Josep Bassaganya-Riera

Summary

Affiliation: Virginia Polytechnic Institute and State University
Country: USA

Publications

  1. pmc Dietary Modulation of Inflammation-Induced Colorectal Cancer through PPARgamma
    Ashlee B Carter
    Cell and Organism Section, Nutritional Immunology and Molecular Nutrition Laboratory, Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    PPAR Res 2009:498352. 2009
  2. pmc Treatment of Obesity-Related Complications with Novel Classes of Naturally Occurring PPAR Agonists
    Josep Bassaganya-Riera
    Nutritional Immunology and Molecular Medicine Laboratory, Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    J Obes 2011:897894. 2011
  3. pmc Modeling the role of peroxisome proliferator-activated receptor γ and microRNA-146 in mucosal immune responses to Clostridium difficile
    Monica Viladomiu
    Nutritional Immunology and Molecular Medicine Laboratory, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, VA, USA
    PLoS ONE 7:e47525. 2012
  4. pmc Systems modeling of molecular mechanisms controlling cytokine-driven CD4+ T cell differentiation and phenotype plasticity
    Adria Carbo
    Nutritional Immunology and Molecular Medicine Laboratory, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, USA
    PLoS Comput Biol 9:e1003027. 2013
  5. pmc Preventive and prophylactic mechanisms of action of pomegranate bioactive constituents
    Monica Viladomiu
    Nutritional Immunology and Molecular Medicine Laboratory, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, VA 24060, USA Center for Modeling Immunity to Enteric Pathogens, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, VA 24060, USA
    Evid Based Complement Alternat Med 2013:789764. 2013
  6. pmc Immunoregulatory mechanisms of macrophage PPAR-γ in mice with experimental inflammatory bowel disease
    R Hontecillas
    CyberInfrastructure Division, Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA
    Mucosal Immunol 4:304-13. 2011
  7. ncbi request reprint Lanthionine synthetase component C-like protein 2: a new drug target for inflammatory diseases and diabetes
    Pinyi Lu
    Laboratory of Nutritional Immunology and Molecular Medicine Laboratory www nimml org, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, VA 24061, USA
    Curr Drug Targets 15:565-72. 2014
  8. pmc Helicobacter pylori colonization ameliorates glucose homeostasis in mice through a PPAR γ-dependent mechanism
    Josep Bassaganya-Riera
    Nutritional Immunology and Molecular Medicine Laboratory, Center for Modeling Immunity to Enteric Pathogens, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America
    PLoS ONE 7:e50069. 2012
  9. pmc Probiotic bacteria produce conjugated linoleic acid locally in the gut that targets macrophage PPAR γ to suppress colitis
    Josep Bassaganya-Riera
    Nutritional Immunology and Molecular Medicine Laboratory, Center for Modeling Immunity to Enteric Pathogens, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America
    PLoS ONE 7:e31238. 2012
  10. doi request reprint Conjugated linoleic acid modulates immune responses in patients with mild to moderately active Crohn's disease
    Josep Bassaganya-Riera
    Nutritional Immunology and Molecular Medicine Laboratory and Center for Modeling Immunity to Enteric Pathogens, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, VA 24060, USA
    Clin Nutr 31:721-7. 2012

Research Grants

  1. Mechanisms of Immune Modulation by Abscisic Acid
    Josep Bassaganya Riera; Fiscal Year: 2007
  2. Mechanisms of Immune Modulation by Abscisic Acid
    Josep Bassaganya Riera; Fiscal Year: 2009
  3. Mechanisms of Immune Modulation by Abscisic Acid
    Josep Bassaganya Riera; Fiscal Year: 2010

Collaborators

Detail Information

Publications66

  1. pmc Dietary Modulation of Inflammation-Induced Colorectal Cancer through PPARgamma
    Ashlee B Carter
    Cell and Organism Section, Nutritional Immunology and Molecular Nutrition Laboratory, Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    PPAR Res 2009:498352. 2009
    ..This review will focus on the use of orally active, naturally occurring chemopreventive approaches against inflammation-induced CRC that target PPARgamma and therefore down-modulate inflammation...
  2. pmc Treatment of Obesity-Related Complications with Novel Classes of Naturally Occurring PPAR Agonists
    Josep Bassaganya-Riera
    Nutritional Immunology and Molecular Medicine Laboratory, Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    J Obes 2011:897894. 2011
    ....
  3. pmc Modeling the role of peroxisome proliferator-activated receptor γ and microRNA-146 in mucosal immune responses to Clostridium difficile
    Monica Viladomiu
    Nutritional Immunology and Molecular Medicine Laboratory, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, VA, USA
    PLoS ONE 7:e47525. 2012
    ..In conclusion, our data indicates that miRNA-146b and PPARγ activation may be implicated in the regulation of Th17 responses and colitis in C. difficile-infected mice...
  4. pmc Systems modeling of molecular mechanisms controlling cytokine-driven CD4+ T cell differentiation and phenotype plasticity
    Adria Carbo
    Nutritional Immunology and Molecular Medicine Laboratory, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, USA
    PLoS Comput Biol 9:e1003027. 2013
    ..Thus, for the first time we provide novel molecular evidence in vivo demonstrating that PPARγ in addition to regulating CD4+ T cell differentiation also plays a major role controlling Th17 and iTreg plasticity in the gut mucosa...
  5. pmc Preventive and prophylactic mechanisms of action of pomegranate bioactive constituents
    Monica Viladomiu
    Nutritional Immunology and Molecular Medicine Laboratory, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, VA 24060, USA Center for Modeling Immunity to Enteric Pathogens, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, VA 24060, USA
    Evid Based Complement Alternat Med 2013:789764. 2013
    ..The aim of this review is to summarize the health effects and mechanisms of action of pomegranate extracts in chronic inflammatory diseases...
  6. pmc Immunoregulatory mechanisms of macrophage PPAR-γ in mice with experimental inflammatory bowel disease
    R Hontecillas
    CyberInfrastructure Division, Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA
    Mucosal Immunol 4:304-13. 2011
    ..Moreover, macrophage PPAR-γ was required for accelerating pioglitazone-mediated recovery from dextran sodium sulfate (DSS) colitis, providing a cellular target for the anti-inflammatory effects of PPAR-γ agonists in IBD...
  7. ncbi request reprint Lanthionine synthetase component C-like protein 2: a new drug target for inflammatory diseases and diabetes
    Pinyi Lu
    Laboratory of Nutritional Immunology and Molecular Medicine Laboratory www nimml org, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, VA 24061, USA
    Curr Drug Targets 15:565-72. 2014
    ..This review discusses the value of LANCL2 as a novel therapeutic target for the discovery and development of new classes of orally active drugs against chronic metabolic, immune-mediated and infectious diseases. ..
  8. pmc Helicobacter pylori colonization ameliorates glucose homeostasis in mice through a PPAR γ-dependent mechanism
    Josep Bassaganya-Riera
    Nutritional Immunology and Molecular Medicine Laboratory, Center for Modeling Immunity to Enteric Pathogens, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America
    PLoS ONE 7:e50069. 2012
    ..We hypothesized that gastric colonization with H. pylori strains differing in cag PAI status exert distinct effects on metabolic and inflammatory phenotypes...
  9. pmc Probiotic bacteria produce conjugated linoleic acid locally in the gut that targets macrophage PPAR γ to suppress colitis
    Josep Bassaganya-Riera
    Nutritional Immunology and Molecular Medicine Laboratory, Center for Modeling Immunity to Enteric Pathogens, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America
    PLoS ONE 7:e31238. 2012
    ..This study aimed to investigate the cellular and molecular mechanisms underlying the anti-inflammatory efficacy of probiotic bacteria using a mouse model of colitis...
  10. doi request reprint Conjugated linoleic acid modulates immune responses in patients with mild to moderately active Crohn's disease
    Josep Bassaganya-Riera
    Nutritional Immunology and Molecular Medicine Laboratory and Center for Modeling Immunity to Enteric Pathogens, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, VA 24060, USA
    Clin Nutr 31:721-7. 2012
    ..We investigated the immunoregulatory efficacy of CLA in patients with mild to moderate Crohn's disease (CD)...
  11. pmc Immunoregulatory mechanisms underlying prevention of colitis-associated colorectal cancer by probiotic bacteria
    Josep Bassaganya-Riera
    Center for Modeling Immunity to Enteric Pathogens, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America
    PLoS ONE 7:e34676. 2012
    ..This study aimed to investigate the cellular and molecular mechanisms underlying the efficacy of probiotic bacteria in mouse models of cancer...
  12. doi request reprint Activation of PPARγ and δ by dietary punicic acid ameliorates intestinal inflammation in mice
    Josep Bassaganya-Riera
    Laboratory of Nutritional Immunology and Molecular Nutrition, Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    Br J Nutr 106:878-86. 2011
    ..We provide in vivo molecular evidence demonstrating that PUA ameliorates experimental IBD by regulating macrophage and T-cell function through PPARγ- and δ-dependent mechanisms...
  13. ncbi request reprint Mechanisms of action and medicinal applications of abscisic Acid
    J Bassaganya-Riera
    Nutritional Immunology and Molecular Nutrition Group, Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    Curr Med Chem 17:467-78. 2010
    ..The use of ABA in the treatment of type II diabetes, offers encouragement for further studies concerning the biomedical applications of ABA...
  14. doi request reprint Soluble fibers and resistant starch ameliorate disease activity in interleukin-10-deficient mice with inflammatory bowel disease
    Josep Bassaganya-Riera
    Nutritional Immunology and Molecular Medicine Laboratory, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, VA 24061, USA
    J Nutr 141:1318-25. 2011
    ..These data suggest that soluble fibers and resistant starch influence Treg cells, IFNγ, and colonic PPARγ expression to suppress gut inflammation...
  15. pmc PPAR gamma is highly expressed in F4/80(hi) adipose tissue macrophages and dampens adipose-tissue inflammation
    Josep Bassaganya-Riera
    Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, 24061, United States
    Cell Immunol 258:138-46. 2009
    ..Thus, PPAR gamma is differentially expressed in F4/80(hi) versus F4/80(low) ATM subsets and its deficiency favors a predominance of M1 markers in WAT...
  16. ncbi request reprint Arachidonic acid-and docosahexaenoic acid-enriched formulas modulate antigen-specific T cell responses to influenza virus in neonatal piglets
    Josep Bassaganya-Riera
    Nutritional Immunology and Molecular Nutrition Laboratory, Department of Human Nutrition Foods and Exercise, Virginia Tech University, Blacksburg, VA 24060, USA
    Am J Clin Nutr 85:824-36. 2007
    ....
  17. pmc Dietary conjugated linoleic acid and n-3 polyunsaturated fatty acids in inflammatory bowel disease
    Josep Bassaganya-Riera
    Laboratory of Nutritional Immunology and Molecular Nutrition, Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    Curr Opin Clin Nutr Metab Care 13:569-73. 2010
    ..The purpose of this review is to summarize the current understanding of mechanisms of action underlying the anti-inflammatory actions of conjugated linoleic acid (CLA) and n-3 polyunsaturated fatty acids (PUFAs) in IBD...
  18. ncbi request reprint CLA and n-3 PUFA differentially modulate clinical activity and colonic PPAR-responsive gene expression in a pig model of experimental IBD
    Josep Bassaganya-Riera
    Laboratory of Nutritional Immunology and Molecular Nutrition, Department of Human Nutrition, Foods and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    Clin Nutr 25:454-65. 2006
    ..We evaluated the ability of CLA and n-3 PUFA alone or in combination to modulate IBD in a pig model of dextran sodium sulfate (DSS)-induced colitis...
  19. ncbi request reprint Conjugated linoleic acid ameliorates viral infectivity in a pig model of virally induced immunosuppression
    Josep Bassaganya-Riera
    Nutritional Immunology and Molecular Nutrition Laboratory, Department of Human Nutrition, Foods and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    J Nutr 133:3204-14. 2003
    ..At the molecular level, these cellular immunoregulatory properties were associated with differential patterns of peroxisome proliferator-activated receptor (alpha and gamma) mRNA expression between diets in virally infected pigs...
  20. ncbi request reprint Impact of immunizations with porcine reproductive and respiratory syndrome virus on lymphoproliferative recall responses of CD8+ T cells
    Josep Bassaganya-Riera
    Department of Veterinary Microbiology and Preventive Medicine, Iowa State University, Ames, Iowa, USA
    Viral Immunol 17:25-37. 2004
    ....
  21. ncbi request reprint Activation of PPAR gamma and delta by conjugated linoleic acid mediates protection from experimental inflammatory bowel disease
    Josep Bassaganya-Riera
    Laboratory of Nutritional Immunology and Molecular Nutrition, Department of Human Nutrition, Foods and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA
    Gastroenterology 127:777-91. 2004
    ..We used a loss-of-function approach to investigate whether CLA ameliorated colitis through a peroxisome proliferator-activated receptor gamma (PPAR gamma)-dependent mechanism...
  22. ncbi request reprint Activation of PPAR gamma and alpha by punicic acid ameliorates glucose tolerance and suppresses obesity-related inflammation
    Raquel Hontecillas
    Laboratory of Nutritional Immunology and Molecular Nutrition, Virginia Bioinformatics Institute, Virginia Tech, 1 Washington Street, Blacksburg, VA 24061, USA
    J Am Coll Nutr 28:184-95. 2009
    ..The objective of this study was to test the hypothesis that PUA activates PPAR gamma and thereby ameliorates glucose homeostasis and obesity-related inflammation...
  23. pmc The role of T cell PPAR gamma in mice with experimental inflammatory bowel disease
    Amir J Guri
    Nutritional Immunology and Molecular Nutrition Laboratory, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    BMC Gastroenterol 10:60. 2010
    ..The objective of this study was to investigate the mechanisms by which the deletion of PPAR gamma in T cells modulates immune cell distribution and colonic gene expression and the severity of experimental IBD...
  24. pmc Computational modeling-based discovery of novel classes of anti-inflammatory drugs that target lanthionine synthetase C-like protein 2
    Pinyi Lu
    Center for Modeling Immunity to Enteric Pathogens, Virginia Tech, Blacksburg, Virginia, United States of America
    PLoS ONE 7:e34643. 2012
    ..Recently, LANCL2 is a target for the binding and signaling of abscisic acid (ABA), a plant hormone with anti-diabetic and anti-inflammatory effects...
  25. pmc Immunoregulatory actions of epithelial cell PPAR gamma at the colonic mucosa of mice with experimental inflammatory bowel disease
    Saroj K Mohapatra
    Nutritional Immunology and Molecular Nutrition Laboratory, Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America
    PLoS ONE 5:e10215. 2010
    ..The objective of this study was to investigate the effect of targeted deletion of PPAR gamma in IEC on progression of experimental inflammatory bowel disease (IBD)...
  26. pmc Conjugated linoleic acid ameliorates inflammation-induced colorectal cancer in mice through activation of PPARgamma
    Nicholas P Evans
    Nutritional Immunology and Molecular Nutrition Laboratory, Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    J Nutr 140:515-21. 2010
    ..This study suggests CLA ameliorates colitis and prevents tumor formation in part through a PPARgamma-dependent mechanism...
  27. pmc The role of peroxisome proliferator-activated receptor γ in immune responses to enteroaggregative Escherichia coli infection
    Casandra W Philipson
    Nutritional Immunology and Molecular Medicine Laboratory, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America
    PLoS ONE 8:e57812. 2013
    ..This study presents a new mouse model and investigates the role of peroxisome proliferator-activated receptor gamma (PPARγ) in the modulation of host responses to EAEC in nourished and malnourished mice...
  28. pmc Abscisic acid regulates inflammation via ligand-binding domain-independent activation of peroxisome proliferator-activated receptor gamma
    Josep Bassaganya-Riera
    Nutritional Immunology and Molecular Medicine Group, Virginia Bioinformatics Institute, Blacksburg, Virginia 24061, USA
    J Biol Chem 286:2504-16. 2011
    ..In conclusion, ABA decreases LPS-mediated inflammation and regulates innate immune responses through a bifurcating pathway involving LANCL2 and an alternative, ligand-binding domain-independent mechanism of PPAR γ activation...
  29. pmc Predictive computational modeling of the mucosal immune responses during Helicobacter pylori infection
    Adria Carbo
    Nutritional Immunology and Molecular Medicine Laboratory, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America Center for Modeling Immunity to Enteric Pathogens Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America
    PLoS ONE 8:e73365. 2013
    ..These integrated immunoinformatics approaches characterized the induction of mucosal effector and regulatory pathways controlled by PPARγ during H. pylori infection affecting disease outcomes. ..
  30. pmc Dietary abscisic acid ameliorates influenza-virus-associated disease and pulmonary immunopathology through a PPARγ-dependent mechanism
    Raquel Hontecillas
    Nutritional Immunology and Molecular Medicine Laboratory www nimml org, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, VA 24061, USA
    J Nutr Biochem 24:1019-27. 2013
    ..Our results show that ABA, given preventively or therapeutically, ameliorates influenza-virus-induced pathology by activating PPARγ in pulmonary immune cells, suppressing initial proinflammatory responses and promoting resolution...
  31. ncbi request reprint Dietary abscisic acid ameliorates glucose tolerance and obesity-related inflammation in db/db mice fed high-fat diets
    Amir J Guri
    Laboratory of Nutritional Immunology and Molecular Nutrition, Department of Human Nutrition, Foods and Exercise, Virginia Polytechnic Institute and State University, 319 Wallace Hall, Blacksburg, VA 24061, USA
    Clin Nutr 26:107-16. 2007
    ..We have investigated whether abscisic acid (ABA), a naturally occurring phytochemical with structural similarities to TZDs, could be used as an alternative to TZDs to improve glucose homeostasis...
  32. ncbi request reprint Catalpic acid decreases abdominal fat deposition, improves glucose homeostasis and upregulates PPAR alpha expression in adipose tissue
    Raquel Hontecillas
    Laboratory of Nutritional Immunology and Molecular Nutrition, Virginia Bioinformatics Institute, Virginia Tech, VA, USA
    Clin Nutr 27:764-72. 2008
    ..The objective of this study was to investigate whether CAT decreases obesity and ameliorates insulin sensitivity and glucose tolerance in mice fed high-fat diets...
  33. ncbi request reprint Loss of PPAR gamma in immune cells impairs the ability of abscisic acid to improve insulin sensitivity by suppressing monocyte chemoattractant protein-1 expression and macrophage infiltration into white adipose tissue
    Amir J Guri
    Laboratory of Nutritional Immunology and Molecular Nutrition, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    J Nutr Biochem 19:216-28. 2008
    ..We provide molecular evidence in vivo demonstrating that ABA improves insulin sensitivity and obesity-related inflammation by inhibiting MCP-1 expression and F4/80(hi) ATM infiltration through a PPARgamma-dependent mechanism...
  34. pmc Helicobacter pylori infection in a pig model is dominated by Th1 and cytotoxic CD8+ T cell responses
    Barbara Kronsteiner
    Nutritional Immunology and Molecular Medicine Laboratory and Center for Modeling Immunity to Enteric Pathogens, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, USA
    Infect Immun 81:3803-13. 2013
    ..This novel pig model of infection closely mimics human gastric pathology and presents a suitable avenue for studying effector and regulatory responses toward H. pylori described in humans. ..
  35. pmc Abscisic acid synergizes with rosiglitazone to improve glucose tolerance and down-modulate macrophage accumulation in adipose tissue: possible action of the cAMP/PKA/PPAR γ axis
    Amir J Guri
    Nutritional Immunology and Molecular Nutrition Laboratory, Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    Clin Nutr 29:646-53. 2010
    ....
  36. pmc ENteric Immunity SImulator: a tool for in silico study of gastroenteric infections
    Katherine V Wendelsdorf
    Network Dynamics and Simulation Science Laboratory, and Center for Modeling Immunity to Enteric Pathogens, Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    IEEE Trans Nanobioscience 11:273-88. 2012
    ....
  37. pmc CD4+ T-cell responses and distribution at the colonic mucosa during Brachyspira hyodysenteriae-induced colitis in pigs
    Raquel Hontecillas
    Immunobiology Program, Laboratory of Nutritional Immunology and Molecular Nutrition, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    Immunology 115:127-35. 2005
    ..These results indicate that infection with B. hyodysenteriae induces a mucosal CD4(+) T-cell response and points to CD4(+) T cells being important contributors to the immunopathogenesis of swine dysentery...
  38. pmc Nutritional protective mechanisms against gut inflammation
    Monica Viladomiu
    Nutritional Immunology and Molecular Medicine Laboratory, Virginia Bioinformatics Institute, Blacksburg, VA 24060, USA
    J Nutr Biochem 24:929-39. 2013
    ....
  39. pmc Model of colonic inflammation: immune modulatory mechanisms in inflammatory bowel disease
    Katherine Wendelsdorf
    Virginia Bioinformatics Institute, Virginia Polytechnic Institute and University, Washington Street, MC 0477 Blacksburg, VA 24061, USA
    J Theor Biol 264:1225-39. 2010
    ..In addition, we propose that the primary mechanism behind the association of PPARgamma mutation with IBD is its ability to mediate the M1 to M2 switch...
  40. ncbi request reprint Nutritional regulation of porcine bacterial-induced colitis by conjugated linoleic acid
    Raquel Hontecillas
    Veterinary Medical Research Institute, Nutritional Immunology, College of Veterinary Medicine, Ames, IA 50011, USA
    J Nutr 132:2019-27. 2002
    ..Therefore, CLA fed preventively before the onset of enteric disease attenuated inflammatory lesion development and growth failure...
  41. pmc Abscisic acid ameliorates atherosclerosis by suppressing macrophage and CD4+ T cell recruitment into the aortic wall
    Amir J Guri
    Nutritional Immunology and Molecular Nutrition Laboratory, Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    J Nutr Biochem 21:1178-85. 2010
    ..This is the first report showing that ABA prevents or ameliorates atherosclerosis-induced hypertension, immune cell recruitment into the aortic root wall and up-regulates aortic eNOS expression in ApoE(-/-) mice...
  42. doi request reprint Dietary modulators of peroxisome proliferator-activated receptors: implications for the prevention and treatment of metabolic syndrome
    Amir J Guri
    Laboratory of Nutritional Immunology and Molecular Nutrition, Department of Human Nutrition, Foods and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA
    J Nutrigenet Nutrigenomics 1:126-35. 2008
    ....
  43. pmc Modulation of hepatic PPAR expression during Ft LVS LPS-induced protection from Francisella tularensis LVS infection
    Saroj K Mohapatra
    Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    BMC Infect Dis 10:10. 2010
    ..It has been shown previously that administration of Francisella tularensis (Ft) Live Vaccine Strain (LVS) lipopolysaccharide (LPS) protects mice against subsequent challenge with Ft LVS and blunts the pro-inflammatory cytokine response...
  44. pmc Suppression of intestinal inflammation and inflammation-driven colon cancer in mice by dietary sphingomyelin: importance of peroxisome proliferator-activated receptor γ expression
    Joseph C Mazzei
    Department of Human Nutrition, Foods and Exercise, Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    J Nutr Biochem 22:1160-71. 2011
    ..In conclusion, dietary SM modulated inflammatory responses at the early stages of the disease by activating PPAR-γ, but its anticarcinogenic effects followed a PPAR-γ-independent pattern...
  45. pmc Dietary α-eleostearic acid ameliorates experimental inflammatory bowel disease in mice by activating peroxisome proliferator-activated receptor-γ
    Stephanie N Lewis
    Genetics, Bioinformatics, and Computational Biology Program, Virginia Tech, Blacksburg, Virginia, United States of America
    PLoS ONE 6:e24031. 2011
    ..For this project, compounds were screened to identify naturally occurring PPARγ agonists as a means to identify novel anti-inflammatory therapeutics for experimental assessment of efficacy...
  46. doi request reprint Dysregulated intracellular signaling and inflammatory gene expression during initial disease onset in Duchenne muscular dystrophy
    Nicholas P Evans
    Department of Human Nutrition, Foods and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA
    Am J Phys Med Rehabil 88:502-22. 2009
    ....
  47. doi request reprint Molecular modeling of lanthionine synthetase component C-like protein 2: a potential target for the discovery of novel type 2 diabetes prophylactics and therapeutics
    Pinyi Lu
    Genetics, Bioinformatics, and Computational Biology Program, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    J Mol Model 17:543-53. 2011
    ..The identification of a binding site for PPAR γ agonists will facilitate the high-throughput virtual screening of large compound libraries and may shed new light on alternative mechanisms of PPAR γ activation...
  48. pmc Green tea extract decreases muscle pathology and NF-kappaB immunostaining in regenerating muscle fibers of mdx mice
    Nicholas P Evans
    Department of Human Nutrition, Foods and Exercise, Virginia Polytechnic Institute and State University, 338 Wallace Hall, Blacksburg, VA 24061, USA
    Clin Nutr 29:391-8. 2010
    ..The purpose of this study was to determine if dystrophic muscle pathology and inflammation were decreased by pre-natal and early dietary intervention with green tea extract...
  49. ncbi request reprint Differential requirements for proliferation of CD4+ and gammadelta+ T cells to spirochetal antigens
    Raquel Hontecillas
    Immunobiology Program, Veterinary Medical Research Institute, Iowa State University, Ames, IA 50010, USA
    Cell Immunol 224:38-46. 2003
    ..We conclude that these differences are due, in part, to the enhanced gammadelta+ T cell responsiveness to IL-2...
  50. pmc Abscisic acid ameliorates experimental IBD by downregulating cellular adhesion molecule expression and suppressing immune cell infiltration
    Amir J Guri
    Laboratory of Nutritional Immunology and Molecular Nutrition, Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    Clin Nutr 29:824-31. 2010
    ..The objective of this study was to determine whether ABA prevents or ameliorates experimental inflammatory bowel disease (IBD)...
  51. ncbi request reprint Peroxisome proliferator-activated receptor gamma is required for regulatory CD4+ T cell-mediated protection against colitis
    Raquel Hontecillas
    Laboratory of Nutritional Immunology and Molecular Nutrition, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    J Immunol 178:2940-9. 2007
    ..In conclusion, our data suggest that endogenous PPAR-gamma activation represents a Treg intrinsic mechanism of down-regulation of effector CD4+ T cell function and prevention of colitis...
  52. pmc T cell PPARγ is required for the anti-inflammatory efficacy of abscisic acid against experimental IBD
    Amir J Guri
    Nutritional Immunology and Molecular Medicine Laboratory, Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    J Nutr Biochem 22:812-9. 2011
    ..We conclude that dietary ABA ameliorates experimental inflammatory bowel disease by enhancing T(reg) cell accumulation in the colonic lamina propria through a PPARγ-dependent mechanism...
  53. pmc Genistein induces pancreatic beta-cell proliferation through activation of multiple signaling pathways and prevents insulin-deficient diabetes in mice
    Zhuo Fu
    Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA 24060, USA
    Endocrinology 151:3026-37. 2010
    ..These results demonstrate that genistein may be a natural antidiabetic agent by directly modulating pancreatic beta-cell function via activation of the cAMP/PKA-dependent ERK1/2 signaling pathway...
  54. ncbi request reprint Peroxisome proliferator-activated receptors: bridging metabolic syndrome with molecular nutrition
    Amir J Guri
    Laboratory of Nutritional Immunology and Molecular Nutrition, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    Clin Nutr 25:871-85. 2006
    ....
  55. pmc Preclinical Studies of Amixicile, a Systemic Therapeutic Developed for Treatment of Clostridium difficile Infections That Also Shows Efficacy against Helicobacter pylori
    Paul S Hoffman
    Department of Medicine, Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, Virginia, USA Department of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, Virginia, USA
    Antimicrob Agents Chemother 58:4703-12. 2014
    ....
  56. pmc Animal models of enteroaggregative Escherichia coli infection
    Casandra W Philipson
    Nutritional Immunology and Molecular Medicine Laboratory Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, VA USA
    Gut Microbes 4:281-91. 2013
    ..Additionally, current animal models and their limitations will be discussed along with the value of applying systems-wide approaches such as computational modeling to study host-EAEC interactions. ..
  57. pmc Mutations to essential orphan response regulator HP1043 of Helicobacter pylori result in growth-stage regulatory defects
    Igor N Olekhnovich
    Department of Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, USA
    Infect Immun 81:1439-49. 2013
    ..Our studies show that mutations that affect DNA-binding affinity can be used to identify new members of the HP1043 regulon...
  58. doi request reprint Genetics and molecular specificity of sialylation of Histophilus somni lipooligosaccharide (LOS) and the effect of LOS sialylation on Toll-like receptor-4 signaling
    Michael D Howard
    Virginia Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061, United States
    Vet Microbiol 153:163-72. 2011
    ..Therefore, sialylation inhibited LOS signaling through TLR-4. In conclusion, H. somni utilizes linkage-specific sialyltransferases to sialylate its LOS to avoid innate host defense mechanisms despite simultaneous epitope phase variation...
  59. pmc Immune-mediated mechanisms potentially regulate the disease time-course of duchenne muscular dystrophy and provide targets for therapeutic intervention
    Nicholas P Evans
    Department of Human Nutrition, Foods and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061 0002, USA
    PM R 1:755-68. 2009
    ....
  60. pmc The human-bacterial pathogen protein interaction networks of Bacillus anthracis, Francisella tularensis, and Yersinia pestis
    Matthew D Dyer
    Virginia Bioinformatics Institute, Blacksburg, Virginia, United States of America
    PLoS ONE 5:e12089. 2010
    ..However, the interactions between human proteins and proteins in these bacteria remain poorly characterized leading to an incomplete understanding of their pathogenesis and mechanisms of immune evasion...
  61. doi request reprint PPAR-gamma activation as an anti-inflammatory therapy for respiratory virus infections
    Josep Bassaganya-Riera
    Nutritional Immunology and Molecular Medicine Laboratory, Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA
    Viral Immunol 23:343-52. 2010
    ..This review focuses on the potential use of PPAR-gamma agonists to downregulate the inflammatory responses to respiratory virus-related pulmonary inflammation...
  62. pmc Deletion of PPAR-γ in immune cells enhances susceptibility to antiglomerular basement membrane disease
    Cristen Chafin
    Department of Biomedical Sciences and Pathobiology, Virginia Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA
    J Inflamm Res 3:127-34. 2010
    ..Taken together, these studies show that the lack of PPAR-γ expression enhances inflammatory renal disease in the anti-GBM antibody-induced glomerulonephritis mouse model and suggests targeting PPAR-γ may have therapeutic efficacy...
  63. doi request reprint Early evidence of increased risk for metabolic syndrome in young men with latent obstructive sleep apnea
    Stephen Guill
    Laboratory for Health and Exercise Science, Department of Human Nutrition, Foods, and Exercise, Virginia Tech, Blacksburg, Virginia 24061, USA
    Metab Syndr Relat Disord 8:33-8. 2010
    ..Although OSA appears to increase risk for metabolic syndrome in middle-aged adults, no data currently exist in a younger, preclinical cohort...
  64. ncbi request reprint Putting the pieces of the puzzle together - a series of hypotheses on the etiology and pathogenesis of type 1 diabetes
    William E Barbeau
    Department of Human Nutrition, Foods and Exercise, Virginia Polytechnic Institute and State University Virginia Tech, 327 Wallace Hall, Blacksburg, VA 24061 0430, USA
    Med Hypotheses 68:607-19. 2007
    ....
  65. pmc Host-interactive genes in Amerindian Helicobacter pylori diverge from their Old World homologs and mediate inflammatory responses
    S P Mane
    Virginia Bioinformatics Institute, Virginia Tech, 1 Washington Street, Blacksburg, VA 24060, USA
    J Bacteriol 192:3078-92. 2010
    ..Thus, the unusual V225d cag architecture was fully functional via conserved elements, but the natural deletion of 13 cag pathogenicity island genes and the truncation of CagA impaired the ability to induce inflammation...
  66. ncbi request reprint Immunomodulatory properties of conjugated linoleic acid
    Marianne O'Shea
    Loders Croklaan, Lipid Nutrition, Channahon, IL 60410, USA
    Am J Clin Nutr 79:1199S-1206S. 2004
    ....

Research Grants4

  1. Mechanisms of Immune Modulation by Abscisic Acid
    Josep Bassaganya Riera; Fiscal Year: 2007
    ..The mechanistic understanding of the immune modulatory properties of botanicals such as ABA will aid in the development of more efficacious CAM approaches for modulating immune function and ameliorating infectious diseases. ..
  2. Mechanisms of Immune Modulation by Abscisic Acid
    Josep Bassaganya Riera; Fiscal Year: 2009
    ..The mechanistic understanding of the immune modulatory properties of botanicals such as ABA will aid in the development of more efficacious CAM approaches for modulating immune function and ameliorating infectious diseases. ..
  3. Mechanisms of Immune Modulation by Abscisic Acid
    Josep Bassaganya Riera; Fiscal Year: 2010
    ..The mechanistic understanding of the immune modulatory properties of botanicals such as ABA will aid in the development of more efficacious CAM approaches for modulating immune function and ameliorating infectious diseases. ..