Michelle Block

Summary

Affiliation: Virginia Commonwealth University
Country: USA

Publications

  1. pmc Chronic apocynin treatment attenuates beta amyloid plaque size and microglial number in hAPP(751)(SL) mice
    Melinda E Lull
    Department of Anatomy and Neurobiology, Virginia Commonwealth University Medical Campus, Richmond, Virginia, United States of America
    PLoS ONE 6:e20153. 2011
  2. pmc Diesel exhaust activates and primes microglia: air pollution, neuroinflammation, and regulation of dopaminergic neurotoxicity
    Shannon Levesque
    Department of Anatomy and Neurobiology, Virginia Commonwealth University Medical Campus, Richmond, Virginia, USA
    Environ Health Perspect 119:1149-55. 2011
  3. pmc Microglial activation decreases retention of the protease inhibitor saquinavir: implications for HIV treatment
    Shannon Dallas
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA
    J Neuroinflammation 10:58. 2013
  4. pmc The outdoor air pollution and brain health workshop
    Michelle L Block
    Department of Anatomy and Neurobiology, Virginia Commonwealth University Medical Campus, Richmond, VA, USA
    Neurotoxicology 33:972-84. 2012
  5. pmc Air pollution & the brain: Subchronic diesel exhaust exposure causes neuroinflammation and elevates early markers of neurodegenerative disease
    Shannon Levesque
    Department of Anatomy and Neurobiology, Virginia Commonwealth University Medical Campus, Richmond, VA 23298, USA
    J Neuroinflammation 8:105. 2011
  6. pmc Air pollution: mechanisms of neuroinflammation and CNS disease
    Michelle L Block
    Department of Anatomy and Neurobiology, Virginia Commonwealth University Medical Campus, Richmond, VA 23298, USA
    Trends Neurosci 32:506-16. 2009
  7. ncbi request reprint Chronic microglial activation and progressive dopaminergic neurotoxicity
    M L Block
    Neuropharmacology Section, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, U S A
    Biochem Soc Trans 35:1127-32. 2007
  8. doi request reprint Curcumin protects dopaminergic neuron against LPS induced neurotoxicity in primary rat neuron/glia culture
    Sufen Yang
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental, Health Sciences, National Institutes of Health, PO Box 12233, Research Triangle Park, NC 27709, USA
    Neurochem Res 33:2044-53. 2008
  9. pmc Formyl-methionyl-leucyl-phenylalanine-induced dopaminergic neurotoxicity via microglial activation: a mediator between peripheral infection and neurodegeneration?
    Xi Gao
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Environ Health Perspect 116:593-8. 2008
  10. ncbi request reprint Reactive microgliosis participates in MPP+-induced dopaminergic neurodegeneration: role of 67 kDa laminin receptor
    Tongguang Wang
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, North Carolina, USA
    FASEB J 20:906-15. 2006

Collaborators

Detail Information

Publications12

  1. pmc Chronic apocynin treatment attenuates beta amyloid plaque size and microglial number in hAPP(751)(SL) mice
    Melinda E Lull
    Department of Anatomy and Neurobiology, Virginia Commonwealth University Medical Campus, Richmond, Virginia, United States of America
    PLoS ONE 6:e20153. 2011
    ....
  2. pmc Diesel exhaust activates and primes microglia: air pollution, neuroinflammation, and regulation of dopaminergic neurotoxicity
    Shannon Levesque
    Department of Anatomy and Neurobiology, Virginia Commonwealth University Medical Campus, Richmond, Virginia, USA
    Environ Health Perspect 119:1149-55. 2011
    ..Air pollution is linked to central nervous system disease, but the mechanisms responsible are poorly understood...
  3. pmc Microglial activation decreases retention of the protease inhibitor saquinavir: implications for HIV treatment
    Shannon Dallas
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA
    J Neuroinflammation 10:58. 2013
    ..HIV/AIDS patients frequently suffer bacterial and viral co-infections, leading to deregulation of glial cell function and release of pro-inflammatory mediators including cytokines, chemokines, and nitric oxide...
  4. pmc The outdoor air pollution and brain health workshop
    Michelle L Block
    Department of Anatomy and Neurobiology, Virginia Commonwealth University Medical Campus, Richmond, VA, USA
    Neurotoxicology 33:972-84. 2012
    ....
  5. pmc Air pollution & the brain: Subchronic diesel exhaust exposure causes neuroinflammation and elevates early markers of neurodegenerative disease
    Shannon Levesque
    Department of Anatomy and Neurobiology, Virginia Commonwealth University Medical Campus, Richmond, VA 23298, USA
    J Neuroinflammation 8:105. 2011
    ..Increasing evidence links diverse forms of air pollution to neuroinflammation and neuropathology in both human and animal models, but the effects of long-term exposures are poorly understood...
  6. pmc Air pollution: mechanisms of neuroinflammation and CNS disease
    Michelle L Block
    Department of Anatomy and Neurobiology, Virginia Commonwealth University Medical Campus, Richmond, VA 23298, USA
    Trends Neurosci 32:506-16. 2009
    ....
  7. ncbi request reprint Chronic microglial activation and progressive dopaminergic neurotoxicity
    M L Block
    Neuropharmacology Section, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, U S A
    Biochem Soc Trans 35:1127-32. 2007
    ..Here, we review proposed mechanisms responsible for chronic neuroinflammation and explain the interconnected relationship between deleterious microglial activation, DA neuron damage and neurodegenerative disease...
  8. doi request reprint Curcumin protects dopaminergic neuron against LPS induced neurotoxicity in primary rat neuron/glia culture
    Sufen Yang
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental, Health Sciences, National Institutes of Health, PO Box 12233, Research Triangle Park, NC 27709, USA
    Neurochem Res 33:2044-53. 2008
    ..Taken together, our study implicated that curcumin might be a potential preventive and therapeutic strategy for inflammation-related neurodegenerative diseases...
  9. pmc Formyl-methionyl-leucyl-phenylalanine-induced dopaminergic neurotoxicity via microglial activation: a mediator between peripheral infection and neurodegeneration?
    Xi Gao
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Environ Health Perspect 116:593-8. 2008
    ..Microglial activation is important in the pathogenesis of PD...
  10. ncbi request reprint Reactive microgliosis participates in MPP+-induced dopaminergic neurodegeneration: role of 67 kDa laminin receptor
    Tongguang Wang
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, North Carolina, USA
    FASEB J 20:906-15. 2006
    ..Laminin is a potential ligand for activating this LR receptor. This study also suggests that laminin/LR is a potential target for developing new therapeutic drugs against neurodegenerative disorders such as PD...
  11. ncbi request reprint Potent regulation of microglia-derived oxidative stress and dopaminergic neuron survival: substance P vs. dynorphin
    M L Block
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    FASEB J 20:251-8. 2006
    ..Here we demonstrate a tightly regulated mechanism governing microglia-derived oxidative stress, where the neuropeptide balance of dynorphin and substance P is critical to DA neuron survival...
  12. ncbi request reprint Nanometer size diesel exhaust particles are selectively toxic to dopaminergic neurons: the role of microglia, phagocytosis, and NADPH oxidase
    M L Block
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    FASEB J 18:1618-20. 2004
    ..Together, these in vitro data indicate that DEP selectively damages DA neurons through the phagocytic activation of microglial NADPH oxidase and consequent oxidative insult...

Research Grants3

  1. Protein radicals in microglia: environmental mechanisms of chronic neurotoxicity
    Michelle Block; Fiscal Year: 2009
    ..Finally, this work will provide valuable insight into the identification and timing of novel therapeutic targets capable of slowing Parkinson's disease progression. ..
  2. Protein radicals in microglia: environmental mechanisms of chronic neurotoxicity
    Michelle L Block; Fiscal Year: 2010
    ..Finally, this work will provide valuable insight into the identification and timing of novel therapeutic targets capable of slowing Parkinson's disease progression. ..