Kay Castagnoli

Summary

Affiliation: Virginia Polytechnic Institute and State University
Country: USA

Publications

  1. ncbi Neuroprotection in the MPTP Parkinsonian C57BL/6 mouse model by a compound isolated from tobacco
    K P Castagnoli
    Harvey W Peters Center, Department of Chemistry, Virginia Tech, Blacksburg, Virginia 24061 0212, USA
    Chem Res Toxicol 14:523-7. 2001
  2. ncbi Tobacco leaf, smoke and smoking, MAO inhibitors, Parkinson's disease and neuroprotection; are there links?
    Kay Castagnoli
    Harvey W Peters Center for the Study of Parkinson s Disease, Department of Chemistry, Virginia Tech, Blacksburg, VA 24061 0212, USA
    Neurotoxicology 25:279-91. 2004
  3. ncbi Enhancement of auditory sensory gating and stimulus-bound gamma band (40 Hz) oscillations in heavy tobacco smokers
    Helen J Crawford
    Department of Psychology, Virginia Polytechnic Institute and State University, Blacksburg, VA 24060, USA
    Neurosci Lett 317:151-5. 2002
  4. ncbi Studies on the oxidation of 1,4-disubstituted-1,2,3,6-tetrahydropyridines
    Neal Castagnoli
    Department of Chemistry, Virginia Tech, Blacksburg 24061 0212, USA
    Drug Metab Rev 34:533-47. 2002
  5. ncbi Monoamine oxidase B inhibition and neuroprotection: studies on selective adenosine A2A receptor antagonists
    Neal Castagnoli
    Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061 0212, USA
    Neurology 61:S62-8. 2003
  6. ncbi Synthesis and biological evaluation of MAO-A selective 1,4-disubstituted-1,2,3,6-tetrahydropyridinyl substrates
    Philippe Bissel
    Department of Chemistry, Virginia Polytechnic Institute and State University, 107 Davidson Hall, Blacksburg, VA 24061-0212, USA
    Bioorg Med Chem 10:3031-41. 2002
  7. ncbi Neuroprotection by caffeine and more specific A2A receptor antagonists in animal models of Parkinson's disease
    Michael A Schwarzschild
    Department of Neurology, Massachusetts General Hospital, Boston, MA 02129, USA
    Neurology 61:S55-61. 2003
  8. ncbi Neurotoxicity studies with the monoamine oxidase B substrate 1-methyl-3-phenyl-3-pyrroline
    Modupe O Ogunrombi
    Pharmaceutical Chemistry, School of Pharmacy, North West University, Private Bag X6001, Potchefstroom, 2520, South Africa
    Life Sci 81:458-67. 2007
  9. ncbi 8-(3-Chlorostyryl)caffeine may attenuate MPTP neurotoxicity through dual actions of monoamine oxidase inhibition and A2A receptor antagonism
    Jiang Fan Chen
    Department of Neurology, Molecular Neurobiology Laboratory, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    J Biol Chem 277:36040-4. 2002

Detail Information

Publications9

  1. ncbi Neuroprotection in the MPTP Parkinsonian C57BL/6 mouse model by a compound isolated from tobacco
    K P Castagnoli
    Harvey W Peters Center, Department of Chemistry, Virginia Tech, Blacksburg, Virginia 24061 0212, USA
    Chem Res Toxicol 14:523-7. 2001
    ..These results support the hypothesis that the inhibition of MAO by constituents of tobacco smoke may be related to the decreased incidence of Parkinson's disease in smokers...
  2. ncbi Tobacco leaf, smoke and smoking, MAO inhibitors, Parkinson's disease and neuroprotection; are there links?
    Kay Castagnoli
    Harvey W Peters Center for the Study of Parkinson s Disease, Department of Chemistry, Virginia Tech, Blacksburg, VA 24061 0212, USA
    Neurotoxicology 25:279-91. 2004
    ..In this chapter we report on the results of these studies and present a discussion of potential avenues of research and their implication with respect to PD, smoking and monoamine oxidase...
  3. ncbi Enhancement of auditory sensory gating and stimulus-bound gamma band (40 Hz) oscillations in heavy tobacco smokers
    Helen J Crawford
    Department of Psychology, Virginia Polytechnic Institute and State University, Blacksburg, VA 24060, USA
    Neurosci Lett 317:151-5. 2002
    ..GBO analyses showed earlier sensory gating in smokers. These chronic effects of greater cortical activation and sensory gating may reflect persistent dopaminergic activation due to the inhibition of monoamine oxidase observed in smokers...
  4. ncbi Studies on the oxidation of 1,4-disubstituted-1,2,3,6-tetrahydropyridines
    Neal Castagnoli
    Department of Chemistry, Virginia Tech, Blacksburg 24061 0212, USA
    Drug Metab Rev 34:533-47. 2002
    ..This paper examines the impact that various structural features of 1,4-disubstituted-1,2,3,6-tetrahydropyridinyl derivatives have on the oxidative fate of this class of compound...
  5. ncbi Monoamine oxidase B inhibition and neuroprotection: studies on selective adenosine A2A receptor antagonists
    Neal Castagnoli
    Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061 0212, USA
    Neurology 61:S62-8. 2003
    ..The results raise the possibility that a single structure may offer the combined benefits of two pharmacologic strategies, each with symptomatic and potential neuroprotective benefits, for the management of PD...
  6. ncbi Synthesis and biological evaluation of MAO-A selective 1,4-disubstituted-1,2,3,6-tetrahydropyridinyl substrates
    Philippe Bissel
    Department of Chemistry, Virginia Polytechnic Institute and State University, 107 Davidson Hall, Blacksburg, VA 24061-0212, USA
    Bioorg Med Chem 10:3031-41. 2002
    ..Kinetic parameters and MAO-A selectivity indicate that 1-allyl- and 1-propyl-4-(1-methylpyrrol-2-yl)-1,2,3,6-tetrahydropyridine should be good candidates to develop a robust spectrophotometric-based assay that is selective for MAO-A...
  7. ncbi Neuroprotection by caffeine and more specific A2A receptor antagonists in animal models of Parkinson's disease
    Michael A Schwarzschild
    Department of Neurology, Massachusetts General Hospital, Boston, MA 02129, USA
    Neurology 61:S55-61. 2003
    ....
  8. ncbi Neurotoxicity studies with the monoamine oxidase B substrate 1-methyl-3-phenyl-3-pyrroline
    Modupe O Ogunrombi
    Pharmaceutical Chemistry, School of Pharmacy, North West University, Private Bag X6001, Potchefstroom, 2520, South Africa
    Life Sci 81:458-67. 2007
    ..The rapid clearance of 1-methyl-3-phenylpyrroles from the brain may contribute to their lack of neurotoxicity...
  9. ncbi 8-(3-Chlorostyryl)caffeine may attenuate MPTP neurotoxicity through dual actions of monoamine oxidase inhibition and A2A receptor antagonism
    Jiang Fan Chen
    Department of Neurology, Molecular Neurobiology Laboratory, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    J Biol Chem 277:36040-4. 2002
    ..Together, these data indicate that CSC possesses dual actions of MAO-B inhibition and A(2A) receptor antagonism, a unique combination suggesting a new class of compounds with the potential for enhanced neuroprotective properties...