LAURENCE ZWIEBELSummaryAffiliation: Vanderbilt University Country: USA Publications
Research Grants
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Publications
Blockade of insect odorant receptor currents by amiloride derivativesGregory M Pask
Department of Biological Sciences, Vanderbilt University, Nashville, TN, USA
Chem Senses 38:221-9. 2013..Amiloride derivatives therefore represent a valuable class of channel blockers that can be used to investigate the pharmacological and biophysical properties of insect OR function...- The molecular receptive range of a lactone receptor in Anopheles gambiaeGregory M Pask
Department of Biological Sciences, Vanderbilt University, Nashville, Tennesse, USA
Chem Senses 38:19-25. 2013..Investigation of the molecular receptive range of this lactone receptor may contribute to a greater understanding of ligand-OR interactions and provide insight into the chemical ecology of An. gambiae... - Antennal sensilla of two female anopheline sibling species with differing host rangesR Jason Pitts
Department of Biological Sciences, Program in Developmental Biology, Institute for Chemical Biology and Center for Molecular Neuroscience, Vanderbilt University, Station B 351634, Nashville, TN 37235 3582, USA
Malar J 5:26. 2006..In the present study, the external anatomy of the antenna, the principle olfactory organ in the female mosquito of both species, was examined as an initial step toward more detailed comparisons... - Transcriptome profiling of chemosensory appendages in the malaria vector Anopheles gambiae reveals tissue- and sex-specific signatures of odor codingR Jason Pitts
Department of Biological Sciences, Vanderbilt University, Nashville, TN, USA
BMC Genomics 12:271. 2011..gambiae... - Olfactory regulation of mosquito-host interactionsL J Zwiebel
Department of Biological Sciences, Program in Developmental Biology and Center for Molecular Neuroscience, Vanderbilt University, VU Station, B 3582, Nashville, TN 37235 3582, USA
Insect Biochem Mol Biol 34:645-52. 2004.... - Conservation of indole responsive odorant receptors in mosquitoes reveals an ancient olfactory traitJonathan D Bohbot
Department of Biological Sciences and Pharmacology, Center for Molecular Neuroscience, Programs in Developmental Biology and Genetics, Institutes for Chemical Biology and Global Health, Vanderbilt University, Nashville, TN 37235, USA
Chem Senses 36:149-60. 2011.... - Candidate odorant receptors from the malaria vector mosquito Anopheles gambiae and evidence of down-regulation in response to blood feedingA N Fox
Department of Biological Sciences, Program in Developmental Biology and Center for Molecular Neuroscience, Vanderbilt University, Nashville, TN 37235, USA
Proc Natl Acad Sci U S A 98:14693-7. 2001..Taken together, these data suggest these genes encode a family of odorant receptors in A. gambiae, whose further study may aid in the design of novel antimalarial programs... 
Molecular biology of insect olfaction: recent progress and conceptual modelsM Rutzler
Department of Biological Sciences, Program in Developmental Biology and Center for Molecular Neuroscience, Vanderbilt University, VU Station B 351634, Nashville, TN 37235 3582, USA
J Comp Physiol A Neuroethol Sens Neural Behav Physiol 191:777-90. 2005..This review intends to summarize much of this progress and to point out some areas where advances can be expected in the near future...- Odorant-specific requirements for arrestin function in Drosophila olfactionC Elaine Merrill
Department of Biological Sciences, Vanderbilt University, 465 21st Avenue South, Nashville, Tennessee 37232, USA
J Neurobiol 63:15-28. 2005.... - Molecular characterization of arrestin family members in the malaria vector mosquito, Anopheles gambiaeC E Merrill
Department of Biological Sciences, Program in Developmental Biology and Center for Molecular Neuroscience, Vanderbilt University Nashville, TN 37235, USA
Insect Mol Biol 12:641-50. 2003..female A. gambiae mosquitoes. This finding is consistent with the hypothesis that AgARR2 may be important for the regulation of olfactory-driven behaviours particular to male mosquitoes... - Visual arrestins in olfactory pathways of Drosophila and the malaria vector mosquito Anopheles gambiaeC E Merrill
Department of Biological Sciences, Program in Developmental Biology and Center for Molecular Neuroscience, VU Station B35 1812, Vanderbilt University, Nashville, TN 37235 1812, USA
Proc Natl Acad Sci U S A 99:1633-8. 2002.... - A cluster of candidate odorant receptors from the malaria vector mosquito, Anopheles gambiaeA N Fox
Department of Biological Sciences, Program in Developmental Biology and Center for Molecular Neuroscience, Vanderbilt University, Nashville, TN 37235, USA
Chem Senses 27:453-9. 2002..Analysis of the developmental expression within members of this AgOR gene cluster reveals considerable variation between these AgORs as compared to candidate odorant receptors from D. melanogaster... - Odor coding in the maxillary palp of the malaria vector mosquito Anopheles gambiaeTan Lu
Department of Biological Sciences, Center for Molecular Neuroscience, Institute of Chemical Biology and Global Health and Program in Developmental Biology, Vanderbilt University, Nashville, Tennessee 37235, USA
Curr Biol 17:1533-44. 2007..However, the molecular and cellular basis of such olfactory responses remains largely unknown... - G protein-coupled receptors in Anopheles gambiaeCatherine A Hill
Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA
Science 298:176-8. 2002..Examples of lineage-specific gene expansions were observed as well as a single instance of unusually high sequence conservation... - The molecular and cellular basis of olfactory-driven behavior in Anopheles gambiae larvaeYuanfeng Xia
Department of Biological Sciences and Pharmacology, Center for Molecular Neuroscience, Institutes of Chemical Biology and Global Health and Program in Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37235, USA
Proc Natl Acad Sci U S A 105:6433-8. 2008..These advances may ultimately enhance the development of vector control strategies, targeting olfactory pathways in larval-stage mosquitoes to reduce the catastrophic effects of malaria and other diseases... - A highly conserved candidate chemoreceptor expressed in both olfactory and gustatory tissues in the malaria vector Anopheles gambiaeR Jason Pitts
Department of Biological Sciences, Center for Molecular Neuroscience and Program in Developmental Biology, Vanderbilt University, Nashville, TN 37235, USA
Proc Natl Acad Sci U S A 101:5058-63. 2004..These results are consistent with a role for AgOr7 in both olfaction and gustation in An. gambiae and raise the possibility that AgOr7 orthologs may also be of general importance to both modalities of chemosensation in other insects... - Galpha encoding gene family of the malaria vector mosquito Anopheles gambiae: expression analysis and immunolocalization of AGalphaq and AGalphao in female antennaeMichael Rutzler
Department of Biological Sciences, Program in Developmental Biology, Centers for Molecular Neuroscience and Chemical Biology, Institute for Global Health, Vanderbilt University, Nashville, Tennessee 37235, USA
J Comp Neurol 499:533-45. 2006..In contrast, AGalphao is localized along the flagellar axon bundle but is absent from chemosensory sensilla, which suggests that this G-protein alpha subunit does not participate in olfactory signal transduction... - Olfactory responses in a gustatory organ of the malaria vector mosquito Anopheles gambiaeHyung-Wook Kwon
Department of Biological Sciences, Center for Molecular Neuroscience, Institute of Chemical Biology, and Program in Developmental Biology, Vanderbilt University, Nashville, TN 37235, USA
Proc Natl Acad Sci U S A 103:13526-31. 2006..This result is consistent with an important role for the labellum in the close-range discrimination of bloodmeal hosts that directly impacts the ability of A. gambiae to transmit malaria and other diseases... - Olfaction: mosquito receptor for human-sweat odorantElissa A Hallem
Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA
Nature 427:212-3. 2004..Compounds designed to activate or block receptors of this type could function as attractants for trapping mosquitoes or as insect repellents in helping to control Anopheles and other insect pests... - Identification and characterization of an odorant receptor from the West Nile virus mosquito, Culex quinquefasciatusYuanfeng Xia
Department of Biological Sciences, Center for Molecular Neuroscience and the Institute for Chemical Biology, Vanderbilt University, Nashville, TN 37235, USA
Insect Biochem Mol Biol 36:169-76. 2006..These results suggest that CqOR7 and its orthologs are likely to play a role in the chemosensory processes of Culicine and other mosquitoes that underlie their vectorial capacity...
Research Grants
- Examination of Odorant Receptors in Anopheles gambiaeLAURENCE ZWIEBEL; Fiscal Year: 2007..AgOR's role in the olfactory processes that underlie disease transmission, will we propose to conduct a series of detailed experiments to examine the temporal kinetics of AgOR expression in response to blood feeding ..
- Examination of Odorant Receptors in Anopheles gambiaeLAURENCE ZWIEBEL; Fiscal Year: 2006..abstract_text> ..
- MOLECULAR GENETICS OF OLFACTION IN ANOPHELINE MOSQUITOESLAURENCE ZWIEBEL; Fiscal Year: 2004..gambiae s.s. and it's zoophilic non-vector sibling An. quadriannulatus to identify and characterize peripheral olfactory genes, which are specifically associated with anthropophily and/or zoophily. ..
- Examination of Odorant Receptors in Anopheles gambiaeLAURENCE ZWIEBEL; Fiscal Year: 2003....
- Examination of Odorant Receptors in Vector MosquitoesLaurence J Zwiebel; Fiscal Year: 2010..gambiae (AgORs) and Ae. aegypti (AaORs) that lie at the heart of the olfactory signaling pathway. ..