Research Topics
Species | C LinSummaryAffiliation: Vertex Pharmaceuticals Country: USA Publications
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Detail Information
Publications
Discovery and development of VX-950, a novel, covalent, and reversible inhibitor of hepatitis C virus NS3.4A serine proteaseC Lin
Departments of Infectious Diseases and Medicinal Chemistry, Vertex Pharmaceuticals Incorporated, 130 Waverly Street, Cambridge, MA 02139, USA
Infect Disord Drug Targets 6:3-16. 2006..The median viral load reduction was 4.4 log(10) for the best dose group after 14 days of dosing. The pre-clinical profile and early clinical data of VX-950 will be discussed in this review...- In vitro resistance studies of hepatitis C virus serine protease inhibitors, VX-950 and BILN 2061: structural analysis indicates different resistance mechanismsChao Lin
Vertex Pharmaceuticals Inc, Cambridge, Massachusetts 02139, USA
J Biol Chem 279:17508-14. 2004..Modeling analysis suggests that there are different mechanisms of resistance to VX-950 and BILN 2061... - In vitro studies of cross-resistance mutations against two hepatitis C virus serine protease inhibitors, VX-950 and BILN 2061Chao Lin
Vertex Pharmaceuticals Incorporated, Cambridge, Massachusetts 02139, USA
J Biol Chem 280:36784-91. 2005..Both cross-resistance mutations (A156V and A156T) displayed significantly diminished fitness (or replication capacity) in a transient replicon cell system... - Hepatitis C virus NS3 RNA helicase domain with a bound oligonucleotide: the crystal structure provides insights into the mode of unwindingJ L Kim
Vertex Pharmaceuticals Incorporated, Cambridge, Massachusetts 02139 4242, USA
Structure 6:89-100. 1998..The structures of several helicases have been published but the structural details as to how ATP binding and hydrolysis are coupled to RNA unwinding are unknown... 
Structure-based mutagenesis study of hepatitis C virus NS3 helicaseC Lin
Vertex Pharmaceuticals Incorporated, Cambridge, Massachusetts 02139, USA
J Virol 73:8798-807. 1999..Given the conservation of some of these residues in other DNA and RNA helicases, their role in the mechanism of unwinding of double-stranded nucleic acid is discussed...- The hepatitis C virus NS4A protein: interactions with the NS4B and NS5A proteinsC Lin
Vertex Pharmaceuticals Incorporated, Cambridge, Massachusetts 02139 4242, USA
J Virol 71:6465-71. 1997..Finally, the possible mechanisms by which these viral proteins interact with each other are discussed... - Bovine viral diarrhea virus NS3 serine proteinase: polyprotein cleavage sites, cofactor requirements, and molecular model of an enzyme essential for pestivirus replicationJ Xu
Department of Molecular Microbiology, Washington University School of Medicine, St Louis, Missouri 63110 1093, USA
J Virol 71:5312-22. 1997..Finally, using a full-length functional BVDV cDNA clone, we demonstrate that a catalytically active NS3 serine proteinase is essential for pestivirus replication... - Progress in designing nucleic acid structures and fine-tuning their interactionsH H Klump
Department of Molecular and Cellular Biology, University of Cape Town, Rondebosch 7800, Private Bag, South Africa
Arch Biochem Biophys 453:93-100. 2006..We call the reaction cycle that exemplifies our approach 'A handshake from a hairpin on the way to a double helix.'.. - Autocrine stimulation by erythropoietin in transgenic mice results in erythroid proliferation without neoplastic transformationA Madan
Division of Neonatology, Department of Pediatrics, Stanford School of Medicine, CA 94305, USA
Blood Cells Mol Dis 30:82-9. 2003..These studies show that 5'HS-2 can be used to target Epo gene expression to erythroid tissue. These mice could provide a model system for studying autocrine growth regulation... - [The antioxidative effect of procyanidins from pine bark in vitro]C Lin
Medical College of Jinan University, Guangzhou 510632
Zhong Yao Cai 24:882-4. 2001..01). CONCLUSION: Procyanidins had good antioxidative function. It can prevent RBC membrane, plasmid DNA suffering from oxygen free radical damage in vitro... - Mechanism-based inactivation of CYP2D6 by 5-fluoro-2-[4-[(2-phenyl-1H-imidazol-5-yl)methyl]-1-piperazinyl]pyrimidineJ R Palamanda
Department of Drug Metabolism and Pharmacokinetics, Schering-Plough Research Institute, Kenilworth, New Jersey 07033, USA
Drug Metab Dispos 29:863-7. 2001..These results demonstrate that SCH 66712 is a potent and fairly selective mechanism-based inhibitor of CYP2D6... - Hb Ube-2 [alpha68(E17)Asn-Asp] and Hb Hafnia [beta116(G18)His-->Gln] observed during neonatal screening in BrusselsF Cotton
Department of Clinical Chemistry, , , Brussels, Belgium
Hemoglobin 24:65-9. 2000 - A novel mutation of the doublecortin gene in Japanese patients with X-linked lissencephaly and subcortical band heterotopiaM Kato
Department of Pediatrics, Yamagata University School of Medicine, Japan
Hum Genet 104:341-4. 1999..Although the number of cases studied remains limited, exon 5 may be a common mutational site in Japanese patients in contrast to many previous reports concerning exons 2 and 3... - Four novel mutations of the connexin 32 gene in four Japanese families with Charcot-Marie-Tooth disease type 1T Ikegami
Department of Pediatrics, Yamagata University School of Medicine, Japan
Am J Med Genet 80:352-5. 1998..Therefore, molecular analysis is useful for molecular pathology of their disease... - A novel Leu171Pro mutation in presenilin-1 gene in a Mexican family with early onset Alzheimer diseaseM G Ramírez-Dueñas
Departamento de Fisiologia, Universidad de Guadalajara, Jalisco, Mexico
Ann Genet 41:149-53. 1998..The pedigree analysis and the literature data strongly suggest an etiopathogenic relationship of the mutation with the disorder... - Heteroligomers of type-I and type-III inositol trisphosphate receptors in WB rat liver epithelial cellsS K Joseph
Department of Pathology, Thomas Jefferson University School of Medicine, Philadelphia, Pennsylvania 19107, USA
J Biol Chem 270:23310-6. 1995..We conclude that the WB cell contains both type-I and type-III IP3R isoforms and that a proportion of these receptors exist as heterotetramers...