Research Topics
Genomes and Genes
| Xiangning ChenSummaryAffiliation: Virginia Commonwealth University Country: USA Publications
Research Grants
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Detail Information
Publications
Apoptotic engulfment pathway and schizophreniaXiangning Chen
Department of Psychiatry and Virginia Institute for Psychiatric and Behavior Genetics, Virginia Commonwealth University, Richmond, Virginia, USA
PLoS ONE 4:e6875. 2009..In this study, we followed the apoptotic engulfment pathway involving the MEGF10, GULP1, ABCA1 and ABCA7 genes and tested their association with the disease...- Variants in nicotinic acetylcholine receptors alpha5 and alpha3 increase risks to nicotine dependenceXiangning Chen
Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia, USA
Am J Med Genet B Neuropsychiatr Genet 150:926-33. 2009..However, the opposite effects with nicotine dependence and alcohol abuse/dependence were puzzling and future studies are necessary to resolve this issue... - Cannabinoid receptor 1 gene association with nicotine dependenceXiangning Chen
Virginia Institute for Psychiatric and Behavioral Genetics and Department of Psychiatry, Virginia Commonwealth University, 800 Leigh St, Ste 1 110, Richmond, VA 23298, USA
Arch Gen Psychiatry 65:816-24. 2008..The cannabinoid receptor 1 (CNR1) gene is 1 of the 2 receptors expressed in the brain. It has been reported to be associated with alcoholism and multiple drug abuse and dependence... - MEGF10 association with schizophreniaXiangning Chen
Department of Psychiatry, Virginia Institute for Psychiatric and Behavior Genetics, Virginia Commonwealth University, Richmond, VA 23298, USA
Biol Psychiatry 63:441-8. 2008..In this study, we carried out independent replication and expression studies of the MEGF10 gene... 
RhoA, encoding a Rho GTPase, is associated with smoking initiationX Chen
Virginia Institute for Psychiatric and Behavioral Genetics and Department of Psychiatry, Richmond, VA, USA
Genes Brain Behav 6:689-97. 2007..Our results indicated that the RhoA gene is likely involved in initiation of tobacco smoking and ND. Replication and future model system studies will be needed to validate the role of RhoA gene in SI and ND...- Interleukin 3 and schizophrenia: the impact of sex and family historyX Chen
Department of Psychiatry and Virginia Institute for Psychiatric and Behavior Genetics, Virginia Commonwealth University, Richmond, VA 23298, USA
Mol Psychiatry 12:273-82. 2007..They may explain the sex-specific associations and be functional for the expression of IL3 gene... - GWA study data mining and independent replication identify cardiomyopathy-associated 5 (CMYA5) as a risk gene for schizophreniaX Chen
Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298 0424, USA
Mol Psychiatry 16:1117-29. 2011..On the basis of these results, we concluded that CMYA5 is associated with schizophrenia and further investigation of the gene is warranted... - Haplotypes spanning SPEC2, PDZ-GEF2 and ACSL6 genes are associated with schizophreniaXiangning Chen
Department of Psychiatry and Virginia Institute for Psychiatric and Behavior Genetics, Virginia Commonwealth University, Richimond, VA 23298, USA
Hum Mol Genet 15:3329-42. 2006..However, due to the extended high LD in this region, we were unable to distinguish whether the association signals came from one or more of these genes... - Single nucleotide polymorphism genotyping: biochemistry, protocol, cost and throughputX Chen
Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, 800 E Leigh Street, Richmond, VA 23298 0424, USA
Pharmacogenomics J 3:77-96. 2003..Finally, we describe some popular techniques and the applications that are suitable for these techniques... - Variants in the catechol-o-methyltransferase (COMT) gene are associated with schizophrenia in Irish high-density familiesX Chen
Department of Psychiatry and Virginia Institute for Psychiatric and Behavior Genetics, Virginia Commonwealth University, 800 E Leigh Street, Richmond, VA 23298, USA
Mol Psychiatry 9:962-7. 2004..We concluded that COMT gene is associated with schizophrenia and carries a small but significant risk to the susceptibility in the Irish subjects... - Fluorescence polarization for single nucleotide polymorphism genotypingXiangning Chen
Virginia Institute for Psychiatric and Behavior Genetics, Department of Psychiatry, Commonwealth University, Richmond, Virginia 23298, USA
Comb Chem High Throughput Screen 6:213-23. 2003..It is hoped that readers could get useful information for the applications of FP in SNP genotyping and some insights of the FP-TDI assay... - Association study of the Epac gene and tobacco smoking and nicotine dependenceXiangning Chen
Virginia Institute for Psychiatric and Behavior Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia 23298, USA
Am J Med Genet B Neuropsychiatr Genet 129:116-9. 2004.... - Regulator of G-protein signaling 4 (RGS4) gene is associated with schizophrenia in Irish high density familiesXiangning Chen
Department of Psychiatry and Virginia Institute for Psychiatric and Behavior Genetics, Virginia Commonwealth University, Richmond, Virginia 23298, USA
Am J Med Genet B Neuropsychiatr Genet 129:23-6. 2004..While P values were not corrected for multiple testing because of the clear prior hypothesis, these results could be interpreted as supporting evidence for the association between RGS4 and schizophrenia... - Is the histidine triad nucleotide-binding protein 1 (HINT1) gene a candidate for schizophrenia?Qi Chen
Department of Psychiatry and Virginia Institute for Psychiatric and Behavior Genetics, Virginia Commonwealth University, 800 E Leigh Street, Richmond, VA 23298, United States
Schizophr Res 106:200-7. 2008..It was also found to be associated with the dysregulation of postsynaptic dopamine transmission, thus suggesting a potential role in several neuropsychiatric diseases... - Catechol-O-methyltransferase contributes to genetic susceptibility shared among anxiety spectrum phenotypesJohn M Hettema
Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, 23298 0126, USA
Biol Psychiatry 64:302-10. 2008..Catechol-O-methyltransferase (COMT) has been investigated for its possible role in a wide range of psychiatric phenotypes. In particular, several studies support association of this gene with panic disorder and other anxiety-related traits... - Association study between GABA receptor genes and anxiety spectrum disordersXuan Pham
Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298 0126, USA
Depress Anxiety 26:998-1003. 2009..In this investigation, we explored four GABA receptor genes for their possible associations with genetic risk for anxiety disorders and depression... - Genetic variation in the serotonin 2A receptor and suicidal ideation in a sample of 270 Irish high-density schizophrenia familiesAyman H Fanous
Washington VA Medical Center, Virginia Commonwealth University, Richmond, Virginia, USA
Am J Med Genet B Neuropsychiatr Genet 150:411-7. 2009..Because of multiple testing, these results do not provide support for HTR2A as a susceptibility gene for psychotic illness, or for suicidal ideation within psychotic illness... - FBXL21 association with schizophrenia in Irish family and case-control samplesXiangning Chen
Department of Psychiatry, Virginia Institute for Psychiatric and Behavior Genetics, Virginia Commonwealth University, Richmond, Virginia
Am J Med Genet B Neuropsychiatr Genet 147:1231-7. 2008..0437) and was overrepresented in the ICCSS (P = 0.0177). For both samples, the associated alleles and haplotypes were identical. These data suggested that FBXL21 may be associated with schizophrenia in the Irish samples... - A twin association study of nicotine dependence with markers in the CHRNA3 and CHRNA5 genesHermine H Maes
Department of Human and Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, P O Box 980003, Richmond, VA 23298 0003, USA
Behav Genet 41:680-90. 2011..Including phenotypic data on ungenotyped relatives can improve the statistical power to detect the effects of genetic variants when they contribute to individual differences in the phenotype... 
Lack of association between the amiloride-sensitive cation channel 2 (ACCN2) gene and anxiety spectrum disordersJohn M Hettema
Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298 0126, USA
Psychiatr Genet 18:73-9. 2008..In this study, we examined, for the first time, the human analog of ASIC1, the amiloride-sensitive cation channel 2 (ACCN2) gene, for its association with genetic risk across a range of anxiety spectrum phenotypes...- Association study of CREB1 with Major Depressive Disorder and related phenotypesJohn M Hettema
Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, 23298 0126, USA
Am J Med Genet B Neuropsychiatr Genet 150:1128-32. 2009..However, none of these markers were significant in stage 2 in either sex individually or combined. Our data suggests that common variations in the CREB1 gene do not appear to increase susceptibility for MDD or related phenotypes... - Association of the phosphatase and tensin homolog gene (PTEN) with smoking initiation and nicotine dependenceLan Zhang
Department of Psychiatry, Virginia Institute of Psychiatric and Behavioral Genetics, Virginia Commonwealth University, 800 Leigh Street, Suite 1 110, Richmond, VA 23298, USA
Am J Med Genet B Neuropsychiatr Genet 141:10-4. 2006..These results suggest that the PTEN gene may be involved in the etiology of both smoking initiation and nicotine dependence... - Prioritization and association analysis of murine-derived candidate genes in anxiety-spectrum disordersJohn M Hettema
Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298 0126, USA
Biol Psychiatry 70:888-96. 2011.... - Association and expression study of synapsin III and schizophreniaQi Chen
Department of Psychiatry and Virginia Institute for Psychiatric and Behavior Genetics, Virginia Commonwealth University, 800 E Leigh Street, Richmond, VA 23298, United States
Neurosci Lett 465:248-51. 2009..507) was observed between patients and controls. Both the association studies and expression studies didn't support a major role for SYN3 in the susceptibility of schizophrenia in Irish and Chinese populations... - Interleukin 3 and schizophreniaXiangning Chen
UT Southwestern Medical Center, Department of Psychiatry, 5323 Harry Hines Blvd, NE5.110, Dallas, TX 75390-9070, USA
Am J Psychiatry 165:13-4. 2008 - Two non-synonymous markers in PTPN21, identified by genome-wide association study data-mining and replication, are associated with schizophreniaJingchun Chen
Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Suite 390, 800 E Leigh Street, Richmond, VA 23298, USA
Schizophr Res 131:43-51. 2011..Given the results that 2 non-synonymous markers in PTPN21 are associated with schizophrenia, further investigation of this locus is warranted... - Association study of CSF2RB with schizophrenia in Irish family and case - control samplesQ Chen
Department of Psychiatry and Virginia Institute for Psychiatric and Behavior Genetics, Virginia Commonwealth University, Richmond, VA 23298 0424, USA
Mol Psychiatry 13:930-8. 2008..Since CSF2RB is essential for IL3 signaling, the findings that both IL3 and CSF2RB showed sex-specific and FH-dependent associations suggest that the IL3 pathway is involved in schizophrenia... - Genetic association between RGS1 and internalizing disordersJohn M Hettema
Departments of aPsychiatry bHuman Genetics, Virginia Institute for Psychiatric and Behavioral Genetics cDepartment of Pharmacy, Center for Biomarker Research and Personalized Medicine, Virginia Commonwealth University, Richmond, Virginia dGeneral Studies and Basic Education, Northeast Wisconsin Technical College, Green Bay, Wisconsin, USA
Psychiatr Genet 23:56-60. 2013..In this study, we investigated whether internalizing disorders (anxiety disorders, major depression, and neuroticism) were associated with a region on human chromosome 1 syntenic with a quantitative trait locus for rodent emotionality... - Recent advances in the genetic epidemiology and molecular genetics of substance use disordersKenneth S Kendler
Virginia Institute of Psychiatric and Behavioral Genetics, Medical College of Virginia and Virginia Commonwealth University, Richmond, Virginia, USA
Nat Neurosci 15:181-9. 2012..Identifying these risk genes and understanding their action will require large clinical samples, and interaction between these studies and work in model organisms... - ACSL6 is associated with the number of cigarettes smoked and its expression is altered by chronic nicotine exposureJingchun Chen
Department of Psychiatry and Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia, United States of America
PLoS ONE 6:e28790. 2011..The independent associations of this locus with schizophrenia and with numCIG in non-schizophrenic subjects suggest that this locus may be a common liability to both conditions... - The AVPR1A gene and substance use disorders: association, replication, and functional evidenceBrion S Maher
Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia, USA
Biol Psychiatry 70:519-27. 2011..The liability to addiction has been shown to be highly genetically correlated across drug classes, suggesting nondrug-specific mechanisms... - Variants in the 15q25 gene cluster are associated with risk for schizophrenia and bipolar disorderKia J Jackson
Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23219, USA
Psychiatr Genet 23:20-8. 2013..To investigate this hypothesis, we examined the association of the 15q25 gene cluster, the most significant candidate region to date implicated in ND and smoking behavior, with schizophrenia and bipolar disorder... - FP-TDI SNP scoring by manual and statistical procedures: a study of error rates and typesE J C G van den Oord
Department of Psychiatry, Virginia Commonwealth University, P O Box 980126, Richmond, VA 23298 0126, USA
Biotechniques 34:610-6, 618-20, 622 passim. 2003..There were 3.3% more missing genotypes in the manual scoring due to errors in data manipulation (1.7%) and conservative scoring (1.6%)... - Association between glutamic acid decarboxylase genes and anxiety disorders, major depression, and neuroticismJ M Hettema
Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298 0126, USA
Mol Psychiatry 11:752-62. 2006..Subject to confirmation in an independent sample, our study suggests that variations in the GAD1 gene may contribute to individual differences in N and impact susceptibility across a range of anxiety disorders and major depression... - Association study between the serotonin 1A receptor (HTR1A) gene and neuroticism, major depression, and anxiety disordersJ M Hettema
Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298 0126, USA
Am J Med Genet B Neuropsychiatr Genet 147:661-6. 2008..Our data suggests that the HTR1A gene may not play a major role in the genetic susceptibility underlying depressive and anxiety-related phenotypes... - Catechol-O-methyltransferase and the clinical features of psychosisJ L McClay
Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University, Richmond, Virginia 23298 0126, USA
Am J Med Genet B Neuropsychiatr Genet 141:935-8. 2006..4). These results suggest a modest affective vulnerability conferred by this allele in psychosis, but will require replication... - Role of alpha5 nicotinic acetylcholine receptors in pharmacological and behavioral effects of nicotine in miceK J Jackson
Department of Psychiatry, Pharmacology Toxicology, Virginia Commonwealth University, Richmond, VA 23298 0613, USA
J Pharmacol Exp Ther 334:137-46. 2010..Receptor number was unaltered in all areas tested. Taken together, results of the study suggest that alpha5 nAChRs are involved in nicotine-mediated behaviors relevant to development of nicotine dependence... - RNA-Seq analysis implicates dysregulation of the immune system in schizophreniaJunzhe Xu
Department of Psychiatry, School of Medicine, University at Buffalo, SUNY, Buffalo, NY 14260, USA
BMC Genomics 13:S2. 2012..We were interested in testing whether integration gene expression and other functional information could facilitate the identification of susceptibility genes and related biological pathways... - Nicotine reward and affective nicotine withdrawal signs are attenuated in calcium/calmodulin-dependent protein kinase IV knockout miceKia J Jackson
Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA
PLoS ONE 7:e51154. 2012..These findings further indicate the importance of calcium-dependent mechanisms in mediating behaviors associated with drugs of abuse... - The neuropeptide galanin and variants in the GalR1 gene are associated with nicotine dependenceKia J Jackson
Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23298 0613, USA
Neuropsychopharmacology 36:2339-48. 2011..Taken together, our data suggest that galanin has a protective role against progression to ND, and these effects may be mediated through GALR1... - A multiplexing single nucleotide polymorphism typing method based on restriction-enzyme-mediated single-base extension and capillary electrophoresisYihua Che
Virginia Institute for Psychiatric and Behavioral Genetics and Department of Psychiatry, Virginia Commonwealth University, 800 E. Leigh Street, Suite 1-110, Richmond, VA 23298, USA
Anal Biochem 329:220-9. 2004..By multiplexing PCR and pooling multiplexed reactions together, this method has the potential to score 50-100 SNPs/capillary/run if the sizes of PCR products are arranged at every 5-10 bases from 100 to 600 base range... - Evaluation of a susceptibility gene for schizophrenia: genotype based meta-analysis of RGS4 polymorphisms from thirteen independent samplesMichael E Talkowski
Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Biol Psychiatry 60:152-62. 2006..Yet, similar to other SCZ candidate genes, studies have been inconsistent with respect to the associated alleles... - Detection of single nucleotide polymorphismsPui Yan Kwok
Cardiovascular Research Institute, University of California, 505 Parnassus Avenue, Long 1332A, Box 0130, San Francisco, CA 94143 0130, USA
Curr Issues Mol Biol 5:43-60. 2003..Despite the considerable gains over the last decade, new approaches must be developed to lower the cost and increase the speed of SNP detection... - Association between the 5q31.1 gene neurogenin1 and schizophreniaAyman H Fanous
Washington VA Medical Center, Washington, District of Columbia, USA
Am J Med Genet B Neuropsychiatr Genet 144:207-14. 2007..This gene should be tested in additional and larger samples...
Research Grants
- GENETICS OF NICOTINE AND OTHER ABUSED SUBSTANCESXiangning Chen; Fiscal Year: 2007In this mentored scientist development award for Dr. Xiangning Chen, sponsored by Dr. Kenneth Kendler, describes a 5-year, comprehensive training and research program for the genetics of nicotine, alcohol and other abused substances...