Donald A Vessey
- Vessey D, Li L, Kelley M. Pannexin-I/P2X 7 purinergic receptor channels mediate the release of cardioprotectants induced by ischemic pre- and postconditioning. J Cardiovasc Pharmacol Ther. 2010;15:190-5 pubmed publisher..Inhibitors of other P2X receptors, P2Y receptors, or connexins did not affect IPC. We conclude that a pannexin-1/P2X(7) channel is responsible for the release of cardioprotectants induced by ischemic pre- and postconditioning. ..
- Vessey D, Li L, Kelley M. Ischemic preconditioning requires opening of pannexin-1/P2X(7) channels not only during preconditioning but again after index ischemia at full reperfusion. Mol Cell Biochem. 2011;351:77-84 pubmed publisher..This correlates with an inability to generate phospho-Akt at reperfusion. IPC prevents this loss and thereby primes the cell for response to cardioprotectants released at full reperfusion. ..
- Vessey D, Li L, Kelley M. P2X7 receptor agonists pre- and postcondition the heart against ischemia-reperfusion injury by opening pannexin-1/P2X? channels. Am J Physiol Heart Circ Physiol. 2011;301:H881-7 pubmed publisher..The data point out for the first time the potential of P2X(7) agonists as cardioprotectants. ..
- Vessey D, Li L, Jin Z, Kelley M, Honbo N, Zhang J, et al. A sphingosine kinase form 2 knockout sensitizes mouse myocardium to ischemia/reoxygenation injury and diminishes responsiveness to ischemic preconditioning. Oxid Med Cell Longev. 2011;2011:961059 pubmed publisher..Thus, deletion of the SphK2 gene sensitizes the myocardium to IR injury and diminishes the protective effect of IPC. ..