CYNTHIA CORNELISSEN

Summary

Affiliation: Virginia Commonwealth University
Country: USA

Publications

  1. ncbi request reprint Transferrin-iron uptake by Gram-negative bacteria
    Cynthia Nau Cornelissen
    Department of Microbiology and Immunology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298 0678, USA
    Front Biosci 8:d836-47. 2003
  2. pmc The iron-repressed, AraC-like regulator MpeR activates expression of fetA in Neisseria gonorrhoeae
    Aimee Hollander
    Department of Microbiology, Virginia Commonwealth University Medical Center, Richmond, Virginia 232981, USA
    Infect Immun 79:4764-76. 2011
  3. pmc Identification and characterization of gonococcal iron transport systems as potential vaccine antigens
    C N Cornelissen
    Department of Microbiology and Immunology, Virginia Commonwealth University, PO Box 980678, Richmond, VA 23298 0678, USA
    Future Microbiol 3:287-98. 2008
  4. pmc Kinetic analysis of ligand interaction with the gonococcal transferrin-iron acquisition system
    Amanda J DeRocco
    Department of Microbiology, Virginia Commonwealth University Medical Center, PO Box 980678, Richmond, VA 23298 0678, USA
    Biometals 22:439-51. 2009
  5. pmc Identification of TbpA residues required for transferrin-iron utilization by Neisseria gonorrhoeae
    Jennifer M Noto
    Department of Microbiology and Immunology, Virginia Commonwealth University Medical Center, Richmond, VA 23298 0678, USA
    Infect Immun 76:1960-9. 2008
  6. pmc Identification of transferrin-binding domains in TbpB expressed by Neisseria gonorrhoeae
    Amanda J DeRocco
    Department of Microbiology and Immunology, Virginia Commonwealth University Medical Center, Richmond, VA 23298 0678, USA
    Infect Immun 75:3220-32. 2007
  7. pmc Specific ligand binding attributable to individual epitopes of gonococcal transferrin binding protein A
    Heather P Masri
    Department of Microbiology and Immunology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia 23298 0678, USA
    Infect Immun 70:732-40. 2002
  8. pmc Growth of Neisseria gonorrhoeae in the female mouse genital tract does not require the gonococcal transferrin or hemoglobin receptors and may be enhanced by commensal lactobacilli
    Ann E Jerse
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, USA
    Infect Immun 70:2549-58. 2002
  9. pmc The fbpABC operon is required for Ton-independent utilization of xenosiderophores by Neisseria gonorrhoeae strain FA19
    Heather R Strange
    Department of Microbiology and Immunology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Infect Immun 79:267-78. 2011
  10. ncbi request reprint Neisseria gonorrhoeae requires expression of TonB and the putative transporter TdfF to replicate within cervical epithelial cells
    Tracey A Hagen
    Department of Microbiology and Immunology, Virginia Commonwealth University Medical Center, Richmond, VA 23298, USA
    Mol Microbiol 62:1144-57. 2006

Research Grants

  1. A MOLECULAR STUDY OF THE GONOCOCCAL TRANSFERRIN RECEPTOR
    Cynthia Nau Cornelissen; Fiscal Year: 2010
  2. Iron acquisition systems in Neisseria gonorrhoeae
    CYNTHIA CORNELISSEN; Fiscal Year: 2007
  3. A MOLECULAR STUDY OF THE GONOCOCCAL TRANSFERRIN RECEPTOR
    CYNTHIA CORNELISSEN; Fiscal Year: 2006
  4. A MOLECULAR STUDY OF THE GONOCOCCAL TRANSFERRIN RECEPTOR
    CYNTHIA CORNELISSEN; Fiscal Year: 2007
  5. A MOLECULAR STUDY OF THE GONOCOCCAL TRANSFERRIN RECEPTOR
    CYNTHIA CORNELISSEN; Fiscal Year: 2005
  6. Iron acquisition mechanisms utilized by Neisseria gonorrhoeae
    Cynthia Nau Cornelissen; Fiscal Year: 2010

Collaborators

  • ANN JERSE
  • Michael Russell
  • TODD O KITTEN
  • M M Hobbs
  • Gregory A Price
  • Amanda J DeRocco
  • Heather R Strange
  • Tracey A Zola
  • Mary Kate Yost-Daljev
  • Christopher D Kenney
  • Aimee Hollander
  • Heather P Masri
  • Jennifer M Noto
  • Tracey A Hagen
  • Sehmi Paik
  • Alexandra Dubon Mercante
  • William M Shafer
  • Nadia M Dominguez
  • Joseph P Dillard
  • Aimee M Hollander
  • Cindy L Munro
  • Arunsri Brown

Detail Information

Publications17

  1. ncbi request reprint Transferrin-iron uptake by Gram-negative bacteria
    Cynthia Nau Cornelissen
    Department of Microbiology and Immunology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298 0678, USA
    Front Biosci 8:d836-47. 2003
    ..The contribution of these proteins to pathogenesis and vaccine development based on TbpA and TbpB are also discussed...
  2. pmc The iron-repressed, AraC-like regulator MpeR activates expression of fetA in Neisseria gonorrhoeae
    Aimee Hollander
    Department of Microbiology, Virginia Commonwealth University Medical Center, Richmond, Virginia 232981, USA
    Infect Immun 79:4764-76. 2011
    ..gonorrhoeae. The regulatory nidus that links these systems, MpeR, is expressed exclusively by pathogenic neisseriae and is therefore expected to be an important virulence factor...
  3. pmc Identification and characterization of gonococcal iron transport systems as potential vaccine antigens
    C N Cornelissen
    Department of Microbiology and Immunology, Virginia Commonwealth University, PO Box 980678, Richmond, VA 23298 0678, USA
    Future Microbiol 3:287-98. 2008
    ..These antigens, and others predicted from genome sequence data, could be developed into a vaccine that protects against neisserial infections...
  4. pmc Kinetic analysis of ligand interaction with the gonococcal transferrin-iron acquisition system
    Amanda J DeRocco
    Department of Microbiology, Virginia Commonwealth University Medical Center, PO Box 980678, Richmond, VA 23298 0678, USA
    Biometals 22:439-51. 2009
    ....
  5. pmc Identification of TbpA residues required for transferrin-iron utilization by Neisseria gonorrhoeae
    Jennifer M Noto
    Department of Microbiology and Immunology, Virginia Commonwealth University Medical Center, Richmond, VA 23298 0678, USA
    Infect Immun 76:1960-9. 2008
    ....
  6. pmc Identification of transferrin-binding domains in TbpB expressed by Neisseria gonorrhoeae
    Amanda J DeRocco
    Department of Microbiology and Immunology, Virginia Commonwealth University Medical Center, Richmond, VA 23298 0678, USA
    Infect Immun 75:3220-32. 2007
    ..We propose that TbpB is comprised of two transferrin-binding-competent lobes, both of which are critical for efficient iron uptake from human transferrin...
  7. pmc Specific ligand binding attributable to individual epitopes of gonococcal transferrin binding protein A
    Heather P Masri
    Department of Microbiology and Immunology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia 23298 0678, USA
    Infect Immun 70:732-40. 2002
    ..These results suggest that individual epitopes of TbpA are both immunogenic and functional with respect to ligand binding capabilities, and the vaccine implications of these findings are discussed...
  8. pmc Growth of Neisseria gonorrhoeae in the female mouse genital tract does not require the gonococcal transferrin or hemoglobin receptors and may be enhanced by commensal lactobacilli
    Ann E Jerse
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, USA
    Infect Immun 70:2549-58. 2002
    ..In summary, these studies support the potential role of nontransferrin, nonhemoglobin iron sources during gonococcal infection of the female genital tract...
  9. pmc The fbpABC operon is required for Ton-independent utilization of xenosiderophores by Neisseria gonorrhoeae strain FA19
    Heather R Strange
    Department of Microbiology and Immunology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Infect Immun 79:267-78. 2011
    ....
  10. ncbi request reprint Neisseria gonorrhoeae requires expression of TonB and the putative transporter TdfF to replicate within cervical epithelial cells
    Tracey A Hagen
    Department of Microbiology and Immunology, Virginia Commonwealth University Medical Center, Richmond, VA 23298, USA
    Mol Microbiol 62:1144-57. 2006
    ..Expression was further modulated by iron availability. To our knowledge, this study is the first to demonstrate the specific requirement for a single iron transporter in the survival of a bacterial pathogen within host epithelial cells...
  11. pmc Demonstration and characterization of a specific interaction between gonococcal transferrin binding protein A and TonB
    Christopher D Kenney
    Department of Pathology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond 23298 0678, USA
    J Bacteriol 184:6138-45. 2002
    ..The results of the present study thus begin to define the requirements for a functional interaction between gonococcal TbpA and TonB...
  12. pmc Determination of surface-exposed, functional domains of gonococcal transferrin-binding protein A
    Mary Kate Yost-Daljev
    Department of Microbiology and Immunology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia 23298 0678, USA
    Infect Immun 72:1775-85. 2004
    ..This is the first demonstration of the ability of TbpB to compensate for a mutation in TbpA...
  13. pmc Type IV secretion machinery promotes ton-independent intracellular survival of Neisseria gonorrhoeae within cervical epithelial cells
    Tracey A Zola
    Department of Microbiology and Immunology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Infect Immun 78:2429-37. 2010
    ..This study provides the first link between expression of the T4SS apparatus and intracellular survival of gonococci...
  14. pmc Gonococcal transferrin binding protein chimeras induce bactericidal and growth inhibitory antibodies in mice
    Gregory A Price
    Department of Microbiology and Immunology, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298, USA
    Vaccine 25:7247-60. 2007
    ..This study highlights the potential of using protective epitopes instead of full-length proteins in the development of an efficacious gonococcal vaccine...
  15. pmc Immunogenicity of gonococcal transferrin binding proteins during natural infections
    Gregory A Price
    Department of Microbiology and Immunology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia 23298 0678, USA
    Infect Immun 72:277-83. 2004
    ....
  16. pmc The sloABCR operon of Streptococcus mutans encodes an Mn and Fe transport system required for endocarditis virulence and its Mn-dependent repressor
    Sehmi Paik
    The Philips Institute of Oral and Craniofacial Molecular Biology, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    J Bacteriol 185:5967-75. 2003
    ..Finally, a sloA mutant demonstrated loss of virulence in a rat model of endocarditis, suggesting that metal transport is required for endocarditis pathogenesis...
  17. pmc Intranasal administration of recombinant Neisseria gonorrhoeae transferrin binding proteins A and B conjugated to the cholera toxin B subunit induces systemic and vaginal antibodies in mice
    Gregory A Price
    Department of Microbiology and Immunology, Medical College of Virginia Campus of Virginia Commonwealth University, Richmond, Virginia 23298 0678, USA
    Infect Immun 73:3945-53. 2005
    ..By contrast, antibodies elicited via subcutaneous immunization were not cross-bactericidal against heterologous strains, indicating that IN vaccination could be the preferred route for elicitation of biologically functional antibodies...

Research Grants14

  1. A MOLECULAR STUDY OF THE GONOCOCCAL TRANSFERRIN RECEPTOR
    Cynthia Nau Cornelissen; Fiscal Year: 2010
    ..Selected antigens, combined with mucosal adjuvants,will befurther evaluated for their ability to elicit a protective immune response in mice. ..
  2. Iron acquisition systems in Neisseria gonorrhoeae
    CYNTHIA CORNELISSEN; Fiscal Year: 2007
    ....
  3. A MOLECULAR STUDY OF THE GONOCOCCAL TRANSFERRIN RECEPTOR
    CYNTHIA CORNELISSEN; Fiscal Year: 2006
    ..Elected antigens, combined with mucosal adjuvants, will be further evaluated for their ability to elicit a protective immune response in mice. ..
  4. A MOLECULAR STUDY OF THE GONOCOCCAL TRANSFERRIN RECEPTOR
    CYNTHIA CORNELISSEN; Fiscal Year: 2007
    ..Selected antigens, combined with mucosal adjuvants, will be further evaluated for their ability to elicit a protective immune response in mice. ..
  5. A MOLECULAR STUDY OF THE GONOCOCCAL TRANSFERRIN RECEPTOR
    CYNTHIA CORNELISSEN; Fiscal Year: 2005
    ..We will also immunize rabbits with all or parts of the transferrin receptor to determine whether functional antibodies can be elicited. ..
  6. Iron acquisition mechanisms utilized by Neisseria gonorrhoeae
    Cynthia Nau Cornelissen; Fiscal Year: 2010
    ..Finally, the contribution that TdfF provides to growth and survival within cultured cells will be evaluated using intracellular survival assays and state-of-the-art immunofluorescence microscopy techniques. ..