Edwards A, Rollmann S, Morgan T, Mackay T. Quantitative genomics of aggressive behavior in Drosophila melanogaster. PLoS Genet. 2006;2:e154 pubmed
..Expression profiling of genetically divergent lines is an effective strategy for identifying genes affecting complex traits. ..
Edwards A, Mackay T. Quantitative trait loci for aggressive behavior in Drosophila melanogaster. Genetics. 2009;182:889-97 pubmed publisher
..Extensive epistasis poses a serious challenge for understanding the genetic basis of complex traits. ..
Edwards A, Zwarts L, Yamamoto A, Callaerts P, Mackay T. Mutations in many genes affect aggressive behavior in Drosophila melanogaster. BMC Biol. 2009;7:29 pubmed publisher
..Given the conservation of aggressive behavior among different animal species, these are novel candidate genes for future study in other animals, including humans. ..
Edwards A, Ayroles J, Stone E, Carbone M, Lyman R, Mackay T. A transcriptional network associated with natural variation in Drosophila aggressive behavior. Genome Biol. 2009;10:R76 pubmed publisher
Edwards A, Dodge K, Latendresse S, Lansford J, Bates J, Pettit G, et al
. MAOA-uVNTR and early physical discipline interact to influence delinquent behavior. J Child Psychol Psychiatry. 2010;51:679-87 pubmed publisher
..The adverse consequences of physical discipline on forms of externalizing behavior are exacerbated by an underlying biological risk conferred by MAOA genotype. ..
Edwards A, Maes H, Pedersen N, Kendler K. A population-based twin study of the genetic and environmental relationship of major depression, regular tobacco use and nicotine dependence. Psychol Med. 2011;41:395-405 pubmed publisher
..Differences between previous reports and results presented in the current study are suggestive of population differences in how MD and tobacco use inter-relate. ..
Dick D, Aliev F, Krueger R, Edwards A, Agrawal A, Lynskey M, et al
. Genome-wide association study of conduct disorder symptomatology. Mol Psychiatry. 2011;16:800-8 pubmed publisher
..None of the top signals resided in traditional candidate genes, underscoring the importance of a genome-wide approach for identifying novel variants involved in this serious childhood disorder. ..
Edwards A, Sihvola E, Korhonen T, Pulkkinen L, Moilanen I, Kaprio J, et al
. Depressive symptoms and alcohol use are genetically and environmentally correlated across adolescence. Behav Genet. 2011;41:476-87 pubmed publisher
..These influences are also temporally dynamic, complicating efforts to understand factors contributing to the relationship between these outcomes. ..
Edwards A, Larsson H, Lichtenstein P, Kendler K. Early environmental influences contribute to covariation between internalizing symptoms and alcohol intoxication frequency across adolescence. Addict Behav. 2011;36:175-82 pubmed publisher
..Early environmental factors contribute to the association between these traits, but this shared liability diminishes across adolescence. ..
Edwards A, Rose R, Kaprio J, Dick D. Pubertal development moderates the importance of environmental influences on depressive symptoms in adolescent girls and boys. J Youth Adolesc. 2011;40:1383-93 pubmed publisher
..Thus, the importance of environmental influences on depressive symptoms during adolescence changes as a function of pubertal development, and the timing of this effect differs across the sexes. ..