Paul B Fisher

Summary

Affiliation: Virginia Commonwealth University
Country: USA

Publications

  1. pmc Identification of genes potentially regulated by human polynucleotide phosphorylase (hPNPase old-35) using melanoma as a model
    Upneet K Sokhi
    Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia, United States of America
    PLoS ONE 8:e76284. 2013
  2. pmc Src kinase activation is mandatory for MDA-9/syntenin-mediated activation of nuclear factor-kappaB
    H Boukerche
    Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA, USA
    Oncogene 29:3054-66. 2010
  3. doi request reprint Non-BRAF targeted therapies for melanoma: protein kinase inhibitors in Phase II clinical trials
    Shilpa Bhatia
    Virginia Commonwealth University, School of Medicine, Department of Human and Molecular Genetics, Richmond, VA, USA
    Expert Opin Investig Drugs 23:489-500. 2014
  4. ncbi request reprint Chemoprevention gene therapy (CGT) of pancreatic cancer using perillyl alcohol and a novel chimeric serotype cancer terminator virus
    S Sarkar
    Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, P O Box 980678, Richmond, VA 23298 067, USA
    Curr Mol Med 14:125-40. 2014
  5. pmc MDA-9/syntenin is a key regulator of glioma pathogenesis
    Timothy P Kegelman
    Corresponding author Paul B Fisher, MPH, PhD, Professor and Chairman, Department of Human and Molecular Genetics, Director, VCU Institute of Molecular Medicine, VCU Massey Cancer Center, Virginia Commonwealth University, School of Medicine, 1101 East Marshall Street, Sanger Hall Building, Room 11 015, Richmond, VA 23298 0033
    Neuro Oncol 16:50-61. 2014
  6. ncbi request reprint Chemoprevention gene therapy (CGT): novel combinatorial approach for preventing and treating pancreatic cancer
    S Sarkar
    Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298, USA
    Curr Mol Med 13:1140-59. 2013
  7. pmc Targeting the Bcl-2 family for cancer therapy
    Shibu Thomas
    Virginia Commonwealth University, Department of Human and Molecular Genetics, Richmond, VA 23298, USA
    Expert Opin Ther Targets 17:61-75. 2013
  8. pmc Selected approaches for rational drug design and high throughput screening to identify anti-cancer molecules
    Michael Hedvat
    Sanford Burnham Medical Research Institute, La Jolla, California, USA
    Anticancer Agents Med Chem 12:1143-55. 2012
  9. pmc Targeting Mcl-1 for the therapy of cancer
    Bridget A Quinn
    Virginia Commonwealth University, School of Medicine, Department of Human and Molecular Genetics, Richmond, VA, USA
    Expert Opin Investig Drugs 20:1397-411. 2011
  10. ncbi request reprint MDA-7 regulates cell growth and radiosensitivity in vitro of primary (non-established) human glioma cells
    Adly Yacoub
    Department of Radiation Oncology, Virginia Commonwealth University, Richmond, Virginia 23298 0058, USA
    Cancer Biol Ther 3:739-51. 2004

Research Grants

  1. Mda-7: Novel Cancer Therapeutic Gene
    Paul Fisher; Fiscal Year: 2006
  2. Mda-5: Novel Apoptosis Inducing Gene
    Paul Fisher; Fiscal Year: 2006
  3. Novel Approaches for Pancreatic Cancer Therapy
    Paul Fisher; Fiscal Year: 2006
  4. ANALYSIS OF PROGRESSION OF THE TRANSFORMED PHENOTYPE
    Paul Fisher; Fiscal Year: 2006
  5. Mda-7: Novel Cancer Therapeutic Gene
    Paul Fisher; Fiscal Year: 2005
  6. Mda-5: Novel Apoptosis Inducing Gene
    Paul Fisher; Fiscal Year: 2005
  7. ANALYSIS OF PROGRESSION OF THE TRANSFORMED PHENOTYPE
    Paul Fisher; Fiscal Year: 2005
  8. Novel Approaches for Pancreatic Cancer Therapy
    Paul Fisher; Fiscal Year: 2005
  9. ANALYSIS OF PROGRESSION OF THE TRANSFORMED PHENOTYPE
    Paul Fisher; Fiscal Year: 2007
  10. Novel Approaches for Pancreatic Cancer Therapy
    Paul Fisher; Fiscal Year: 2007

Detail Information

Publications107 found, 100 shown here

  1. pmc Identification of genes potentially regulated by human polynucleotide phosphorylase (hPNPase old-35) using melanoma as a model
    Upneet K Sokhi
    Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia, United States of America
    PLoS ONE 8:e76284. 2013
    ....
  2. pmc Src kinase activation is mandatory for MDA-9/syntenin-mediated activation of nuclear factor-kappaB
    H Boukerche
    Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA, USA
    Oncogene 29:3054-66. 2010
    ..These findings underscore PDZ domains of MDA-9/syntenin as promising potential therapeutic targets for intervening in a decisive component of cancer progression, namely, metastatic tumor spread...
  3. doi request reprint Non-BRAF targeted therapies for melanoma: protein kinase inhibitors in Phase II clinical trials
    Shilpa Bhatia
    Virginia Commonwealth University, School of Medicine, Department of Human and Molecular Genetics, Richmond, VA, USA
    Expert Opin Investig Drugs 23:489-500. 2014
    ..The management of patients with advanced melanoma poses a significant challenge considering that the disease is refractory to most conventional therapies...
  4. ncbi request reprint Chemoprevention gene therapy (CGT) of pancreatic cancer using perillyl alcohol and a novel chimeric serotype cancer terminator virus
    S Sarkar
    Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, P O Box 980678, Richmond, VA 23298 067, USA
    Curr Mol Med 14:125-40. 2014
    ..5/3-CTV-M7 plus POH in PDAC treatment, where all other current treatment strategies in clinical settings show minimal efficacy. ..
  5. pmc MDA-9/syntenin is a key regulator of glioma pathogenesis
    Timothy P Kegelman
    Corresponding author Paul B Fisher, MPH, PhD, Professor and Chairman, Department of Human and Molecular Genetics, Director, VCU Institute of Molecular Medicine, VCU Massey Cancer Center, Virginia Commonwealth University, School of Medicine, 1101 East Marshall Street, Sanger Hall Building, Room 11 015, Richmond, VA 23298 0033
    Neuro Oncol 16:50-61. 2014
    ..To determine whether MDA-9/syntenin is a relevant target in GBM, we investigated its expression in tumor samples and involvement in GBM invasion and angiogenesis...
  6. ncbi request reprint Chemoprevention gene therapy (CGT): novel combinatorial approach for preventing and treating pancreatic cancer
    S Sarkar
    Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298, USA
    Curr Mol Med 13:1140-59. 2013
    ..This novel chemoprevention gene therapy (CGT) strategy holds promise for both prevention and treatment of pancreatic cancers where all other strategies have proven ineffective. ..
  7. pmc Targeting the Bcl-2 family for cancer therapy
    Shibu Thomas
    Virginia Commonwealth University, Department of Human and Molecular Genetics, Richmond, VA 23298, USA
    Expert Opin Ther Targets 17:61-75. 2013
    ..These genes are well documented in cancer with aberrant expression being strongly associated with resistance to chemotherapy and radiation...
  8. pmc Selected approaches for rational drug design and high throughput screening to identify anti-cancer molecules
    Michael Hedvat
    Sanford Burnham Medical Research Institute, La Jolla, California, USA
    Anticancer Agents Med Chem 12:1143-55. 2012
    ....
  9. pmc Targeting Mcl-1 for the therapy of cancer
    Bridget A Quinn
    Virginia Commonwealth University, School of Medicine, Department of Human and Molecular Genetics, Richmond, VA, USA
    Expert Opin Investig Drugs 20:1397-411. 2011
    ..One strategy is to overexpress proteins that suppress apoptosis, such as the Bcl-2 family protein Mcl-1. The Mcl-1 protein plays a pivotal role in protecting cells from apoptosis and is overexpressed in a variety of human cancers...
  10. ncbi request reprint MDA-7 regulates cell growth and radiosensitivity in vitro of primary (non-established) human glioma cells
    Adly Yacoub
    Department of Radiation Oncology, Virginia Commonwealth University, Richmond, Virginia 23298 0058, USA
    Cancer Biol Ther 3:739-51. 2004
    ....
  11. pmc 17-allylamino-17-demethoxygeldanamycin and MEK1/2 inhibitors kill GI tumor cells via Ca2+-dependent suppression of GRP78/BiP and induction of ceramide and reactive oxygen species
    Teneille Walker
    Department of Biochemistry, Virginia Commonwealth University, Richmond, Virginia, USA
    Mol Cancer Ther 9:1378-95. 2010
    ..Thus, treatment of tumor cells with MEK1/2 inhibitor and 17AAG induces cytosolic Ca(2+) and loss of GRP78/BiP function, leading to de novo ceramide synthesis pathway activation that plays a key role in ROS generation and CD95 activation...
  12. pmc Caspase-, cathepsin-, and PERK-dependent regulation of MDA-7/IL-24-induced cell killing in primary human glioma cells
    Adly Yacoub
    Department of Biochemistry, Virginia Commonwealth University, Richmond, VA 23298 0035, USA
    Mol Cancer Ther 7:297-313. 2008
    ....
  13. pmc Vorinostat and sorafenib increase CD95 activation in gastrointestinal tumor cells through a Ca(2+)-de novo ceramide-PP2A-reactive oxygen species-dependent signaling pathway
    Margaret A Park
    Department of Biochemistry, Virginia Commonwealth University, Richmond, Virginia 23298 0035, USA
    Cancer Res 70:6313-24. 2010
    ..Our findings show that induction of cytosolic Ca(2+) by sorafenib and vorinostat is a primary event that elevates dihydroceramide levels, each essential steps in ROS generation that promotes CD95 activation...
  14. pmc Sorafenib enhances pemetrexed cytotoxicity through an autophagy-dependent mechanism in cancer cells
    M Danielle Bareford
    Department of Neurosurgery, Virginia Commonwealth University, Richmond, VA, USA
    Autophagy 7:1261-2. 2011
    ....
  15. doi request reprint Regulation of GST-MDA-7 toxicity in human glioblastoma cells by ERBB1, ERK1/2, PI3K, and JNK1-3 pathway signaling
    Adly Yacoub
    Department of Biochemistry, Virginia Commonwealth University, Richmond, VA 23298 0035, USA
    Mol Cancer Ther 7:314-29. 2008
    ....
  16. pmc Vorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activation
    Margaret A Park
    Department of Biochemistry, Virginia Commonwealth University, Richmond, VA 23298 0035, USA
    Cancer Biol Ther 7:1648-62. 2008
    ....
  17. pmc Astrocyte elevated gene-1 promotes hepatocarcinogenesis: novel insights from a mouse model
    Jyoti Srivastava
    Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA, USA
    Hepatology 56:1782-91. 2012
    ..Short interfering RNA-mediated knockdown of FXII resulted in profound inhibition of AEG-1-induced angiogenesis...
  18. pmc Multiple cyclin kinase inhibitors promote bile acid-induced apoptosis and autophagy in primary hepatocytes via p53-CD95-dependent signaling
    Guo Zhang
    Department of Biochemistry, Virginia Commonwealth University, Richmond, Virginia 23298 0035, USA
    J Biol Chem 283:24343-58. 2008
    ..Thus, CDK inhibitors suppress MDM2 levels and enhance p53 expression that facilitates bile acid-induced, ceramide-dependent CD95 activation to induce both apoptosis and autophagy in primary hepatocytes...
  19. pmc OSU-03012 enhances Ad.7-induced GBM cell killing via ER stress and autophagy and by decreasing expression of mitochondrial protective proteins
    Hossein A Hamed
    Departments of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, 401 College St, Richmond, VA 23298, USA
    Cancer Biol Ther 9:526-36. 2010
    ..Collectively, our data demonstrate that the induction of autophagy and mitochondrial dysfunction by a combinatorial treatment approach represents a potentially viable strategy to kill primary human GBM cells...
  20. pmc Mitogen-activated protein kinase kinase 1/2 inhibitors and 17-allylamino-17-demethoxygeldanamycin synergize to kill human gastrointestinal tumor cells in vitro via suppression of c-FLIP-s levels and activation of CD95
    Margaret A Park
    Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, 401 College Street, Massey Cancer Center, Box 980035, Richmond, VA 23298 0035, USA
    Mol Cancer Ther 7:2633-48. 2008
    ..Our data show that treatment of tumor cells with MEK1/2 inhibitors and 17AAG induces activation of the extrinsic pathway and that suppression of c-FLIP-s expression is [Mol Cancer Ther 2008;7(9):2633-48]...
  21. pmc Novel Mechanism of MDA-7/IL-24 Cancer-Specific Apoptosis through SARI Induction
    Rupesh Dash
    Authors Affiliations Institute of Life Sciences, Bhubaneshwar, Orissa, India Department of Human and Molecular Genetics, VCU Institute of Molecular Medicine, and VCU Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia
    Cancer Res 74:563-74. 2014
    ..mda-7 infection. These findings reveal the significance of the mda-7/IL-24-SARI axis in cancer-specific killing and provide a potential strategy for treating both local and metastatic disease. Cancer Res; 74(2); 563-74. ©2013 AACR. ..
  22. pmc A multifunctional chimeric chaperone serves as a novel immune modulator inducing therapeutic antitumor immunity
    Xiaofei Yu
    Department of Human and Molecular Genetics, VCU Institute of Molecular Medicine, VCU Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
    Cancer Res 73:2093-103. 2013
    ....
  23. pmc PERK-dependent regulation of ceramide synthase 6 and thioredoxin play a key role in mda-7/IL-24-induced killing of primary human glioblastoma multiforme cells
    Adly Yacoub
    Department of Biochemistry and Molecular Biology, VCU Institute of Molecular Medicine, Neurosurgery, Virginia Commonwealth University, School of Medicine, Richmond, Virginia 23298 0035, USA
    Cancer Res 70:1120-9. 2010
    ..Our findings indicate that mda-7/IL-24 induces an endoplasmic reticulum stress response that triggers production of ceramide, Ca(2+), and ROS, which in turn promote glioma cell autophagy and cell death...
  24. pmc A serotype 5/3 adenovirus expressing MDA-7/IL-24 infects renal carcinoma cells and promotes toxicity of agents that increase ROS and ceramide levels
    Margaret A Park
    Department of Neurosurgery, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298 0035, USA
    Mol Pharmacol 79:368-80. 2011
    ..Our data indicate that in RCCs, Ad.5/3-mda-7-induced ceramide generation plays a central role in tumor cell killing and inhibition of multiple signaling pathways may have utility in promoting MDA-7/IL-24 lethality in renal cancer...
  25. doi request reprint Ceramide plays a prominent role in MDA-7/IL-24-induced cancer-specific apoptosis
    Moira Sauane
    Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, Virginia
    J Cell Physiol 222:546-55. 2010
    ..Additionally, recombinant MDA-7/IL-24 protein induced cancer-specific production of ceramide. These studies define ceramide as a key mediator of an ER stress pathway that may underlie mda-7/IL-24 induction of cancer-specific killing...
  26. pmc Transcription factor Late SV40 Factor (LSF) functions as an oncogene in hepatocellular carcinoma
    Byoung Kwon Yoo
    Departments of Human and Molecular Genetics, Virginia Commonwealth University Institute of Molecular Medicine, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
    Proc Natl Acad Sci U S A 107:8357-62. 2010
    ..Together, these data establish a regulatory role of LSF in cancer, particularly HCC pathogenesis, and validate LSF as a viable target for therapeutic intervention...
  27. pmc PERK-dependent regulation of MDA-7/IL-24-induced autophagy in primary human glioma cells
    Margaret A Park
    Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, Virginia 23298 0035, USA
    Autophagy 4:513-5. 2008
    ....
  28. pmc Mechanism of autophagy to apoptosis switch triggered in prostate cancer cells by antitumor cytokine melanoma differentiation-associated gene 7/interleukin-24
    Sujit K Bhutia
    Department of Human and Molecular Genetics, VCU Institute of Molecular Medicine, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298, USA
    Cancer Res 70:3667-76. 2010
    ....
  29. pmc Enhancing mda-7/IL-24 therapy in renal carcinoma cells by inhibiting multiple protective signaling pathways using sorafenib and by Ad.5/3 gene delivery
    Patrick J Eulitt
    Departments of Biochemistry and Molecular Biology, Virginia Commonwealth University, School of Medicine, 401 College St, Richmond, VA 23298, USA
    Cancer Biol Ther 10:1290-305. 2010
    ..Treatment of RCC tumors in vivo with sorafenib also enhanced Ad.5/3-mda-7 toxicity and prolonged animal survival. Future combinations of these approaches hold promise for developing a more effective therapy for kidney cancer...
  30. ncbi request reprint Melanoma differentiation-associated 7 (interleukin 24) inhibits growth and enhances radiosensitivity of glioma cells in vitro and in vivo
    Adly Yacoub
    Department of Radiation Oncology, Virginia Commonwealth University, Richmond, Virginia 23298 0058, USA
    Clin Cancer Res 9:3272-81. 2003
    ..Despite therapeutic interventions including surgery, chemotherapy, and radiotherapy, glioblastoma multiforme (GBM) has a very poor prognosis and novel therapies are required...
  31. pmc MDA-7/IL-24 as a cancer therapeutic: from bench to bedside
    Paul Dent
    Department of Neurosurgery, Virginia Commonwealth University, Richmond, 23298 0035, USA
    Anticancer Drugs 21:725-31. 2010
    ..This review describes what is known about the impact of MDA-7/IL-24 on tumor cell biology and its potential therapeutic applications...
  32. pmc Enhanced endoplasmic reticulum entry of tumor antigen is crucial for cross-presentation induced by dendritic cell-targeted vaccination
    Hongxia Wang
    Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA 23298
    J Immunol 191:6010-21. 2013
    ..These results also reinforce the importance of the ER-associated protein quality control machinery and the mode of the Ag delivery in regulating DC-elicited immune outcomes. ..
  33. ncbi request reprint PERK-dependent regulation of HSP70 expression and the regulation of autophagy
    Margaret A Park
    Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, Virginia, USA
    Autophagy 4:364-7. 2008
    ..These findings may help explain why, in a cell type and stimulus-dependent fashion; autophagy has been noted to act either as a protective or as a toxic signal in cells...
  34. pmc Enhanced delivery of mda-7/IL-24 using a serotype chimeric adenovirus (Ad.5/3) in combination with the Apogossypol derivative BI-97C1 (Sabutoclax) improves therapeutic efficacy in low CAR colorectal cancer cells
    Belal Azab
    Department of Human and Molecular Genetics, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA
    J Cell Physiol 227:2145-53. 2012
    ..5/3-mda-7 alone or in combination with BI-97C1 would be predicted to exert significantly improved therapeutic efficacy in colorectal cancer patients...
  35. pmc Vorinostat and sorafenib synergistically kill tumor cells via FLIP suppression and CD95 activation
    Guo Zhang
    Department of Biochemistry, Virginia Commonwealth University, Richmond, Virginia 23298 0035, USA
    Clin Cancer Res 14:5385-99. 2008
    ..Mechanism(s) by which the multikinase inhibitor sorafenib and the histone deacetylase inhibitor vorinostat interact to kill hepatic, renal, and pancreatic adenocarcinoma cells has been defined...
  36. pmc Molecular mechanism of chemoresistance by astrocyte elevated gene-1
    Byoung Kwon Yoo
    Department of Human and Molecular Genetics, VCU Institute of Molecular Medicine, and VCU Massey Cancer Center, Virginia Commonwealth University, School of Medicine, Richmond, Virginia 23298, USA
    Cancer Res 70:3249-58. 2010
    ..e., translational and posttranslational regulation of proteins). Inhibition of AEG-1 might provide a means of more effectively using chemotherapy to treat HCC, which displays inherent chemoresistance with aggressive pathology...
  37. pmc Mechanism by which Mcl-1 regulates cancer-specific apoptosis triggered by mda-7/IL-24, an IL-10-related cytokine
    Rupesh Dash
    Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, Virginia 23298, USA
    Cancer Res 70:5034-45. 2010
    ..As Mcl-1 is overexpressed in the majority of prostate cancers, mda-7/IL-24 might provide an effective therapeutic for this disease...
  38. pmc Histone deacetylase inhibitors interact with melanoma differentiation associated-7/interleukin-24 to kill primary human glioblastoma cells
    Hossein A Hamed
    Department of Neurosurgery, Virginia Commonwealth University, Richmond, VA, USA
    Mol Pharmacol 84:171-81. 2013
    ..Collectively our data demonstrate that HDACIs enhance MDA-7/IL-24 lethality, and adenoviral delivery of mda-7/IL-24 combined with tumor-specific viral replication is an effective preclinical GBM therapeutic. ..
  39. ncbi request reprint Enhanced prostate cancer gene transfer and therapy using a novel serotype chimera cancer terminator virus (Ad.5/3-CTV)
    Belal M Azab
    Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, Virginia
    J Cell Physiol 229:34-43. 2014
    ..Considering the significant responses in a Phase I clinical trial of a non-replicating Ad.5-mda-7 in advanced cancers, Ad.5/3-CTV may exert improved therapeutic benefit in a clinical setting...
  40. pmc Sorafenib enhances pemetrexed cytotoxicity through an autophagy-dependent mechanism in cancer cells
    M Danielle Bareford
    Departments of Neurosurgery, Massey Cancer Center, Box 980035, Virginia Commonwealth University, Richmond, VA 23298 0035, USA
    Cancer Res 71:4955-67. 2011
    ....
  41. pmc Cisplatin enhances protein kinase R-like endoplasmic reticulum kinase- and CD95-dependent melanoma differentiation-associated gene-7/interleukin-24-induced killing in ovarian carcinoma cells
    Adly Yacoub
    Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, VA 23298 0035, USA
    Mol Pharmacol 77:298-310. 2010
    ..Collectively, our data demonstrate that MDA-7/IL-24 induces an endoplasmic reticulum stress response that activates multiple proapoptotic pathways, culminating in decreased ovarian tumor cell survival...
  42. ncbi request reprint MDA-7/IL-24 plus radiation enhance survival in animals with intracranial primary human GBM tumors
    Adly Yacoub
    Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, Virginia 23298 0035, USA
    Cancer Biol Ther 7:917-33. 2008
    ....
  43. pmc Melanoma differentiation associated gene-7/interleukin-24 potently induces apoptosis in human myeloid leukemia cells through a process regulated by endoplasmic reticulum stress
    Mohamed Rahmani
    Department of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA
    Mol Pharmacol 78:1096-104. 2010
    ..They also suggest that MDA-7/IL-24 warrants further investigation in myeloid leukemia...
  44. pmc Multifunction protein staphylococcal nuclease domain containing 1 (SND1) promotes tumor angiogenesis in human hepatocellular carcinoma through novel pathway that involves nuclear factor κB and miR-221
    Prasanna Kumar Santhekadur
    Department of Human and Molecular Genetics, Massey Cancer Center, Virginia Commonwealth University, School of Medicine, Richmond, Virginia 23298, USA
    J Biol Chem 287:13952-8. 2012
    ..Because SND1 regulates NF-κB and miR-221, two important determinants of HCC controlling the aggressive phenotype, SND1 inhibition might be an effective strategy to counteract this fatal malady...
  45. pmc mda-7/IL-24 differentially regulates soluble and nuclear clusterin in prostate cancer
    Sujit K Bhutia
    Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, Virginia, USA
    J Cell Physiol 227:1805-13. 2012
    ..Our findings reveal novel aspects relative to the role of sCLU/nCLU in regulating the anticancer properties of MDA-7/IL-24 that may be exploited for developing enhanced therapies for prostate cancer...
  46. pmc Late SV40 factor (LSF) enhances angiogenesis by transcriptionally up-regulating matrix metalloproteinase-9 (MMP-9)
    Prasanna K Santhekadur
    Department of Human and Molecular Genetics, School of Medicine, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    J Biol Chem 287:3425-32. 2012
    ..The present findings identify a novel target of LSF contributing to its oncogenic properties...
  47. pmc MDA-7/IL-24-induced cell killing in malignant renal carcinoma cells occurs by a ceramide/CD95/PERK-dependent mechanism
    Margaret A Park
    Department of Biochemistry and Molecular Biology, Massey Cancer Center, School of Medicine, Virginia Commonwealth University, Richmond, Virginia 23298 0035, USA
    Mol Cancer Ther 8:1280-91. 2009
    ..Our data show that in kidney cancer cells GST-MDA-7 induces ceramide-dependent activation of CD95, which is causal in promoting an endoplasmic reticulum stress response that activates multiple proapoptotic pathways to decrease survival...
  48. pmc Inhibition of multiple protective signaling pathways and Ad.5/3 delivery enhances mda-7/IL-24 therapy of malignant glioma
    Hossein A Hamed
    Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, School of Medicine, Richmond, Virginia 23298 0035, USA
    Mol Ther 18:1130-42. 2010
    ..5/3-mda-7. Ad.5/3-mda-7 more effectively infected and killed GBM cells in vitro and in vivo than Ad.5-mda-7. Future combinations of these approaches hold promise for developing an effective therapy for GBM...
  49. pmc Autophagy switches to apoptosis in prostate cancer cells infected with melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24)
    Sujit K Bhutia
    Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA, USA
    Autophagy 7:1076-7. 2011
    ..These new insights into MDA-7/IL-24 action provide intriguing leads for developing innovative combinatorial approaches for prostate cancer therapy...
  50. pmc Novel role of MDA-9/syntenin in regulating urothelial cell proliferation by modulating EGFR signaling
    Santanu Dasgupta
    Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298, USA
    Clin Cancer Res 19:4621-33. 2013
    ..The key molecules involved in metastatic progression and its early detection require clarification. The present study defines a seminal role of the metastasis-associated gene MDA-9/Syntenin in UCC progression...
  51. pmc Human polynucleotide phosphorylase selectively and preferentially degrades microRNA-221 in human melanoma cells
    Swadesh K Das
    Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
    Proc Natl Acad Sci U S A 107:11948-53. 2010
    ..Targeted overexpression of hPNPase(old-35) might provide an effective therapeutic strategy for miR-221-overexpressing and IFN-resistant tumors, such as melanoma...
  52. ncbi request reprint Targeting breast cancer-initiating/stem cells with melanoma differentiation-associated gene-7/interleukin-24
    Sujit K Bhutia
    Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA
    Int J Cancer 133:2726-36. 2013
    ....
  53. pmc Expression patterns of MDA-9/syntenin during development of the mouse embryo
    Hyun Yong Jeon
    Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Sanger Hall 11 015, 1101 East Marshall Street, Richmond, VA 23298, USA
    J Mol Histol 44:159-66. 2013
    ..Additionally, temporal regulation of MDA-9/syntenin expression may be required during specific stages and in specific tissues during development...
  54. pmc The development of MDA-7/IL-24 as a cancer therapeutic
    Paul Dent
    Department of Neurosurgery, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298, USA
    Pharmacol Ther 128:375-84. 2010
    ..This review describes what is presently known about the impact of MDA-7/IL-24 on tumor cell biology and its potential therapeutic applications...
  55. doi request reprint Chapter One---Cancer terminator viruses and approaches for enhancing therapeutic outcomes
    Swadesh K Das
    Department of Human and Molecular Genetics, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA
    Adv Cancer Res 115:1-38. 2012
    ..This review focuses on these viruses and ways to improve their delivery systemically and enhance their therapeutic efficacy...
  56. pmc Apogossypol derivative BI-97C1 (Sabutoclax) targeting Mcl-1 sensitizes prostate cancer cells to mda-7/IL-24-mediated toxicity
    Rupesh Dash
    Department of Human and Molecular Genetics, Virginia Commonwealth University Institute of Molecular Medicine, and Virginia Commonwealth University Massey Cancer Center, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA
    Proc Natl Acad Sci U S A 108:8785-90. 2011
    ....
  57. ncbi request reprint MDA-9/syntenin: a positive gatekeeper of melanoma metastasis
    Swadesh K Das
    Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298, USA
    Front Biosci (Landmark Ed) 17:1-15. 2012
    ..The present review provides a current perspective of our understanding of the important features of MDA-9/syntenin and its significant role in tumor cell metastasis with special focus on molecular mechanism of action...
  58. ncbi request reprint Human chorionic gonadotropin (hCG) interacts with lovastatin and ionizing radiation to modulate prostate cancer cell viability in vivo
    Hossein Hamed
    Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, Virginia 23298 0058, USA
    Cancer Biol Ther 7:587-93. 2008
    ..Collectively, our findings argue that treatment of PC-3 prostate cancer tumors with hCG, lovastatin and radiation represents a potential novel therapeutic approach...
  59. pmc Astrocyte elevated gene-1 (AEG-1): A multifunctional regulator of normal and abnormal physiology
    Byoung Kwon Yoo
    Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298, USA
    Pharmacol Ther 130:1-8. 2011
    ..The present review provides a snapshot of the current literature along with future perspectives on this unique molecule...
  60. pmc Lapatinib resistance in HCT116 cells is mediated by elevated MCL-1 expression and decreased BAK activation and not by ERBB receptor kinase mutation
    Aditi Pandya Martin
    Department of Biochemistry, Virginia Commonwealth University, Richmond, VA 23298 0035, USA
    Mol Pharmacol 74:807-22. 2008
    ..Thus, in HCT116 cells, lapatinib adaptation can be mediated by altered expression of pro- and antiapoptotic proteins that maintain mitochondrial function...
  61. pmc Astrocyte elevated gene-1 induces protective autophagy
    Sujit K Bhutia
    Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
    Proc Natl Acad Sci U S A 107:22243-8. 2010
    ..In summary, the present study reveals a previously unknown aspect of AEG-1 function by identifying it as a potential regulator of protective autophagy, an important feature of AEG-1 that may contribute to its tumor-promoting properties...
  62. ncbi request reprint Low-dose BBR3610 toxicity in colon cancer cells is p53-independent and enhanced by inhibition of epidermal growth factor receptor (ERBB1)-phosphatidyl inositol 3 kinase signaling
    Clint Mitchell
    Department of Biochemistry, Virginia Commonwealth University, Richmond, VA 23298 0035, USA
    Mol Pharmacol 72:704-14. 2007
    ....
  63. pmc Insulin-like growth factor-binding protein-7 (IGFBP7): a promising gene therapeutic for hepatocellular carcinoma (HCC)
    Dong Chen
    Department of Pathology, Virginia Commonwealth University, School of Medicine, Richmond, Virginia 23298, USA
    Mol Ther 21:758-66. 2013
    ..These findings indicate that Ad.IGFBP7 might be a potent therapeutic eradicating both primary HCC and distant metastasis and might be an effective treatment option for terminal HCC patients...
  64. pmc MDA-9/syntenin and IGFBP-2 promote angiogenesis in human melanoma
    Swadesh K Das
    Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, Virginia 23298, USA
    Cancer Res 73:844-54. 2013
    ....
  65. pmc In situ vaccination with CD204 gene-silenced dendritic cell, not unmodified dendritic cell, enhances radiation therapy of prostate cancer
    Chunqing Guo
    Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, PO Box 980033, Richmond, VA 23298, USA
    Mol Cancer Ther 11:2331-41. 2012
    ..Further studies are warranted to test this novel combinatorial approach for translating into improved clinical outcomes in patients with prostate cancer...
  66. ncbi request reprint MEK1/2 inhibition promotes Taxotere lethality in mammary tumors in vivo
    Adly Yacoub
    Department of Biochemistry, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Cancer Biol Ther 5:1332-9. 2006
    ..Based on the cell lines used in these studies, our findings argue that the interaction of Taxotere and PD184352 is independent of p53 status, estrogen dependency, caspase 3 levels or oncogenic K-RAS expression...
  67. pmc Insulin-like growth factor-binding protein-7 functions as a potential tumor suppressor in hepatocellular carcinoma
    Dong Chen
    Department of Pathology, Virginia Commonwealth University, School of Medicine, Richmond, Virginia 23298, USA
    Clin Cancer Res 17:6693-701. 2011
    ..The present study focuses on analyzing potential tumor suppressor functions of IGFBP7 in HCC and the relevance of IGFBP7 downregulation in mediating AEG-1 function...
  68. ncbi request reprint Searching for a cure: gene therapy for glioblastoma
    Paul Dent
    Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, School of Medicine, Richmond, Virginia 23298 0035, USA
    Cancer Biol Ther 7:1335-40. 2008
    ..The concerted use of established and novel signal transduction modulatory agents on GBM survival may have potential to lower the apoptotic threshold and facilitate killing in this lethal malignancy...
  69. pmc Adenovirus-mediated hPNPase(old-35) gene transfer as a therapeutic strategy for neuroblastoma
    Tom Van Maerken
    Department of Human and Molecular Genetics, School of Medicine, Virginia Commonwealth University, Richmond, Virginia, USA
    J Cell Physiol 219:707-15. 2009
    ..J. Cell. Physiol. 219: 707-715, 2009. (c) 2009 Wiley-Liss, Inc...
  70. pmc Raf kinase inhibitor RKIP inhibits MDA-9/syntenin-mediated metastasis in melanoma
    Swadesh K Das
    Department of Human and Molecular Genetics, VCU Institute of Molecular Medicine, VCU Massey Cancer Center, Virginia Commonwealth University, School of Medicine, Richmond, Virginia, USA
    Cancer Res 72:6217-26. 2012
    ..Taken together, these findings establish RKIP as an inhibitor of MDA-9-dependent melanoma metastasis, with potential implications for targeting this process therapeutically...
  71. pmc Mitochondrial DNA mutations in respiratory complex-I in never-smoker lung cancer patients contribute to lung cancer progression and associated with EGFR gene mutation
    Santanu Dasgupta
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University, Baltimore, Maryland, USA
    J Cell Physiol 227:2451-60. 2012
    ..Signature mtDNA mutations provide a basis to develop novel biomarkers and therapeutic strategies for never-smoker lung cancer patients...
  72. ncbi request reprint Extrinsic pathway- and cathepsin-dependent induction of mitochondrial dysfunction are essential for synergistic flavopiridol and vorinostat lethality in breast cancer cells
    Clint Mitchell
    Department of Biochemistry, Box 980035, Virginia Commonwealth University, Richmond, VA 23298 0035, USA
    Mol Cancer Ther 6:3101-12. 2007
    ....
  73. ncbi request reprint Developing an effective gene therapy for prostate cancer: New technologies with potential to translate from the laboratory into the clinic
    Rupesh Dash
    Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, 23298, USA
    Discov Med 11:46-56. 2011
    ..These unique strategies for enhancing the efficacy of gene therapy provide a direct path to translation from the laboratory into the clinic for developing an effective gene therapy of prostate cancer...
  74. ncbi request reprint Human chorionic gonadotropin modulates prostate cancer cell survival after irradiation or HMG CoA reductase inhibitor treatment
    Adly Yacoub
    Department of Biochemistry, 401 College St, Massey Cancer Center, Room 2 108, Box 980035, Virginia Commonwealth University, Richmond VA 23298 0035, USA
    Mol Pharmacol 71:259-75. 2007
    ..Thus, hCG, in combination with radiation and lovastatin, may represent a novel approach to kill prostate cancer cells...
  75. pmc mda-7/IL-24: a unique member of the IL-10 gene family promoting cancer-targeted toxicity
    Rupesh Dash
    Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, VA, United States
    Cytokine Growth Factor Rev 21:381-91. 2010
    ....
  76. pmc c-Met activation through a novel pathway involving osteopontin mediates oncogenesis by the transcription factor LSF
    Byoung Kwon Yoo
    Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298, USA
    J Hepatol 55:1317-24. 2011
    ..The present study aims at a better understanding of LSF function by analyzing the signaling pathway modulated by LSF...
  77. pmc Lapatinib and obatoclax kill tumor cells through blockade of ERBB1/3/4 and through inhibition of BCL-XL and MCL-1
    Nichola Cruickshanks
    Department of Neurosurgery, Virginia Commonwealth University, Richmond, VA 23298 0035, USA
    Mol Pharmacol 81:748-58. 2012
    ..Treatment of animals carrying orthotopic CNS tumor isolates with lapatinib- and obatoclax-prolonged survival. Altogether, our data show that lapatinib and obatoclax therapy could be of use in the treatment of tumors located in the CNS...
  78. pmc Regulation of autophagy by ceramide-CD95-PERK signaling
    Margaret A Park
    Department of Biochemistry, Virginia Commonwealth University, Richmond, Virginia 23298 0035, USA
    Autophagy 4:929-31. 2008
    ..Finally, death receptor induced apoptosis and autophagy could be potential targets for therapeutic intervention...
  79. ncbi request reprint MDA-7/IL-24 regulates proliferation, invasion and tumor cell radiosensitivity: a new cancer therapy?
    Paul Dent
    Department of Biochemistry, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    J Cell Biochem 95:712-9. 2005
    ..This review describes what is known about the impact of IL-24 on tumor cell biology in addition to approaches that may enhance the toxicity of this novel cytokine...
  80. ncbi request reprint Approaches for monitoring signal transduction changes in normal and cancer cells
    Paul Dent
    Department of Biochemistry, Virginia Commonwealth University, Richmond, USA
    Methods Mol Biol 383:259-76. 2007
    ..The strengths and weaknesses of each approach in determining protein kinase activity will also be discussed...
  81. pmc Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression
    Byoung Kwon Yoo
    Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
    J Clin Invest 119:465-77. 2009
    ..Targeted inhibition of AEG1 might lead to the shutdown of key elemental characteristics of HCC and could lead to an effective therapeutic strategy for HCC...
  82. ncbi request reprint MDA-7 (interleukin-24) inhibits the proliferation of renal carcinoma cells and interacts with free radicals to promote cell death and loss of reproductive capacity
    Adly Yacoub
    Department of Radiation Oncology, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Mol Cancer Ther 2:623-32. 2003
    ..Collectively, these findings demonstrate that MDA-7 protein, in combination with agents that generate free radicals, may have potential in the treatment of RCC...
  83. pmc CHK1 inhibitors in combination chemotherapy: thinking beyond the cell cycle
    Paul Dent
    Department of Neurosurgery, Virginia Commonwealth University, Massey Cancer Center, 401 College Street, Richmond, VA 23298 0035, USA
    Mol Interv 11:133-40. 2011
    ..An understanding of Chk1 inhibition in multiple signaling contexts will be essential to the therapeutic development of Chk1 inhibitors...
  84. pmc Role of excitatory amino acid transporter-2 (EAAT2) and glutamate in neurodegeneration: opportunities for developing novel therapeutics
    Keetae Kim
    Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, Virginia 23298, USA
    J Cell Physiol 226:2484-93. 2011
    ....
  85. pmc Histone deacetylase inhibitors activate NF-kappaB in human leukemia cells through an ATM/NEMO-related pathway
    Roberto R Rosato
    Department of Medicine, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    J Biol Chem 285:10064-77. 2010
    ....
  86. doi request reprint Model cell culture system for defining the molecular and biochemical events mediating terminal differentiation of human melanoma cells
    Michelle R Staudt
    Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, Virginia, USA
    J Cell Physiol 218:304-14. 2009
    ....
  87. pmc mda-9/Syntenin promotes metastasis in human melanoma cells by activating c-Src
    Habib Boukerche
    Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298, USA
    Proc Natl Acad Sci U S A 105:15914-9. 2008
    ..These provocative findings highlight mda-9/syntenin and its interacting partners as promising therapeutic targets for intervention of metastasis...
  88. pmc Cloning and characterization of SARI (suppressor of AP-1, regulated by IFN)
    Zao Zhong Su
    Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
    Proc Natl Acad Sci U S A 105:20906-11. 2008
    ..These findings uncover a novel mode of IFN-induced anti-tumor growth suppression and suggest potential gene therapy applications for SARI...
  89. ncbi request reprint Radiotherapy-induced signal transduction
    Adly Yacoub
    Department of Biochemistry, Virginia Commonwealth University, 401 College Street, Richmond, Virginia 23298, USA
    Endocr Relat Cancer 13:S99-114. 2006
    ..g. loss of activated RAS function, to maintain tumor cell growth and viability...
  90. pmc Astrocyte elevated gene-1: far more than just a gene regulated in astrocytes
    Devanand Sarkar
    Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Cancer Res 69:8529-35. 2009
    ..The present review critically evaluates what is currently known about AEG-1 and provides new perspectives relative to this intriguing molecule that may provide a rational target for intervening in the cancer phenotype...
  91. pmc Expression patterns of astrocyte elevated gene-1 (AEG-1) during development of the mouse embryo
    Hyun Yong Jeon
    Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
    Gene Expr Patterns 10:361-7. 2010
    ....
  92. pmc Synergistic combinations of signaling pathway inhibitors: mechanisms for improved cancer therapy
    Paul Dent
    Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, School of Medicine, 401 College St, Richmond, VA 23298, USA
    Drug Resist Updat 12:65-73. 2009
    ..This review will discuss some of the approaches that have been taken to combine signal transduction modulatory agents to achieve enhanced tumor cell killing...
  93. pmc Increased RNA-induced silencing complex (RISC) activity contributes to hepatocellular carcinoma
    Byoung Kwon Yoo
    Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, VA, USA
    Hepatology 53:1538-48. 2011
    ..As a corollary, stable overexpression of SND1 augmented and siRNA-mediated inhibition of SND1 abrogated growth of human HCC cells in vitro and in vivo, thus revealing a potential role of SND1 in hepatocarcinogenesis...
  94. pmc Identification of genes conferring resistance to 5-fluorouracil
    Byoung Kwon Yoo
    Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
    Proc Natl Acad Sci U S A 106:12938-43. 2009
    ..Inhibition of AEG-1 might be exploited as a therapeutic strategy along with 5-FU-based combinatorial chemotherapy for HCC, a highly fatal cancer with currently very limited therapeutic options...
  95. pmc Functions of the cytoplasmic RNA sensors RIG-I and MDA-5: key regulators of innate immunity
    Paola M Barral
    Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, VA, USA
    Pharmacol Ther 124:219-34. 2009
    ..We also consider the function of these cytoplasmic sensors in apoptosis, development and differentiation, and diabetes...
  96. pmc OSU-03012 stimulates PKR-like endoplasmic reticulum-dependent increases in 70-kDa heat shock protein expression, attenuating its lethal actions in transformed cells
    Margaret A Park
    Department of Biochemistry, 401 College Street, Massey Cancer Center, Room 280a, Box 980035, Virginia Commonwealth University, Richmond, VA 23298 0035, USA
    Mol Pharmacol 73:1168-84. 2008
    ..OSU-03012 also increased expression of HSP70 in a PERK-dependent fashion, providing support for the contention that OSU-03012-induced PERK signaling promotes both cell survival and cell death processes...
  97. ncbi request reprint MAPK pathways in radiation responses
    Paul Dent
    Department of Radiation Oncology, Virginia Commonwealth University, Richmond, VA 23298 0058, USA
    Oncogene 22:5885-96. 2003
    ..This review will describe the enzymes within the known MAPK signaling pathways and discuss their activation and roles in cellular radiation responses...
  98. ncbi request reprint Radiation-induced cell signaling: inside-out and outside-in
    Kristoffer Valerie
    Department of Biochemistry, Virginia Commonwealth University, 401 College Street, Box 980035, Richmond, VA 23298, USA
    Mol Cancer Ther 6:789-801. 2007
    ..Thus, tumor cells are dynamic with respect to their reliance on specific cell signaling pathways to exist and rapidly adapt to repeated toxic challenges in an attempt to maintain tumor cell survival...
  99. pmc Evolution of MDA-5/RIG-I-dependent innate immunity: independent evolution by domain grafting
    Devanand Sarkar
    Department of Human and Molecular Genetics, Institute of Molecular Medicine, Massey Cancer Center, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA
    Proc Natl Acad Sci U S A 105:17040-5. 2008
    ....
  100. ncbi request reprint The regulation of tumor suppressor genes by oncogenes
    Paul Dent
    Department of Radiation Oncology, Virginia Commonwealth University, Medical College of Virginia, Richmond, USA
    Methods Mol Biol 222:269-92. 2003
  101. ncbi request reprint Acquired and innate resistance to the cancer-specific apoptosis-inducing cytokine, mda-7/IL-24: not insurmountable therapeutic problems
    Devanand Sarkar
    Department of Human Genetics and Biochemistry and Massey Cancer Center, Virginia Commonwealth University, School of Medicine, Richmond, Virginia 23298, USA
    Cancer Biol Ther 7:109-12. 2008
    ..In these contexts, should resistance to monotherapy with mda-7/IL-24 occur, combinatorial therapies with this cytokine might provide a viable path for potentially curing patients of primary and metastatic cancer...

Research Grants40

  1. Mda-7: Novel Cancer Therapeutic Gene
    Paul Fisher; Fiscal Year: 2006
    ..Understanding the mode of action of mda-7 will promote translational applications for cancer therapy. ..
  2. Mda-5: Novel Apoptosis Inducing Gene
    Paul Fisher; Fiscal Year: 2006
    ..Additionally, based on its chromosomal location, 2q24, the present studies could also shed light on a potential role of mda-5 in specific cancer etiologies as well as enhance our appreciation of the carcinogenic process. ..
  3. Novel Approaches for Pancreatic Cancer Therapy
    Paul Fisher; Fiscal Year: 2006
    ..abstract_text> ..
  4. ANALYSIS OF PROGRESSION OF THE TRANSFORMED PHENOTYPE
    Paul Fisher; Fiscal Year: 2006
    ..The huPEG-3-like gene may serve as a target for selectively intervening in the progression process, thereby preventing cancer aggressiveness and metastasis. ..
  5. Mda-7: Novel Cancer Therapeutic Gene
    Paul Fisher; Fiscal Year: 2005
    ..Understanding the mode of action of mda-7 will promote translational applications for cancer therapy. ..
  6. Mda-5: Novel Apoptosis Inducing Gene
    Paul Fisher; Fiscal Year: 2005
    ..Additionally, based on its chromosomal location, 2q24, the present studies could also shed light on a potential role of mda-5 in specific cancer etiologies as well as enhance our appreciation of the carcinogenic process. ..
  7. ANALYSIS OF PROGRESSION OF THE TRANSFORMED PHENOTYPE
    Paul Fisher; Fiscal Year: 2005
    ..The huPEG-3-like gene may serve as a target for selectively intervening in the progression process, thereby preventing cancer aggressiveness and metastasis. ..
  8. Novel Approaches for Pancreatic Cancer Therapy
    Paul Fisher; Fiscal Year: 2005
    ..abstract_text> ..
  9. ANALYSIS OF PROGRESSION OF THE TRANSFORMED PHENOTYPE
    Paul Fisher; Fiscal Year: 2007
    ..The huPEG-3-like gene may serve as a target for selectively intervening in the progression process, thereby preventing cancer aggressiveness and metastasis. ..
  10. Novel Approaches for Pancreatic Cancer Therapy
    Paul Fisher; Fiscal Year: 2007
    ..abstract_text> ..
  11. AEG-1: Novel Gene Involved in Malignant Glioma
    Paul B Fisher; Fiscal Year: 2010
    ....
  12. Mda-7: Novel Cancer Therapeutic Gene
    Paul B Fisher; Fiscal Year: 2010
    ..The studies we propose will provide valuable information that can be used to define rational approaches for enhancing the cancer therapy applications of mda-7/IL-24. ..
  13. ANALYSIS OF PROGRESSION OF THE TRANSFORMED PHENOTYPE
    Paul Fisher; Fiscal Year: 2007
    ..The huPEG-3-like gene may serve as a target for selectively intervening in the progression process, thereby preventing cancer aggressiveness and metastasis. ..
  14. Pancreatic Cancer Management by Novel Gene Therapy & Dietary Agents
    Paul Fisher; Fiscal Year: 2009
    ....
  15. AEG-1: Novel Gene Involved in Malignant Glioma
    Paul Fisher; Fiscal Year: 2009
    ....
  16. Mda-7: Novel Cancer Therapeutic Gene
    Paul Fisher; Fiscal Year: 2009
    ..The studies we propose will provide valuable information that can be used to define rational approaches for enhancing the cancer therapy applications of mda-7/IL-24. ..
  17. Mda-5: Novel Apoptosis Inducing Gene
    Paul Fisher; Fiscal Year: 2007
    ..Additionally, based on its chromosomal location, 2q24, the present studies could also shed light on a potential role of mda-5 in specific cancer etiologies as well as enhance our appreciation of the carcinogenic process. ..
  18. Mda-5: Novel Apoptosis Inducing Gene
    Paul Fisher; Fiscal Year: 2007
    ..Additionally, based on its chromosomal location, 2q24, the present studies could also shed light on a potential role of mda-5 in specific cancer etiologies as well as enhance our appreciation of the carcinogenic process. ..
  19. Mda-5: Novel Apoptosis Inducing Gene
    Paul Fisher; Fiscal Year: 2004
    ..Additionally, based on its chromosomal location, 2q24, the present studies could also shed light on a potential role of mda-5 in specific cancer etiologies as well as enhance our appreciation of the carcinogenic process. ..
  20. Mda-7: Novel Cancer Therapeutic Gene
    Paul Fisher; Fiscal Year: 2004
    ..Understanding the mode of action of mda-7 will promote translational applications for cancer therapy. ..
  21. PROGRESSION OF THE TRANSFORMED PHENOTYPE
    Paul Fisher; Fiscal Year: 2000
    ..As such, this gene may serve as a target for selectively intervening in the progression process, thereby attenuating or eliminating cancer aggressiveness and metastasis. ..
  22. NOVEL PROSTATE CANCER GENE AND MONOCLONAL ANTIBODY
    Paul Fisher; Fiscal Year: 1999
    ..Findings from these proposed studies should provide the background for direct translational applications for the improved diagnosis, staging and therapy of prostate cancer. ..
  23. NOVEL PROSTATE CANCER GENE AND MONOCLONAL ANTIBODY
    Paul Fisher; Fiscal Year: 1999
    ..Findings from these proposed studies should provide the background for direct translational applications for the improved diagnosis, staging and therapy of prostate cancer. ..
  24. PROGRESSION OF THE TRANSFORMED PHENOTYPE
    Paul Fisher; Fiscal Year: 1999
    ..As such, this gene may serve as a target for selectively intervening in the progression process, thereby attenuating or eliminating cancer aggressiveness and metastasis. ..
  25. NOVEL PROSTATE CANCER GENE AND MONOCLONAL ANTIBODY
    Paul Fisher; Fiscal Year: 2000
    ..Findings from these proposed studies should provide the background for direct translational applications for the improved diagnosis, staging and therapy of prostate cancer. ..
  26. NOVEL PROSTATE CANCER GENE AND MONOCLONAL ANTIBODY
    Paul Fisher; Fiscal Year: 2001
    ..Findings from these proposed studies should provide the background for direct translational applications for the improved diagnosis, staging and therapy of prostate cancer. ..
  27. ANALYSIS OF PROGRESSION OF THE TRANSFORMED PHENOTYPE
    Paul Fisher; Fiscal Year: 2004
    ..The huPEG-3-like gene may serve as a target for selectively intervening in the progression process, thereby preventing cancer aggressiveness and metastasis. ..
  28. Novel Approaches for Pancreatic Cancer Therapy
    Paul Fisher; Fiscal Year: 2004
    ..abstract_text> ..
  29. Mda-7: Novel Cancer Therapeutic Gene
    Paul Fisher; Fiscal Year: 2003
    ..Understanding the mode of action of mda-7 will promote translational applications for cancer therapy. ..
  30. ANALYSIS OF PROGRESSION OF THE TRANSFORMED PHENOTYPE
    Paul Fisher; Fiscal Year: 2003
    ..The huPEG-3-like gene may serve as a target for selectively intervening in the progression process, thereby preventing cancer aggressiveness and metastasis. ..
  31. Novel Approaches for Pancreatic Cancer Therapy
    Paul Fisher; Fiscal Year: 2003
    ..abstract_text> ..
  32. Mda-7: Novel Cancer Therapeutic Gene
    Paul Fisher; Fiscal Year: 2002
    ..Understanding the mode of action of mda-7 will promote translational applications for cancer therapy. ..
  33. NOVEL PROSTATE CANCER GENE AND MONOCLONAL ANTIBODY
    Paul Fisher; Fiscal Year: 2002
    ..Findings from these proposed studies should provide the background for direct translational applications for the improved diagnosis, staging and therapy of prostate cancer. ..
  34. PROGRESSION OF THE TRANSFORMED PHENOTYPE
    Paul Fisher; Fiscal Year: 2001
    ..As such, this gene may serve as a target for selectively intervening in the progression process, thereby attenuating or eliminating cancer aggressiveness and metastasis. ..
  35. Pancreatic Cancer Management by Novel Gene Therapy & Dietary Agents
    Paul B Fisher; Fiscal Year: 2010
    ....