Marion Ehrich

Summary

Affiliation: Virginia Polytechnic Institute and State University
Country: USA

Publications

  1. doi request reprint Fullerene antioxidants decrease organophosphate-induced acetylcholinesterase inhibition in vitro
    Marion Ehrich
    Virginia Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061, USA
    Toxicol In Vitro 25:301-7. 2011
  2. ncbi request reprint Neurotoxicity and immunotoxicity assessment in CBA/J mice with chronic Toxoplasma gondii infection and single-dose exposure to methylmercury
    Marquea D King
    Department of Biomedical Sciences and Pathobiology, Virginia Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061 0442, USA
    Int J Toxicol 22:53-61. 2003
  3. ncbi request reprint Neurologic and immunologic effects of exposure to corticosterone, chlorpyrifos, and multiple doses of tri-ortho-tolyl phosphate over a 28-day period in rats
    M Ehrich
    Laboratory of Neurotoxicity Studies, Virginia Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, Virginia 24016 0442, USA
    J Toxicol Environ Health A 67:431-57. 2004
  4. doi request reprint Calcium signaling in neuronal cells exposed to the munitions compound Cyclotrimethylenetrinitramine (RDX)
    Marion Ehrich
    Virginia Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, Virginia 24061, USA
    Int J Toxicol 28:425-35. 2009
  5. ncbi request reprint Early effects of neuropathy-inducing organophosphates on in vivo concentrations of three neurotrophins
    M J Pomeroy-Black
    Department of Biomedical Sciences and Pathobiology, Virginia Maryland Regional College of Veterinary Medicine, 1 Duckpond Drive, Blacksburg, VA 24061, USA
    Neurotox Res 11:85-91. 2007
  6. doi request reprint Comparison of two blood-brain barrier in vitro systems: cytotoxicity and transfer assessments of malathion/oxon and lead acetate
    Pergentino Balbuena
    Virginia Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, Virginia 24061, USA
    Toxicol Sci 114:260-71. 2010
  7. ncbi request reprint Examination of concurrent exposure to repeated stress and chlorpyrifos on cholinergic, glutamatergic, and monoamine neurotransmitter systems in rat forebrain regions
    Thitiya Pung
    Department of Biomedical Sciences and Pathobiology, Virginia Maryland Regional College of Veterinary Medicine, Blacksburg, Virginia 24061 0442, USA
    Int J Toxicol 25:65-80. 2006
  8. doi request reprint Malathion/oxon and lead acetate increase gene expression and protein levels of transient receptor potential canonical channel subunits TRPC1 and TRPC4 in rat endothelial cells of the blood-brain barrier
    Pergentino Balbuena
    Virginia Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061, USA
    Int J Toxicol 31:238-49. 2012
  9. doi request reprint Distribution of SH-SY5Y human neuroblastoma cells in the cell cycle following exposure to organophosphorus compounds
    Kent Carlson
    Virginia Maryland Regional College of Veterinary Medicine, Blacksburg, VA 24061, USA
    J Biochem Mol Toxicol 22:187-201. 2008
  10. ncbi request reprint Chlorpyrifos alters functional integrity and structure of an in vitro BBB model: co-cultures of bovine endothelial cells and neonatal rat astrocytes
    Damani K Parran
    Laboratory for Neurotoxicity Studies, Virginia Maryland Regional College of Veterinary Medicine, Virginia Tech, 1 Duckpond Drive, Blacksburg, VA 24061 0442, USA
    Neurotoxicology 26:77-88. 2005

Collaborators

Detail Information

Publications20

  1. doi request reprint Fullerene antioxidants decrease organophosphate-induced acetylcholinesterase inhibition in vitro
    Marion Ehrich
    Virginia Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061, USA
    Toxicol In Vitro 25:301-7. 2011
    ..These studies suggest that derivatized fullerene nanomaterials have potential capability to ameliorate OP-induced AChE inhibition resulting in toxicities...
  2. ncbi request reprint Neurotoxicity and immunotoxicity assessment in CBA/J mice with chronic Toxoplasma gondii infection and single-dose exposure to methylmercury
    Marquea D King
    Department of Biomedical Sciences and Pathobiology, Virginia Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061 0442, USA
    Int J Toxicol 22:53-61. 2003
    ..gondii. These data indicate that exposure to both MeHg and T. gondii has synergistic effects, with effects of MeHg especially on the immune system...
  3. ncbi request reprint Neurologic and immunologic effects of exposure to corticosterone, chlorpyrifos, and multiple doses of tri-ortho-tolyl phosphate over a 28-day period in rats
    M Ehrich
    Laboratory of Neurotoxicity Studies, Virginia Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, Virginia 24016 0442, USA
    J Toxicol Environ Health A 67:431-57. 2004
    ..Neuropathological examination revealed early stages of dose-related increased distal myelinated fiber axonal degeneration seen in the medullary fasciculus gracilis at only the highest dose of TOTP (300 mg/kg)...
  4. doi request reprint Calcium signaling in neuronal cells exposed to the munitions compound Cyclotrimethylenetrinitramine (RDX)
    Marion Ehrich
    Virginia Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, Virginia 24061, USA
    Int J Toxicol 28:425-35. 2009
    ....
  5. ncbi request reprint Early effects of neuropathy-inducing organophosphates on in vivo concentrations of three neurotrophins
    M J Pomeroy-Black
    Department of Biomedical Sciences and Pathobiology, Virginia Maryland Regional College of Veterinary Medicine, 1 Duckpond Drive, Blacksburg, VA 24061, USA
    Neurotox Res 11:85-91. 2007
    ..This suggests that these neurotrophins alone do not contribute to a sustained regenerative effort in the CNS...
  6. doi request reprint Comparison of two blood-brain barrier in vitro systems: cytotoxicity and transfer assessments of malathion/oxon and lead acetate
    Pergentino Balbuena
    Virginia Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, Virginia 24061, USA
    Toxicol Sci 114:260-71. 2010
    ..Results suggest that differences in endothelial cell source can affect the outcome of studies on toxicant transfer through in vitro BBB systems...
  7. ncbi request reprint Examination of concurrent exposure to repeated stress and chlorpyrifos on cholinergic, glutamatergic, and monoamine neurotransmitter systems in rat forebrain regions
    Thitiya Pung
    Department of Biomedical Sciences and Pathobiology, Virginia Maryland Regional College of Veterinary Medicine, Blacksburg, Virginia 24061 0442, USA
    Int J Toxicol 25:65-80. 2006
    ..05 were restricted to attenuation of elevated aspartate in the hippocampus of restrained with swim rats and decreased K(d) of acetylcholine receptors in the cerebral cortex of swum rats and restrained rats...
  8. doi request reprint Malathion/oxon and lead acetate increase gene expression and protein levels of transient receptor potential canonical channel subunits TRPC1 and TRPC4 in rat endothelial cells of the blood-brain barrier
    Pergentino Balbuena
    Virginia Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061, USA
    Int J Toxicol 31:238-49. 2012
    ..Therefore, upregulation and activation of the TRPC1/TRPC4 may be a mechanism by which these neurotoxicants affect BBB permeability...
  9. doi request reprint Distribution of SH-SY5Y human neuroblastoma cells in the cell cycle following exposure to organophosphorus compounds
    Kent Carlson
    Virginia Maryland Regional College of Veterinary Medicine, Blacksburg, VA 24061, USA
    J Biochem Mol Toxicol 22:187-201. 2008
    ..Changes in cell cycle, however, did not differentiate between OP compounds that are known for their ability to acutely inhibit acetylcholinesterase versus those inducing type I and type II delayed neurotoxicity...
  10. ncbi request reprint Chlorpyrifos alters functional integrity and structure of an in vitro BBB model: co-cultures of bovine endothelial cells and neonatal rat astrocytes
    Damani K Parran
    Laboratory for Neurotoxicity Studies, Virginia Maryland Regional College of Veterinary Medicine, Virginia Tech, 1 Duckpond Drive, Blacksburg, VA 24061 0442, USA
    Neurotoxicology 26:77-88. 2005
    ..CPF and its metabolites, especially CPF-oxon, contribute to the inhibition of CaE and ChE activity, as well as the alteration of BBB integrity and structure...
  11. doi request reprint Assessments of tight junction proteins occludin, claudin 5 and scaffold proteins ZO1 and ZO2 in endothelial cells of the rat blood-brain barrier: cellular responses to neurotoxicants malathion and lead acetate
    Pergentino Balbuena
    Virginia Maryland Regional College of Veterinary Medicine, 1 Duck Pond Drive, Virginia Tech, Blacksburg, VA, USA
    Neurotoxicology 32:58-67. 2011
    ..Gene expression determinations did not correlate with the decreases in protein, indicating that the effects on these proteins were post-translational...
  12. ncbi request reprint Bridging the gap between in vitro and in vivo toxicology testing
    Marion Ehrich
    Laboratory for Neurotoxicity Studies, Virginia Tech, Virginia Maryland Regional College of Veterinary Medicine, Blacksburg, VA 24061 0442, USA
    Altern Lab Anim 31:267-71. 2003
    ..The toxicities of organophosphorus compounds, which inhibit esterases, and 1,2,3,6-tetrahydropyridine (MPTP), which depletes dopamine, can be studied in human neuroblastoma cells...
  13. ncbi request reprint Effects of thimerosal on NGF signal transduction and cell death in neuroblastoma cells
    Damani K Parran
    Virginia Maryland Regional College of Veterinary Medicine, Laboratory for Neurotoxicity Studies, Virginia Tech, 1 Duckpond Drive, Blacksburg, Virginia 24061 0442, USA
    Toxicol Sci 86:132-40. 2005
    ..These data demonstrate that thimerosal could alter NGF-induced signaling in neurotrophin-treated cells at concentrations lower than those responsible for cell death...
  14. ncbi request reprint Neuropathological studies of rats following multiple exposure to tri-ortho-tolyl phosphate, chlorpyrifos and stress
    Bernard S Jortner
    Laboratory for Neurotoxicity Studies, Virginia Maryland Regional College of Veterinary Medicine, Virginia Tech Blacksburg Virginia 24061 0442 USA
    Toxicol Pathol 33:378-85. 2005
    ....
  15. doi request reprint Potent induction of total cellular and mitochondrial antioxidants and phase 2 enzymes by cruciferous sulforaphane in rat aortic smooth muscle cells: cytoprotection against oxidative and electrophilic stress
    Hong Zhu
    Division of Biomedical Sciences, Edward Via Virginia College of Osteopathic Medicine, Virginia Tech Corporate Research Center, Blacksburg, VA 24060, USA
    Cardiovasc Toxicol 8:115-25. 2008
    ....
  16. ncbi request reprint Corticosterone in drinking water: altered kinetics of a single oral dose of corticosterone and concentrations of plasma sodium, albumin, globulin, and total protein
    Thitiya Pung
    Department of Biomedical Sciences and Pathology, Virginia Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061 0442, USA
    Toxicol Ind Health 19:171-82. 2003
    ..A single oral dose of corticosterone reduced neurotoxic esterase activity in the cerebral cortex (P < 0.05) and increased norepinephrine concentrations in the hippocampus (P < 0.05)...
  17. ncbi request reprint Organophosphorus compound-induced delayed neurotoxicity in white leghorn hens assessed by Fluoro-Jade
    Kent Carlson
    Laboratory for Neurotoxicity Studies, Virginia Tech, Virginia Maryland Regional College of Veterinary Medicine, Blacksburg, Virginia 24061, USA
    Int J Toxicol 23:259-66. 2004
    ..H&E-stained sections revealed fewer sites of neurodegeneration when compared to Fluoro-Jade. These results demonstrate that Fluoro-Jade is a sensitive method for staining neural tissue affected by OPIDN...
  18. doi request reprint Transient alterations of the blood-brain barrier tight junction and receptor potential channel gene expression by chlorpyrifos
    Wen Li
    Department of Biomedical Sciences and Pathobiology, Virginia Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, VA
    J Appl Toxicol 33:1187-91. 2013
    ..These results suggest that altering gene expression for claudin5, TRPC4 and ZO1 by CPF may directly contribute to BBB disruption, and that the alteration is reversible upon removal of CPF. Copyright © 2012 John Wiley & Sons, Ltd. ..
  19. ncbi request reprint Morphological effects of neuropathy-inducing organophosphorus compounds in primary dorsal root ganglia cell cultures
    Christiane Massicotte
    Laboratory for Neurotoxicity Studies, Virginia Maryland Regional College of Veterinary Medicine, Virginia Tech, 1 Duckpond Drive, Blacksburg, VA 24061 0442, USA
    Neurotoxicology 24:787-96. 2003
    ..Paraoxon-treated and DMSO control neuronal cell cultures did not show such evident ultrastructural changes. This study demonstrates that chick DRG show pathological changes following exposure to neuropathy-inducing OP compounds...
  20. ncbi request reprint The effect of stress on the acute neurotoxicity of the organophosphate insecticide chlorpyrifos
    Sandra Hancock
    Laboratory for Neurotoxicity Studies Virginia Maryland Regional College of Veterinary Medicine Virginia Tech Blacksburg, VA 24061 0442, USA
    Toxicol Appl Pharmacol 219:136-41. 2007
    ..This had no effect on subsequent levels of plasma corticosterone. There were no stress-related differences in the degree of chlorpyrifos-induced inhibition of brain acetylcholinesterase in animals sacrificed on day 43...