Kimberly Forsten-Williams

Summary

Affiliation: Virginia Polytechnic Institute and State University
Country: USA

Publications

  1. ncbi request reprint Ligand rebinding: self-consistent mean-field theory and numerical simulations applied to surface plasmon resonance studies
    Manoj Gopalakrishnan
    Department of Physics, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    Eur Biophys J 34:943-58. 2005
  2. pmc Sucrose octasulfate regulates fibroblast growth factor-2 binding, transport, and activity: potential for regulation of tumor growth
    Michael Fannon
    Department of Ophthalmology and Visual Science, University of Kentucky, Lexington, Kentucky, USA
    J Cell Physiol 215:434-41. 2008
  3. doi request reprint Self-consistent theory of reversible ligand binding to a spherical cell
    Shivam Ghosh
    Harish Chandra Research Institute, Jhunsi, Allahabad 211 019, India
    Phys Biol 4:344-54. 2007
  4. pmc Complex receptor-ligand dynamics control the response of the VEGF system to protease injury
    Kimberly Forsten-Williams
    Department of Chemical Engineering, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    BMC Syst Biol 5:170. 2011
  5. pmc Control of growth factor networks by heparan sulfate proteoglycans
    Kimberly Forsten-Williams
    Department of Chemical Engineering, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    Ann Biomed Eng 36:2134-48. 2008
  6. ncbi request reprint Enhanced insulin-like growth factor-I (IGF-I) cell association at reduced pH is dependent on IGF binding protein-3 (IGFBP-3) interaction
    Kimberly Forsten-Williams
    Department of Chemical Engineering, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA
    J Cell Physiol 210:298-308. 2007
  7. ncbi request reprint Regulation of insulin-like growth factor-I (IGF-I) delivery by IGF binding proteins and receptors
    Julie M D Paye
    Department of Chemical Engineering, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA
    Ann Biomed Eng 34:618-32. 2006
  8. ncbi request reprint The kinetics of FGF-2 binding to heparan sulfate proteoglycans and MAP kinase signaling
    Kimberly Forsten-Williams
    Department of Chemical Engineering and Virginia Tech Wake Forest University School of Biomedical Engineering and Sciences, Virginia Polytechnic Institute and State University, 141 Randolph Hall, Blacksburg, VA 24061, USA
    J Theor Biol 233:483-99. 2005
  9. ncbi request reprint Autocrine production of insulin-like growth factor-I (IGF-I) affects paracellular transport across epithelial cells in vitro
    Julie M D Paye
    Department of Chemical Engineering, Virginia Polytechnic Institute and State University, Blacksburg 24061, Virginia, USA
    Cell Commun Adhes 14:85-98. 2007
  10. ncbi request reprint Design and application of an oscillatory compression device for cell constructs
    Theresa R Cassino
    Department of Chemical Engineering, Virginia Polytechnic Institute and State University, Virginia, USA
    Biotechnol Bioeng 98:211-20. 2007

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Ligand rebinding: self-consistent mean-field theory and numerical simulations applied to surface plasmon resonance studies
    Manoj Gopalakrishnan
    Department of Physics, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    Eur Biophys J 34:943-58. 2005
    ..Our results provide a means for analyzing SPR biosensor data where rebinding is problematic and a methodology to do so is presented...
  2. pmc Sucrose octasulfate regulates fibroblast growth factor-2 binding, transport, and activity: potential for regulation of tumor growth
    Michael Fannon
    Department of Ophthalmology and Visual Science, University of Kentucky, Lexington, Kentucky, USA
    J Cell Physiol 215:434-41. 2008
    ..Our results suggest that molecules such as SOS have the potential to remove growth factors from tumor microenvironments and the approach offers an attractive area for further study...
  3. doi request reprint Self-consistent theory of reversible ligand binding to a spherical cell
    Shivam Ghosh
    Harish Chandra Research Institute, Jhunsi, Allahabad 211 019, India
    Phys Biol 4:344-54. 2007
    ..Implications of our results for binding experiments and numerical simulations of ligand-receptor systems are also discussed...
  4. pmc Complex receptor-ligand dynamics control the response of the VEGF system to protease injury
    Kimberly Forsten-Williams
    Department of Chemical Engineering, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    BMC Syst Biol 5:170. 2011
    ..We hypothesized that the generation and presence of VEGFf would have significant effects on the binding distribution of VEGF...
  5. pmc Control of growth factor networks by heparan sulfate proteoglycans
    Kimberly Forsten-Williams
    Department of Chemical Engineering, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    Ann Biomed Eng 36:2134-48. 2008
    ..Exogenous manipulation of cellular responses to growth factors in complex living systems will require understanding the HSPG-controlled network...
  6. ncbi request reprint Enhanced insulin-like growth factor-I (IGF-I) cell association at reduced pH is dependent on IGF binding protein-3 (IGFBP-3) interaction
    Kimberly Forsten-Williams
    Department of Chemical Engineering, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA
    J Cell Physiol 210:298-308. 2007
    ..Identifying the pH-dependent binding partner(s) for IGFBP-3 is a necessary next step in deciphering this process...
  7. ncbi request reprint Regulation of insulin-like growth factor-I (IGF-I) delivery by IGF binding proteins and receptors
    Julie M D Paye
    Department of Chemical Engineering, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA
    Ann Biomed Eng 34:618-32. 2006
    ....
  8. ncbi request reprint The kinetics of FGF-2 binding to heparan sulfate proteoglycans and MAP kinase signaling
    Kimberly Forsten-Williams
    Department of Chemical Engineering and Virginia Tech Wake Forest University School of Biomedical Engineering and Sciences, Virginia Polytechnic Institute and State University, 141 Randolph Hall, Blacksburg, VA 24061, USA
    J Theor Biol 233:483-99. 2005
    ....
  9. ncbi request reprint Autocrine production of insulin-like growth factor-I (IGF-I) affects paracellular transport across epithelial cells in vitro
    Julie M D Paye
    Department of Chemical Engineering, Virginia Polytechnic Institute and State University, Blacksburg 24061, Virginia, USA
    Cell Commun Adhes 14:85-98. 2007
    ....
  10. ncbi request reprint Design and application of an oscillatory compression device for cell constructs
    Theresa R Cassino
    Department of Chemical Engineering, Virginia Polytechnic Institute and State University, Virginia, USA
    Biotechnol Bioeng 98:211-20. 2007
    ..These studies indicate the utility of our device for studying cell activity in response to compression and suggest further studies regarding how the load and strain spectrum impact chondrocyte activity...
  11. ncbi request reprint Alginate encapsulation impacts the insulin-like growth factor-I system of monolayer-expanded equine articular chondrocytes and cell response to interleukin-1beta
    Ryan M Porter
    Department of Chemical Engineering, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061 0211, USA
    Tissue Eng 13:1333-45. 2007
    ..Consideration of hormonal regulators may be an essential element to improve chondrocyte culture protocols used in tissue engineering applications...
  12. ncbi request reprint Implementation of an optical method for the real-time determination of uniaxial strain and vessel mechanics
    Selim Elhadj
    Department of Chemical Engineering, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    IEEE Trans Biomed Eng 51:536-8. 2004
    ..The advantages of this technique are its relative low cost, ease of implementation, high resolution, and flexibility stemming from its modular setup...
  13. ncbi request reprint Transcriptional and proteolytic regulation of the insulin-like growth factor-I system of equine articular chondrocytes by recombinant equine interleukin-1beta
    Ryan M Porter
    Department of Chemical Engineering, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061 0211, USA
    J Cell Physiol 209:542-50. 2006
    ....
  14. ncbi request reprint Ligand-induced coupling versus receptor pre-association: cellular automaton simulations of FGF-2 binding
    Manoj Gopalakrishnan
    Department of Physics, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061 0435, USA
    J Theor Biol 227:239-51. 2004
    ....
  15. ncbi request reprint Chronic pulsatile shear stress alters insulin-like growth factor-I (IGF-I) binding protein release in vitro
    Selim Elhadj
    Department of Chemical Engineering, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    Ann Biomed Eng 31:163-70. 2003
    ....
  16. ncbi request reprint Chronic pulsatile shear stress impacts synthesis of proteoglycans by endothelial cells: effect on platelet aggregation and coagulation
    Selim Elhadj
    Department of Chemical Engineering, Virginia Polytechnic Institute and State University, Blacksburg 24061, USA
    J Cell Biochem 86:239-50. 2002
    ..Our data suggests that shear stress, by altering proteoglycan synthesis and fine structure, may play a role in maintaining vascular hemodynamics and hemostasis...
  17. ncbi request reprint Both post-Golgi and intra-Golgi cycling affect the distribution of the Golgi phosphoprotein GPP130
    Tregei Starr
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72205, USA
    Traffic 8:1265-79. 2007
    ..Our analysis indicates that the effect is greatest at the trans Golgi, the most acidic portion of the Golgi apparatus. In sum, multiple, regulated steps affect the trafficking of GPP130...
  18. pmc Effects of receptor clustering on ligand dissociation kinetics: theory and simulations
    Manoj Gopalakrishnan
    Department of Biological Physics, Max Planck Institut fur Physik komplexer Systeme, Dresden, Germany
    Biophys J 89:3686-700. 2005
    ..We further present an analysis of an additional cooperative internal-diffusion model that might be used by other systems to increase ligand retention when simple rebinding is insufficient...
  19. ncbi request reprint Binding inhibition of angiogenic factors by heparan sulfate proteoglycans in aqueous humor: potential mechanism for maintenance of an avascular environment
    Michael Fannon
    Department of Surgery, The Children s Hospital, 300 Longwood Ave, Boston, Massachusetts 02115, USA
    FASEB J 17:902-4. 2003
    ..This mechanism suggests a physiological process to control bioavailability of angiogenic growth factors in the cornea...
  20. ncbi request reprint Heparan sulfate proteoglycans function as receptors for fibroblast growth factor-2 activation of extracellular signal-regulated kinases 1 and 2
    Ceres C Chua
    Department of Biochemistry, Boston University School of Medicine, Boston, Mass 02118, USA
    Circ Res 94:316-23. 2004
    ..Activation of ERK1/2 via cell-surface proteoglycans could have significant biological consequences, potentially directing cell response toward growth, migration, or differentiation...
  21. ncbi request reprint The steady-state distribution of glycosyltransferases between the Golgi apparatus and the endoplasmic reticulum is approximately 90:10
    Sung Wu Rhee
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72205, USA
    Traffic 6:978-90. 2005
    ..In conclusion, we find the ER pool of cycling Golgi glycosyltransferases is small and approximately 1/100 the concentration found in the Golgi apparatus...