Karolina Aberg

Summary

Affiliation: Virginia Commonwealth University
Country: USA

Publications

  1. ncbi request reprint Testing two models describing how methylome-wide studies in blood are informative for psychiatric conditions
    Karolina A Aberg
    Center for Biomarker Research and Personalized Medicine, School of Pharmacy, Virginia Commonwealth University, 1112 East Clay Street, PO Box 980533, Richmond, VA 23298, USA
    Epigenomics 5:367-77. 2013
  2. pmc High quality methylome-wide investigations through next-generation sequencing of DNA from a single archived dry blood spot
    Karolina A Aberg
    Center for Biomarker Research and Personalized Medicine, School of Pharmacy, Virginia Commonwealth University, Richmond, VA, USA
    Epigenetics 8:542-7. 2013
  3. pmc Estimation of CpG coverage in whole methylome next-generation sequencing studies
    Edwin J C G van den Oord
    Center for Biomarker Research and Personalized Medicine, School of Pharmacy, Virginia Commonwealth University, 1112 East Clay Street, P O Box 980533, Richmond, VA 23298, USA
    BMC Bioinformatics 14:50. 2013
  4. pmc MethylPCA: a toolkit to control for confounders in methylome-wide association studies
    Wenan Chen
    Department of Biostatistics, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA
    BMC Bioinformatics 14:74. 2013
  5. pmc Methylome-wide comparison of human genomic DNA extracted from whole blood and from EBV-transformed lymphocyte cell lines
    Karolina Aberg
    Center for Biomarker Research and Personalized Medicine, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298, USA
    Eur J Hum Genet 20:953-5. 2012
  6. pmc Genome-wide association study of antipsychotic-induced QTc interval prolongation
    K Aberg
    Center for Biomarker Research and Personalized Medicine, School of Pharmacy, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA 23298, USA
    Pharmacogenomics J 12:165-72. 2012
  7. pmc Suggestive linkage detected for blood pressure related traits on 2q and 22q in the population on the Samoan islands
    Karolina Aberg
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto St, Pittsburgh, PA 15261, USA
    BMC Med Genet 10:107. 2009
  8. pmc Genomewide association study of movement-related adverse antipsychotic effects
    Karolina Aberg
    Center for Biomarker Research and Personalized Medicine, School of Pharmacy, Medical College of Virginia of Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Biol Psychiatry 67:279-82. 2010
  9. doi request reprint Genome-wide association study of patient-rated and clinician-rated global impression of severity during antipsychotic treatment
    Shaunna L Clark
    Center for Biomarker Research and Personalized Medicine, School of Pharmacy, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298 0581, USA
    Pharmacogenet Genomics 23:69-77. 2013
  10. pmc Susceptibility loci for adiposity phenotypes on 8p, 9p, and 16q in American Samoa and Samoa
    Karolina Aberg
    Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Obesity (Silver Spring) 17:518-24. 2009

Detail Information

Publications15

  1. ncbi request reprint Testing two models describing how methylome-wide studies in blood are informative for psychiatric conditions
    Karolina A Aberg
    Center for Biomarker Research and Personalized Medicine, School of Pharmacy, Virginia Commonwealth University, 1112 East Clay Street, PO Box 980533, Richmond, VA 23298, USA
    Epigenomics 5:367-77. 2013
    ..Despite the treatment inducing a large number of methylation changes, this correlation remains high...
  2. pmc High quality methylome-wide investigations through next-generation sequencing of DNA from a single archived dry blood spot
    Karolina A Aberg
    Center for Biomarker Research and Personalized Medicine, School of Pharmacy, Virginia Commonwealth University, Richmond, VA, USA
    Epigenetics 8:542-7. 2013
    ..In general, the amount of DNA extracted from a single blood spot is sufficient for methylome-wide investigations with the MBD-seq approach. ..
  3. pmc Estimation of CpG coverage in whole methylome next-generation sequencing studies
    Edwin J C G van den Oord
    Center for Biomarker Research and Personalized Medicine, School of Pharmacy, Virginia Commonwealth University, 1112 East Clay Street, P O Box 980533, Richmond, VA 23298, USA
    BMC Bioinformatics 14:50. 2013
    ..This hampers several aspects of the data analysis such as the calculation of enrichment measures that are based on the number of fragments covering the CpGs...
  4. pmc MethylPCA: a toolkit to control for confounders in methylome-wide association studies
    Wenan Chen
    Department of Biostatistics, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA
    BMC Bioinformatics 14:74. 2013
    ..This approach is, however, computationally very challenging due to the extremely large number of methylation sites in the human genome...
  5. pmc Methylome-wide comparison of human genomic DNA extracted from whole blood and from EBV-transformed lymphocyte cell lines
    Karolina Aberg
    Center for Biomarker Research and Personalized Medicine, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298, USA
    Eur J Hum Genet 20:953-5. 2012
    ..2 × 10(-16)). Our study shows that there are substantial differences in the DNA methylation patterns between LCL and WB. Thus, LCL DNA should not be used as a proxy for WB DNA in methylome-wide studies...
  6. pmc Genome-wide association study of antipsychotic-induced QTc interval prolongation
    K Aberg
    Center for Biomarker Research and Personalized Medicine, School of Pharmacy, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA 23298, USA
    Pharmacogenomics J 12:165-72. 2012
    ..However, some genes may also be unique for drug-induced prolongation. This study demonstrates the potential of GWAS to discover genes and pathways that mediate antipsychotic-induced QT prolongation...
  7. pmc Suggestive linkage detected for blood pressure related traits on 2q and 22q in the population on the Samoan islands
    Karolina Aberg
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto St, Pittsburgh, PA 15261, USA
    BMC Med Genet 10:107. 2009
    ..We adjusted the traits for a number of environmental covariates such as smoking, alcohol consumption, physical activity and material life style...
  8. pmc Genomewide association study of movement-related adverse antipsychotic effects
    Karolina Aberg
    Center for Biomarker Research and Personalized Medicine, School of Pharmacy, Medical College of Virginia of Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Biol Psychiatry 67:279-82. 2010
    ..Understanding individual differences in the development of extrapyramidal side effects (EPS) as a response to antipsychotic therapy is essential to individualize treatment...
  9. doi request reprint Genome-wide association study of patient-rated and clinician-rated global impression of severity during antipsychotic treatment
    Shaunna L Clark
    Center for Biomarker Research and Personalized Medicine, School of Pharmacy, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298 0581, USA
    Pharmacogenet Genomics 23:69-77. 2013
    ..To examine the unique and congruent findings between multiple raters in a genome-wide association study (GWAS) in the context of understanding individual differences in treatment response during antipsychotic therapy for schizophrenia...
  10. pmc Susceptibility loci for adiposity phenotypes on 8p, 9p, and 16q in American Samoa and Samoa
    Karolina Aberg
    Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Obesity (Silver Spring) 17:518-24. 2009
    ..These results strongly encourage further genetic studies of adiposity-related phenotypes where extended sets of carefully measured environmental factors are taken into account...
  11. pmc Applying novel genome-wide linkage strategies to search for loci influencing type 2 diabetes and adult height in American Samoa
    Karolina Aberg
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, A300 Crabtree Hall, 130 DeSoto St, Pittsburgh, PA 15261, USA
    Hum Biol 80:99-123. 2008
    ..Our finding suggests that the 9q31 region may be a strong quantitative trait locus for adult height, which is likely to be of importance across populations...
  12. pmc Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia
    Joseph L McClay
    Center for Biomarker Research and Personalized Medicine, School of Pharmacy, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298 0533, USA
    Neuropsychopharmacology 36:616-26. 2011
    ..This study has generated several novel candidate genes for antipsychotic response. However, our findings will require replication and functional validation. To facilitate replication efforts, we provide all GWAS p-values for download...
  13. pmc A genome-wide linkage scan identifies multiple chromosomal regions influencing serum lipid levels in the population on the Samoan islands
    Karolina Aberg
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    J Lipid Res 49:2169-78. 2008
    ..In conclusion, chromosome 6p and 12q may host promising susceptibility loci influencing lipid levels; however, the low degree of overlap between the three study samples strongly encourages further studies of the lipid-related traits...
  14. pmc Genotype-based ancestral background consistently predicts efficacy and side effects across treatments in CATIE and STAR*D
    DANIEL E ADKINS
    Center for Biomarker Research and Personalized Medicine, School of Pharmacy, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, USA
    PLoS ONE 8:e55239. 2013
    ..As relatively few new psychiatric drugs are currently under development, such personalized medicine offers a promising approach toward optimizing pharmacotherapy for psychiatric conditions...
  15. pmc Merging microsatellite data: enhanced methodology and software to combine genotype data for linkage and association analysis
    Angela P Presson
    Department of Human Genetics, University of California, Los Angeles, CA 90095, USA
    BMC Bioinformatics 9:317. 2008
    ..A consequence of such alignments is that codominant genotypes must often be analyzed as phenotypes. In this paper we describe several extensions that are implemented in MicroMerge version 2 (v2)...