A Fanous

Summary

Affiliation: Virginia Commonwealth University
Country: USA

Publications

  1. ncbi request reprint Relationship between positive and negative symptoms of schizophrenia and schizotypal symptoms in nonpsychotic relatives
    A Fanous
    Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, USA
    Arch Gen Psychiatry 58:669-73. 2001
  2. ncbi request reprint Clinical features of psychotic disorders and polymorphisms in HT2A, DRD2, DRD4, SLC6A3 (DAT1), and BDNF: a family based association study
    Ayman H Fanous
    Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia, USA
    Am J Med Genet B Neuropsychiatr Genet 125:69-78. 2004
  3. ncbi request reprint Significant correlation in linkage signals from genome-wide scans of schizophrenia and schizotypy
    A H Fanous
    Mental Health Service Line, Washington VA Medical Center, Washington, DC 20422, USA
    Mol Psychiatry 12:958-65. 2007
  4. ncbi request reprint Association study of CSF2RB with schizophrenia in Irish family and case - control samples
    Q Chen
    Department of Psychiatry and Virginia Institute for Psychiatric and Behavior Genetics, Virginia Commonwealth University, Richmond, VA 23298 0424, USA
    Mol Psychiatry 13:930-8. 2008
  5. ncbi request reprint Catechol-O-methyltransferase and the clinical features of psychosis
    J L McClay
    Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University, Richmond, Virginia 23298 0126, USA
    Am J Med Genet B Neuropsychiatr Genet 141:935-8. 2006
  6. ncbi request reprint Interleukin 3 and schizophrenia: the impact of sex and family history
    X Chen
    Department of Psychiatry and Virginia Institute for Psychiatric and Behavior Genetics, Virginia Commonwealth University, Richmond, VA 23298, USA
    Mol Psychiatry 12:273-82. 2007
  7. ncbi request reprint A region of 35 kb containing the trace amine associate receptor 6 (TAAR6) gene is associated with schizophrenia in the Irish study of high-density schizophrenia families
    V Vladimirov
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298 0424, USA
    Mol Psychiatry 12:842-53. 2007
  8. pmc Association study of SNAP25 and schizophrenia in Irish family and case-control samples
    A H Fanous
    Washington VA Medical Center, Washington, DC 20422, USA
    Am J Med Genet B Neuropsychiatr Genet 153:663-74. 2010
  9. pmc Replication of association between schizophrenia and ZNF804A in the Irish Case-Control Study of Schizophrenia sample
    B Riley
    Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23298 0424, USA
    Mol Psychiatry 15:29-37. 2010
  10. ncbi request reprint Neuroticism, major depression and gender: a population-based twin study
    A Fanous
    Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University and Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, USA
    Psychol Med 32:719-28. 2002

Research Grants

Detail Information

Publications18

  1. ncbi request reprint Relationship between positive and negative symptoms of schizophrenia and schizotypal symptoms in nonpsychotic relatives
    A Fanous
    Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, USA
    Arch Gen Psychiatry 58:669-73. 2001
    ..We therefore sought to clarify the relationship between positive and negative symptoms of schizophrenic probands and dimensions of schizotypy in their first-degree relatives...
  2. ncbi request reprint Clinical features of psychotic disorders and polymorphisms in HT2A, DRD2, DRD4, SLC6A3 (DAT1), and BDNF: a family based association study
    Ayman H Fanous
    Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia, USA
    Am J Med Genet B Neuropsychiatr Genet 125:69-78. 2004
    ..However, given prior evidence of involvement of the proteins encoded by these genes in psychopathology, our results suggest that more attention should be focused on the impact of these alleles on clinical features of schizophrenia...
  3. ncbi request reprint Significant correlation in linkage signals from genome-wide scans of schizophrenia and schizotypy
    A H Fanous
    Mental Health Service Line, Washington VA Medical Center, Washington, DC 20422, USA
    Mol Psychiatry 12:958-65. 2007
    ..Power may therefore be increased in molecular genetic studies of schizophrenia if they incorporate measures of schizotypy in non-psychotic relatives...
  4. ncbi request reprint Association study of CSF2RB with schizophrenia in Irish family and case - control samples
    Q Chen
    Department of Psychiatry and Virginia Institute for Psychiatric and Behavior Genetics, Virginia Commonwealth University, Richmond, VA 23298 0424, USA
    Mol Psychiatry 13:930-8. 2008
    ..Since CSF2RB is essential for IL3 signaling, the findings that both IL3 and CSF2RB showed sex-specific and FH-dependent associations suggest that the IL3 pathway is involved in schizophrenia...
  5. ncbi request reprint Catechol-O-methyltransferase and the clinical features of psychosis
    J L McClay
    Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University, Richmond, Virginia 23298 0126, USA
    Am J Med Genet B Neuropsychiatr Genet 141:935-8. 2006
    ..4). These results suggest a modest affective vulnerability conferred by this allele in psychosis, but will require replication...
  6. ncbi request reprint Interleukin 3 and schizophrenia: the impact of sex and family history
    X Chen
    Department of Psychiatry and Virginia Institute for Psychiatric and Behavior Genetics, Virginia Commonwealth University, Richmond, VA 23298, USA
    Mol Psychiatry 12:273-82. 2007
    ..They may explain the sex-specific associations and be functional for the expression of IL3 gene...
  7. ncbi request reprint A region of 35 kb containing the trace amine associate receptor 6 (TAAR6) gene is associated with schizophrenia in the Irish study of high-density schizophrenia families
    V Vladimirov
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298 0424, USA
    Mol Psychiatry 12:842-53. 2007
    ..004) and hallucinations (P<0.0004), supporting the family-based association with schizophrenia...
  8. pmc Association study of SNAP25 and schizophrenia in Irish family and case-control samples
    A H Fanous
    Washington VA Medical Center, Washington, DC 20422, USA
    Am J Med Genet B Neuropsychiatr Genet 153:663-74. 2010
    ..Although we failed to replicate this in an independent sample, this gene should be further tested in other samples...
  9. pmc Replication of association between schizophrenia and ZNF804A in the Irish Case-Control Study of Schizophrenia sample
    B Riley
    Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23298 0424, USA
    Mol Psychiatry 15:29-37. 2010
    ..This study replicates the original reported association of ZNF804A with schizophrenia and suggests that there is a consistent link between the A allele of rs1344706, increased expression of ZNF804A and risk for schizophrenia...
  10. ncbi request reprint Neuroticism, major depression and gender: a population-based twin study
    A Fanous
    Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University and Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, USA
    Psychol Med 32:719-28. 2002
    ..Females have both higher levels of N and higher rates of MD than males, suggesting that these traits may be more genetically correlated in females...
  11. ncbi request reprint Genetic heterogeneity, modifier genes, and quantitative phenotypes in psychiatric illness: searching for a framework
    A H Fanous
    Washington VA Medical Center, Georgetown University Medical Center Schizophrenia Research Program, Washington DC 20008, USA
    Mol Psychiatry 10:6-13. 2005
    ..We describe five classes of genes and their predictions of the outcomes of family, twin, and several types of linkage studies. We go on to explore how these predictions can in turn be used to aid in the design of linkage studies...
  12. ncbi request reprint Association between the 5q31.1 gene neurogenin1 and schizophrenia
    Ayman H Fanous
    Washington VA Medical Center, Washington, District of Columbia, USA
    Am J Med Genet B Neuropsychiatr Genet 144:207-14. 2007
    ..This gene should be tested in additional and larger samples...
  13. ncbi request reprint Relationship between a high-risk haplotype in the DTNBP1 (dysbindin) gene and clinical features of schizophrenia
    Ayman H Fanous
    Washington VA Medical Center Georgetown University Medical Center Schizophrenia Research Program, 50 Irving St NW, Washington, DC 20422, USA
    Am J Psychiatry 162:1824-32. 2005
    ....
  14. doi request reprint Novel linkage to chromosome 20p using latent classes of psychotic illness in 270 Irish high-density families
    Ayman H Fanous
    Washington VA Medical Center, Washington, DC, USA
    Biol Psychiatry 64:121-7. 2008
    ..Genetic heterogeneity may decrease the signal-to-noise ratio in linkage and association studies. Therefore, linkage studies of clinically homogeneous classes of psychotic illness may result in greater power to detect at least some loci...
  15. ncbi request reprint Genetics of clinical features and subtypes of schizophrenia: a review of the recent literature
    Ayman H Fanous
    Washington VA Medical Center, 50 Irving Street NW, Washington, DC 20422, USA
    Curr Psychiatry Rep 10:164-70. 2008
    ..Future directions include using whole-genome association studies to search for genetic modifiers of schizophrenia...
  16. ncbi request reprint A genome-wide scan for modifier loci in schizophrenia
    Ayman H Fanous
    Washington VA Medical Center, Washington, DC 20422, USA
    Am J Med Genet B Neuropsychiatr Genet 144:589-95. 2007
    ..06. We conclude that genes located near 9q33.1 and 14q24.2 may modify the clinical course and severity of schizophrenia. A gene in 6q may affect several clinical features of illness...
  17. ncbi request reprint A longitudinal study of personality and major depression in a population-based sample of male twins
    Ayman H Fanous
    Washington VA Medical Center, Washington, DC 20422, USA
    Psychol Med 37:1163-72. 2007
    ..The relationship between personality and psychiatric illness is complex. It is not clear whether one directly causes the other...
  18. ncbi request reprint The genetic relationship of personality to major depression and schizophrenia
    Ayman H Fanous
    Washington VA Medical Center Georgetown University Medical Center Schizophrenia Research Program, 50 Irving St NW, Washington, DC 20422, USA
    Neurotox Res 6:43-50. 2004
    ..Furthermore, although several putative susceptibility genes for schizophrenia have been reported and replicated, only one--catechol-O-methyltransferase (COMT)--has been tested in schizotypy...

Research Grants1

  1. An Association Study of Neurogenin 1 and Schizophrenia
    Ayman Fanous; Fiscal Year: 2002
    ..If there are resources left over, we plan to genotype 400 normal controls and perform a case-control analysis using a chi-squared test to confirm any suggestive findings. ..