Danielle M Dick

Summary

Affiliation: Virginia Commonwealth University
Country: USA

Publications

  1. ncbi Family-based association analyses of alcohol dependence phenotypes across DRD2 and neighboring gene ANKK1
    Danielle M Dick
    Washington University in St Louis, St Louis, Missouri, USA
    Alcohol Clin Exp Res 31:1645-53. 2007
  2. ncbi Gender differences in friends' influences on adolescent drinking: a genetic epidemiological study
    Danielle M Dick
    Washington University, St Louis, Missouri, USA
    Alcohol Clin Exp Res 31:2012-9. 2007
  3. pmc Incorporating genetics into your studies: a guide for social scientists
    Danielle M Dick
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University Richmond, VA, USA
    Front Psychiatry 2:17. 2011
  4. pmc Multi-species data integration and gene ranking enrich significant results in an alcoholism genome-wide association study
    Zhongming Zhao
    Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    BMC Genomics 13:S16. 2012
  5. pmc How phenotype and developmental stage affect the genes we find: GABRA2 and impulsivity
    Danielle M Dick
    Department of Psychiatry, Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA, USA
    Twin Res Hum Genet 16:661-9. 2013
  6. pmc Measures of current alcohol consumption and problems: two independent twin studies suggest a complex genetic architecture
    Danielle M Dick
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, USA
    Alcohol Clin Exp Res 35:2152-61. 2011
  7. pmc A Systematic single nucleotide polymorphism screen to fine-map alcohol dependence genes on chromosome 7 identifies association with a novel susceptibility gene ACN9
    Danielle M Dick
    Washington University in St Louis, St Louis, Missouri, USA
    Biol Psychiatry 63:1047-53. 2008
  8. pmc CHRM2, parental monitoring, and adolescent externalizing behavior: evidence for gene-environment interaction
    Danielle M Dick
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Psychol Sci 22:481-9. 2011
  9. pmc Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts
    Danielle M Dick
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Am J Med Genet B Neuropsychiatr Genet 153:1179-88. 2010
  10. ncbi Using dimensional models of externalizing psychopathology to aid in gene identification
    Danielle M Dick
    Washington University, St Louis, Missouri, USA
    Arch Gen Psychiatry 65:310-8. 2008

Detail Information

Publications96

  1. ncbi Family-based association analyses of alcohol dependence phenotypes across DRD2 and neighboring gene ANKK1
    Danielle M Dick
    Washington University in St Louis, St Louis, Missouri, USA
    Alcohol Clin Exp Res 31:1645-53. 2007
    ..Recently the genetic polymorphism most widely analyzed in DRD2, Taq1A, has been discovered to reside in a neighboring gene, ankyrin repeat and kinase domain containing 1 (ANKK1), located 10 kb downstream from DRD2...
  2. ncbi Gender differences in friends' influences on adolescent drinking: a genetic epidemiological study
    Danielle M Dick
    Washington University, St Louis, Missouri, USA
    Alcohol Clin Exp Res 31:2012-9. 2007
    ....
  3. pmc Incorporating genetics into your studies: a guide for social scientists
    Danielle M Dick
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University Richmond, VA, USA
    Front Psychiatry 2:17. 2011
    ..Through this review, we hope to equip social scientists with a deeper understanding of the many considerations that go into genetics research, in an effort to foster more meaningful cross-disciplinary initiatives...
  4. pmc Multi-species data integration and gene ranking enrich significant results in an alcoholism genome-wide association study
    Zhongming Zhao
    Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    BMC Genomics 13:S16. 2012
    ..Integration of these heterogeneous data can be used to produce a ranked target gene list for additional investigation...
  5. pmc How phenotype and developmental stage affect the genes we find: GABRA2 and impulsivity
    Danielle M Dick
    Department of Psychiatry, Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA, USA
    Twin Res Hum Genet 16:661-9. 2013
    ..Phenotypic measurement has been offered as one explanation, although most of this discussion has focused on problems with binary diagnoses...
  6. pmc Measures of current alcohol consumption and problems: two independent twin studies suggest a complex genetic architecture
    Danielle M Dick
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, USA
    Alcohol Clin Exp Res 35:2152-61. 2011
    ..Further, there are many different aspects of AC that can be assessed (e.g., frequency of use, quantity of use, and frequency of intoxication)...
  7. pmc A Systematic single nucleotide polymorphism screen to fine-map alcohol dependence genes on chromosome 7 identifies association with a novel susceptibility gene ACN9
    Danielle M Dick
    Washington University in St Louis, St Louis, Missouri, USA
    Biol Psychiatry 63:1047-53. 2008
    ..To follow up on this linkage region, we systematically screened single nucleotide polymorphisms (SNPs) across a 2 LOD support interval surrounding the alcohol dependence peak...
  8. pmc CHRM2, parental monitoring, and adolescent externalizing behavior: evidence for gene-environment interaction
    Danielle M Dick
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Psychol Sci 22:481-9. 2011
    ..The difficulties involved in distinguishing mechanisms of gene-environment interaction are discussed...
  9. pmc Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts
    Danielle M Dick
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Am J Med Genet B Neuropsychiatr Genet 153:1179-88. 2010
    ..Further, none of the genes were located directly under the primary COGA linkage peak, which has implications for association tests following-up linkage peaks...
  10. ncbi Using dimensional models of externalizing psychopathology to aid in gene identification
    Danielle M Dick
    Washington University, St Louis, Missouri, USA
    Arch Gen Psychiatry 65:310-8. 2008
    ..However, this information has not been widely used in gene identification efforts, which have focused on specific disorders diagnosed using traditional psychiatric classification systems...
  11. pmc Genome-wide association study of conduct disorder symptomatology
    D M Dick
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA
    Mol Psychiatry 16:800-8. 2011
    ..None of the top signals resided in traditional candidate genes, underscoring the importance of a genome-wide approach for identifying novel variants involved in this serious childhood disorder...
  12. pmc Understanding the construct of impulsivity and its relationship to alcohol use disorders
    Danielle M Dick
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Addict Biol 15:217-26. 2010
    ....
  13. pmc Role of GABRA2 in trajectories of externalizing behavior across development and evidence of moderation by parental monitoring
    Danielle M Dick
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Department of Psychiatry, PO Box 980126, Richmond, VA 23298 0126, USA
    Arch Gen Psychiatry 66:649-57. 2009
    ....
  14. pmc Gene-environment interaction in psychological traits and disorders
    Danielle M Dick
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298 0126, USA
    Annu Rev Clin Psychol 7:383-409. 2011
    ..Taking research on gene-environment interactions to the next level will necessitate close collaborations between psychologists and geneticists so that each field can take advantage of the knowledge base of the other...
  15. pmc The role of socioregional factors in moderating genetic influences on early adolescent behavior problems and alcohol use
    Danielle M Dick
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298 0126, USA
    Alcohol Clin Exp Res 33:1739-48. 2009
    ..Here, we extend these findings to test for moderating effects of these socioregional factors on alcohol use and behavior problems assessed in a younger sample of adolescent Finnish twins...
  16. ncbi Association of CHRM2 with IQ: converging evidence for a gene influencing intelligence
    Danielle M Dick
    Department of Psychiatry, Washington University in St Louis, 660 South Euclid Ave, Box 8134, St Louis, MO 63130, USA
    Behav Genet 37:265-72. 2007
    ..These results remain significant after taking into account alcohol dependence and depression diagnoses in the sample...
  17. pmc Changing environmental influences on substance use across development
    Danielle M Dick
    Washington University, Department of Psychiatry, St Louis, MO 63110, USA
    Twin Res Hum Genet 10:315-26. 2007
    ..Furthermore, they illustrate the importance of using a developmental perspective to understand how specific influences may vary across different ages, and across different phenotypes...
  18. ncbi Association of GABRA2 with drug dependence in the collaborative study of the genetics of alcoholism sample
    Arpana Agrawal
    Department of Psychiatry, Washington University in St Louis, St Louis, MO, USA
    Behav Genet 36:640-50. 2006
    ..There was no association with other genes in the GABAA cluster on chromosome 4 with illicit drug dependence...
  19. ncbi Alcohol dependence with comorbid drug dependence: genetic and phenotypic associations suggest a more severe form of the disorder with stronger genetic contribution to risk
    Danielle M Dick
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Addiction 102:1131-9. 2007
    ....
  20. pmc Linkage scan for quantitative traits identifies new regions of interest for substance dependence in the Collaborative Study on the Genetics of Alcoholism (COGA) sample
    Arpana Agrawal
    Washington University School of Medicine, St Louis, MO 63110, USA
    Drug Alcohol Depend 93:12-20. 2008
    ..0 on chromosome 2 (3.2, 234 cM), 10 (2.4 and 2.6 at 60 cM and 116 cM) and 13 (2.1 at 64 cM). These regions may harbor genes that contribute to the biological basis of alcohol and drug dependence...
  21. pmc Differential susceptibility to adolescent externalizing trajectories: examining the interplay between CHRM2 and peer group antisocial behavior
    Shawn J Latendresse
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, PO Box 980126, Richmond, VA 23298 0126, USA
    Child Dev 82:1797-814. 2011
    ....
  22. ncbi Functional variants in TAS2R38 and TAS2R16 influence alcohol consumption in high-risk families of African-American origin
    Jen C Wang
    Washington University in St Louis, MO 63110, USA
    Alcohol Clin Exp Res 31:209-15. 2007
    ..The perceived bitterness of PROP has also been associated with oral sensation and drinking behaviors...
  23. pmc Limited associations of dopamine system genes with alcohol dependence and related traits in the Irish Affected Sib Pair Study of Alcohol Dependence (IASPSAD)
    Laura M Hack
    Department of Human and Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, USA
    Alcohol Clin Exp Res 35:376-85. 2011
    ..Many linkage and association studies have examined these relationships with inconsistent results, possibly because of low power, poor marker coverage, and/or an inappropriate correction for multiple testing...
  24. ncbi Association between GABRA1 and drinking behaviors in the collaborative study on the genetics of alcoholism sample
    Danielle M Dick
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Alcohol Clin Exp Res 30:1101-10. 2006
    ....
  25. pmc Multiple-domain predictors of problematic alcohol use in young adulthood
    John R Kramer
    Department of Psychiatry, Medical Education Building, University of Iowa School of Medicine, 500 Newton Road, Iowa City, Iowa 52242 1000, USA
    J Stud Alcohol Drugs 69:649-59. 2008
    ..The goal of this study was to identify predictors of problematic young adult alcohol use...
  26. pmc Genome-wide association study of comorbid depressive syndrome and alcohol dependence
    Alexis C Edwards
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298 0126, USA
    Psychiatr Genet 22:31-41. 2012
    ....
  27. pmc Parenting mechanisms in links between parents' and adolescents' alcohol use behaviors
    Shawn J Latendresse
    Washington University, St Louis, Missouri, USA
    Alcohol Clin Exp Res 32:322-30. 2008
    ..Despite this prevalence of findings, whether and how these distinct associations are related to one another is still not entirely clear...
  28. ncbi Endophenotypes successfully lead to gene identification: results from the collaborative study on the genetics of alcoholism
    Danielle M Dick
    Washington University School of Medicine, St Louis, MO, USA
    Behav Genet 36:112-26. 2006
    ..Our results provide an illustration of the successful use of endophenotypes to identify genes involved in the predisposition to a complex psychiatric phenotype, a strategy originally proposed by Gottesman and Shields in 1972...
  29. pmc A principal components analysis of the abbreviated Desires for Alcohol Questionnaire (DAQ)
    John R Kramer
    Department of Psychiatry, Medical Education Building, University of Iowa School of Medicine, 500 Newton Road, Iowa City, Iowa 52242 1000, USA
    J Stud Alcohol Drugs 71:150-5. 2010
    ..The aim of this study was to examine the abbreviated Desires for Alcohol Questionnaire (DAQ) with respect to component structure and concurrent validity...
  30. pmc Variants in nicotinic receptors and risk for nicotine dependence
    Laura Jean Bierut
    Department of Psychiatry, Washington University School of Medicine, Box 8134, 660 South Euclid Ave, St Louis, MO 63110, USA
    Am J Psychiatry 165:1163-71. 2008
    ....
  31. pmc Evidence for association between polymorphisms in the cannabinoid receptor 1 (CNR1) gene and cannabis dependence
    Arpana Agrawal
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Med Genet B Neuropsychiatr Genet 150:736-40. 2009
    ..05) and rs806380 (P = 0.009)]. Haplotype analyses revealed the association to be largely driven by the SNP rs806380. These results suggest a role for the cannabinoid receptor 1 gene in cannabis dependence...
  32. ncbi Linkage analyses of IQ in the collaborative study on the genetics of alcoholism (COGA) sample
    Danielle M Dick
    Department of Psychiatry, Washington University in St Louis, St Louis, MO, USA
    Behav Genet 36:77-86. 2006
    ..Our findings provide further support that chromosome 6p contains gene(s) affecting intelligence...
  33. ncbi The role of GABRA2 in risk for conduct disorder and alcohol and drug dependence across developmental stages
    Danielle M Dick
    Department of Psychiatry and Psychology, Washington University School of Medicine, St Louis, MO 63110, USA
    Behav Genet 36:577-90. 2006
    ..GABRA2 is also associated with other drug dependence in our sample, both in adolescence and adulthood...
  34. pmc DSM-5 cannabis use disorder: a phenotypic and genomic perspective
    Arpana Agrawal
    Washington University School of Medicine, Department of Psychiatry, St Louis, MO, USA Electronic address
    Drug Alcohol Depend 134:362-9. 2014
    ..We also estimate the heritability of DSM-5 cannabis use disorders explained by these common SNPs...
  35. pmc Dimensions of parental alcohol use/problems and offspring temperament, externalizing behaviors, and alcohol use/problems
    Kenneth S Kendler
    Virginia Institute of Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, Virginia Department of Psychiatry, Virginia Commonwealth University School of Medicine, Richmond, Virginia Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, Virginia
    Alcohol Clin Exp Res 37:2118-27. 2013
    ..parental AC and AP are present in the large prospectively followed Avon Longitudinal Study of Parents and Children cohort? Would these factors be uniquely associated with various temperamental and alcohol-related outcomes in the children?..
  36. pmc MAOA-uVNTR and early physical discipline interact to influence delinquent behavior
    Alexis C Edwards
    Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA
    J Child Psychol Psychiatry 51:679-87. 2010
    ..We expand on the current literature in our assessment of externalizing, incorporating information across multiple reporters and over a broad developmental time period, and in our understanding of environmental risk...
  37. ncbi Teenagers are right--parents do not know much: an analysis of adolescent-parent agreement on reports of adolescent substance use, abuse, and dependence
    Sherri L Fisher
    Washington University School of Medicine, St Louis, Missouri 63110, USA
    Alcohol Clin Exp Res 30:1699-710. 2006
    ..The purpose of this study was to analyze correspondence between adolescent and parent reports of adolescent substance use and abuse or dependence...
  38. ncbi Marital status, alcohol dependence, and GABRA2: evidence for gene-environment correlation and interaction
    Danielle M Dick
    Department of Psychiatry, Washington University in St Louis, Box 8134, 660 South Euclid Ave, St Louis, MO 63130, USA
    J Stud Alcohol 67:185-94. 2006
    ..This article explores how this genetic risk factor interacts with marital status, another factor previously shown to be associated with the risk for alcohol dependence...
  39. pmc Depressive symptoms and alcohol use are genetically and environmentally correlated across adolescence
    Alexis C Edwards
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Behav Genet 41:476-87. 2011
    ..These influences are also temporally dynamic, complicating efforts to understand factors contributing to the relationship between these outcomes...
  40. pmc Parental socialization and adolescents' alcohol use behaviors: predictive disparities in parents' versus adolescents' perceptions of the parenting environment
    Shawn J Latendresse
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23219 1534, USA
    J Clin Child Adolesc Psychol 38:232-44. 2009
    ....
  41. pmc A genome-wide association study of DSM-IV cannabis dependence
    Arpana Agrawal
    Department of Psychiatry, Washington University School of Medicine, 660 S Euclid, Saint Louis, MO 63110, USA
    Addict Biol 16:514-8. 2011
    ..While replication is required, this study represents an important first step toward clarifying the biological underpinnings of cannabis dependence...
  42. pmc Examining the etiology of associations between perceived parenting and adolescents' alcohol use: common genetic and/or environmental liabilities?
    Shawn J Latendresse
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Biotech 1, Suite 100, Richmond, Virginia 23298 0126, USA
    J Stud Alcohol Drugs 71:313-25. 2010
    ..Furthermore, despite evidence linking parents' socialization practices with adolescents' alcohol-use behaviors, this study is the first attempt to determine the sources of this covariation...
  43. pmc The association between DRD2/ANKK1 and genetically informed measures of alcohol use and problems
    Jacquelyn L Meyers
    Virginia Institute of Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Department of Psychiatry, Richmond, VA 23298 0126, USA
    Addict Biol 18:523-36. 2013
    ....
  44. pmc Genetic and environmental influences on stages of alcohol use across adolescence and into young adulthood
    Jason L Pagan
    Department of Psychiatry, Washington University in St Louis, St Louis, MO 63110, USA
    Behav Genet 36:483-97. 2006
    ..Unique environmental factors were largely specific to each stage, with some overlap between alcohol problems and frequency of use at age 25...
  45. ncbi Association analyses of the serotonin transporter gene with lifetime depression and alcohol dependence in the Collaborative Study on the Genetics of Alcoholism (COGA) sample
    Danielle M Dick
    Department of Psychiatry, Washington University in St Louis, St Louis, Missouri 63110, USA
    Psychiatr Genet 17:35-8. 2007
    ..No evidence was found for the association with alcohol dependence in either the stress or the no-stress groups...
  46. pmc A genome-wide association study of alcohol dependence
    Laura J Bierut
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 107:5082-7. 2010
    ..11 and 1.16. Further dissection of the alcoholism phenotype, to disentangle the influence of comorbid substance-use disorders, will be a next step in identifying genetic variants associated with alcohol dependence...
  47. pmc An evaluation of the full level of response to alcohol model of heavy drinking and problems in COGA offspring
    Marc A Schuckit
    Department of Psychiatry, University of California, San Diego, California, USA
    J Stud Alcohol Drugs 70:436-45. 2009
    ..This article presents the first full test of this LR-based model in young subjects from the Collaborative Study on the Genetics of Alcoholism (COGA)...
  48. pmc Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers
    Sarah M Hartz
    Washington University School of Medicine, St Louis, Missouri, USA
    Arch Gen Psychiatry 69:854-60. 2012
    ..Recent studies have shown an association between cigarettes per day (CPD) and a nonsynonymous single-nucleotide polymorphism in CHRNA5, rs16969968...
  49. pmc Rutgers alcohol problem index scores at age 18 predict alcohol dependence diagnoses 7 years later
    Danielle M Dick
    Department of Psychiatry, Virginia Commonwealth University, Richmond, USA
    Alcohol Clin Exp Res 35:1011-4. 2011
    ..The Rutgers Alcohol Problem Index (RAPI) is widely used to assess adolescent drinking-related problems. We asked how well RAPI, administered in late adolescence, predicts alcohol diagnoses at age 25 in a 7-year follow-up...
  50. pmc The next challenge for psychiatric genetics: characterizing the risk associated with identified genes
    Danielle M Dick
    Washington University in St Louis, Department of Psychology, St Louis, Missouri 63110, USA
    Ann Clin Psychiatry 18:223-31. 2006
    ....
  51. pmc Directional relationships between alcohol use and antisocial behavior across adolescence
    Seung Bin Cho
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia
    Alcohol Clin Exp Res 38:2024-33. 2014
    ..We used longitudinal data to examine the directional relationship between the 2 behaviors across adolescence...
  52. pmc Parental monitoring moderates the importance of genetic and environmental influences on adolescent smoking
    Danielle M Dick
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    J Abnorm Psychol 116:213-8. 2007
    ..These analyses demonstrate that the etiology of adolescent smoking varies dramatically as a function of parenting...
  53. pmc Pubertal development moderates the importance of environmental influences on depressive symptoms in adolescent girls and boys
    Alexis C Edwards
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, P O Box 980126, Richmond, VA 23298 0126, USA
    J Youth Adolesc 40:1383-93. 2011
    ..Thus, the importance of environmental influences on depressive symptoms during adolescence changes as a function of pubertal development, and the timing of this effect differs across the sexes...
  54. pmc Genetic and environmental risk factors for adolescent-onset substance use disorders
    Jacquelyn L Meyers
    Department of Human and Molecular Genetics, Virginia Institute of Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Child Adolesc Psychiatr Clin N Am 19:465-77. 2010
    ..This article reviews the genetic origins of adolescent substance use problems and the potential this field of research offers for prevention...
  55. ncbi Linkage and linkage disequilibrium of evoked EEG oscillations with CHRM2 receptor gene polymorphisms: implications for human brain dynamics and cognition
    Kevin A Jones
    Department of Psychiatry, Neurodynamics Laboratory, SUNY Health Science Center, 450 Clarkson Avenue, Box 1203, Brooklyn, NY 11203, USA
    Int J Psychophysiol 53:75-90. 2004
    ..001). These findings were not observed for the equivalent non-target case data, suggesting a role for the CHRM2 gene in higher cognitive processing in humans...
  56. pmc Genetic association of bipolar disorder with the β(3) nicotinic receptor subunit gene
    Sarah M Hartz
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, USA
    Psychiatr Genet 21:77-84. 2011
    ....
  57. ncbi Novelty seeking as a moderator of familial risk for alcohol dependence
    Richard A Grucza
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Alcohol Clin Exp Res 30:1176-83. 2006
    ..We examined this possibility by analyzing the association between NS and alcohol dependence in individuals at intermediate and high levels of familial risk for alcohol dependence...
  58. pmc Adolescent alcohol use is predicted by childhood temperament factors before age 5, with mediation through personality and peers
    Danielle M Dick
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia
    Alcohol Clin Exp Res 37:2108-17. 2013
    ....
  59. pmc Nature and nurture in neuropsychiatric genetics: where do we stand?
    Danielle M Dick
    Department of Psychiatry, Virginia Institute of Psychiatric and Behavioral Genetics, Richmond 23298, USA
    Dialogues Clin Neurosci 12:7-23. 2010
    ..We will review the fields of genetic epidemiology and molecular genetics, providing examples from the literature to illustrate the key concepts emerging from this work...
  60. ncbi Understanding the covariation among childhood externalizing symptoms: genetic and environmental influences on conduct disorder, attention deficit hyperactivity disorder, and oppositional defiant disorder symptoms
    Danielle M Dick
    Department of Psychiatry, Washington University in St Louis, St Louis, Missouri USA
    J Abnorm Child Psychol 33:219-29. 2005
    ..Our data suggest the comorbidity among CD, ADHD, and ODD is primarily explained by shared genetic influences; however, each disorder was also under unique genetic influence, supporting the distinction of each disorder...
  61. ncbi Evidence of common and specific genetic effects: association of the muscarinic acetylcholine receptor M2 (CHRM2) gene with alcohol dependence and major depressive syndrome
    Jen C Wang
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Hum Mol Genet 13:1903-11. 2004
    ..These findings provide strong evidence that variants within or close to the CHRM2 locus influence risk for two common psychiatric disorders...
  62. pmc Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample
    Kenneth S Kendler
    Virginia Institute of Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University School of Medicine, Richmond, 23298, USA
    Alcohol Clin Exp Res 35:963-75. 2011
    ..While genetic influences on alcohol dependence (AD) are substantial, progress in the identification of individual genetic variants that impact on risk has been difficult...
  63. ncbi Drinking expectancies and motives: a genetic study of young adult women
    Arpana Agrawal
    Washington University School of Medicine, Department of Psychiatry, St Louis, MO 63110, USA
    Addiction 103:194-204. 2008
    ..However, little is known of the extent to which genetic and environmental influences contribute to individual differences in expectancies and motives...
  64. pmc Socioeconomic status and alcohol-related behaviors in mid- to late adolescence in the Avon Longitudinal Study of Parents and Children
    Kenneth S Kendler
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, Virginia, Department of Psychiatry, Virginia Commonwealth University School of Medicine, Richmond, Virginia, Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, Virginia
    J Stud Alcohol Drugs 75:541-5. 2014
    ..Few studies have examined all three major SES indicators and a broad range of alcohol-related outcomes at different ages...
  65. pmc Childhood internalizing symptoms are negatively associated with early adolescent alcohol use
    Alexis C Edwards
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia
    Alcohol Clin Exp Res 38:1680-8. 2014
    ..The relationship between childhood internalizing problems and early adolescent alcohol use has been infrequently explored and remains unclear...
  66. pmc A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts
    Gursharan Kalsi
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, 800 E Leigh Street, Richmond, VA 23298, USA
    Hum Mol Genet 19:2497-506. 2010
    ..Haplotype-specific expression measurements in post-mortem tissue samples suggested a functional role for DKK2. This evidence notwithstanding, replication is needed before confidence can be placed in these findings...
  67. pmc Genetic linkage to chromosome 22q12 for a heavy-smoking quantitative trait in two independent samples
    Scott F Saccone
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Hum Genet 80:856-66. 2007
    ..Fine mapping of this linkage region may reveal variants contributing to heaviness of smoking, which will lead to a better understanding of the genetic mechanisms underlying nicotine dependence...
  68. ncbi The genetics of alcohol dependence
    Danielle M Dick
    Department of Psychiatry, Box 8134, 660 South Euclid Avenue, St Louis, MO 63130, USA
    Curr Psychiatry Rep 8:151-7. 2006
    ....
  69. doi Family-based association of FKBP5 in bipolar disorder
    V L Willour
    Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    Mol Psychiatry 14:261-8. 2009
    ..Ongoing whole-genome association studies in bipolar disorder and major depression should further clarify the role of FKBP5 and other HPA genes in these illnesses...
  70. pmc Measuring alcohol consumption for genomic meta-analyses of alcohol intake: opportunities and challenges
    Arpana Agrawal
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Clin Nutr 95:539-47. 2012
    ..In this review, we discuss the challenges associated with harmonizing alcohol-consumption data from studies with widely different assessment instruments, with a particular focus on large-scale genetic studies...
  71. ncbi Molecular psychiatry meeting, February 2003, Lake Louise, Canada
    Danielle M Dick
    Department of Psychiatry, Indiana University Medical Center, Indianapolis, Indiana 46202 4887, USA
    Psychiatr Genet 14:183-6. 2004
    ..The host was Bill Byerley (University of California, Irvine, California, USA), and the meeting was supported by Janssen Pharmaceutica and the Department of Psychiatry, University of California, Irvine, California, USA...
  72. pmc The AVPR1A gene and substance use disorders: association, replication, and functional evidence
    Brion S Maher
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia, USA
    Biol Psychiatry 70:519-27. 2011
    ..The liability to addiction has been shown to be highly genetically correlated across drug classes, suggesting nondrug-specific mechanisms...
  73. pmc The impact of gene-environment interaction on alcohol use disorders
    Danielle M Dick
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia
    Alcohol Res 34:318-24. 2012
    ..Conversely, the gene-environment literature that has been developed surrounding specific genes has focused largely on the role of stress as a moderator of genetic effects...
  74. ncbi Genetic strategies to detect genes involved in alcoholism and alcohol-related traits
    Danielle M Dick
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Alcohol Res Health 26:172-80. 2002
    ..The results of these analyses are likely to have implications for fields such as genetic counseling, gene therapy, and pharmacogenetics...
  75. ncbi Genome-wide scan and conditional analysis in bipolar disorder: evidence for genomic interaction in the National Institute of Mental Health genetics initiative bipolar pedigrees
    Melvin G McInnis
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21287 7463, USA
    Biol Psychiatry 54:1265-73. 2003
    ..The first 97 pedigrees showed evidence of linkage to chromosomes 1, 6, 7, 10, 16, and 22 (Nurnberger et al 1997). An additional 56 bipolar families have been genotyped, and the combined sample of 153 pedigrees studied...
  76. ncbi It does take a village: nonfamilial environments and children's behavior
    Richard J Rose
    Department of Psychology, Indiana University, Bloomington 47405, USA
    Psychol Sci 14:273-7. 2003
    ..Familial self-selection of residential neighborhoods may have contributed to these results, but direct effects of variation across communities, neighborhoods, and schools cannot be dismissed, and such effects warrant further study...
  77. pmc Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations
    Howard J Edenberg
    Indiana University School of Medicine, Indianapolis 46202, USA
    Am J Hum Genet 74:705-14. 2004
    ....
  78. ncbi Femininity and fertility in sisters with twin brothers: prenatal androgenization? Cross-sex socialization?
    Richard J Rose
    Indiana University, Department of Psychology, Bloomington 47405 7007, USA
    Psychol Sci 13:263-7. 2002
    ..Results of each comparison were unambiguously negative: There was no evidence of differences between sisters from same- and opposite-sex twin pairs, and thus, no evidence of either androgenization or cross-sex socialization...
  79. ncbi Apparent replication of suggestive linkage on chromosome 16 in the NIMH genetics initiative bipolar pedigrees
    Danielle M Dick
    Indiana University School of Medicine, Indianapolis, Indiana 46202 4887, USA
    Am J Med Genet 114:407-12. 2002
    ..Combining the initial and replication samples further increased the evidence of linkage to this region, with a peak lod score of 2.8...
  80. ncbi Association of alcohol craving with alpha-synuclein (SNCA)
    Tatiana Foroud
    Indiana University School of Medicine, Indianapolis, Indiana 46202 5251, USA
    Alcohol Clin Exp Res 31:537-45. 2007
    ..Studies in humans have provided support for an association between SNCA and craving for alcohol...
  81. ncbi Lack of association of alcohol dependence and habitual smoking with catechol-O-methyltransferase
    Tatiana Foroud
    Indiana University School of Medicine, Indianapolis, Indiana 46202 3002, USA
    Alcohol Clin Exp Res 31:1773-9. 2007
    ....
  82. ncbi Association of NFKB1, which encodes a subunit of the transcription factor NF-kappaB, with alcohol dependence
    Howard J Edenberg
    Indiana University School of Medicine, Indianapolis, IN, USA
    Hum Mol Genet 17:963-70. 2008
    ..Thus, variations in NFKB1 appear to affect the risk for alcoholism, particularly contributing to an earlier onset of the disease...
  83. pmc Genetic and environmental factors affecting self-esteem from age 14 to 17: a longitudinal study of Finnish twins
    Anu Raevuori
    Department of Public Health, University of Helsinki, Finland
    Psychol Med 37:1625-33. 2007
    ..We analysed genetic and environmental influences on self-esteem and its stability in adolescence...
  84. pmc Minor depression in adolescence: phenomenology and clinical correlates
    Elina Sihvola
    Department of Public Health, University of Helsinki, Finland
    J Affect Disord 97:211-8. 2007
    ....
  85. pmc Whole-genome association study of bipolar disorder
    P Sklar
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Mol Psychiatry 13:558-69. 2008
    ..Given the heritability of BP disorder, the lack of agreement between studies emphasizes that susceptibility alleles are likely to be modest in effect size and require even larger samples for detection...
  86. ncbi Association of alcohol dehydrogenase genes with alcohol dependence: a comprehensive analysis
    Howard J Edenberg
    Indiana University School of Medicine, Indianapolis, USA
    Hum Mol Genet 15:1539-49. 2006
    ..01) There was weaker evidence that variations in ADH1A and ADH1B might also play a role in modifying risk. Among African-Americans, there was evidence that the ADH1B*3 allele was protective...
  87. pmc Verification of self-report of zygosity determined via DNA testing in a subset of the NAS-NRC twin registry 40 years later
    Terry Reed
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Twin Res Hum Genet 8:362-7. 2005
    ....
  88. ncbi No association of the GABAA receptor genes on chromosome 5 with alcoholism in the collaborative study on the genetics of alcoholism sample
    Danielle M Dick
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, 975 West Walnut St, Indianapolis, IN 46202 525, USA
    Am J Med Genet B Neuropsychiatr Genet 132:24-8. 2005
    ..Future studies are planned to test whether these genes are more important in influencing behavioral endophenotypes related to the risk of alcohol dependence...
  89. ncbi Suggestive linkage on chromosome 1 for a quantitative alcohol-related phenotype
    Danielle M Dick
    Indiana University School of Medicine, Indianapolis, Indiana 46202 525, USA
    Alcohol Clin Exp Res 26:1453-60. 2002
    ..Here, we develop quantitative phenotypes that characterize drinking patterns among both alcoholic and nonalcoholic subjects, and use these phenotypes in subsequent linkage analyses...
  90. ncbi Candidate genes for alcohol dependence: a review of genetic evidence from human studies
    Danielle M Dick
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, 975 W Walnut Street, Indianapolis, IN 46202 0525, USA
    Alcohol Clin Exp Res 27:868-79. 2003
  91. pmc Genomewide linkage analyses of bipolar disorder: a new sample of 250 pedigrees from the National Institute of Mental Health Genetics Initiative
    Danielle M Dick
    Institute of Psychiatric Research, Indiana University School of Medicine, 791 Union Drive, Indianapolis, IN 46202 4887, USA
    Am J Hum Genet 73:107-14. 2003
    ..10), on chromosomes 2p, 3q, and 8q. This study, which is based on the largest linkage sample for bipolar disorder analyzed to date, indicates that several genes contribute to bipolar disorder...
  92. ncbi Heritability and validity of healthy physical aging (wellness) in elderly male twins
    Terry Reed
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis 46202, USA
    Twin Res 6:227-34. 2003
    ..Kappa values for wellness were 0.82 for the broader definition and 0.74 if high blood pressure was included. Fraternal twin-pairs concordant for the wellness definitions are currently being recruited for linkage studies...
  93. ncbi Genetic and environmental effects on conduct disorder and alcohol dependence symptoms and their covariation at age 14
    Richard J Rose
    Department of Psychology, Indiana University, Bloomington, Indiana 47405 1301, USA
    Alcohol Clin Exp Res 28:1541-8. 2004
    ..Is their association due to shared genetic and environmental liabilities? We addressed that question with data obtained from structured interviews of 14-year-old Finnish twins...
  94. ncbi Association of GABRG3 with alcohol dependence
    Danielle M Dick
    Indiana University School of Medicine, Indianapolis, Indiana, USA
    Alcohol Clin Exp Res 28:4-9. 2004
    ..Both linkage and association to the region on chromosome 15q that contains a cluster of GABAA receptor genes have previously been reported, but the role of these genes in alcoholism remains inconclusive...
  95. ncbi Genome-wide scan for a healthy aging phenotype provides support for a locus near D4S1564 promoting healthy aging
    Terry Reed
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis 46202 5251, USA
    J Gerontol A Biol Sci Med Sci 59:227-32. 2004
    ..Our results provide independent evidence that a locus on the long arm of chromosome 4 is associated with better physical aging and/or longevity...

Research Grants8

  1. Gene-Environment Interplay in Adolescent Alcohol Use
    Danielle Dick; Fiscal Year: 2008
    ..abstract_text> ..
  2. Gene-Environment Interplay in Adolescent Alcohol Use
    Danielle Dick; Fiscal Year: 2007
    ..abstract_text> ..
  3. Gene-Environment Interplay in Adolescent Alcohol Use
    Danielle Dick; Fiscal Year: 2009
    ..Understanding how environmental context moderates the risk associated with specific, measured genes will be critical for developing more informed prevention and intervention efforts in the future. ..
  4. Pathways to Alcohol Use Disorders in ALSPAC: A Genetic-Developmental Study
    KENNETH SEEDMAN KENDLER; Fiscal Year: 2010
    ....
  5. Gene-Environment Interplay in Adolescent Alcohol Use
    Danielle M Dick; Fiscal Year: 2010
    ..abstract_text> ..
  6. Gene-Environment Interplay in Adolescent Alcohol Use
    Danielle Dick; Fiscal Year: 2005
    ..abstract_text> ..
  7. Gene-Environment Interplay in Adolescent Alcohol Use
    Danielle Dick; Fiscal Year: 2006
    ..abstract_text> ..
  8. Gene-Environment Interplay in Adolescent Alcohol Use
    Danielle Dick; Fiscal Year: 2009
    ..abstract_text> ..