Lindon J Eaves

Summary

Affiliation: Virginia Commonwealth University
Country: USA

Publications

  1. ncbi request reprint Genetic and environmental influences on the relative timing of pubertal change
    Lindon Eaves
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298 0003, USA
    Twin Res 7:471-81. 2004
  2. ncbi request reprint Revisiting the children of twins: can they be used to resolve the environmental effects of dyadic parental treatment on child behavior?
    Lindon J Eaves
    Virginia Institute of Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298, USA
    Twin Res Hum Genet 8:283-90. 2005
  3. ncbi request reprint Application of Bayesian inference using Gibbs sampling to item-response theory modeling of multi-symptom genetic data
    Lindon Eaves
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Human Genetics, Virginia Commonwealth University, Richmond, VA 23298 0003, USA
    Behav Genet 35:765-80. 2005
  4. ncbi request reprint Parent-child feedback predicts sibling contrast: using twin studies to test theories of parent-offspring interaction in infant behavior
    Lindon J Eaves
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Twin Res Hum Genet 8:1-4. 2005
  5. ncbi request reprint Genotype x Environment interaction in psychopathology: fact or artifact?
    Lindon J Eaves
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298, USA
    Twin Res Hum Genet 9:1-8. 2006
  6. pmc Flexible Mx specification of various extended twin kinship designs
    Hermine H Maes
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298 0003, United States of America
    Twin Res Hum Genet 12:26-34. 2009
  7. ncbi request reprint Genetic and cultural transmission of antisocial behavior: an extended twin parent model
    Hermine H Maes
    Department of Human Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298 0003, USA
    Twin Res Hum Genet 10:136-50. 2007
  8. pmc The impact of environmental experiences on symptoms of anxiety and depression across the life span
    Kenneth S Kendler
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298, USA
    Psychol Sci 22:1343-52. 2011
  9. doi request reprint The mediating effect of parental neglect on adolescent and young adult anti-sociality: a longitudinal study of twins and their parents
    Lindon J Eaves
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
    Behav Genet 40:425-37. 2010
  10. ncbi request reprint A twin study of genetic and environmental influences on tobacco initiation, regular tobacco use and nicotine dependence
    Hermine H Maes
    Departments of Human Genetics and Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298 0003, USA
    Psychol Med 34:1251-61. 2004

Detail Information

Publications50

  1. ncbi request reprint Genetic and environmental influences on the relative timing of pubertal change
    Lindon Eaves
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298 0003, USA
    Twin Res 7:471-81. 2004
    ..0+/-3.6% in boys. Shared environmental influences account for 3.6+/-3.4% in girls and 0% in boys. In girls, nonshared environmental effects explain 0.1+/-0.1% of the total residual variance. The comparable figure in boys is 12.0+/-3.6%...
  2. ncbi request reprint Revisiting the children of twins: can they be used to resolve the environmental effects of dyadic parental treatment on child behavior?
    Lindon J Eaves
    Virginia Institute of Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298, USA
    Twin Res Hum Genet 8:283-90. 2005
    ..The fact that many candidate environments, such as parental divorce, are dyadic gives reason to question the interpretation of their correlations with behavior in the children of twins...
  3. ncbi request reprint Application of Bayesian inference using Gibbs sampling to item-response theory modeling of multi-symptom genetic data
    Lindon Eaves
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Human Genetics, Virginia Commonwealth University, Richmond, VA 23298 0003, USA
    Behav Genet 35:765-80. 2005
    ..Additional benefits of the IRT approach are discussed including the estimation of latent trait scores, including genetic factor scores, and their sampling errors...
  4. ncbi request reprint Parent-child feedback predicts sibling contrast: using twin studies to test theories of parent-offspring interaction in infant behavior
    Lindon J Eaves
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Twin Res Hum Genet 8:1-4. 2005
    ....
  5. ncbi request reprint Genotype x Environment interaction in psychopathology: fact or artifact?
    Lindon J Eaves
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298, USA
    Twin Res Hum Genet 9:1-8. 2006
    ..There is therefore reason to question the biological significance of published findings...
  6. pmc Flexible Mx specification of various extended twin kinship designs
    Hermine H Maes
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298 0003, United States of America
    Twin Res Hum Genet 12:26-34. 2009
    ..Results indicate that biases in the estimation of variance components depend both on the types of relative available for analysis, and on the underlying genetic and environmental architecture of the phenotype of interest...
  7. ncbi request reprint Genetic and cultural transmission of antisocial behavior: an extended twin parent model
    Hermine H Maes
    Department of Human Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298 0003, USA
    Twin Res Hum Genet 10:136-50. 2007
    ..This study showed significant heritability, which is slightly increased by assortative mating, and significant effects of primarily nonparental shared environment on CD...
  8. pmc The impact of environmental experiences on symptoms of anxiety and depression across the life span
    Kenneth S Kendler
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298, USA
    Psychol Sci 22:1343-52. 2011
    ..By middle adulthood, environmental experiences contributed substantially to stable and predictable interindividual differences in levels of anxiety and depression...
  9. doi request reprint The mediating effect of parental neglect on adolescent and young adult anti-sociality: a longitudinal study of twins and their parents
    Lindon J Eaves
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
    Behav Genet 40:425-37. 2010
    ..The longitudinal study of twins and their parents makes it possible to demonstrate there is a direct causal effect of childhood adversity on child conduct disorder over and above any indirect genetic correlation...
  10. ncbi request reprint A twin study of genetic and environmental influences on tobacco initiation, regular tobacco use and nicotine dependence
    Hermine H Maes
    Departments of Human Genetics and Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298 0003, USA
    Psychol Med 34:1251-61. 2004
    ..As the development of ND requires regular tobacco use (RTU) which in turn requires TI, a conditional approach is necessary...
  11. doi request reprint Developmental-genetic effects on level and change in childhood fears of twins during adolescence
    Lindon J Eaves
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23298 0003, USA
    J Child Psychol Psychiatry 49:1201-10. 2008
    ....
  12. ncbi request reprint Childhood adversity, monoamine oxidase a genotype, and risk for conduct disorder
    Debra L Foley
    Department of Human Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virgoinia Commonwaelth University, Richmond, 23298 0003, USA
    Arch Gen Psychiatry 61:738-44. 2004
    ..Very little is known about how different sets of risk factors interact to influence risk for psychiatric disorder...
  13. pmc Genetic and environmental transmission of body mass index fluctuation
    Jocilyn E Bergin
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, MCV, P O Box 980126, Richmond, VA 23298, USA
    Behav Genet 42:867-74. 2012
    ....
  14. pmc Unraveling the effect of genes and environment in the transmission of parental antisocial behavior to children's conduct disturbance, depression and hyperactivity
    Judy L Silberg
    Department of Human and Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298 0003, USA
    J Child Psychol Psychiatry 53:668-77. 2012
    ....
  15. ncbi request reprint Genetic and cultural transmission of smoking initiation: an extended twin kinship model
    Hermine H Maes
    Department of Human Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, 980003, 23298 0003, Richmond, VA 23298 0003, USA
    Behav Genet 36:795-808. 2006
    ....
  16. pmc Racial differences in genetic and environmental risk to preterm birth
    Timothy P York
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, Virginia, United States of America
    PLoS ONE 5:e12391. 2010
    ..This study provides a comprehensive description of the relative genetic and environmental contributions to racial differences in gestational age...
  17. pmc A longitudinal twin study of fears from middle childhood to early adulthood: evidence for a developmentally dynamic genome
    Kenneth S Kendler
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University Medical School, Box 980126, 800 E Leigh St, Room 1 123, Richmond, VA 23298 0126, USA
    Arch Gen Psychiatry 65:421-9. 2008
    ..While the nature of common fears changes over development, we do not know whether genetic effects on fear-proneness are developmentally stable or developmentally dynamic...
  18. ncbi request reprint Epistatic and environmental control of genome-wide gene expression
    Timothy P York
    Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia 23298 0003, USA
    Twin Res Hum Genet 8:5-15. 2005
    ....
  19. ncbi request reprint Modulation of gene expression by genetic and environmental heterogeneity in timing of a developmental milestone
    Lindon J Eaves
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298 0003, USA
    Behav Genet 33:1-6. 2003
    ..The impact of these effects on age patterns in twin correlations is examined and their relevance to current data on developmental change discussed briefly...
  20. ncbi request reprint Familial influences on alcohol use in adolescent female twins: testing for genetic and environmental interactions
    Donna R Miles
    Department of Human Genetics, Virginia Commonwealth University, Virginia Institute for Psychiatric and Behavioral Genetics, P O Box 980003, 800 East Leigh St, Biotech One, Suite 100, Richmond, Virginia, 23298 0003, USA
    J Stud Alcohol 66:445-51. 2005
    ..The present study examined whether measures of family adaptability and cohesion may moderate the genetic influence on risk for alcohol use among female adolescents...
  21. ncbi request reprint Markov Chain Monte Carlo approaches to analysis of genetic and environmental components of human developmental change and G x E interaction
    Lindon Eaves
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Human Genetics, Virginia Commonwealth University, PO Box 980003, Richmond, Virginia 23298 0003, USA
    Behav Genet 33:279-99. 2003
    ..Possible limitations of MCMC methods are discussed. Further studies are necessary explore the value of an approach that could extend the horizons of research in developmental genetic epidemiology...
  22. ncbi request reprint Multivariate adaptive regression splines: a powerful method for detecting disease-risk relationship differences among subgroups
    Timothy P York
    Massey Cancer Center, Virginia Commonwealth University, Virginia Institute for Psychiatric and Behavioral Genetics, P O Box 980003, Richmond, VA 23298 0003, USA
    Stat Med 25:1355-67. 2006
    ..It was shown that power was higher even if the regression curve was linear, that gains increased with the complexity of the curve, and that for highly non-linear curves model-free methods such as MARS might be the only alternative...
  23. ncbi request reprint Course and short-term outcomes of separation anxiety disorder in a community sample of twins
    Debra L Foley
    Human Genetics Department, Virginia Commonwealth University, Richmond 23298 0003, USA
    J Am Acad Child Adolesc Psychiatry 43:1107-14. 2004
    ..To assess the course and short-term outcomes associated with separation anxiety disorder (SAD) in a community setting...
  24. ncbi request reprint Risks for conduct disorder symptoms associated with parental alcoholism in stepfather families versus intact families from a community sample
    Debra L Foley
    Department of Human Genetics, Virginia Commonwealth University, Richmond, VA 23298, USA
    J Child Psychol Psychiatry 45:687-96. 2004
    ....
  25. ncbi request reprint Genetic and environmental influences on temperament in the first year of life: the Puerto Rico Infant Twin Study (PRINTS)
    Judy L Silberg
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Human Genetics, Virginia Commonwealth University, Richmond, Virginia, USA
    Twin Res Hum Genet 8:328-36. 2005
    ..In contrast, a significant effect of the shared environment on the temperamental trait of unadaptability has not been reported previously...
  26. doi request reprint Childhood separation anxiety disorder and adult onset panic attacks share a common genetic diathesis
    Roxann Roberson-Nay
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Depress Anxiety 29:320-7. 2012
    ....
  27. pmc Genetic and environmental influences on the transmission of parental depression to children's depression and conduct disturbance: an extended Children of Twins study
    Judy L Silberg
    Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA, USA
    J Child Psychol Psychiatry 51:734-44. 2010
    ....
  28. ncbi request reprint Maternal smoking during pregnancy and risk to boys' conduct disturbance: an examination of the causal hypothesis
    Judy L Silberg
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298 0003, USA
    Biol Psychiatry 53:130-5. 2003
    ..We undertook this study to determine whether the widely replicated link between maternal smoking and conduct disturbance (Cd) is better explained by a model of direct causation or of mother-offspring transmission of a latent Cd variable...
  29. doi request reprint Transmission of attitudes toward abortion and gay rights: effects of genes, social learning and mate selection
    Lindon J Eaves
    Departments of Human Genetics and Psychiatry, Virginia Commonwealth University, Richmond, VA, USA
    Behav Genet 38:247-56. 2008
    ..By contrast, the choice of mate is a social action that has a marked impact on the polarization of social attitudes and on the long-term influence that parents exert upon the next generation...
  30. ncbi request reprint The relationship between separation anxiety and impairment
    Debra L Foley
    Virginia Institute for Psychiatric and Behavioral Genetics, Medical College of Virginia Commonwealth University, USA
    J Anxiety Disord 22:635-41. 2008
    ..The results indicate that impairment may index current treatment need but symptom levels provide the best information about severity and prognosis...
  31. ncbi request reprint Resolving multiple epigenetic pathways to adolescent depression
    Lindon Eaves
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond 23298 0003, USA
    J Child Psychol Psychiatry 44:1006-14. 2003
    ..The causes of the environmental variation, therefore, need to be modeled at the same time as the primary outcome...
  32. ncbi request reprint Genetic and environmental risk factors in adolescent substance use
    Judy Silberg
    Department of Human Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond 23298 0003, USA
    J Child Psychol Psychiatry 44:664-76. 2003
    ..The present study was undertaken with the goal of understanding the causes of association between substance use and both conduct disturbance (CD) and depression in adolescent boys and girls...
  33. ncbi request reprint Etiological heterogeneity in the development of antisocial behavior: the Virginia Twin Study of Adolescent Behavioral Development and the Young Adult Follow-Up
    Judy L Silberg
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Human Genetics, Virginia Commonwealth University, Richmond, VA 23298 0003, USA
    Psychol Med 37:1193-202. 2007
    ..Longitudinal, genetically informed, prospective data collected on a large population of male twins (n=1037) were used to examine developmental differences in the etiology of antisocial behavior...
  34. ncbi request reprint Has the "Equal Environments" assumption been tested in twin studies?
    Lindon Eaves
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298 0003, USA
    Twin Res 6:486-9. 2003
    ..The stratification approach to testing the equal environments assumption may be misleading and the results of such tests may actually be consistent with a simpler theory of the role of genetic factors in niche selection...
  35. ncbi request reprint Informant disagreement for separation anxiety disorder
    Debra Foley
    Human Genetics Department, Virginia Commonwealth University, Richmond 23298 0003, USA
    J Am Acad Child Adolesc Psychiatry 43:452-60. 2004
    ..To characterize informant disagreement for separation anxiety disorder (SAD)...
  36. pmc Increased frequency of micronuclei in adults with a history of childhood sexual abuse: a discordant monozygotic twin study
    Timothy P York
    Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia, United States of America
    PLoS ONE 8:e55337. 2013
    ....
  37. pmc Genetic and environmental effects on diurnal dehydroepiandrosterone sulfate concentrations in middle-aged men
    Elizabeth C Prom-Wormley
    Virginia Institute for Behavioral and Psychiatric Genetics, Virginia Commonwealth University, Richmond, VA 23298 0126, United States
    Psychoneuroendocrinology 36:1441-52. 2011
    ..The characterization of the genetic and environmental contributions to daily DHEAS concentrations is thus important for understanding the genetics of health and aging...
  38. pmc Estimating fetal and maternal genetic contributions to premature birth from multiparous pregnancy histories of twins using MCMC and maximum-likelihood approaches
    Timothy P York
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, Virginia 32398 0003, United States of America
    Twin Res Hum Genet 12:333-42. 2009
    ..We anticipate the flexibility of MCMC methods to handle increasingly complex models to be of particular relevance for the study of birth outcomes...
  39. ncbi request reprint Evaluation of analyses of univariate discrete twin data
    Patrick F Sullivan
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University Richmond, 23298 0126, USA
    Behav Genet 32:221-7. 2002
    ..These results suggest that the use of AIC to guide twin modeling for univariate discrete traits should either be abandoned or used with great caution...
  40. ncbi request reprint Assessment of the within-family environment in twins: absolute versus differential ratings, and relationship with conduct problems
    Rene Carbonneau
    Virginia Institute for Psychiatric and Behavioral Genetics, USA
    J Child Psychol Psychiatry 43:1064-74. 2002
    ..The aim was to compare the psychometric properties of absolute versus differential ratings of the within-family environments and to examine their associations with conduct problems in 8-16-year-old twins...
  41. pmc Epistasis between COMT and MTHFR in maternal-fetal dyads increases risk for preeclampsia
    Lori D Hill
    Department of Obstetrics and Gynecology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, United States of America
    PLoS ONE 6:e16681. 2011
    ..341 and P = 0.219, respectively). Our findings demonstrate a role for both maternal and fetal COMT in preeclampsia and highlight the importance of including allelic variation in MTHFR...
  42. ncbi request reprint cDNA microarray analysis identifies genes induced in common by peptide growth factors and androgen in human prostate epithelial cells
    Timothy P York
    Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Mol Carcinog 44:242-51. 2005
    ..These results provide comprehensive and unique insights into potential mechanisms by which peptide growth factors provide alternate pathways to control prostate epithelial cell proliferation in malignant states...
  43. pmc The phenotype of persons having mosaicism for trisomy 21/Down syndrome reflects the percentage of trisomic cells present in different tissues
    Paulie Papavassiliou
    Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia 23298 0662, USA
    Am J Med Genet A 149:573-83. 2009
    ..The results of this study should enable geneticists and other health care professionals to provide information regarding optimal diagnostic approaches and anticipated clinical outcomes...
  44. doi request reprint Putting the 'human' back in genetics: modeling the extended kinships of twins
    Lindon Eaves
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, Virginia, United States of America
    Twin Res Hum Genet 12:1-7. 2009
    ....
  45. ncbi request reprint Analysis and interpretation of twin studies including measures of the shared environment
    Eric Turkheimer
    Department of Psychology, University of Virginia, Charlottesville 22904 4400, USA
    Child Dev 76:1217-33. 2005
    ....
  46. ncbi request reprint The role of the children of twins design in elucidating causal relations between parent characteristics and child outcomes
    Brian M D'Onofrio
    Department of Psychology, University of Virginia, Charlottesville 22904 4400, USA
    J Child Psychol Psychiatry 44:1130-44. 2003
    ..This paper discusses the strength of the Children of Twins (COT) design to highlight the role of specific environments...
  47. pmc A Children of Twins Study of parental divorce and offspring psychopathology
    Brian M D'Onofrio
    Department of Psychological and Brain Sciences, Indiana University 47405, USA
    J Child Psychol Psychiatry 48:667-75. 2007
    ..The relations may be due to genetic or environmental selection factors, characteristics that lead to both marital separation and offspring functioning...
  48. pmc Genetic and environmental influences on individual differences in attitudes toward homosexuality: an Australian twin study
    Karin J H Verweij
    Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, 300 Herston Road, Brisbane 4029, QLD, Australia
    Behav Genet 38:257-65. 2008
    ..The results suggest that variation in attitudes toward homosexuality is substantially inherited, and that social environmental influences are relatively minor...
  49. ncbi request reprint Genetics of verbal working memory processes: a twin study of middle-aged men
    William S Kremen
    Department of Psychiatry, Center for Behavioral Genomics, University of California, San Diego, CA 92093 0738, USA
    Neuropsychology 21:569-80. 2007
    ..The genetic influences that were specific to reading span were concluded to most likely reflect an executive function component. Implications for genetic studies of aging and prefrontal brain function are discussed...
  50. pmc Storage and executive components of working memory: integrating cognitive psychology and behavior genetics in the study of aging
    William S Kremen
    Department of Psychiatry, Center for Behavioral Genomics, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, USA
    J Gerontol B Psychol Sci Soc Sci 63:P84-91. 2008
    ..We discuss the findings in the context of research suggesting that new genetic influences come into play if demand continues to increase beyond a certain threshold, a threshold that may change with task difficulty and with age...