Alexis Edwards

Summary

Publications

  1. Edwards A, Rollmann S, Morgan T, Mackay T. Quantitative genomics of aggressive behavior in Drosophila melanogaster. PLoS Genet. 2006;2:e154 pubmed
    ..Expression profiling of genetically divergent lines is an effective strategy for identifying genes affecting complex traits. ..
  2. Edwards A, Mackay T. Quantitative trait loci for aggressive behavior in Drosophila melanogaster. Genetics. 2009;182:889-97 pubmed publisher
    ..Extensive epistasis poses a serious challenge for understanding the genetic basis of complex traits. ..
  3. Edwards A, Zwarts L, Yamamoto A, Callaerts P, Mackay T. Mutations in many genes affect aggressive behavior in Drosophila melanogaster. BMC Biol. 2009;7:29 pubmed publisher
    ..Given the conservation of aggressive behavior among different animal species, these are novel candidate genes for future study in other animals, including humans. ..
  4. Edwards A, Ayroles J, Stone E, Carbone M, Lyman R, Mackay T. A transcriptional network associated with natural variation in Drosophila aggressive behavior. Genome Biol. 2009;10:R76 pubmed publisher
    ....
  5. Edwards A, Dodge K, Latendresse S, Lansford J, Bates J, Pettit G, et al. MAOA-uVNTR and early physical discipline interact to influence delinquent behavior. J Child Psychol Psychiatry. 2010;51:679-87 pubmed publisher
    ..The adverse consequences of physical discipline on forms of externalizing behavior are exacerbated by an underlying biological risk conferred by MAOA genotype. ..
  6. Edwards A, Maes H, Pedersen N, Kendler K. A population-based twin study of the genetic and environmental relationship of major depression, regular tobacco use and nicotine dependence. Psychol Med. 2011;41:395-405 pubmed publisher
    ..Differences between previous reports and results presented in the current study are suggestive of population differences in how MD and tobacco use inter-relate. ..
  7. Dick D, Aliev F, Krueger R, Edwards A, Agrawal A, Lynskey M, et al. Genome-wide association study of conduct disorder symptomatology. Mol Psychiatry. 2011;16:800-8 pubmed publisher
    ..None of the top signals resided in traditional candidate genes, underscoring the importance of a genome-wide approach for identifying novel variants involved in this serious childhood disorder. ..
  8. Edwards A, Sihvola E, Korhonen T, Pulkkinen L, Moilanen I, Kaprio J, et al. Depressive symptoms and alcohol use are genetically and environmentally correlated across adolescence. Behav Genet. 2011;41:476-87 pubmed publisher
    ..These influences are also temporally dynamic, complicating efforts to understand factors contributing to the relationship between these outcomes. ..
  9. Edwards A, Larsson H, Lichtenstein P, Kendler K. Early environmental influences contribute to covariation between internalizing symptoms and alcohol intoxication frequency across adolescence. Addict Behav. 2011;36:175-82 pubmed publisher
    ..Early environmental factors contribute to the association between these traits, but this shared liability diminishes across adolescence. ..
  10. Edwards A, Rose R, Kaprio J, Dick D. Pubertal development moderates the importance of environmental influences on depressive symptoms in adolescent girls and boys. J Youth Adolesc. 2011;40:1383-93 pubmed publisher
    ..Thus, the importance of environmental influences on depressive symptoms during adolescence changes as a function of pubertal development, and the timing of this effect differs across the sexes. ..

Detail Information

Publications14

  1. Edwards A, Rollmann S, Morgan T, Mackay T. Quantitative genomics of aggressive behavior in Drosophila melanogaster. PLoS Genet. 2006;2:e154 pubmed
    ..Expression profiling of genetically divergent lines is an effective strategy for identifying genes affecting complex traits. ..
  2. Edwards A, Mackay T. Quantitative trait loci for aggressive behavior in Drosophila melanogaster. Genetics. 2009;182:889-97 pubmed publisher
    ..Extensive epistasis poses a serious challenge for understanding the genetic basis of complex traits. ..
  3. Edwards A, Zwarts L, Yamamoto A, Callaerts P, Mackay T. Mutations in many genes affect aggressive behavior in Drosophila melanogaster. BMC Biol. 2009;7:29 pubmed publisher
    ..Given the conservation of aggressive behavior among different animal species, these are novel candidate genes for future study in other animals, including humans. ..
  4. Edwards A, Ayroles J, Stone E, Carbone M, Lyman R, Mackay T. A transcriptional network associated with natural variation in Drosophila aggressive behavior. Genome Biol. 2009;10:R76 pubmed publisher
    ....
  5. Edwards A, Dodge K, Latendresse S, Lansford J, Bates J, Pettit G, et al. MAOA-uVNTR and early physical discipline interact to influence delinquent behavior. J Child Psychol Psychiatry. 2010;51:679-87 pubmed publisher
    ..The adverse consequences of physical discipline on forms of externalizing behavior are exacerbated by an underlying biological risk conferred by MAOA genotype. ..
  6. Edwards A, Maes H, Pedersen N, Kendler K. A population-based twin study of the genetic and environmental relationship of major depression, regular tobacco use and nicotine dependence. Psychol Med. 2011;41:395-405 pubmed publisher
    ..Differences between previous reports and results presented in the current study are suggestive of population differences in how MD and tobacco use inter-relate. ..
  7. Dick D, Aliev F, Krueger R, Edwards A, Agrawal A, Lynskey M, et al. Genome-wide association study of conduct disorder symptomatology. Mol Psychiatry. 2011;16:800-8 pubmed publisher
    ..None of the top signals resided in traditional candidate genes, underscoring the importance of a genome-wide approach for identifying novel variants involved in this serious childhood disorder. ..
  8. Edwards A, Sihvola E, Korhonen T, Pulkkinen L, Moilanen I, Kaprio J, et al. Depressive symptoms and alcohol use are genetically and environmentally correlated across adolescence. Behav Genet. 2011;41:476-87 pubmed publisher
    ..These influences are also temporally dynamic, complicating efforts to understand factors contributing to the relationship between these outcomes. ..
  9. Edwards A, Larsson H, Lichtenstein P, Kendler K. Early environmental influences contribute to covariation between internalizing symptoms and alcohol intoxication frequency across adolescence. Addict Behav. 2011;36:175-82 pubmed publisher
    ..Early environmental factors contribute to the association between these traits, but this shared liability diminishes across adolescence. ..
  10. Edwards A, Rose R, Kaprio J, Dick D. Pubertal development moderates the importance of environmental influences on depressive symptoms in adolescent girls and boys. J Youth Adolesc. 2011;40:1383-93 pubmed publisher
    ..Thus, the importance of environmental influences on depressive symptoms during adolescence changes as a function of pubertal development, and the timing of this effect differs across the sexes. ..
  11. Edwards A, Kendler K. Nicotine withdrawal-induced negative affect is a function of nicotine dependence and not liability to depression or anxiety. Nicotine Tob Res. 2011;13:677-85 pubmed publisher
    ..Though psychopathology might be indirectly related to withdrawal-induced symptoms through its correlation with ND, it is not directly predictive of withdrawal symptoms. ..
  12. Edwards A, Aliev F, Bierut L, Bucholz K, Edenberg H, Hesselbrock V, et al. Genome-wide association study of comorbid depressive syndrome and alcohol dependence. Psychiatr Genet. 2012;22:31-41 pubmed publisher
    ..These results underscore the complex genomic influences on psychiatric phenotypes and suggest that a comorbid phenotype is partially influenced by genetic variants that do not affect AD alone. ..
  13. Rollmann S, Zwarts L, Edwards A, Yamamoto A, Callaerts P, Norga K, et al. Pleiotropic effects of Drosophila neuralized on complex behaviors and brain structure. Genetics. 2008;179:1327-36 pubmed publisher
    ....
  14. Edwards A, Kendler K. Twin study of the relationship between adolescent attention-deficit/hyperactivity disorder and adult alcohol dependence. J Stud Alcohol Drugs. 2012;73:185-94 pubmed
    ..However, the ADHD factors inattention and forgetfulness are not uniquely predictive of genetic/environmental risk for alcohol dependence. ..