J S Bajaj

Summary

Affiliation: Virginia Commonwealth University
Country: USA

Publications

  1. doi request reprint Review article: the modern management of hepatic encephalopathy
    J S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, VA 23249, USA
    Aliment Pharmacol Ther 31:537-47. 2010
  2. ncbi request reprint Cirrhosis, bile acids and gut microbiota: unraveling a complex relationship
    Jason M Ridlon
    Department of Microbiology and Immunology Virginia Commonwealth University Richmond, VA USA McGuire VA Medical Center Richmond, VA USA
    Gut Microbes 4:382-7. 2013
  3. ncbi request reprint Altered profile of human gut microbiome is associated with cirrhosis and its complications
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, VA, United States Electronic address
    J Hepatol 60:940-7. 2014
  4. pmc Cognitive dysfunction is associated with poor socioeconomic status in patients with cirrhosis: an international multicenter study
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, Virginia Electronic address
    Clin Gastroenterol Hepatol 11:1511-6. 2013
  5. pmc Non-selective beta-blockers are not associated with serious infections in veterans with cirrhosis
    J S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire Veterans Affairs Medical Center, Richmond, VA 23249, USA
    Aliment Pharmacol Ther 38:407-14. 2013
  6. pmc Modulation of the metabiome by rifaximin in patients with cirrhosis and minimal hepatic encephalopathy
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire Veterans Affairs Medical Center, Richmond, Virginia, United States of America
    PLoS ONE 8:e60042. 2013
  7. pmc Proton pump inhibitors are associated with a high rate of serious infections in veterans with decompensated cirrhosis
    J S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire Veterans Affairs Medical Center, Richmond, VA, USA
    Aliment Pharmacol Ther 36:866-74. 2012
  8. pmc Second infections independently increase mortality in hospitalized patients with cirrhosis: the North American consortium for the study of end-stage liver disease (NACSELD) experience
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, VA 23249, USA
    Hepatology 56:2328-35. 2012
  9. pmc Asymmetric dimethylarginine is strongly associated with cognitive dysfunction and brain MR spectroscopic abnormalities in cirrhosis
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, VA 23249, USA
    J Hepatol 58:38-44. 2013
  10. pmc Cognitive performance as a predictor of hepatic encephalopathy in pretransplant patients with cirrhosis receiving psychoactive medications: a prospective study
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University McGuire VA Medical Center, Richmond, VA 23249, USA
    Liver Transpl 18:1179-87. 2012

Detail Information

Publications23

  1. doi request reprint Review article: the modern management of hepatic encephalopathy
    J S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, VA 23249, USA
    Aliment Pharmacol Ther 31:537-47. 2010
    ..BACKGROUND; Hepatic encephalopathy, both overt and minimal, forms a continuum of cognitive change in cirrhosis. Strategies to diagnose and treat hepatic encephalopathy have evolved considerably...
  2. ncbi request reprint Cirrhosis, bile acids and gut microbiota: unraveling a complex relationship
    Jason M Ridlon
    Department of Microbiology and Immunology Virginia Commonwealth University Richmond, VA USA McGuire VA Medical Center Richmond, VA USA
    Gut Microbes 4:382-7. 2013
    ..The balance between this equilibrium is critical for human health and disease. ..
  3. ncbi request reprint Altered profile of human gut microbiome is associated with cirrhosis and its complications
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, VA, United States Electronic address
    J Hepatol 60:940-7. 2014
    ..We aimed to study changes in the microbiome over cirrhosis severity, its stability over time and its longitudinal alterations with decompensation...
  4. pmc Cognitive dysfunction is associated with poor socioeconomic status in patients with cirrhosis: an international multicenter study
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, Virginia Electronic address
    Clin Gastroenterol Hepatol 11:1511-6. 2013
    ..We investigated the association between SES and cognition in a multicenter study of cirrhosis...
  5. pmc Non-selective beta-blockers are not associated with serious infections in veterans with cirrhosis
    J S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire Veterans Affairs Medical Center, Richmond, VA 23249, USA
    Aliment Pharmacol Ther 38:407-14. 2013
    ..Studies evaluating outcomes associated with non-selective beta-blockers (NSBB) in cirrhosis have yielded mixed results. A major cause of death in decompensated cirrhosis is infection...
  6. pmc Modulation of the metabiome by rifaximin in patients with cirrhosis and minimal hepatic encephalopathy
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire Veterans Affairs Medical Center, Richmond, Virginia, United States of America
    PLoS ONE 8:e60042. 2013
    ..Aim To perform a systems biology analysis of the microbiome, metabolome and cognitive change after rifaximin in MHE...
  7. pmc Proton pump inhibitors are associated with a high rate of serious infections in veterans with decompensated cirrhosis
    J S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire Veterans Affairs Medical Center, Richmond, VA, USA
    Aliment Pharmacol Ther 36:866-74. 2012
    ..There is increasing evidence that proton pump inhibitors (PPIs) increase the rate of infections in patients with decompensated cirrhosis...
  8. pmc Second infections independently increase mortality in hospitalized patients with cirrhosis: the North American consortium for the study of end-stage liver disease (NACSELD) experience
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, VA 23249, USA
    Hepatology 56:2328-35. 2012
    ..The model for mortality included admission MELD (odds ratio [OR]: 1.12), heart rate (OR: 1.03) albumin (OR: 0.5), and second infection (OR: 4.42) as significant variables...
  9. pmc Asymmetric dimethylarginine is strongly associated with cognitive dysfunction and brain MR spectroscopic abnormalities in cirrhosis
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, VA 23249, USA
    J Hepatol 58:38-44. 2013
    ..We aimed at evaluating the association of ADMA with cognition and brain MR spectroscopy (MRS) in cirrhosis...
  10. pmc Cognitive performance as a predictor of hepatic encephalopathy in pretransplant patients with cirrhosis receiving psychoactive medications: a prospective study
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University McGuire VA Medical Center, Richmond, VA 23249, USA
    Liver Transpl 18:1179-87. 2012
    ..In conclusion, cognitive tests (particularly the ICT) remain valid predictors of HE in the face of psychiatric diseases and medications. SSRI use is associated with better cognitive performance and a reduced likelihood of developing HE...
  11. pmc Colonic mucosal microbiome differs from stool microbiome in cirrhosis and hepatic encephalopathy and is linked to cognition and inflammation
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University, Richmond, 23249, USA
    Am J Physiol Gastrointest Liver Physiol 303:G675-85. 2012
    ....
  12. doi request reprint A longitudinal systems biology analysis of lactulose withdrawal in hepatic encephalopathy
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, 23249, USA
    Metab Brain Dis 27:205-15. 2012
    ..HE recurrence post-lactulose withdrawal can be predicted by baseline cognitive performance and is accompanied by disrupted choline metabolism...
  13. pmc Diagnosis and treatment of minimal hepatic encephalopathy to prevent motor vehicle accidents: a cost-effectiveness analysis
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, VA 23249, USA
    Hepatology 55:1164-71. 2012
    ..Conclusion: Detection of MHE, especially using the ICT, and subsequent treatment with lactulose could substantially reduce societal costs by preventing MVAs...
  14. doi request reprint Predictors of the recurrence of hepatic encephalopathy in lactulose-treated patients
    J S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, VA 23249, USA
    Aliment Pharmacol Ther 31:1012-7. 2010
    ..Lactulose is considered first-line therapy for hepatic encephalopathy. However, the effect of adherence with lactulose on recurrence of hepatic encephalopathy outside clinical trials remains unclear...
  15. pmc Persistence of cognitive impairment after resolution of overt hepatic encephalopathy
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, Virginia 23249, USA
    Gastroenterology 138:2332-40. 2010
    ..In patients with cirrhosis, hepatic encephalopathy (HE) has acute but reversible as well as chronic components. We investigated the extent of residual cognitive impairment following clinical resolution of overt HE (OHE)...
  16. pmc Rifaximin improves driving simulator performance in a randomized trial of patients with minimal hepatic encephalopathy
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, Virginia 23249, USA
    Gastroenterology 140:478-487.e1. 2011
    ..We evaluated whether performance on a driving simulator improves in patients with MHE after treatment with rifaximin...
  17. doi request reprint Review article: the design of clinical trials in hepatic encephalopathy--an International Society for Hepatic Encephalopathy and Nitrogen Metabolism (ISHEN) consensus statement
    J S Bajaj
    Virginia Commonwealth University and McGuire VA Medical Center, 1201 Broad Rock Boulevard, Richmond, VA 23249, USA
    Aliment Pharmacol Ther 33:739-47. 2011
    ..The clinical classification of hepatic encephalopathy is largely subjective, which has led to difficulties in designing trials in this field...
  18. doi request reprint The multi-dimensional burden of cirrhosis and hepatic encephalopathy on patients and caregivers
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University, McGuire VA Medical Center, Richmond, Virginia 23249, USA
    Am J Gastroenterol 106:1646-53. 2011
    ..The aim was to study the emotional and socioeconomic burden of cirrhosis and HE on patients and informal caregivers...
  19. doi request reprint Driving simulation can improve insight into impaired driving skills in cirrhosis
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, 1201 Broad Rock Boulevard, Richmond, VA 23249, USA
    Dig Dis Sci 57:554-60. 2012
    ..Minimal hepatic encephalopathy (MHE) is associated with poor driving skills and insight. Increasing insight may improve receptiveness for therapy or driving restrictions...
  20. doi request reprint PROMIS computerised adaptive tests are dynamic instruments to measure health-related quality of life in patients with cirrhosis
    J S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University, McGuire VA Medical Center, Richmond, 23249, USA
    Aliment Pharmacol Ther 34:1123-32. 2011
    ..CAT presents five to seven questions/domain depending on the patient's response, from large validated question banks. This provides brevity and precision equivalent to the entire question bank...
  21. pmc Linkage of gut microbiome with cognition in hepatic encephalopathy
    Jasmohan S Bajaj
    Div of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth Univ and McGuire VA Medical Ctr, 1201, Broad Rock Blvd, Richmond, VA 23249, USA
    Am J Physiol Gastrointest Liver Physiol 302:G168-75. 2012
    ..Specific bacterial families (Alcaligeneceae, Porphyromonadaceae, Enterobacteriaceae) are strongly associated with cognition and inflammation in HE...
  22. pmc Modified-orientation log to assess hepatic encephalopathy
    M Salam
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University, Richmond, USA
    Aliment Pharmacol Ther 35:913-20. 2012
    ..The new HE classification has emphasised assessment of orientation. The modified-orientation log (MO-log, eight questions, scores 0-24; 24 normal) is adapted from a validated brain injury measure...
  23. ncbi request reprint Randomised clinical trial: Lactobacillus GG modulates gut microbiome, metabolome and endotoxemia in patients with cirrhosis
    J S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VAMC, Richmond, VA, USA
    Aliment Pharmacol Ther 39:1113-25. 2014
    ..Safety of individual probiotic strains approved under Investigational New Drug (IND) policies in cirrhosis with minimal hepatic encephalopathy (MHE) is not clear...