J O Falkinham

Summary

Affiliation: Virginia Polytechnic Institute and State University
Country: USA

Publications

  1. pmc Effect of growth in biofilms on chlorine susceptibility of Mycobacterium avium and Mycobacterium intracellulare
    Keesha A Steed
    Department of Biological Sciences, Virginia Tech, Blacksburg, VA 24061 0406, USA
    Appl Environ Microbiol 72:4007-11. 2006
  2. doi request reprint Reducing human exposure to Mycobacterium avium
    Joseph O Falkinham
    Department of Biological Sciences, Virginia Tech, Blacksburg, VA 24061, USA
    Ann Am Thorac Soc 10:378-82. 2013
  3. doi request reprint Ecology of nontuberculous mycobacteria--where do human infections come from?
    Joseph O Falkinham
    Department of Biological Sciences, Virginia Tech, Blacksburg, Virginia 24061, USA
    Semin Respir Crit Care Med 34:95-102. 2013
  4. doi request reprint Antibacterial activities of dendritic amphiphiles against nontuberculous mycobacteria
    Joseph O Falkinham
    Department of Biological Science 0406, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    Tuberculosis (Edinb) 92:173-81. 2012
  5. ncbi request reprint Effect of different cell fractions of Mycobacterium avium and vaccination regimens on Mycobacterium avium infection
    J O Falkinham
    Department of Biology, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA
    Scand J Immunol 59:478-84. 2004
  6. ncbi request reprint Nontuberculous mycobacteria in the environment
    Joseph O Falkinham
    Department of Biology, Fralin Biotechnology Center, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061 0346, USA
    Clin Chest Med 23:529-51. 2002
  7. pmc Nontuberculous mycobacteria from household plumbing of patients with nontuberculous mycobacteria disease
    Joseph O Falkinham
    Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061 0406, USA
    Emerg Infect Dis 17:419-24. 2011
  8. doi request reprint Hospital water filters as a source of Mycobacterium avium complex
    Joseph O Falkinham
    Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061 0406, USA
    J Med Microbiol 59:1198-202. 2010
  9. ncbi request reprint Impact of human activities on the ecology of nontuberculous mycobacteria
    Joseph O Falkinham
    Department of Biological Sciences, Virginia Tech, Blacksburg, VA 24061 0406, USA
    Future Microbiol 5:951-60. 2010
  10. pmc Factors influencing numbers of Mycobacterium avium, Mycobacterium intracellulare, and other Mycobacteria in drinking water distribution systems
    J O Falkinham
    Fralin Biotechnology Center, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061 0346, USA
    Appl Environ Microbiol 67:1225-31. 2001

Collaborators

  • Andrea M Dietrich
  • F W Pierson
  • C D Norton
  • M L Failla
  • M D Iseman
  • Amy Pruden
  • José M Cerrato
  • F Q Alali
  • Todd P Primm
  • Mark W LeChevallier
  • Dick van Soolingen
  • Eko W Sugandhi
  • Richard D Gandour
  • Richard V Macri
  • André A Williams
  • S N Mullis
  • Sonal Mazumder
  • Alan R Esker
  • Carla Slebodnick
  • Mary Ann De Groote
  • Keesha A Steed
  • Chen Li
  • Fransisca M Setyowati
  • Mansukh C Wani
  • Norman R Farnsworth
  • Dongho Lee
  • Soedarsono Riswan
  • A Douglas Kinghorn
  • Nicholas H Oberlies
  • David J Kroll
  • Tyler N Graf
  • Jian Qiao Gu
  • Jefferson J Jones
  • Carolyn Kirby
  • Sally N Jewell
  • H E Cowan
  • J E Stanek
  • E D Strahl
  • Ishwar K Puri
  • Bhadreshkumar B Maisuria
  • Xiaosong Du
  • Gustavo F Doncel
  • Janka Karlovska
  • Brett L Kite
  • Kayte Fulton
  • Norman R Pace
  • Djaja D Soejarto
  • Yuka Nakanishi
  • Sharnelle S Phifer
  • Achmad M Saribi
  • Jason P Burgess
  • Hee Byung Chai
  • Steven M Swanson
  • Monroe E Wall
  • Qiuwen Mi
  • Leonardus B S Kardono
  • Geoffrey A Cordell
  • Rachman Ismail
  • John M Pezzuto
  • Al Waring
  • Robert H Waldo
  • Nigel D F Grindley
  • Keith M Derbyshire
  • Cody C Cain
  • Thomas J Griffin
  • G E Gillaspy
  • R A Kirschner
  • B C Parker
  • M T Jucker
  • F X Erardi

Detail Information

Publications41

  1. pmc Effect of growth in biofilms on chlorine susceptibility of Mycobacterium avium and Mycobacterium intracellulare
    Keesha A Steed
    Department of Biological Sciences, Virginia Tech, Blacksburg, VA 24061 0406, USA
    Appl Environ Microbiol 72:4007-11. 2006
    ..There was a strong correlation between the chlorine susceptibility of cells of both M. avium and M. intracellulare and cell surface hydrophobicity measured by contact angle for both biofilm- and suspension-grown cells...
  2. doi request reprint Reducing human exposure to Mycobacterium avium
    Joseph O Falkinham
    Department of Biological Sciences, Virginia Tech, Blacksburg, VA 24061, USA
    Ann Am Thorac Soc 10:378-82. 2013
    ..avium and should be avoided. When gardening, avoid the inhalation of soil dusts by using a mask or wetting the soil because peat-rich potting soils have high numbers of mycobacteria. ..
  3. doi request reprint Ecology of nontuberculous mycobacteria--where do human infections come from?
    Joseph O Falkinham
    Department of Biological Sciences, Virginia Tech, Blacksburg, Virginia 24061, USA
    Semin Respir Crit Care Med 34:95-102. 2013
    ..g., Mycobacterium avium) is quite broad, and virulence determinants have not been identified...
  4. doi request reprint Antibacterial activities of dendritic amphiphiles against nontuberculous mycobacteria
    Joseph O Falkinham
    Department of Biological Science 0406, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    Tuberculosis (Edinb) 92:173-81. 2012
    ....
  5. ncbi request reprint Effect of different cell fractions of Mycobacterium avium and vaccination regimens on Mycobacterium avium infection
    J O Falkinham
    Department of Biology, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA
    Scand J Immunol 59:478-84. 2004
    ..avium vaccine preparations. Post-infection vaccination of M. avium-infected chickens was also shown to significantly reduce the number of lesions and colony counts...
  6. ncbi request reprint Nontuberculous mycobacteria in the environment
    Joseph O Falkinham
    Department of Biology, Fralin Biotechnology Center, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061 0346, USA
    Clin Chest Med 23:529-51. 2002
    ..In the absence of competitors, even the slowly growing mycobacteria can grow in the distribution system [33]. It is likely that hypersensitivity pneumonitis in lifeguards and therapy pool attendants [139] is caused by a similar scenario...
  7. pmc Nontuberculous mycobacteria from household plumbing of patients with nontuberculous mycobacteria disease
    Joseph O Falkinham
    Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061 0406, USA
    Emerg Infect Dis 17:419-24. 2011
    ..1532)...
  8. doi request reprint Hospital water filters as a source of Mycobacterium avium complex
    Joseph O Falkinham
    Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061 0406, USA
    J Med Microbiol 59:1198-202. 2010
    ..Five of the 22 (23 %) M. avium patient bronchoscopy isolates and 42 of the 56 (75 %) M. intracellulare patient bronchoscopy isolates could have been due to contamination from the water supply...
  9. ncbi request reprint Impact of human activities on the ecology of nontuberculous mycobacteria
    Joseph O Falkinham
    Department of Biological Sciences, Virginia Tech, Blacksburg, VA 24061 0406, USA
    Future Microbiol 5:951-60. 2010
    ..NTM selection may also occur as a consequence of antibiotics in drinking water sources...
  10. pmc Factors influencing numbers of Mycobacterium avium, Mycobacterium intracellulare, and other Mycobacteria in drinking water distribution systems
    J O Falkinham
    Fralin Biotechnology Center, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061 0346, USA
    Appl Environ Microbiol 67:1225-31. 2001
    ..Evidently, the ecological niches of M. avium and M. intracellulare are distinct...
  11. pmc Proliferation of antibiotic-producing bacteria and concomitant antibiotic production as the basis for the antibiotic activity of Jordan's red soils
    Joseph O Falkinham
    Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061 0406, USA
    Appl Environ Microbiol 75:2735-41. 2009
    ..These results suggest that the antibiotic activity of Jordan's red soils is due to the proliferation of antibiotic-producing bacteria...
  12. ncbi request reprint Growth in catheter biofilms and antibiotic resistance of Mycobacterium avium
    Joseph O Falkinham
    Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    J Med Microbiol 56:250-4. 2007
    ..5x10(4) c.f.u. cm-2 by 4 weeks. Cells grown in catheter biofilms were significantly more resistant to clarithromycin and rifamycin than cells grown in suspension...
  13. doi request reprint Mycobacterium avium in a shower linked to pulmonary disease
    Joseph O Falkinham
    Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061 0406, USA
    J Water Health 6:209-13. 2008
    ..avium isolates from the hot and cold water and showerhead sediment demonstrated a clonal relationship with the patient's M. avium isolate. The data provide evidence that showers may serve as sources of infection by waterborne M. avium...
  14. doi request reprint Surrounded by mycobacteria: nontuberculous mycobacteria in the human environment
    J O Falkinham
    Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061 0406, USA
    J Appl Microbiol 107:356-67. 2009
    ....
  15. pmc Factors influencing the chlorine susceptibility of Mycobacterium avium, Mycobacterium intracellulare, and Mycobacterium scrofulaceum
    Joseph O Falkinham
    Department of Biology, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA
    Appl Environ Microbiol 69:5685-9. 2003
    ..Chlorine-resistant MAIS strains were more hydrophobic and resistant to Tween 80, para-nitrobenzoate, hydroxylamine, and nitrite than were the chlorine-sensitive strains...
  16. ncbi request reprint Epidemiology of infection by nontuberculous mycobacteria. Mycobacterium avium, Mycobacterium intracellulare, and Mycobacterium scrofulaceum in acid, brown-water swamps of the southeastern United States and their association with environmental variables
    R A Kirschner
    Department of Biology, Virginia Polytechnic Institute and State University, Balcksburg 24061
    Am Rev Respir Dis 145:271-5. 1992
    ....
  17. ncbi request reprint Epidemiology of infection by nontuberculous mycobacteria. VIII. Absence of mycobacteria in chicken litter
    J O Falkinham
    Department of Biology, Virginia Polytechnic Institute and State University, Blacksburg 24061
    Am Rev Respir Dis 139:1347-9. 1989
    ..Further, litter appears bactericidal to these organisms in that less than 1% of cells inoculated survived more than 6 wk, probably because of the high pH of litters...
  18. ncbi request reprint Epidemiology of infection by nontuberculous mycobacteria IX. Evidence for two DNA homology groups among small plasmids in Mycobacterium avium, Mycobacterium intracellulare, and Mycobacterium scrofulaceum
    M T Jucker
    Department of Biology, Virginia Polytechnic Institute and State University, Blacksburg 24061
    Am Rev Respir Dis 142:858-62. 1990
    ..3 to 25 kb from environmental and clinical (AIDS and non-AIDS) isolates. There was no hybridization between pVT2 and pLR7. Thus, these two probes define two different groups of small mycobacterial plasmids...
  19. ncbi request reprint Arylsulfatase activity of Mycobacterium avium, M. intracellulare, and M. scrofulaceum
    J O Falkinham
    Department of Biology, Virginia Polytechnic Institute and State University, Blacksburg 24061
    Int J Syst Bacteriol 40:66-70. 1990
    ..avium, three in M. intracellulare [82, 5, and 13%], and two in M. scrofulaceum [60 and 40%])...
  20. doi request reprint Adherence and biofilm formation of Mycobacterium avium, Mycobacterium intracellulare and Mycobacterium abscessus to household plumbing materials
    S N Mullis
    Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061 USA
    J Appl Microbiol 115:908-14. 2013
    ....
  21. ncbi request reprint A luciferase-based method for assessing chlorine-susceptibility of Mycobacterium avium
    H E Cowan
    Department of Biology and Fralin Biotechnology Center, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061 0346, USA
    J Microbiol Methods 46:209-15. 2001
    ..It was discovered that chlorine was rapidly lost from suspensions containing 10(6) M. avium cells/ml. The luciferase-based test can be used to rapidly measure susceptibility of M. avium to different disinfectants used in water treatment...
  22. pmc Fluorescent acid-fast microscopy for measuring phagocytosis of Mycobacterium avium, Mycobacterium intracellulare, and Mycobacterium scrofulaceum by Tetrahymena pyriformis and their intracellular growth
    E D Strahl
    Department of Biology, Fralin Biotechnology Center, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061 0346, USA
    Appl Environ Microbiol 67:4432-9. 2001
    ..The growth and viability of T. pyriformis were not affected by mycobacterial infection. The results suggest that free-living phagocytic protozoa may be natural hosts and reservoirs for M. avium, M. intracellulare, and M. scrofulaceum...
  23. pmc Decolorization of malachite green and crystal violet by waterborne pathogenic mycobacteria
    Jefferson J Jones
    Department of Biology, Virginia Union University, Richmond, Virginia 23220, USA
    Antimicrob Agents Chemother 47:2323-6. 2003
    ..Decolorization activity of membrane fractions was stimulated by ferrous ion and inhibited by dinitrophenol and metyrapone...
  24. pmc Mycobacterial aerosols and respiratory disease
    Joseph O Falkinham
    Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA
    Emerg Infect Dis 9:763-7. 2003
    ..Disinfection may select for the predominance and growth of mycobacteria. Therefore, mycobacteria may be responsible, in part, for many outbreaks of hypersensitivity pneumonitis and other respiratory problems in the workplace and home...
  25. doi request reprint Manganese-oxidizing and -reducing microorganisms isolated from biofilms in chlorinated drinking water systems
    José M Cerrato
    The Charles E Via Jr Department of Civil and Environmental Engineering, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061 0246, USA
    Water Res 44:3935-45. 2010
    ..This has important implications for Mn-management strategies, which typically assume Mn-reduction is not possible in the presence of chlorine and oxidizing conditions...
  26. pmc Accumulation and transport of cadmium by tolerant and susceptible strains of Mycobacterium scrofulaceum
    F X Erardi
    Department of Biology, Virginia Polytechnic Institute and State University, Blacksburg 24061
    Antimicrob Agents Chemother 33:350-5. 1989
    ..Increased Cd2+ in culture medium resulted in decreased Mn2+ and Zn2+ in cells of the susceptible strain but did not reduce the Mn2+ and Zn2+ content of cells of the tolerant strain...
  27. pmc Effects of biocides and other metal removal fluid constituents on Mycobacterium immunogenum
    Joseph O Falkinham
    Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061 0406, USA
    Appl Environ Microbiol 75:2057-61. 2009
    ..immunogenum cells from MRF systems...
  28. doi request reprint Role of hydrophobicity in bacterial adherence to carbon nanostructures and biofilm formation
    Sonal Mazumder
    Department of Engineering Science and Mechanics, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA
    Biofouling 26:333-9. 2010
    ..Biofilm formation led to alterations in the hydrophobicity of the substratum surfaces, demonstrating that bacterial cells attached to CNs are capable of modifying the surface characteristics...
  29. ncbi request reprint Synthesis and antimicrobial evaluation of water-soluble, dendritic derivatives of epimeric 5alpha-cholestan-3-amines and 5alpha-cholestan-3-yl aminoethanoates
    Eko W Sugandhi
    Department of Chemistry MC 0212, Virginia Tech, Blacksburg, VA 24061, United States
    Steroids 72:615-26. 2007
    ..aureus. The best activity, a minimal inhibitory concentration (MIC) of 27 microM, was found for the 3beta epimer of 1 against MRSA...
  30. ncbi request reprint Synthesis, critical micelle concentrations, and antimycobacterial properties of homologous, dendritic amphiphiles. Probing intrinsic activity and the "cutoff" effect
    Eko W Sugandhi
    Department of Chemistry, Virginia Tech, Blacksburg, Virginia 24061, USA
    J Med Chem 50:1645-50. 2007
    ..The hexadecyl homologue is the most active at inhibiting growth with an MIC0 equal to 3.5 x 10-5 M, which is 100-fold below the CMC...
  31. ncbi request reprint Antimicrobial activity of long-chain, water-soluble, dendritic tricarboxylato amphiphiles
    André A Williams
    Department of Chemistry MC 0212, Virginia Tech, Blacksburg, VA 24061, USA
    J Antimicrob Chemother 59:451-8. 2007
    ..To measure the antimicrobial activities of three series of homologous, dendritic tricarboxylato (three-headed) amphiphiles against a battery of bacteria and fungi...
  32. doi request reprint Comparing anti-HIV, antibacterial, antifungal, micellar, and cytotoxic properties of tricarboxylato dendritic amphiphiles
    Richard V Macri
    Department of Chemistry 0212, Virginia Tech, Blacksburg, VA 24061, United States
    Bioorg Med Chem 17:3162-8. 2009
    ....
  33. ncbi request reprint Rapid coliphage detection assay
    J E Stanek
    Department of Biology, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061-0406, USA
    J Virol Methods 91:93-8. 2001
    ..The assay could detect as few as five coliphage per sample without an overnight incubation period. The range of acceptable assay parameters was identified...
  34. ncbi request reprint Synthesis and antimicrobial activity of symmetrical two-tailed dendritic tricarboxylato amphiphiles
    Eko W Sugandhi
    Department of Chemistry MC 0212, Virginia Tech, Blacksburg, VA 24061, USA
    Bioorg Med Chem 15:3842-53. 2007
    ..The one case where two-tailed compounds displayed the lowest MICs-3(10,10), 15 microM; 3(11,11), 7.2microM; and 3(12,12), 6.9 microM-was against Cryptococcus neoformans...
  35. ncbi request reprint Rapid detection of lytic antimicrobial activity against yeast and filamentous fungi
    Sally N Jewell
    Fralin Biotechnology Center, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061 0346, USA
    J Microbiol Methods 49:1-9. 2002
    ..The anti-yeast assay has been adapted to a 96-well microtiter format. Both assays provided a rapid, sensitive, and reproducible detection of lytic anti-yeast and anti-fungal activity...
  36. pmc Health impacts of environmental mycobacteria
    Todd P Primm
    Department of Biological Sciences and Border Biomedical Research Center, University of Texas at El Paso, El Paso, Texas 79968, USA
    Clin Microbiol Rev 17:98-106. 2004
    ..In addition to outright infection, environmental mycobacteria may also play a role in chronic bowl diseases, allergies, immunity to other pulmonary infections, and the efficacy of bacillus Calmette-Guerin vaccination...
  37. pmc Relationships between Mycobacterium isolates from patients with pulmonary mycobacterial infection and potting soils
    Mary Ann De Groote
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA
    Appl Environ Microbiol 72:7602-6. 2006
    ..Thus, potting soils are potential sources of infection by environmental mycobacteria. Use of dust-excluding masks should be considered during potting or other activities that generate aerosol with soil...
  38. pmc A hexacyclic ent-trachylobane diterpenoid possessing an oxetane ring from Mitrephora glabra
    Chen Li
    Natural Products Laboratory, Research Triangle Institute, P O Box 12194, Research Triangle Park, North Carolina 27709 2194, USA
    Org Lett 7:5709-12. 2005
    ..All compounds were evaluated for cytotoxicity against a panel of cancer cells, where 1 displayed the most potent and broadest activity, and against a battery of antimicrobial assays, where all compounds were approximately equipotent...
  39. ncbi request reprint Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia
    Jian Qiao Gu
    Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA
    J Nat Prod 67:1156-61. 2004
    ..Plumbagin (1) and maritinone (2) were evaluated also for in vivo antitumor activity in the hollow fiber assay, but both were found to be inactive...
  40. ncbi request reprint Survival of Mycobacterium avium in a model distribution system
    Cheryl D Norton
    American Water, Quality Control and Research Laboratory, 1115 South Illinois Street, Belleville, IL 62220, USA
    Water Res 38:1457-66. 2004
    ..avium complex in drinking water biofilms...
  41. ncbi request reprint Cryptic plasmids of Mycobacterium avium: Tn552 to the rescue
    Carolyn Kirby
    Department of Biomedical Sciences, State University of New York at Albany, NY, USA
    Mol Microbiol 43:173-86. 2002
    ..Using this approach, we identified a putative conjugative relaxase, suggesting this myco-bacterial plasmid is transferable, and three genes required for plasmid establishment and replication...