John DeSimone

Summary

Affiliation: Virginia Commonwealth University
Country: USA

Publications

  1. doi request reprint Sodium in the food supply: challenges and opportunities
    John A DeSimone
    Department of Physiology and Biophysics, Virginia Commonwealth University, Richmond, Virginia 23298 0551, USA
    Nutr Rev 71:52-9. 2013
  2. pmc Regulation of the putative TRPV1t salt taste receptor by phosphatidylinositol 4,5-bisphosphate
    Vijay Lyall
    Dept of Physiology and Biophysics, Virginia Commonwealth Univ, Molecular Medical Research Bldg 5052, 1220 East Broad St, Richmond, VA 23298, USA
    J Neurophysiol 103:1337-49. 2010
  3. pmc Regulation of the benzamil-insensitive salt taste receptor by intracellular Ca2+, protein kinase C, and calcineurin
    Vijay Lyall
    Department of Physiology and Biophysics, Virginia Commonwealth University, Sanger Hall, Room 3 010, 1101 E Marshall St, Richmond, VA 23298 0551, USA
    J Neurophysiol 102:1591-605. 2009
  4. ncbi request reprint Effect of nicotine on chorda tympani responses to salty and sour stimuli
    Vijay Lyall
    Department of Physiology, Virginia Commonwealth University, Sanger Hall 3010, 1101 E Marshall St, Richmond, VA 23298 0551, USA
    J Neurophysiol 98:1662-74. 2007
  5. ncbi request reprint Taste receptors in the gastrointestinal tract III. Salty and sour taste: sensing of sodium and protons by the tongue
    John A DeSimone
    Department of Physiology, Virginia Commonwealth University, Richmond, Virginia 23298 0551, USA
    Am J Physiol Gastrointest Liver Physiol 291:G1005-10. 2006
  6. pmc Intracellular pH modulates taste receptor cell volume and the phasic part of the chorda tympani response to acids
    Vijay Lyall
    Department of Physiology, Virginia Commonwealth University, Richmond, VA 23298, USA
    J Gen Physiol 127:15-34. 2006
  7. pmc Ethanol modulates the VR-1 variant amiloride-insensitive salt taste receptor. II. Effect on chorda tympani salt responses
    Vijay Lyall
    Department of Physiology, Division of Nephrology, Virginia Commonwealth University, Richmond, VA 23298, USA
    J Gen Physiol 125:587-600. 2005
  8. pmc Ethanol modulates the VR-1 variant amiloride-insensitive salt taste receptor. I. Effect on TRC volume and Na+ flux
    Vijay Lyall
    Department of Physiology, Division of Nephrology, Virginia Commonwealth University, Richmond, VA 23298, USA
    J Gen Physiol 125:569-85. 2005
  9. ncbi request reprint A novel vanilloid receptor-1 (VR-1) variant mammalian salt taste receptor
    Vijay Lyall
    Department of Physiology, Virginia Commonwealth University, Richmond, VA 23298 0551, USA
    Chem Senses 30:i42-3. 2005
  10. pmc The mammalian amiloride-insensitive non-specific salt taste receptor is a vanilloid receptor-1 variant
    Vijay Lyall
    Department of Physiology, Virginia Commonwealth University, Richmond, VA 23298 0551, USA
    J Physiol 558:147-59. 2004

Research Grants

  1. PHYSICOCHEMICAL INVESTIGATION OF TASTE
    John DeSimone; Fiscal Year: 2000
  2. VOLTAGE CLAMP PROBE OF TASTE RESPONSES IN DEVELOPMENT
    John DeSimone; Fiscal Year: 2003
  3. Physiochemical Investigation of Taste
    John DeSimone; Fiscal Year: 2003
  4. A PHYSICOCHEMICAL INVESTIGATION OF TASTE
    John DeSimone; Fiscal Year: 1993
  5. PHYSICOCHEMICAL INVESTIGATION OF TASTE
    John DeSimone; Fiscal Year: 2007

Collaborators

Detail Information

Publications16

  1. doi request reprint Sodium in the food supply: challenges and opportunities
    John A DeSimone
    Department of Physiology and Biophysics, Virginia Commonwealth University, Richmond, Virginia 23298 0551, USA
    Nutr Rev 71:52-9. 2013
    ..Information from these presentations, as well as literature references, are provided in this article...
  2. pmc Regulation of the putative TRPV1t salt taste receptor by phosphatidylinositol 4,5-bisphosphate
    Vijay Lyall
    Dept of Physiology and Biophysics, Virginia Commonwealth Univ, Molecular Medical Research Bldg 5052, 1220 East Broad St, Richmond, VA 23298, USA
    J Neurophysiol 103:1337-49. 2010
    ..e., the TRPV1 ion channel or its taste receptor variant, TRPV1t...
  3. pmc Regulation of the benzamil-insensitive salt taste receptor by intracellular Ca2+, protein kinase C, and calcineurin
    Vijay Lyall
    Department of Physiology and Biophysics, Virginia Commonwealth University, Sanger Hall, Room 3 010, 1101 E Marshall St, Richmond, VA 23298 0551, USA
    J Neurophysiol 102:1591-605. 2009
    ..We conclude that TRPV1 or its variant TRPV1t is phosphorylated and dephosphorylated by PKC and PP2B, respectively, and either sensitizes or desensitizes the Bz-insensitive NaCl chorda tympani responses to RTX stimulation...
  4. ncbi request reprint Effect of nicotine on chorda tympani responses to salty and sour stimuli
    Vijay Lyall
    Department of Physiology, Virginia Commonwealth University, Sanger Hall 3010, 1101 E Marshall St, Richmond, VA 23298 0551, USA
    J Neurophysiol 98:1662-74. 2007
    ..At pH(o) >8, nicotine also inhibited the phasic component of the HCl CT response. We conclude that the effects of nicotine on ENaC and the phasic HCl CT response arise from increases in TRC pH(i) and volume...
  5. ncbi request reprint Taste receptors in the gastrointestinal tract III. Salty and sour taste: sensing of sodium and protons by the tongue
    John A DeSimone
    Department of Physiology, Virginia Commonwealth University, Richmond, Virginia 23298 0551, USA
    Am J Physiol Gastrointest Liver Physiol 291:G1005-10. 2006
    ..Adaptation to sour arises from the activation of the basolateral sodium-hydrogen exchanger isoform-1 by an increase in intracellular calcium that sustains the tonic phase of the sour taste response...
  6. pmc Intracellular pH modulates taste receptor cell volume and the phasic part of the chorda tympani response to acids
    Vijay Lyall
    Department of Physiology, Virginia Commonwealth University, Richmond, VA 23298, USA
    J Gen Physiol 127:15-34. 2006
    ....
  7. pmc Ethanol modulates the VR-1 variant amiloride-insensitive salt taste receptor. II. Effect on chorda tympani salt responses
    Vijay Lyall
    Department of Physiology, Division of Nephrology, Virginia Commonwealth University, Richmond, VA 23298, USA
    J Gen Physiol 125:587-600. 2005
    ..VR-1 KO mice demonstrated no Bz-insensitive CT response to NaCl and no sensitivity to ethanol. We conclude that ethanol increases salt taste sensitivity by its direct action on the Bz-insensitive VR-1 variant salt taste receptor...
  8. pmc Ethanol modulates the VR-1 variant amiloride-insensitive salt taste receptor. I. Effect on TRC volume and Na+ flux
    Vijay Lyall
    Department of Physiology, Division of Nephrology, Virginia Commonwealth University, Richmond, VA 23298, USA
    J Gen Physiol 125:569-85. 2005
    ..We conclude that in the presence of mineral salts, ethanol modulates the Bz-insensitive VR-1 variant salt taste receptor...
  9. ncbi request reprint A novel vanilloid receptor-1 (VR-1) variant mammalian salt taste receptor
    Vijay Lyall
    Department of Physiology, Virginia Commonwealth University, Richmond, VA 23298 0551, USA
    Chem Senses 30:i42-3. 2005
  10. pmc The mammalian amiloride-insensitive non-specific salt taste receptor is a vanilloid receptor-1 variant
    Vijay Lyall
    Department of Physiology, Virginia Commonwealth University, Richmond, VA 23298 0551, USA
    J Physiol 558:147-59. 2004
    ..VR-1 knockout mice demonstrate no functional amiloride-insensitive salt taste receptor and no salt taste sensitivity to vanilloids and temperature. We conclude that the mammalian non-specific salt taste receptor is a VR-1 variant...
  11. pmc Basolateral Na+-H+ exchanger-1 in rat taste receptor cells is involved in neural adaptation to acidic stimuli
    Vijay Lyall
    Department of Physiology, Virginia Commonwealth University, Sanger Hall 3002, 1101 E Marshall Street, Richmond, VA 23298 0551, USA
    J Physiol 556:159-73. 2004
    ..While cAMP enhances TRC apical H(+) entry and CT responses to strong acid, an increase in Ca(2+) activates NHE-1, and increases neural adaptation to all acidic stimuli...
  12. pmc Modulation of rat chorda tympani NaCl responses and intracellular Na+ activity in polarized taste receptor cells by pH
    Vijay Lyall
    Department of Physiology, Virginia Commonwealth University, Richmond, VA 23298 0551, USA
    J Gen Physiol 120:793-815. 2002
    ..We conclude that TRC pH(i) regulates Na(+)-influx through amiloride-sensitive apical ENaCs and hence modulates NaCl CT responses in acid/salt mixtures...
  13. ncbi request reprint Excitation and adaptation in the detection of hydrogen ions by taste receptor cells: a role for cAMP and Ca(2+)
    Vijay Lyall
    Department of Physiology, Virginia Commonwealth University, Richmond, Virginia 23298 0551, USA
    J Neurophysiol 87:399-408. 2002
    ..However, an increase in [Ca(2+)]i stimulates pH(i) recovery, which, in turn, increases sensory adaptation to acids...
  14. ncbi request reprint A psychophysical and electrophysiological analysis of salt taste in Trpv1 null mice
    Yada Treesukosol
    Department of Psychology and Center for Smell and Taste, University of Florida, Gainesville, FL 32611 2250, USA
    Am J Physiol Regul Integr Comp Physiol 292:R1799-809. 2007
    ..Additionally, there may be other amiloride-insensitive salt transduction mechanisms in taste receptor fields other than the anterior tongue that maintain normal salt detection performance in the KO mice...
  15. ncbi request reprint Na+-H+ exchange activity in taste receptor cells
    Anna K Vinnikova
    Department of Internal Medicine, Virginia Commonwealth University, Richmond, 23298, USA
    J Neurophysiol 91:1297-313. 2004
    ..The results indicate the presence of a functional NHE-1 in the basolateral membranes of TRCs. We hypothesize that NHE-1 is involved in sour taste transduction since its activity is modulated during acid stimulation...
  16. ncbi request reprint Salt-evoked lingual surface potential in humans
    George M Feldman
    Department of Medicine, Virginia Commonwealth University School of Medicine, Richmond, Virginia, 23249, USA
    J Neurophysiol 90:2060-4. 2003
    ..While ENaC is involved in sensing salt, its role appears to vary among individuals...

Research Grants26

  1. PHYSICOCHEMICAL INVESTIGATION OF TASTE
    John DeSimone; Fiscal Year: 2000
    ..The results of these studies will provide new insights into sour (acid) taste reception, which plays an important role in pH balance. ..
  2. VOLTAGE CLAMP PROBE OF TASTE RESPONSES IN DEVELOPMENT
    John DeSimone; Fiscal Year: 2003
    ..Methods will also be developed to determine the buffering properties of the lateral intercellular spaces for hydrogen and calcium. ..
  3. Physiochemical Investigation of Taste
    John DeSimone; Fiscal Year: 2003
    ..Having established a key role for intracellular pH in acid-sensing, these studies involving bitter-tasting compounds will determine if intracellular pH is also a key intermediate in bitter-taste transduction. ..
  4. A PHYSICOCHEMICAL INVESTIGATION OF TASTE
    John DeSimone; Fiscal Year: 1993
    ..Taste is a major factor in determining food intake. The conditions and substances that modulate its expression will have a strong impact in the areas of sodium-sensitive hypertension and feeding disorders such as obesity...
  5. PHYSICOCHEMICAL INVESTIGATION OF TASTE
    John DeSimone; Fiscal Year: 2007
    ..The research will reveal how the sour taste defense mechanism functions to prevent the ingestion of acids. ..