Alexis Edwards

Summary

Publications

  1. pmc Mutations in many genes affect aggressive behavior in Drosophila melanogaster
    Alexis C Edwards
    Department of Genetics, North Carolina State University, Raleigh, NC, USA
    BMC Biol 7:29. 2009
  2. pmc A transcriptional network associated with natural variation in Drosophila aggressive behavior
    Alexis C Edwards
    Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695, USA
    Genome Biol 10:R76. 2009
  3. pmc Quantitative genomics of aggressive behavior in Drosophila melanogaster
    Alexis C Edwards
    Department of Genetics and W M Keck Center for Behavioral Biology, North Carolina State University, Raleigh, North Carolina, United States of America
    PLoS Genet 2:e154. 2006
  4. pmc Genome-wide association study of comorbid depressive syndrome and alcohol dependence
    Alexis C Edwards
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298 0126, USA
    Psychiatr Genet 22:31-41. 2012
  5. pmc Nicotine withdrawal-induced negative affect is a function of nicotine dependence and not liability to depression or anxiety
    Alexis C Edwards
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Nicotine Tob Res 13:677-85. 2011
  6. pmc Pubertal development moderates the importance of environmental influences on depressive symptoms in adolescent girls and boys
    Alexis C Edwards
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, P O Box 980126, Richmond, VA 23298 0126, USA
    J Youth Adolesc 40:1383-93. 2011
  7. pmc Early environmental influences contribute to covariation between internalizing symptoms and alcohol intoxication frequency across adolescence
    Alexis C Edwards
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, 23298 0126, USA
    Addict Behav 36:175-82. 2011
  8. pmc Depressive symptoms and alcohol use are genetically and environmentally correlated across adolescence
    Alexis C Edwards
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Behav Genet 41:476-87. 2011
  9. pmc Genome-wide association study of conduct disorder symptomatology
    D M Dick
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA
    Mol Psychiatry 16:800-8. 2011
  10. pmc A population-based twin study of the genetic and environmental relationship of major depression, regular tobacco use and nicotine dependence
    A C Edwards
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Psychol Med 41:395-405. 2011

Detail Information

Publications17

  1. pmc Mutations in many genes affect aggressive behavior in Drosophila melanogaster
    Alexis C Edwards
    Department of Genetics, North Carolina State University, Raleigh, NC, USA
    BMC Biol 7:29. 2009
    ..Here, we present the results of a screen of 170 Drosophila P-element insertional mutations for quantitative differences in aggressive behavior from their co-isogenic control line...
  2. pmc A transcriptional network associated with natural variation in Drosophila aggressive behavior
    Alexis C Edwards
    Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695, USA
    Genome Biol 10:R76. 2009
    ..Populations of Drosophila melanogaster harbor quantitative genetic variation in aggressive behavior, providing an excellent model system for dissecting the genetic basis of naturally occurring variation in aggression...
  3. pmc Quantitative genomics of aggressive behavior in Drosophila melanogaster
    Alexis C Edwards
    Department of Genetics and W M Keck Center for Behavioral Biology, North Carolina State University, Raleigh, North Carolina, United States of America
    PLoS Genet 2:e154. 2006
    ..Expression profiling of genetically divergent lines is an effective strategy for identifying genes affecting complex traits...
  4. pmc Genome-wide association study of comorbid depressive syndrome and alcohol dependence
    Alexis C Edwards
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298 0126, USA
    Psychiatr Genet 22:31-41. 2012
    ....
  5. pmc Nicotine withdrawal-induced negative affect is a function of nicotine dependence and not liability to depression or anxiety
    Alexis C Edwards
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Nicotine Tob Res 13:677-85. 2011
    ..It is not clear whether these symptoms index liability to negative affect generally or whether such symptoms are a function of nicotine withdrawal and are thus indexed by nicotine dependence (ND)...
  6. pmc Pubertal development moderates the importance of environmental influences on depressive symptoms in adolescent girls and boys
    Alexis C Edwards
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, P O Box 980126, Richmond, VA 23298 0126, USA
    J Youth Adolesc 40:1383-93. 2011
    ..Thus, the importance of environmental influences on depressive symptoms during adolescence changes as a function of pubertal development, and the timing of this effect differs across the sexes...
  7. pmc Early environmental influences contribute to covariation between internalizing symptoms and alcohol intoxication frequency across adolescence
    Alexis C Edwards
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, 23298 0126, USA
    Addict Behav 36:175-82. 2011
    ..Early environmental factors contribute to the association between these traits, but this shared liability diminishes across adolescence...
  8. pmc Depressive symptoms and alcohol use are genetically and environmentally correlated across adolescence
    Alexis C Edwards
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Behav Genet 41:476-87. 2011
    ..These influences are also temporally dynamic, complicating efforts to understand factors contributing to the relationship between these outcomes...
  9. pmc Genome-wide association study of conduct disorder symptomatology
    D M Dick
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA
    Mol Psychiatry 16:800-8. 2011
    ..None of the top signals resided in traditional candidate genes, underscoring the importance of a genome-wide approach for identifying novel variants involved in this serious childhood disorder...
  10. pmc A population-based twin study of the genetic and environmental relationship of major depression, regular tobacco use and nicotine dependence
    A C Edwards
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Psychol Med 41:395-405. 2011
    ..However, few have used a genetically informative design to assess whether these traits share a common genetic and/or environmental liability...
  11. pmc MAOA-uVNTR and early physical discipline interact to influence delinquent behavior
    Alexis C Edwards
    Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA
    J Child Psychol Psychiatry 51:679-87. 2010
    ..We expand on the current literature in our assessment of externalizing, incorporating information across multiple reporters and over a broad developmental time period, and in our understanding of environmental risk...
  12. pmc Quantitative trait loci for aggressive behavior in Drosophila melanogaster
    Alexis C Edwards
    Department of Genetics and W M Keck Center for Behavioral Biology, North Carolina State University, Raleigh, North Carolina 27695, USA
    Genetics 182:889-97. 2009
    ..Extensive epistasis poses a serious challenge for understanding the genetic basis of complex traits...
  13. pmc Pleiotropic effects of Drosophila neuralized on complex behaviors and brain structure
    Stephanie M Rollmann
    Department of Zoology, North Carolina State University, Raleigh, North Carolina 27695 7617, USA
    Genetics 179:1327-36. 2008
    ....
  14. pmc Alcohol consumption in men is influenced by qualitatively different genetic factors in adolescence and adulthood
    A C Edwards
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Psychol Med 43:1857-68. 2013
    ..We used twin modeling methods to explore genetic and environmental influences on alcohol consumption over time...
  15. pmc Assessment of a modified DSM-5 diagnosis of alcohol use disorder in a genetically informative population
    Alexis C Edwards
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia 23298 0126, USA
    Alcohol Clin Exp Res 37:443-51. 2013
    ..Few published studies empirically assess the potential consequences of the proposed changes...
  16. pmc A twin study of depression and nicotine dependence: shared liability or causal relationship?
    Alexis C Edwards
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    J Affect Disord 142:90-7. 2012
    ..We present results from analyses comparing models wherein MD and ND are influenced by a shared latent factor to one in which causal pathways between phenotypes are examined...
  17. pmc Twin study of the relationship between adolescent attention-deficit/hyperactivity disorder and adult alcohol dependence
    Alexis C Edwards
    Virginia Institute for Psychiatric and Behavioral Genetics, and Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia 23298 0126, USA
    J Stud Alcohol Drugs 73:185-94. 2012
    ..This association is partly a result of shared genetic liability. However, it is unclear whether ADHD, or an ADHD subtype, shares genetic influences with alcohol dependence beyond those also shared by conduct disorder...