M I Damaj

Summary

Affiliation: Virginia Commonwealth University
Country: USA

Publications

  1. ncbi Intrathecal CART (55-102) attenuates hyperlagesia and allodynia in a mouse model of neuropathic but not inflammatory pain
    M Imad Damaj
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Box 980613, Richmond, VA 23298 0613, USA
    Peptides 27:2019-23. 2006
  2. ncbi Inhibition of nicotine metabolism by methoxysalen: Pharmacokinetic and pharmacological studies in mice
    M I Damaj
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Box 980613, Richmond, VA 23298 0613, USA
    J Pharmacol Exp Ther 320:250-7. 2007
  3. ncbi In vivo characterization of a novel inhibitor of CNS nicotinic receptors
    M Imad Damaj
    Department Pharmacology and Toxicology, Medical College Virginia Campus, Virginia Commonwealth University, Box 980613, Richmond VA 23298 0613, USA
    Eur J Pharmacol 521:43-8. 2005
  4. ncbi Calcium-acting drugs modulate expression and development of chronic tolerance to nicotine-induced antinociception in mice
    M I Damaj
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, 23298 0613, USA
    J Pharmacol Exp Ther 315:959-64. 2005
  5. ncbi Intrathecal CART (55-102) enhances the spinal analgesic actions of morphine in mice
    M Imad Damaj
    Department of Pharmacology and Toxicology, Medical College of Virginia of Virginia Commonwealth University, P O Box 980613, MCV Sta, Richmond, VA 23298 0613, USA
    Brain Res 1024:146-9. 2004
  6. ncbi Effect of dextrometorphan and dextrorphan on nicotine and neuronal nicotinic receptors: in vitro and in vivo selectivity
    M I Damaj
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Box 980613, Richmond, VA 23298 0613, USA
    J Pharmacol Exp Ther 312:780-5. 2005
  7. ncbi Enantioselective effects of hydroxy metabolites of bupropion on behavior and on function of monoamine transporters and nicotinic receptors
    M Imad Damaj
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, 12 North and Clay Streets, Smith Building, Box 980613, Richmond, VA 23298 0613, USA
    Mol Pharmacol 66:675-82. 2004
  8. ncbi Characterization of spontaneous and precipitated nicotine withdrawal in the mouse
    M I Damaj
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Box 980613, Richmond, VA 23298 0613, USA
    J Pharmacol Exp Ther 307:526-34. 2003
  9. ncbi In vivo enantioselectivity of epibatidine interaction with calcium-modulating drugs
    M Imad Damaj
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Box 980613, Richmond, VA 23298 0613, USA
    Brain Res 982:293-6. 2003
  10. ncbi Genetic approaches identify differential roles for alpha4beta2* nicotinic receptors in acute models of antinociception in mice
    M I Damaj
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Box 980613, Richmond, VA 23298 0613, USA
    J Pharmacol Exp Ther 321:1161-9. 2007

Detail Information

Publications30

  1. ncbi Intrathecal CART (55-102) attenuates hyperlagesia and allodynia in a mouse model of neuropathic but not inflammatory pain
    M Imad Damaj
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Box 980613, Richmond, VA 23298 0613, USA
    Peptides 27:2019-23. 2006
    ..These results suggest the involvement of the CART peptides in the development of hyperalgesia and allodynia associated with neuropathic pain...
  2. ncbi Inhibition of nicotine metabolism by methoxysalen: Pharmacokinetic and pharmacological studies in mice
    M I Damaj
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Box 980613, Richmond, VA 23298 0613, USA
    J Pharmacol Exp Ther 320:250-7. 2007
    ..They also suggest that mice may represent a suitable model for studying variation in nicotine metabolism and its impact on mechanisms of nicotine dependence, including the use of inhibitors to reduce nicotine metabolism...
  3. ncbi In vivo characterization of a novel inhibitor of CNS nicotinic receptors
    M Imad Damaj
    Department Pharmacology and Toxicology, Medical College Virginia Campus, Virginia Commonwealth University, Box 980613, Richmond VA 23298 0613, USA
    Eur J Pharmacol 521:43-8. 2005
    ..These results indicate that TMPH may possess unique selectivity for specific nicotinic receptor subtypes...
  4. ncbi Calcium-acting drugs modulate expression and development of chronic tolerance to nicotine-induced antinociception in mice
    M I Damaj
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, 23298 0613, USA
    J Pharmacol Exp Ther 315:959-64. 2005
    ..In conclusion, our data indicate that calcium-dependent mechanisms such as L-type calcium channels and calcium-dependent calmodulin protein kinase II activation are involved in the expression and development of nicotine tolerance...
  5. ncbi Intrathecal CART (55-102) enhances the spinal analgesic actions of morphine in mice
    M Imad Damaj
    Department of Pharmacology and Toxicology, Medical College of Virginia of Virginia Commonwealth University, P O Box 980613, MCV Sta, Richmond, VA 23298 0613, USA
    Brain Res 1024:146-9. 2004
    ..These results suggest that CART (55-102) potentiates the effects of opioids to inhibit the nociceptive information transmission...
  6. ncbi Effect of dextrometorphan and dextrorphan on nicotine and neuronal nicotinic receptors: in vitro and in vivo selectivity
    M I Damaj
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Box 980613, Richmond, VA 23298 0613, USA
    J Pharmacol Exp Ther 312:780-5. 2005
    ..In that respect, dextrometorphan seems to behave as another mecamylamine, a noncompetitive nicotinic receptor antagonist with a preferential activity to alpha(3)beta(4)(*) neuronal nAChR subtypes...
  7. ncbi Enantioselective effects of hydroxy metabolites of bupropion on behavior and on function of monoamine transporters and nicotinic receptors
    M Imad Damaj
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, 12 North and Clay Streets, Smith Building, Box 980613, Richmond, VA 23298 0613, USA
    Mol Pharmacol 66:675-82. 2004
    ..Furthermore, our data suggest that the (2S,3S)-hydroxybupropion isomer may be a better drug candidate for smoking cessation than bupropion because of its higher potency at the relevant targets...
  8. ncbi Characterization of spontaneous and precipitated nicotine withdrawal in the mouse
    M I Damaj
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Box 980613, Richmond, VA 23298 0613, USA
    J Pharmacol Exp Ther 307:526-34. 2003
    ..The present study demonstrates that our mouse nicotine withdrawal model will be useful for studying the pharmacological, biochemical, and genetic mechanisms involved in nicotine dependence...
  9. ncbi In vivo enantioselectivity of epibatidine interaction with calcium-modulating drugs
    M Imad Damaj
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Box 980613, Richmond, VA 23298 0613, USA
    Brain Res 982:293-6. 2003
    ..c.). Similar results were also observed with the calcium chelator EGTA. Thus, epibatidine isomers pharmacological effect was differentially modulated by calcium signaling process secondary to receptor activation...
  10. ncbi Genetic approaches identify differential roles for alpha4beta2* nicotinic receptors in acute models of antinociception in mice
    M I Damaj
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Box 980613, Richmond, VA 23298 0613, USA
    J Pharmacol Exp Ther 321:1161-9. 2007
    ....
  11. ncbi Pharmacological characterization of nicotine's interaction with cocaine and cocaine analogs
    M I Damaj
    Department of Pharmacology and Toxicology, Medical College of Virginia of Virginia Commonwealth University, Richmond, Virginia
    J Pharmacol Exp Ther 289:1229-36. 1999
    ..Elucidation of the mechanism of action of this new class of antagonists may provide an explanation for the effectiveness of agents such as bupropion for the treatment of smoking cessation...
  12. ncbi Antinociceptive and pharmacological effects of metanicotine, a selective nicotinic agonist
    M I Damaj
    Department of Pharmacology and Toxicology, Medical College of Virginia of Virginia Commonwealth University, Richmond, Virginia, USA
    J Pharmacol Exp Ther 291:390-8. 1999
    ..Thus, metanicotine and related nicotinic agonists may have great potential for development as a new class of analgesics...
  13. ncbi Pharmacological characterization of nicotine-induced seizures in mice
    M I Damaj
    Department of Pharmacology and Toxicology, Medical College of Virginia of Virginia Commonwealth University, Richmond, Virginia 23298 0613, USA
    J Pharmacol Exp Ther 291:1284-91. 1999
    ..Glutamate release in turn stimulates N-methyl-D-aspartate receptors, thus triggering the cascade of events leading to nitric oxide formation and possibly seizure production...
  14. ncbi The involvement of spinal Ca(2+)/calmodulin-protein kinase II in nicotine-induced antinociception in mice
    M I Damaj
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Box 980613, Richmond, VA 23298 0613, USA
    Eur J Pharmacol 404:103-10. 2000
    ..Neuronal Ca(2+), acting via Ca(2+)-dependent CaM kinase II, appears to mediate nicotine-induced antinociception at the spinal level...
  15. ncbi The antinociceptive effects of alpha7 nicotinic agonists in an acute pain model
    M I Damaj
    Department of Pharmacology and Toxicology, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA 23298 0613, USA
    Neuropharmacology 39:2785-91. 2000
    ..This antagonism is probably related to their partial agonistic properties of the alpha(7) receptors. These studies suggest that activation of alpha(7) receptors in the CNS elicits antinociceptive effects in an acute thermal pain model...
  16. ncbi The role of alpha6-containing nicotinic acetylcholine receptors in nicotine reward and withdrawal
    K J Jackson
    Department of Pharmacology and Toxicology, Medical Campus, Virginia Commonwealth University, Richmond, Virginia 23298 0613, USA
    J Pharmacol Exp Ther 331:547-54. 2009
    ..These results suggest a role for the alpha6 nAChR subunit in nicotine reward and affective nicotine withdrawal but not acute nicotine-induced or physical withdrawal behaviors...
  17. ncbi Role of alpha5 nicotinic acetylcholine receptors in pharmacological and behavioral effects of nicotine in mice
    K J Jackson
    Department of Psychiatry, Pharmacology Toxicology, Virginia Commonwealth University, Richmond, VA 23298 0613, USA
    J Pharmacol Exp Ther 334:137-46. 2010
    ..Receptor number was unaltered in all areas tested. Taken together, results of the study suggest that alpha5 nAChRs are involved in nicotine-mediated behaviors relevant to development of nicotine dependence...
  18. ncbi Age-dependent differences in nicotine reward and withdrawal in female mice
    D Kota
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, 410 North 12th Street, Smith Building, P O Box 980613, Richmond, VA 23298 0613, USA
    Psychopharmacology (Berl) 198:201-10. 2008
    ..Research has shown that the commencement of smoking at a young age increases addiction and decreases the probability of successful cessation; however, limited work has focused on nicotine dependence in the female...
  19. ncbi Nicotine-induced antinociception in mice: role of G-proteins and adenylate cyclase
    M I Damaj
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298 0613
    Pharmacol Biochem Behav 48:37-42. 1994
    ..These data implicate the possible involvement of a G-protein and a second messenger system (activation of a cAMP-dependent protein kinase and increase in cyclic AMP levels) in nicotine-induced analgesia in mice...
  20. ncbi In vivo pharmacological effects of dihydro-beta-erythroidine, a nicotinic antagonist, in mice
    M I Damaj
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298 0613, USA
    Psychopharmacology (Berl) 117:67-73. 1995
    ..The mechanism of blockade is different from that of mecamylamine, a classical ganglionic antagonist, and may involve a direct action of DH beta E on nicotine receptor...
  21. ncbi Effect of the selective kappa-opioid receptor antagonist JDTic on nicotine antinociception, reward, and withdrawal in the mouse
    K J Jackson
    Department of Pharmacology and Toxicology, Medical Campus, Virginia Commonwealth University, Richmond, VA 23298, USA
    Psychopharmacology (Berl) 210:285-94. 2010
    ..Specifically, recent findings suggest that the kappa-opioid receptor (KOR) may play a role in aspects of nicotine dependence, which contribute to relapse and continued tobacco smoking...
  22. ncbi 3'-Fluoro substitution in the pyridine ring of epibatidine improves selectivity and efficacy for alpha4beta2 versus alpha3beta4 nAChRs
    Galya R Abdrakhmanova
    Department of Pharmacology and Toxicology G R A, M I D, B R M, Virginia Commonwealth University, Richmond, VA 23298, United States
    Neuropharmacology 55:1287-92. 2008
    ....
  23. ncbi The role of various nicotinic receptor subunits and factors influencing nicotine conditioned place aversion
    K J Jackson
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, 410 N 12th Street, P O Box 980613, Richmond, VA 23298, USA
    Neuropharmacology 56:970-4. 2009
    ..Overall, the results of our study provide some insight into pharmacological and behavioral factors involved in the development of an aversive motivational component associated with nicotine withdrawal...
  24. ncbi Nicotinic regulation of calcium/calmodulin-dependent protein kinase II activation in the spinal cord
    M I Damaj
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Box 980613, Richmond, VA 23298 0613, USA
    J Pharmacol Exp Ther 320:244-9. 2007
    ....
  25. ncbi L-type calcium channels and calcium/calmodulin-dependent kinase II differentially mediate behaviors associated with nicotine withdrawal in mice
    K J Jackson
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Box 980613, Richmond, VA 23298 0613, USA
    J Pharmacol Exp Ther 330:152-61. 2009
    ..Overall, our data show that L-type calcium channels and CaMKII are relevant in nicotine withdrawal and differentially mediate nicotine withdrawal behaviors...
  26. ncbi Beta 2 subunit-containing nicotinic receptors mediate acute nicotine-induced activation of calcium/calmodulin-dependent protein kinase II-dependent pathways in vivo
    K J Jackson
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia 23298 0613, USA
    J Pharmacol Exp Ther 330:541-9. 2009
    ..Taken together, these data suggest that the nicotine-induced increase in CaMKII activity may correlate with the nicotine-induced increase in pSynapsin I and pCREB in the VTA and NAc via beta2 subunit-containing nAChRs...
  27. ncbi Nicotine dependence and reward differ between adolescent and adult male mice
    D Kota
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Box 980613, Richmond, VA 23298 0613, USA
    J Pharmacol Exp Ther 322:399-407. 2007
    ..These data indicate that the underlying receptor mechanisms of nicotine dependence differ for adults and adolescents, suggesting that the effectiveness of smoking cessation therapies will differ for various age groups...
  28. ncbi Differential role of nicotinic acetylcholine receptor subunits in physical and affective nicotine withdrawal signs
    K J Jackson
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Box 980613, Richmond, VA 23298 0613, USA
    J Pharmacol Exp Ther 325:302-12. 2008
    ....
  29. ncbi Binding of nicotine and homoazanicotine analogues at neuronal nicotinic acetylcholinergic (nACh) receptors
    G Ferretti
    Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, VA 23298, USA
    Bioorg Med Chem Lett 13:733-5. 2003
    ..It was found that parallel structural changes in the two series resulted in parallel shifts in affinity. Evidence suggests that the two series are binding in a comparable fashion...
  30. ncbi Effects of the specific α4β2 nAChR antagonist, 2-fluoro-3-(4-nitrophenyl) deschloroepibatidine, on nicotine reward-related behaviors in rats and mice
    K M Tobey
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, 1217 E Marshall St, PO Box 980613, Richmond, VA 23298 0613, USA
    Psychopharmacology (Berl) 223:159-68. 2012
    ..Investigating novel compounds selectively targeting α4β2 nAChRs hypothesized to have a key role in the rewarding effects of nicotine may be a useful approach for future treatment...