Donald A Vessey

Summary

Country: USA

Publications

  1. Vessey D, Li L, Kelley M. Pannexin-I/P2X 7 purinergic receptor channels mediate the release of cardioprotectants induced by ischemic pre- and postconditioning. J Cardiovasc Pharmacol Ther. 2010;15:190-5 pubmed publisher
    ..Inhibitors of other P2X receptors, P2Y receptors, or connexins did not affect IPC. We conclude that a pannexin-1/P2X(7) channel is responsible for the release of cardioprotectants induced by ischemic pre- and postconditioning. ..
  2. Vessey D, Li L, Kelley M. Ischemic preconditioning requires opening of pannexin-1/P2X(7) channels not only during preconditioning but again after index ischemia at full reperfusion. Mol Cell Biochem. 2011;351:77-84 pubmed publisher
    ..This correlates with an inability to generate phospho-Akt at reperfusion. IPC prevents this loss and thereby primes the cell for response to cardioprotectants released at full reperfusion. ..
  3. Vessey D, Li L, Kelley M. P2X7 receptor agonists pre- and postcondition the heart against ischemia-reperfusion injury by opening pannexin-1/P2X? channels. Am J Physiol Heart Circ Physiol. 2011;301:H881-7 pubmed publisher
    ..The data point out for the first time the potential of P2X(7) agonists as cardioprotectants. ..
  4. Vessey D, Li L, Jin Z, Kelley M, Honbo N, Zhang J, et al. A sphingosine kinase form 2 knockout sensitizes mouse myocardium to ischemia/reoxygenation injury and diminishes responsiveness to ischemic preconditioning. Oxid Med Cell Longev. 2011;2011:961059 pubmed publisher
    ..Thus, deletion of the SphK2 gene sensitizes the myocardium to IR injury and diminishes the protective effect of IPC. ..

Detail Information

Publications4

  1. Vessey D, Li L, Kelley M. Pannexin-I/P2X 7 purinergic receptor channels mediate the release of cardioprotectants induced by ischemic pre- and postconditioning. J Cardiovasc Pharmacol Ther. 2010;15:190-5 pubmed publisher
    ..Inhibitors of other P2X receptors, P2Y receptors, or connexins did not affect IPC. We conclude that a pannexin-1/P2X(7) channel is responsible for the release of cardioprotectants induced by ischemic pre- and postconditioning. ..
  2. Vessey D, Li L, Kelley M. Ischemic preconditioning requires opening of pannexin-1/P2X(7) channels not only during preconditioning but again after index ischemia at full reperfusion. Mol Cell Biochem. 2011;351:77-84 pubmed publisher
    ..This correlates with an inability to generate phospho-Akt at reperfusion. IPC prevents this loss and thereby primes the cell for response to cardioprotectants released at full reperfusion. ..
  3. Vessey D, Li L, Kelley M. P2X7 receptor agonists pre- and postcondition the heart against ischemia-reperfusion injury by opening pannexin-1/P2X? channels. Am J Physiol Heart Circ Physiol. 2011;301:H881-7 pubmed publisher
    ..The data point out for the first time the potential of P2X(7) agonists as cardioprotectants. ..
  4. Vessey D, Li L, Jin Z, Kelley M, Honbo N, Zhang J, et al. A sphingosine kinase form 2 knockout sensitizes mouse myocardium to ischemia/reoxygenation injury and diminishes responsiveness to ischemic preconditioning. Oxid Med Cell Longev. 2011;2011:961059 pubmed publisher
    ..Thus, deletion of the SphK2 gene sensitizes the myocardium to IR injury and diminishes the protective effect of IPC. ..