C Lin

Summary

Affiliation: Vertex Pharmaceuticals
Country: USA

Publications

  1. pmc Development of a sensitive RT-PCR method for amplifying and sequencing near full-length HCV genotype 1 RNA from patient samples
    Eileen Z Zhang
    Vertex Pharmaceuticals Incorporated, 130 Waverly Street, Cambridge, MA 02139 4242, USA
    Virol J 10:53. 2013
  2. ncbi request reprint Discovery and development of VX-950, a novel, covalent, and reversible inhibitor of hepatitis C virus NS3.4A serine protease
    C Lin
    Departments of Infectious Diseases and Medicinal Chemistry, Vertex Pharmaceuticals Incorporated, 130 Waverly Street, Cambridge, MA 02139, USA
    Infect Disord Drug Targets 6:3-16. 2006
  3. ncbi request reprint In vitro resistance studies of hepatitis C virus serine protease inhibitors, VX-950 and BILN 2061: structural analysis indicates different resistance mechanisms
    Chao Lin
    Vertex Pharmaceuticals Inc, Cambridge, Massachusetts 02139, USA
    J Biol Chem 279:17508-14. 2004
  4. ncbi request reprint In vitro studies of cross-resistance mutations against two hepatitis C virus serine protease inhibitors, VX-950 and BILN 2061
    Chao Lin
    Vertex Pharmaceuticals Incorporated, Cambridge, Massachusetts 02139, USA
    J Biol Chem 280:36784-91. 2005
  5. ncbi request reprint Hepatitis C virus NS3 RNA helicase domain with a bound oligonucleotide: the crystal structure provides insights into the mode of unwinding
    J L Kim
    Vertex Pharmaceuticals Incorporated, Cambridge, Massachusetts 02139 4242, USA
    Structure 6:89-100. 1998
  6. pmc Structure-based mutagenesis study of hepatitis C virus NS3 helicase
    C Lin
    Vertex Pharmaceuticals Incorporated, Cambridge, Massachusetts 02139, USA
    J Virol 73:8798-807. 1999
  7. pmc The hepatitis C virus NS4A protein: interactions with the NS4B and NS5A proteins
    C Lin
    Vertex Pharmaceuticals Incorporated, Cambridge, Massachusetts 02139 4242, USA
    J Virol 71:6465-71. 1997
  8. pmc Bovine viral diarrhea virus NS3 serine proteinase: polyprotein cleavage sites, cofactor requirements, and molecular model of an enzyme essential for pestivirus replication
    J Xu
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, Missouri 63110 1093, USA
    J Virol 71:5312-22. 1997
  9. ncbi request reprint Progress in designing nucleic acid structures and fine-tuning their interactions
    H H Klump
    Department of Molecular and Cellular Biology, University of Cape Town, Rondebosch 7800, Private Bag, South Africa
    Arch Biochem Biophys 453:93-100. 2006
  10. ncbi request reprint Autocrine stimulation by erythropoietin in transgenic mice results in erythroid proliferation without neoplastic transformation
    A Madan
    Division of Neonatology, Department of Pediatrics, Stanford School of Medicine, CA 94305, USA
    Blood Cells Mol Dis 30:82-9. 2003

Collaborators

  • Kai Lin
  • B Govinda Rao
  • Robert B Perni
  • Ann D Kwong
  • Jinsheng Xu
  • J L Kim
  • H H Klump
  • Akihiko Ito
  • Tomoyoshi Soga
  • Y Yan
  • Eileen Z Zhang
  • A Madan
  • M Kato
  • Doug J Bartels
  • Tara L Kieffer
  • Sheila Seepersaud
  • J Dan Frantz
  • Benjamin Shames
  • Yi Zhou
  • Judith A Lippke
  • J R Palamanda
  • F Cotton
  • K Hayasaka
  • M G Ramírez-Dueñas
  • T Ikegami
  • P T Curtin
  • Z Wang
  • R P Clement
  • L A Norton
  • L V Favreau
  • C N Casciano
  • A A Nomeir
  • P Cochaux
  • B Gulbis
  • J Parma
  • E Damis
  • S K Joseph
  • V Hansen
  • F Vertongen
  • T Kimura
  • S Kodama
  • T Morikawa
  • H Hirayabashi
  • P H St George-Hyslop
  • G A Ramirez-Casillas
  • I Nonaka
  • C A Leal
  • E A Rogaeva
  • J A Hernandez-Romo
  • J M Cantu
  • A Mochizuki
  • Y Shinohara
  • M Kurimura
  • A Itoh
  • A P Thomas
  • S Pierson
  • A R Maranto

Detail Information

Publications17

  1. pmc Development of a sensitive RT-PCR method for amplifying and sequencing near full-length HCV genotype 1 RNA from patient samples
    Eileen Z Zhang
    Vertex Pharmaceuticals Incorporated, 130 Waverly Street, Cambridge, MA 02139 4242, USA
    Virol J 10:53. 2013
    ..In order to assess these effects in patients, a Reverse Transcription Polymerase Chain Reaction (RT-PCR) method was developed to sequence these regions of HCV from patient plasma...
  2. ncbi request reprint Discovery and development of VX-950, a novel, covalent, and reversible inhibitor of hepatitis C virus NS3.4A serine protease
    C Lin
    Departments of Infectious Diseases and Medicinal Chemistry, Vertex Pharmaceuticals Incorporated, 130 Waverly Street, Cambridge, MA 02139, USA
    Infect Disord Drug Targets 6:3-16. 2006
    ..The median viral load reduction was 4.4 log(10) for the best dose group after 14 days of dosing. The pre-clinical profile and early clinical data of VX-950 will be discussed in this review...
  3. ncbi request reprint In vitro resistance studies of hepatitis C virus serine protease inhibitors, VX-950 and BILN 2061: structural analysis indicates different resistance mechanisms
    Chao Lin
    Vertex Pharmaceuticals Inc, Cambridge, Massachusetts 02139, USA
    J Biol Chem 279:17508-14. 2004
    ..Modeling analysis suggests that there are different mechanisms of resistance to VX-950 and BILN 2061...
  4. ncbi request reprint In vitro studies of cross-resistance mutations against two hepatitis C virus serine protease inhibitors, VX-950 and BILN 2061
    Chao Lin
    Vertex Pharmaceuticals Incorporated, Cambridge, Massachusetts 02139, USA
    J Biol Chem 280:36784-91. 2005
    ..Both cross-resistance mutations (A156V and A156T) displayed significantly diminished fitness (or replication capacity) in a transient replicon cell system...
  5. ncbi request reprint Hepatitis C virus NS3 RNA helicase domain with a bound oligonucleotide: the crystal structure provides insights into the mode of unwinding
    J L Kim
    Vertex Pharmaceuticals Incorporated, Cambridge, Massachusetts 02139 4242, USA
    Structure 6:89-100. 1998
    ..The structures of several helicases have been published but the structural details as to how ATP binding and hydrolysis are coupled to RNA unwinding are unknown...
  6. pmc Structure-based mutagenesis study of hepatitis C virus NS3 helicase
    C Lin
    Vertex Pharmaceuticals Incorporated, Cambridge, Massachusetts 02139, USA
    J Virol 73:8798-807. 1999
    ..Given the conservation of some of these residues in other DNA and RNA helicases, their role in the mechanism of unwinding of double-stranded nucleic acid is discussed...
  7. pmc The hepatitis C virus NS4A protein: interactions with the NS4B and NS5A proteins
    C Lin
    Vertex Pharmaceuticals Incorporated, Cambridge, Massachusetts 02139 4242, USA
    J Virol 71:6465-71. 1997
    ..Finally, the possible mechanisms by which these viral proteins interact with each other are discussed...
  8. pmc Bovine viral diarrhea virus NS3 serine proteinase: polyprotein cleavage sites, cofactor requirements, and molecular model of an enzyme essential for pestivirus replication
    J Xu
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, Missouri 63110 1093, USA
    J Virol 71:5312-22. 1997
    ..Finally, using a full-length functional BVDV cDNA clone, we demonstrate that a catalytically active NS3 serine proteinase is essential for pestivirus replication...
  9. ncbi request reprint Progress in designing nucleic acid structures and fine-tuning their interactions
    H H Klump
    Department of Molecular and Cellular Biology, University of Cape Town, Rondebosch 7800, Private Bag, South Africa
    Arch Biochem Biophys 453:93-100. 2006
    ..We call the reaction cycle that exemplifies our approach 'A handshake from a hairpin on the way to a double helix.'..
  10. ncbi request reprint Autocrine stimulation by erythropoietin in transgenic mice results in erythroid proliferation without neoplastic transformation
    A Madan
    Division of Neonatology, Department of Pediatrics, Stanford School of Medicine, CA 94305, USA
    Blood Cells Mol Dis 30:82-9. 2003
    ..These studies show that 5'HS-2 can be used to target Epo gene expression to erythroid tissue. These mice could provide a model system for studying autocrine growth regulation...
  11. ncbi request reprint [The antioxidative effect of procyanidins from pine bark in vitro]
    C Lin
    Medical College of Jinan University, Guangzhou 510632
    Zhong Yao Cai 24:882-4. 2001
    ..01). CONCLUSION: Procyanidins had good antioxidative function. It can prevent RBC membrane, plasmid DNA suffering from oxygen free radical damage in vitro...
  12. ncbi request reprint Mechanism-based inactivation of CYP2D6 by 5-fluoro-2-[4-[(2-phenyl-1H-imidazol-5-yl)methyl]-1-piperazinyl]pyrimidine
    J R Palamanda
    Department of Drug Metabolism and Pharmacokinetics, Schering-Plough Research Institute, Kenilworth, New Jersey 07033, USA
    Drug Metab Dispos 29:863-7. 2001
    ..These results demonstrate that SCH 66712 is a potent and fairly selective mechanism-based inhibitor of CYP2D6...
  13. ncbi request reprint Hb Ube-2 [alpha68(E17)Asn-Asp] and Hb Hafnia [beta116(G18)His-->Gln] observed during neonatal screening in Brussels
    F Cotton
    Department of Clinical Chemistry, Hopital Erasme, Universite Libre de Bruxelles, Brussels, Belgium
    Hemoglobin 24:65-9. 2000
  14. ncbi request reprint A novel mutation of the doublecortin gene in Japanese patients with X-linked lissencephaly and subcortical band heterotopia
    M Kato
    Department of Pediatrics, Yamagata University School of Medicine, Japan
    Hum Genet 104:341-4. 1999
    ..Although the number of cases studied remains limited, exon 5 may be a common mutational site in Japanese patients in contrast to many previous reports concerning exons 2 and 3...
  15. ncbi request reprint Four novel mutations of the connexin 32 gene in four Japanese families with Charcot-Marie-Tooth disease type 1
    T Ikegami
    Department of Pediatrics, Yamagata University School of Medicine, Japan
    Am J Med Genet 80:352-5. 1998
    ..Therefore, molecular analysis is useful for molecular pathology of their disease...
  16. ncbi request reprint A novel Leu171Pro mutation in presenilin-1 gene in a Mexican family with early onset Alzheimer disease
    M G Ramírez-Dueñas
    Departamento de Fisiologia, Universidad de Guadalajara, Jalisco, Mexico
    Ann Genet 41:149-53. 1998
    ..The pedigree analysis and the literature data strongly suggest an etiopathogenic relationship of the mutation with the disorder...
  17. ncbi request reprint Heteroligomers of type-I and type-III inositol trisphosphate receptors in WB rat liver epithelial cells
    S K Joseph
    Department of Pathology, Thomas Jefferson University School of Medicine, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 270:23310-6. 1995
    ..We conclude that the WB cell contains both type-I and type-III IP3R isoforms and that a proportion of these receptors exist as heterotetramers...