Affiliation: Virginia Polytechnic Institute and State University
- Neuroprotection in the MPTP Parkinsonian C57BL/6 mouse model by a compound isolated from tobaccoK P Castagnoli
Harvey W Peters Center, Department of Chemistry, Virginia Tech, Blacksburg, Virginia 24061 0212, USA
Chem Res Toxicol 14:523-7. 2001..These results support the hypothesis that the inhibition of MAO by constituents of tobacco smoke may be related to the decreased incidence of Parkinson's disease in smokers...
- Tobacco leaf, smoke and smoking, MAO inhibitors, Parkinson's disease and neuroprotection; are there links?Kay Castagnoli
Harvey W Peters Center for the Study of Parkinson s Disease, Department of Chemistry, Virginia Tech, Blacksburg, VA 24061 0212, USA
Neurotoxicology 25:279-91. 2004..In this chapter we report on the results of these studies and present a discussion of potential avenues of research and their implication with respect to PD, smoking and monoamine oxidase...
- Enhancement of auditory sensory gating and stimulus-bound gamma band (40 Hz) oscillations in heavy tobacco smokersHelen J Crawford
Department of Psychology, Virginia Polytechnic Institute and State University, Blacksburg, VA 24060, USA
Neurosci Lett 317:151-5. 2002..GBO analyses showed earlier sensory gating in smokers. These chronic effects of greater cortical activation and sensory gating may reflect persistent dopaminergic activation due to the inhibition of monoamine oxidase observed in smokers...
- Studies on the oxidation of 1,4-disubstituted-1,2,3,6-tetrahydropyridinesNeal Castagnoli
Department of Chemistry, Virginia Tech, Blacksburg 24061 0212, USA
Drug Metab Rev 34:533-47. 2002..This paper examines the impact that various structural features of 1,4-disubstituted-1,2,3,6-tetrahydropyridinyl derivatives have on the oxidative fate of this class of compound...
- Monoamine oxidase B inhibition and neuroprotection: studies on selective adenosine A2A receptor antagonistsNeal Castagnoli
Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061 0212, USA
Neurology 61:S62-8. 2003..The results raise the possibility that a single structure may offer the combined benefits of two pharmacologic strategies, each with symptomatic and potential neuroprotective benefits, for the management of PD...
- Synthesis and biological evaluation of MAO-A selective 1,4-disubstituted-1,2,3,6-tetrahydropyridinyl substratesPhilippe Bissel
Department of Chemistry, Virginia Polytechnic Institute and State University, 107 Davidson Hall, Blacksburg, VA 24061-0212, USA
Bioorg Med Chem 10:3031-41. 2002..Kinetic parameters and MAO-A selectivity indicate that 1-allyl- and 1-propyl-4-(1-methylpyrrol-2-yl)-1,2,3,6-tetrahydropyridine should be good candidates to develop a robust spectrophotometric-based assay that is selective for MAO-A...
- Neuroprotection by caffeine and more specific A2A receptor antagonists in animal models of Parkinson's diseaseMichael A Schwarzschild
Department of Neurology, Massachusetts General Hospital, Boston, MA 02129, USA
Neurology 61:S55-61. 2003....
- Neurotoxicity studies with the monoamine oxidase B substrate 1-methyl-3-phenyl-3-pyrrolineModupe O Ogunrombi
Pharmaceutical Chemistry, School of Pharmacy, North West University, Private Bag X6001, Potchefstroom, 2520, South Africa
Life Sci 81:458-67. 2007..The rapid clearance of 1-methyl-3-phenylpyrroles from the brain may contribute to their lack of neurotoxicity...
- 8-(3-Chlorostyryl)caffeine may attenuate MPTP neurotoxicity through dual actions of monoamine oxidase inhibition and A2A receptor antagonismJiang Fan Chen
Department of Neurology, Molecular Neurobiology Laboratory, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
J Biol Chem 277:36040-4. 2002..Together, these data indicate that CSC possesses dual actions of MAO-B inhibition and A(2A) receptor antagonism, a unique combination suggesting a new class of compounds with the potential for enhanced neuroprotective properties...