Nazira El-Hage

Summary

Affiliation: Virginia Commonwealth University
Country: USA

Publications

  1. pmc Morphine exacerbates HIV-1 Tat-induced cytokine production in astrocytes through convergent effects on [Ca(2+)](i), NF-kappaB trafficking and transcription
    Nazira El-Hage
    Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, VA, USA
    PLoS ONE 3:e4093. 2008
  2. pmc Toll-like receptor expression and activation in astroglia: differential regulation by HIV-1 Tat, gp120, and morphine
    Nazira El-Hage
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Medical College of Virginia Campus, Richmond, USA
    Immunol Invest 40:498-522. 2011
  3. pmc HIV-1 coinfection and morphine coexposure severely dysregulate hepatitis C virus-induced hepatic proinflammatory cytokine release and free radical production: increased pathogenesis coincides with uncoordinated host defenses
    Nazira El-Hage
    Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, 1217 East Marshall Street, Richmond, VA 23298 0613, USA
    J Virol 85:11601-14. 2011
  4. pmc Morphine and gp120 toxic interactions in striatal neurons are dependent on HIV-1 strain
    Elizabeth M Podhaizer
    Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298 0613, USA
    J Neuroimmune Pharmacol 7:877-91. 2012
  5. pmc Fractalkine/CX3CL1 protects striatal neurons from synergistic morphine and HIV-1 Tat-induced dendritic losses and death
    Masami Suzuki
    Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298 0613, USA
    Mol Neurodegener 6:78. 2011
  6. pmc Morphine potentiates neurodegenerative effects of HIV-1 Tat through actions at μ-opioid receptor-expressing glia
    Shiping Zou
    Department of Anatomy and Neurobiology, Virginia Commonwealth University, Richmond, VA 23298, USA
    Brain 134:3616-31. 2011
  7. pmc PTEN gene silencing prevents HIV-1 gp120(IIIB)-induced degeneration of striatal neurons
    Shiping Zou
    Department of Anatomy and Neurobiology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
    J Neurovirol 17:41-9. 2011
  8. pmc CCL5/RANTES gene deletion attenuates opioid-induced increases in glial CCL2/MCP-1 immunoreactivity and activation in HIV-1 Tat-exposed mice
    Nazira El-Hage
    Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, 1217 East Marshall Street, Richmond, VA 23298 0613, USA
    J Neuroimmune Pharmacol 3:275-85. 2008
  9. pmc Interactive comorbidity between opioid drug abuse and HIV-1 Tat: chronic exposure augments spine loss and sublethal dendritic pathology in striatal neurons
    Sylvia Fitting
    Department Pharmacology and Toxicology, Virginia Commonwealth University, Medical College of Virginia Campus, Richmond, VA 23298, USA
    Am J Pathol 177:1397-410. 2010

Collaborators

Detail Information

Publications9

  1. pmc Morphine exacerbates HIV-1 Tat-induced cytokine production in astrocytes through convergent effects on [Ca(2+)](i), NF-kappaB trafficking and transcription
    Nazira El-Hage
    Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, VA, USA
    PLoS ONE 3:e4093. 2008
    ....
  2. pmc Toll-like receptor expression and activation in astroglia: differential regulation by HIV-1 Tat, gp120, and morphine
    Nazira El-Hage
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Medical College of Virginia Campus, Richmond, USA
    Immunol Invest 40:498-522. 2011
    ..The results suggest that HIV-1 proteins and/or opioid abuse disrupt the innate immune response of the central nervous system (CNS) which may lead to increased pathogenicity...
  3. pmc HIV-1 coinfection and morphine coexposure severely dysregulate hepatitis C virus-induced hepatic proinflammatory cytokine release and free radical production: increased pathogenesis coincides with uncoordinated host defenses
    Nazira El-Hage
    Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, 1217 East Marshall Street, Richmond, VA 23298 0613, USA
    J Virol 85:11601-14. 2011
    ..The results suggest that opioid abuse and HIV-1 coinfection each further accelerate HCV-mediated liver disease by dysregulating immune defenses...
  4. pmc Morphine and gp120 toxic interactions in striatal neurons are dependent on HIV-1 strain
    Elizabeth M Podhaizer
    Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298 0613, USA
    J Neuroimmune Pharmacol 7:877-91. 2012
    ..Our findings indicate that HIV-1 strain-specific differences in gp120 are critical determinants in shaping both the timing and pattern of neurotoxic interactions with opioid drugs...
  5. pmc Fractalkine/CX3CL1 protects striatal neurons from synergistic morphine and HIV-1 Tat-induced dendritic losses and death
    Masami Suzuki
    Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298 0613, USA
    Mol Neurodegener 6:78. 2011
    ..Time-lapse digital images were continuously recorded at 20 min intervals for up to 72 h using computer-aided microscopy to track the same cells repeatedly...
  6. pmc Morphine potentiates neurodegenerative effects of HIV-1 Tat through actions at μ-opioid receptor-expressing glia
    Shiping Zou
    Department of Anatomy and Neurobiology, Virginia Commonwealth University, Richmond, VA 23298, USA
    Brain 134:3616-31. 2011
    ....
  7. pmc PTEN gene silencing prevents HIV-1 gp120(IIIB)-induced degeneration of striatal neurons
    Shiping Zou
    Department of Anatomy and Neurobiology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
    J Neurovirol 17:41-9. 2011
    ..The selective abatement of PTEN activity in neurons may represent a potential therapeutic strategy for the CNS complications of HIV-1...
  8. pmc CCL5/RANTES gene deletion attenuates opioid-induced increases in glial CCL2/MCP-1 immunoreactivity and activation in HIV-1 Tat-exposed mice
    Nazira El-Hage
    Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, 1217 East Marshall Street, Richmond, VA 23298 0613, USA
    J Neuroimmune Pharmacol 3:275-85. 2008
    ..CCL5 is implicated as mediating the cytokine-driven amplification of CCL2 production by astrocytes and resultant macrophage/microglial recruitment and activation...
  9. pmc Interactive comorbidity between opioid drug abuse and HIV-1 Tat: chronic exposure augments spine loss and sublethal dendritic pathology in striatal neurons
    Sylvia Fitting
    Department Pharmacology and Toxicology, Virginia Commonwealth University, Medical College of Virginia Campus, Richmond, VA 23298, USA
    Am J Pathol 177:1397-410. 2010
    ....