Mutations in many genes affect aggressive behavior in Drosophila melanogasterAlexis C Edwards
Department of Genetics, North Carolina State University, Raleigh, NC, USA
BMC Biol 7:29. 2009
..Here, we present the results of a screen of 170 Drosophila P-element insertional mutations for quantitative differences in aggressive behavior from their co-isogenic control line...
- A transcriptional network associated with natural variation in Drosophila aggressive behavior
Alexis C Edwards
Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695, USA
Genome Biol 10:R76. 2009
..Populations of Drosophila melanogaster harbor quantitative genetic variation in aggressive behavior, providing an excellent model system for dissecting the genetic basis of naturally occurring variation in aggression...
- Quantitative genomics of aggressive behavior in Drosophila melanogaster
Alexis C Edwards
Department of Genetics and W. M. Keck Center for Behavioral Biology, North Carolina State University, Raleigh, North Carolina, United States of America
PLoS Genet 2:e154. 2006
..Expression profiling of genetically divergent lines is an effective strategy for identifying genes affecting complex traits...
- Genome-wide association study of comorbid depressive syndrome and alcohol dependence
Alexis C Edwards
Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298 0126, USA
Psychiatr Genet 22:31-41. 2012
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- Nicotine withdrawal-induced negative affect is a function of nicotine dependence and not liability to depression or anxiety
Alexis C Edwards
Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23298 0126, USA
Nicotine Tob Res 13:677-85. 2011
..It is not clear whether these symptoms index liability to negative affect generally or whether such symptoms are a function of nicotine withdrawal and are thus indexed by nicotine dependence (ND)...
- Pubertal development moderates the importance of environmental influences on depressive symptoms in adolescent girls and boys
Alexis C Edwards
Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, P O Box 980126, Richmond, VA 23298 0126, USA
J Youth Adolesc 40:1383-93. 2011
..Thus, the importance of environmental influences on depressive symptoms during adolescence changes as a function of pubertal development, and the timing of this effect differs across the sexes...
- Early environmental influences contribute to covariation between internalizing symptoms and alcohol intoxication frequency across adolescence
Alexis C Edwards
Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, 23298 0126, USA
Addict Behav 36:175-82. 2011
..Early environmental factors contribute to the association between these traits, but this shared liability diminishes across adolescence...
- Depressive symptoms and alcohol use are genetically and environmentally correlated across adolescence
Alexis C Edwards
Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298 0126, USA
Behav Genet 41:476-87. 2011
..These influences are also temporally dynamic, complicating efforts to understand factors contributing to the relationship between these outcomes...
- Genome-wide association study of conduct disorder symptomatology
D M Dick
Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA
Mol Psychiatry 16:800-8. 2011
..None of the top signals resided in traditional candidate genes, underscoring the importance of a genome-wide approach for identifying novel variants involved in this serious childhood disorder...
- A population-based twin study of the genetic and environmental relationship of major depression, regular tobacco use and nicotine dependence
A C Edwards
Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298 0126, USA
Psychol Med 41:395-405. 2011
..However, few have used a genetically informative design to assess whether these traits share a common genetic and/or environmental liability...
- MAOA-uVNTR and early physical discipline interact to influence delinquent behavior
Alexis C Edwards
Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA
J Child Psychol Psychiatry 51:679-87. 2010
..We expand on the current literature in our assessment of externalizing, incorporating information across multiple reporters and over a broad developmental time period, and in our understanding of environmental risk...
- Quantitative trait loci for aggressive behavior in Drosophila melanogaster
Alexis C Edwards
Department of Genetics and W M Keck Center for Behavioral Biology, North Carolina State University, Raleigh, North Carolina 27695, USA
Genetics 182:889-97. 2009
..Extensive epistasis poses a serious challenge for understanding the genetic basis of complex traits...
- Pleiotropic effects of Drosophila neuralized on complex behaviors and brain structure
Stephanie M Rollmann
Department of Zoology, North Carolina State University, Raleigh, North Carolina 27695 7617, USA
Genetics 179:1327-36. 2008
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- Assessment of a modified DSM-5 diagnosis of alcohol use disorder in a genetically informative population
Alexis C Edwards
Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia 23298 0126, USA
Alcohol Clin Exp Res 37:443-51. 2013
..Few published studies empirically assess the potential consequences of the proposed changes...
- A twin study of depression and nicotine dependence: shared liability or causal relationship?
Alexis C Edwards
Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23298 0126, USA
J Affect Disord 142:90-7. 2012
..We present results from analyses comparing models wherein MD and ND are influenced by a shared latent factor to one in which causal pathways between phenotypes are examined...
- Twin study of the relationship between adolescent attention-deficit/hyperactivity disorder and adult alcohol dependence
Alexis C Edwards
Virginia Institute for Psychiatric and Behavioral Genetics, and Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia 23298 0126, USA
J Stud Alcohol Drugs 73:185-94. 2012
..This association is partly a result of shared genetic liability. However, it is unclear whether ADHD, or an ADHD subtype, shares genetic influences with alcohol dependence beyond those also shared by conduct disorder...
