Carla V Finkielstein
Affiliation: Virginia Polytechnic Institute and State University
Gotoh T, Kim J, Liu J, Vila Caballer M, Stauffer P, Tyson J, et al
. Model-driven experimental approach reveals the complex regulatory distribution of p53 by the circadian factor Period 2. Proc Natl Acad Sci U S A. 2016;113:13516-13521 pubmed
..Our combined theoretical/mathematical approach reveals how clock regulatory nodes can be inferred from oscillating time course data. ..
Liu J, Zou X, Gotoh T, Brown A, Jiang L, Wisdom E, et al
. Distinct control of PERIOD2 degradation and circadian rhythms by the oncoprotein and ubiquitin ligase MDM2. Sci Signal. 2018;11: pubmed publisher
Selfridge J, Gotoh T, Schiffhauer S, Liu J, Stauffer P, Li A, et al
. Chronotherapy: Intuitive, Sound, Founded…But Not Broadly Applied. Drugs. 2016;76:1507-1521 pubmed
Gotoh T, Vila Caballer M, Santos C, Liu J, Yang J, Finkielstein C. The circadian factor Period 2 modulates p53 stability and transcriptional activity in unstressed cells. Mol Biol Cell. 2014;25:3081-93 pubmed publisher
..Overall our findings place hPer2 directly at the heart of the hp53-mediated response by ensuring that basal levels of hp53 are available to precondition the cell when a rapid, hp53-mediated, transcriptional response is needed. ..
Gotoh T, Vila Caballer M, Liu J, Schiffhauer S, Finkielstein C. Association of the circadian factor Period 2 to p53 influences p53's function in DNA-damage signaling. Mol Biol Cell. 2015;26:359-72 pubmed publisher
..Our results provide evidence of the mode by which the circadian tumor suppressor hPer2 modulates hp53 signaling in response to genotoxic stress. ..
Wroble B, Finkielstein C, Sible J. Wee1 kinase alters cyclin E/Cdk2 and promotes apoptosis during the early embryonic development of Xenopus laevis. BMC Dev Biol. 2007;7:119 pubmed
..Collectively, these data implicate Cdc25A as a key player in the developmentally regulated program of apoptosis in X. laevis embryos. ..