SEVERN CHURN

Summary

Affiliation: Virginia Commonwealth University
Country: USA

Publications

  1. ncbi request reprint Modulation of GABAergic receptor binding by activation of calcium and calmodulin-dependent kinase II membrane phosphorylation
    S B Churn
    Department of Neurology, Medical College of Virginia, Virginia Commonwealth University, Box 980599 MCV Station, Richmond, VA 23298 0599, USA
    Brain Res 809:68-76. 1998
  2. ncbi request reprint Chronic inhibition of Ca(2+)/calmodulin kinase II activity in the pilocarpine model of epilepsy
    S B Churn
    Department of Neurology, The Medical College of Virginia, Virginia Commonwealth University, P O Box 980599, MCV Station, Richmond, VA 23298, USA
    Brain Res 875:66-77. 2000
  3. ncbi request reprint Calcium/calmodulin-dependent kinase II phosphorylation of the GABAA receptor alpha1 subunit modulates benzodiazepine binding
    Severn B Churn
    Department of Neurology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298, USA
    J Neurochem 82:1065-76. 2002
  4. ncbi request reprint A significant increase in both basal and maximal calcineurin activity in the rat pilocarpine model of status epilepticus
    J E Kurz
    Department of Biology, Virginia Commonwealth University, Richmond, Virginia, USA
    J Neurochem 78:304-15. 2001
  5. ncbi request reprint Chronic inhibition of cortex microsomal Mg(2+)/Ca(2+) ATPase-mediated Ca(2+) uptake in the rat pilocarpine model following epileptogenesis
    J T Parsons
    Department of Neurology, Medical College of Virginia Commonwealth University, Richmond, Virginia 23298 0599, USA
    J Neurochem 79:319-27. 2001

Research Grants

Collaborators

Detail Information

Publications5

  1. ncbi request reprint Modulation of GABAergic receptor binding by activation of calcium and calmodulin-dependent kinase II membrane phosphorylation
    S B Churn
    Department of Neurology, Medical College of Virginia, Virginia Commonwealth University, Box 980599 MCV Station, Richmond, VA 23298 0599, USA
    Brain Res 809:68-76. 1998
    ....
  2. ncbi request reprint Chronic inhibition of Ca(2+)/calmodulin kinase II activity in the pilocarpine model of epilepsy
    S B Churn
    Department of Neurology, The Medical College of Virginia, Virginia Commonwealth University, P O Box 980599, MCV Station, Richmond, VA 23298, USA
    Brain Res 875:66-77. 2000
    ..This is the first published report of a persistent, post-translational alteration of CaM kinase II activity in a model of epilepsy characterized by spontaneous recurrent seizure activity...
  3. ncbi request reprint Calcium/calmodulin-dependent kinase II phosphorylation of the GABAA receptor alpha1 subunit modulates benzodiazepine binding
    Severn B Churn
    Department of Neurology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298, USA
    J Neurochem 82:1065-76. 2002
    ..The data suggest that the CaM kinase II-dependent phosphorylation of the GABAA receptor alpha1 subunit modulated allosteric modulator binding to the GABAA receptor...
  4. ncbi request reprint A significant increase in both basal and maximal calcineurin activity in the rat pilocarpine model of status epilepticus
    J E Kurz
    Department of Biology, Virginia Commonwealth University, Richmond, Virginia, USA
    J Neurochem 78:304-15. 2001
    ..Finally, increase in calcineurin activity was found to be NMDA-receptor activation dependent. The data demonstrate that status epilepticus resulted in a significant increase in both basal and maximal calcineurin activity...
  5. ncbi request reprint Chronic inhibition of cortex microsomal Mg(2+)/Ca(2+) ATPase-mediated Ca(2+) uptake in the rat pilocarpine model following epileptogenesis
    J T Parsons
    Department of Neurology, Medical College of Virginia Commonwealth University, Richmond, Virginia 23298 0599, USA
    J Neurochem 79:319-27. 2001
    ..The data demonstrate that inhibition of microsomal Mg(2+)/Ca(2+) ATPase-mediated Ca(2+) uptake in the pilocarpine model may underlie some of the long-term plasticity changes associated with epileptogenesis...

Research Grants4

  1. Molecular Mechanisms of Receptor Function in SE
    SEVERN CHURN; Fiscal Year: 2005
    ..Understanding the cellular mechanisms that result in altered GABAAR function in SE is essential to the development of new treatment strategies to manage SE in the clinical setting. ..