University, Blacksburg 24061, Virginia, USA
Cell Commun Adhes 14:85-98. 2007.... - Design and application of an oscillatory compression device for cell constructsTheresa R Cassino
Department of Chemical Engineering, Virginia Polytechnic Institute and State University, Virginia, USA
Biotechnol Bioeng 98:211-20. 2007..These studies indicate the utility of our device for studying cell activity in response to compression and suggest further studies regarding how the load and strain spectrum impact chondrocyte activity... - Alginate encapsulation impacts the insulin-like growth factor-I system of monolayer-expanded equine articular chondrocytes and cell response to interleukin-1betaRyan M Porter
Department of Chemical Engineering, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061 0211, USA
Tissue Eng 13:1333-45. 2007..Consideration of hormonal regulators may be an essential element to improve chondrocyte culture protocols used in tissue engineering applications... - Implementation of an optical method for the real-time determination of uniaxial strain and vessel mechanicsSelim Elhadj
Department of Chemical Engineering, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
IEEE Trans Biomed Eng 51:536-8. 2004..The advantages of this technique are its relative low cost, ease of implementation, high resolution, and flexibility stemming from its modular setup... - Transcriptional and proteolytic regulation of the insulin-like growth factor-I system of equine articular chondrocytes by recombinant equine interleukin-1betaRyan M Porter
Department of Chemical Engineering, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061-0211, USA
J Cell Physiol 209:542-50. 2006.... - Ligand-induced coupling versus receptor pre-association: cellular automaton simulations of FGF-2 bindingManoj Gopalakrishnan
Department of Physics, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061 0435, USA
J Theor Biol 227:239-51. 2004.... - Chronic pulsatile shear stress alters insulin-like growth factor-I (IGF-I) binding protein release in vitroSelim Elhadj
Department of Chemical Engineering, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
Ann Biomed Eng 31:163-70. 2003.... - Chronic pulsatile shear stress impacts synthesis of proteoglycans by endothelial cells: effect on platelet aggregation and coagulationSelim Elhadj
Department of Chemical Engineering, Virginia Polytechnic Institute and State University, Blacksburg 24061, USA
J Cell Biochem 86:239-50. 2002..Our data suggests that shear stress, by altering proteoglycan synthesis and fine structure, may play a role in maintaining vascular hemodynamics and hemostasis... - Both post-Golgi and intra-Golgi cycling affect the distribution of the Golgi phosphoprotein GPP130Tregei Starr
Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72205, USA
Traffic 8:1265-79. 2007..Our analysis indicates that the effect is greatest at the trans Golgi, the most acidic portion of the Golgi apparatus. In sum, multiple, regulated steps affect the trafficking of GPP130... - Effects of receptor clustering on ligand dissociation kinetics: theory and simulationsManoj Gopalakrishnan
Department of Biological Physics, , Dresden, Germany
Biophys J 89:3686-700. 2005..We further present an analysis of an additional cooperative internal-diffusion model that might be used by other systems to increase ligand retention when simple rebinding is insufficient... - Binding inhibition of angiogenic factors by heparan sulfate proteoglycans in aqueous humor: potential mechanism for maintenance of an avascular environmentMichael Fannon
Department of Surgery, The Children s Hospital, 300 Longwood Ave, Boston, Massachusetts 02115, USA
FASEB J 17:902-4. 2003..This mechanism suggests a physiological process to control bioavailability of angiogenic growth factors in the cornea... - Heparan sulfate proteoglycans function as receptors for fibroblast growth factor-2 activation of extracellular signal-regulated kinases 1 and 2Ceres C Chua
Department of Biochemistry, Boston University School of Medicine, Boston, Mass 02118, USA
Circ Res 94:316-23. 2004..Activation of ERK1/2 via cell-surface proteoglycans could have significant biological consequences, potentially directing cell response toward growth, migration, or differentiation... - The steady-state distribution of glycosyltransferases between the Golgi apparatus and the endoplasmic reticulum is approximately 90:10Sung Wu Rhee
Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72205, USA
Traffic 6:978-90. 2005..In conclusion, we find the ER pool of cycling Golgi glycosyltransferases is small and approximately 1/100 the concentration found in the Golgi apparatus...