M I Damaj

Summary

Affiliation: Virginia Commonwealth University
Country: USA

Publications

  1. ncbi request reprint Intrathecal CART (55-102) enhances the spinal analgesic actions of morphine in mice
    M Imad Damaj
    Department of Pharmacology and Toxicology, Medical College of Virginia of Virginia Commonwealth University, P O Box 980613, MCV Sta, Richmond, VA 23298 0613, USA
    Brain Res 1024:146-9. 2004
  2. ncbi request reprint Inhibition of nicotine metabolism by methoxysalen: Pharmacokinetic and pharmacological studies in mice
    M I Damaj
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Box 980613, Richmond, VA 23298 0613, USA
    J Pharmacol Exp Ther 320:250-7. 2007
  3. ncbi request reprint Intrathecal CART (55-102) attenuates hyperlagesia and allodynia in a mouse model of neuropathic but not inflammatory pain
    M Imad Damaj
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Box 980613, Richmond, VA 23298 0613, USA
    Peptides 27:2019-23. 2006
  4. ncbi request reprint In vivo characterization of a novel inhibitor of CNS nicotinic receptors
    M Imad Damaj
    Department Pharmacology and Toxicology, Medical College Virginia Campus, Virginia Commonwealth University, Box 980613, Richmond VA 23298 0613, USA
    Eur J Pharmacol 521:43-8. 2005
  5. ncbi request reprint Calcium-acting drugs modulate expression and development of chronic tolerance to nicotine-induced antinociception in mice
    M I Damaj
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, 23298 0613, USA
    J Pharmacol Exp Ther 315:959-64. 2005
  6. ncbi request reprint Effect of dextrometorphan and dextrorphan on nicotine and neuronal nicotinic receptors: in vitro and in vivo selectivity
    M I Damaj
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Box 980613, Richmond, VA 23298 0613, USA
    J Pharmacol Exp Ther 312:780-5. 2005
  7. ncbi request reprint Enantioselective effects of hydroxy metabolites of bupropion on behavior and on function of monoamine transporters and nicotinic receptors
    M Imad Damaj
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, 12 North and Clay Streets, Smith Building, Box 980613, Richmond, VA 23298 0613, USA
    Mol Pharmacol 66:675-82. 2004
  8. ncbi request reprint Characterization of spontaneous and precipitated nicotine withdrawal in the mouse
    M I Damaj
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Box 980613, Richmond, VA 23298 0613, USA
    J Pharmacol Exp Ther 307:526-34. 2003
  9. ncbi request reprint In vivo enantioselectivity of epibatidine interaction with calcium-modulating drugs
    M Imad Damaj
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Box 980613, Richmond, VA 23298 0613, USA
    Brain Res 982:293-6. 2003
  10. ncbi request reprint Genetic approaches identify differential roles for alpha4beta2* nicotinic receptors in acute models of antinociception in mice
    M I Damaj
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Box 980613, Richmond, VA 23298 0613, USA
    J Pharmacol Exp Ther 321:1161-9. 2007

Detail Information

Publications34

  1. ncbi request reprint Intrathecal CART (55-102) enhances the spinal analgesic actions of morphine in mice
    M Imad Damaj
    Department of Pharmacology and Toxicology, Medical College of Virginia of Virginia Commonwealth University, P O Box 980613, MCV Sta, Richmond, VA 23298 0613, USA
    Brain Res 1024:146-9. 2004
    ..These results suggest that CART (55-102) potentiates the effects of opioids to inhibit the nociceptive information transmission...
  2. ncbi request reprint Inhibition of nicotine metabolism by methoxysalen: Pharmacokinetic and pharmacological studies in mice
    M I Damaj
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Box 980613, Richmond, VA 23298 0613, USA
    J Pharmacol Exp Ther 320:250-7. 2007
    ..They also suggest that mice may represent a suitable model for studying variation in nicotine metabolism and its impact on mechanisms of nicotine dependence, including the use of inhibitors to reduce nicotine metabolism...
  3. ncbi request reprint Intrathecal CART (55-102) attenuates hyperlagesia and allodynia in a mouse model of neuropathic but not inflammatory pain
    M Imad Damaj
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Box 980613, Richmond, VA 23298 0613, USA
    Peptides 27:2019-23. 2006
    ..These results suggest the involvement of the CART peptides in the development of hyperalgesia and allodynia associated with neuropathic pain...
  4. ncbi request reprint In vivo characterization of a novel inhibitor of CNS nicotinic receptors
    M Imad Damaj
    Department Pharmacology and Toxicology, Medical College Virginia Campus, Virginia Commonwealth University, Box 980613, Richmond VA 23298 0613, USA
    Eur J Pharmacol 521:43-8. 2005
    ..These results indicate that TMPH may possess unique selectivity for specific nicotinic receptor subtypes...
  5. ncbi request reprint Calcium-acting drugs modulate expression and development of chronic tolerance to nicotine-induced antinociception in mice
    M I Damaj
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, 23298 0613, USA
    J Pharmacol Exp Ther 315:959-64. 2005
    ..In conclusion, our data indicate that calcium-dependent mechanisms such as L-type calcium channels and calcium-dependent calmodulin protein kinase II activation are involved in the expression and development of nicotine tolerance...
  6. ncbi request reprint Effect of dextrometorphan and dextrorphan on nicotine and neuronal nicotinic receptors: in vitro and in vivo selectivity
    M I Damaj
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Box 980613, Richmond, VA 23298 0613, USA
    J Pharmacol Exp Ther 312:780-5. 2005
    ..In that respect, dextrometorphan seems to behave as another mecamylamine, a noncompetitive nicotinic receptor antagonist with a preferential activity to alpha(3)beta(4)(*) neuronal nAChR subtypes...
  7. ncbi request reprint Enantioselective effects of hydroxy metabolites of bupropion on behavior and on function of monoamine transporters and nicotinic receptors
    M Imad Damaj
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, 12 North and Clay Streets, Smith Building, Box 980613, Richmond, VA 23298 0613, USA
    Mol Pharmacol 66:675-82. 2004
    ..Furthermore, our data suggest that the (2S,3S)-hydroxybupropion isomer may be a better drug candidate for smoking cessation than bupropion because of its higher potency at the relevant targets...
  8. ncbi request reprint Characterization of spontaneous and precipitated nicotine withdrawal in the mouse
    M I Damaj
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Box 980613, Richmond, VA 23298 0613, USA
    J Pharmacol Exp Ther 307:526-34. 2003
    ..The present study demonstrates that our mouse nicotine withdrawal model will be useful for studying the pharmacological, biochemical, and genetic mechanisms involved in nicotine dependence...
  9. ncbi request reprint In vivo enantioselectivity of epibatidine interaction with calcium-modulating drugs
    M Imad Damaj
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Box 980613, Richmond, VA 23298 0613, USA
    Brain Res 982:293-6. 2003
    ..c.). Similar results were also observed with the calcium chelator EGTA. Thus, epibatidine isomers pharmacological effect was differentially modulated by calcium signaling process secondary to receptor activation...
  10. ncbi request reprint Genetic approaches identify differential roles for alpha4beta2* nicotinic receptors in acute models of antinociception in mice
    M I Damaj
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Box 980613, Richmond, VA 23298 0613, USA
    J Pharmacol Exp Ther 321:1161-9. 2007
    ....
  11. ncbi request reprint Pharmacological characterization of nicotine's interaction with cocaine and cocaine analogs
    M I Damaj
    Department of Pharmacology and Toxicology, Medical College of Virginia of Virginia Commonwealth University, Richmond, Virginia
    J Pharmacol Exp Ther 289:1229-36. 1999
    ..Elucidation of the mechanism of action of this new class of antagonists may provide an explanation for the effectiveness of agents such as bupropion for the treatment of smoking cessation...
  12. ncbi request reprint Antinociceptive and pharmacological effects of metanicotine, a selective nicotinic agonist
    M I Damaj
    Department of Pharmacology and Toxicology, Medical College of Virginia of Virginia Commonwealth University, Richmond, Virginia, USA
    J Pharmacol Exp Ther 291:390-8. 1999
    ..Thus, metanicotine and related nicotinic agonists may have great potential for development as a new class of analgesics...
  13. ncbi request reprint Pharmacological characterization of nicotine-induced seizures in mice
    M I Damaj
    Department of Pharmacology and Toxicology, Medical College of Virginia of Virginia Commonwealth University, Richmond, Virginia 23298 0613, USA
    J Pharmacol Exp Ther 291:1284-91. 1999
    ..Glutamate release in turn stimulates N-methyl-D-aspartate receptors, thus triggering the cascade of events leading to nitric oxide formation and possibly seizure production...
  14. ncbi request reprint The involvement of spinal Ca(2+)/calmodulin-protein kinase II in nicotine-induced antinociception in mice
    M I Damaj
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Box 980613, Richmond, VA 23298 0613, USA
    Eur J Pharmacol 404:103-10. 2000
    ..Neuronal Ca(2+), acting via Ca(2+)-dependent CaM kinase II, appears to mediate nicotine-induced antinociception at the spinal level...
  15. ncbi request reprint The antinociceptive effects of alpha7 nicotinic agonists in an acute pain model
    M I Damaj
    Department of Pharmacology and Toxicology, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA 23298 0613, USA
    Neuropharmacology 39:2785-91. 2000
    ..This antagonism is probably related to their partial agonistic properties of the alpha(7) receptors. These studies suggest that activation of alpha(7) receptors in the CNS elicits antinociceptive effects in an acute thermal pain model...
  16. pmc The role of alpha6-containing nicotinic acetylcholine receptors in nicotine reward and withdrawal
    K J Jackson
    Department of Pharmacology and Toxicology, Medical Campus, Virginia Commonwealth University, Richmond, Virginia 23298 0613, USA
    J Pharmacol Exp Ther 331:547-54. 2009
    ..These results suggest a role for the alpha6 nAChR subunit in nicotine reward and affective nicotine withdrawal but not acute nicotine-induced or physical withdrawal behaviors...
  17. pmc Role of alpha5 nicotinic acetylcholine receptors in pharmacological and behavioral effects of nicotine in mice
    K J Jackson
    Department of Psychiatry, Pharmacology Toxicology, Virginia Commonwealth University, Richmond, VA 23298 0613, USA
    J Pharmacol Exp Ther 334:137-46. 2010
    ..Receptor number was unaltered in all areas tested. Taken together, results of the study suggest that alpha5 nAChRs are involved in nicotine-mediated behaviors relevant to development of nicotine dependence...
  18. doi request reprint Age-dependent differences in nicotine reward and withdrawal in female mice
    D Kota
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, 410 North 12th Street, Smith Building, P O Box 980613, Richmond, VA 23298 0613, USA
    Psychopharmacology (Berl) 198:201-10. 2008
    ..Research has shown that the commencement of smoking at a young age increases addiction and decreases the probability of successful cessation; however, limited work has focused on nicotine dependence in the female...
  19. ncbi request reprint Nicotine-induced antinociception in mice: role of G-proteins and adenylate cyclase
    M I Damaj
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298 0613
    Pharmacol Biochem Behav 48:37-42. 1994
    ..These data implicate the possible involvement of a G-protein and a second messenger system (activation of a cAMP-dependent protein kinase and increase in cyclic AMP levels) in nicotine-induced analgesia in mice...
  20. ncbi request reprint In vivo pharmacological effects of dihydro-beta-erythroidine, a nicotinic antagonist, in mice
    M I Damaj
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298 0613, USA
    Psychopharmacology (Berl) 117:67-73. 1995
    ..The mechanism of blockade is different from that of mecamylamine, a classical ganglionic antagonist, and may involve a direct action of DH beta E on nicotine receptor...
  21. pmc Effect of the selective kappa-opioid receptor antagonist JDTic on nicotine antinociception, reward, and withdrawal in the mouse
    K J Jackson
    Department of Pharmacology and Toxicology, Medical Campus, Virginia Commonwealth University, Richmond, VA 23298, USA
    Psychopharmacology (Berl) 210:285-94. 2010
    ..Specifically, recent findings suggest that the kappa-opioid receptor (KOR) may play a role in aspects of nicotine dependence, which contribute to relapse and continued tobacco smoking...
  22. pmc 3'-Fluoro substitution in the pyridine ring of epibatidine improves selectivity and efficacy for alpha4beta2 versus alpha3beta4 nAChRs
    Galya R Abdrakhmanova
    Department of Pharmacology and Toxicology G R A, M I D, B R M, Virginia Commonwealth University, Richmond, VA 23298, United States
    Neuropharmacology 55:1287-92. 2008
    ....
  23. pmc Effects of the specific α4β2 nAChR antagonist, 2-fluoro-3-(4-nitrophenyl) deschloroepibatidine, on nicotine reward-related behaviors in rats and mice
    K M Tobey
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, 1217 E Marshall St, PO Box 980613, Richmond, VA 23298 0613, USA
    Psychopharmacology (Berl) 223:159-68. 2012
    ..Investigating novel compounds selectively targeting α4β2 nAChRs hypothesized to have a key role in the rewarding effects of nicotine may be a useful approach for future treatment...
  24. pmc The role of various nicotinic receptor subunits and factors influencing nicotine conditioned place aversion
    K J Jackson
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, 410 N 12th Street, P O Box 980613, Richmond, VA 23298, USA
    Neuropharmacology 56:970-4. 2009
    ..Overall, the results of our study provide some insight into pharmacological and behavioral factors involved in the development of an aversive motivational component associated with nicotine withdrawal...
  25. ncbi request reprint Nicotinic regulation of calcium/calmodulin-dependent protein kinase II activation in the spinal cord
    M I Damaj
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Box 980613, Richmond, VA 23298 0613, USA
    J Pharmacol Exp Ther 320:244-9. 2007
    ....
  26. doi request reprint The histidine triad nucleotide binding 1 protein is involved in nicotine reward and physical nicotine withdrawal in mice
    K J Jackson
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, 800 East Leigh Street, Biotech I, Suite 390A, Richmond, VA 23219, USA
    Neurosci Lett 550:129-33. 2013
    ..Overall, our data support a role for the HINT1 gene in mediating behaviors associated with nicotine reward and physical nicotine withdrawal, and provide insight into the role of HINT1 in nicotine dependence-like behaviors. ..
  27. pmc L-type calcium channels and calcium/calmodulin-dependent kinase II differentially mediate behaviors associated with nicotine withdrawal in mice
    K J Jackson
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Box 980613, Richmond, VA 23298 0613, USA
    J Pharmacol Exp Ther 330:152-61. 2009
    ..Overall, our data show that L-type calcium channels and CaMKII are relevant in nicotine withdrawal and differentially mediate nicotine withdrawal behaviors...
  28. pmc Beta 2 subunit-containing nicotinic receptors mediate acute nicotine-induced activation of calcium/calmodulin-dependent protein kinase II-dependent pathways in vivo
    K J Jackson
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia 23298 0613, USA
    J Pharmacol Exp Ther 330:541-9. 2009
    ..Taken together, these data suggest that the nicotine-induced increase in CaMKII activity may correlate with the nicotine-induced increase in pSynapsin I and pCREB in the VTA and NAc via beta2 subunit-containing nAChRs...
  29. ncbi request reprint Nicotine dependence and reward differ between adolescent and adult male mice
    D Kota
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Box 980613, Richmond, VA 23298 0613, USA
    J Pharmacol Exp Ther 322:399-407. 2007
    ..These data indicate that the underlying receptor mechanisms of nicotine dependence differ for adults and adolescents, suggesting that the effectiveness of smoking cessation therapies will differ for various age groups...
  30. pmc Effects of the beta-lactam antibiotic ceftriaxone on nicotine withdrawal and nicotine-induced reinstatement of preference in mice
    M Alajaji
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23219, USA
    Psychopharmacology (Berl) 228:419-26. 2013
    ..We hypothesized that ceftriaxone, a GLT-1 and system xC- activator, would decrease murine behavioral aspects of nicotine dependence...
  31. pmc Differential role of nicotinic acetylcholine receptor subunits in physical and affective nicotine withdrawal signs
    K J Jackson
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Box 980613, Richmond, VA 23298 0613, USA
    J Pharmacol Exp Ther 325:302-12. 2008
    ....
  32. ncbi request reprint Binding of nicotine and homoazanicotine analogues at neuronal nicotinic acetylcholinergic (nACh) receptors
    G Ferretti
    Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, VA 23298, USA
    Bioorg Med Chem Lett 13:733-5. 2003
    ..It was found that parallel structural changes in the two series resulted in parallel shifts in affinity. Evidence suggests that the two series are binding in a comparable fashion...
  33. pmc Effects of the kappa opioid receptor antagonist, norbinaltorphimine, on stress and drug-induced reinstatement of nicotine-conditioned place preference in mice
    K J Jackson
    Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23219, USA
    Psychopharmacology (Berl) 226:763-8. 2013
    ..Kappa opioid receptor (KOR) antagonists have been shown to attenuate behavioral responses to stress and stress-induced reinstatement of cocaine and ethanol seeking and preference...
  34. pmc In vivo pharmacological interactions between a type II positive allosteric modulator of α7 nicotinic ACh receptors and nicotinic agonists in a murine tonic pain model
    K Freitas
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298 0613, USA
    Br J Pharmacol 169:567-79. 2013
    ..In this study, we evaluated whether type II α7 positive allosteric modulator PNU-120596 induces antinociception on its own and in combination with choline in the formalin pain model...