Andries Zijlstra

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. ncbi The inhibition of tumor cell intravasation and subsequent metastasis via regulation of in vivo tumor cell motility by the tetraspanin CD151
    Andries Zijlstra
    Department of Cell Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cancer Cell 13:221-34. 2008
  2. ncbi Unexpected effect of matrix metalloproteinase down-regulation on vascular intravasation and metastasis of human fibrosarcoma cells selected in vivo for high rates of dissemination
    Elena I Deryugina
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Cancer Res 65:10959-69. 2005
  3. ncbi Proangiogenic role of neutrophil-like inflammatory heterophils during neovascularization induced by growth factors and human tumor cells
    Andries Zijlstra
    Department of Cell Biology, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Blood 107:317-27. 2006
  4. ncbi Viral nanoparticles as tools for intravital vascular imaging
    John D Lewis
    Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Med 12:354-60. 2006
  5. ncbi Subtractive immunization using highly metastatic human tumor cells identifies SIMA135/CDCP1, a 135 kDa cell surface phosphorylated glycoprotein antigen
    John D Hooper
    Department of Cell Biology, The Scripps Research Intitute, La Jolla, CA 92037, USA
    Oncogene 22:1783-94. 2003
  6. ncbi Genetic reprogramming of tumor cells by zinc finger transcription factors
    Pilar Blancafort
    Department of Molecular Biology and The Skaggs Institute for Chemical Biology, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 102:11716-21. 2005
  7. ncbi Collagenolysis-dependent angiogenesis mediated by matrix metalloproteinase-13 (collagenase-3)
    Andries Zijlstra
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 279:27633-45. 2004
  8. ncbi Endothelial cell serine proteases expressed during vascular morphogenesis and angiogenesis
    Ronald T Aimes
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California, USA
    Thromb Haemost 89:561-72. 2003
  9. ncbi Targeting the proteome/epitome, implementation of subtractive immunization
    Andries Zijlstra
    Division of Vascular Biology, Department of Cell Biology, The Scripps Research Institute, 10550 N. Torrey Pine Road, La Jolla, CA, USA
    Biochem Biophys Res Commun 303:733-44. 2003
  10. ncbi A quantitative analysis of rate-limiting steps in the metastatic cascade using human-specific real-time polymerase chain reaction
    Andries Zijlstra
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Cancer Res 62:7083-92. 2002

Research Grants

  1. The molecular mechanisms of migration of which lead to tumor cell intravasation.
    Andries Zijlstra; Fiscal Year: 2007
  2. Tetraspanin-mediated regulation of tumor cell migration and metastasis
    Andries Zijlstra; Fiscal Year: 2010
  3. Tetraspanin-mediated regulation of tumor cell migration and metastasis
    Andries Zijlstra; Fiscal Year: 2011

Collaborators

Detail Information

Publications10

  1. ncbi The inhibition of tumor cell intravasation and subsequent metastasis via regulation of in vivo tumor cell motility by the tetraspanin CD151
    Andries Zijlstra
    Department of Cell Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cancer Cell 13:221-34. 2008
    ....
  2. ncbi Unexpected effect of matrix metalloproteinase down-regulation on vascular intravasation and metastasis of human fibrosarcoma cells selected in vivo for high rates of dissemination
    Elena I Deryugina
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Cancer Res 65:10959-69. 2005
    ..The results emphasize a rising awareness that targeting certain MMPs might result in an enhanced malignancy, exemplified herein at the intravasation level as this step of the metastatic cascade is dissected and quantified...
  3. ncbi Proangiogenic role of neutrophil-like inflammatory heterophils during neovascularization induced by growth factors and human tumor cells
    Andries Zijlstra
    Department of Cell Biology, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Blood 107:317-27. 2006
    ..Moreover, purified heterophils incorporated into onplants lacking growth factors or tumor cells induced angiogenesis in nontreated embryos, further indicating a direct proangiogenic role for neutrophil-like leukocytes...
  4. ncbi Viral nanoparticles as tools for intravital vascular imaging
    John D Lewis
    Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Med 12:354-60. 2006
    ....
  5. ncbi Subtractive immunization using highly metastatic human tumor cells identifies SIMA135/CDCP1, a 135 kDa cell surface phosphorylated glycoprotein antigen
    John D Hooper
    Department of Cell Biology, The Scripps Research Intitute, La Jolla, CA 92037, USA
    Oncogene 22:1783-94. 2003
    ..Thus, specific immunodetection followed by proteomic analysis allows for the identification and partial characterization of a heretofore uncharacterized human cell surface antigen...
  6. ncbi Genetic reprogramming of tumor cells by zinc finger transcription factors
    Pilar Blancafort
    Department of Molecular Biology and The Skaggs Institute for Chemical Biology, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 102:11716-21. 2005
    ..By co-regulating multiple targets, ATFs can be used as master genetic switches to reprogram and modulate complex neoplastic phenotypes...
  7. ncbi Collagenolysis-dependent angiogenesis mediated by matrix metalloproteinase-13 (collagenase-3)
    Andries Zijlstra
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 279:27633-45. 2004
    ..Altogether, the results of this study extend the physiological role of MMP-13, previously associated with cartilage/bone resorption, to the collagen remodeling involved in the angiogenic cascade...
  8. ncbi Endothelial cell serine proteases expressed during vascular morphogenesis and angiogenesis
    Ronald T Aimes
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California, USA
    Thromb Haemost 89:561-72. 2003
    ..These data suggest a potential role for serine proteases, not previously associated with endothelium, in vascular function and angiogenesis...
  9. ncbi Targeting the proteome/epitome, implementation of subtractive immunization
    Andries Zijlstra
    Division of Vascular Biology, Department of Cell Biology, The Scripps Research Institute, 10550 N. Torrey Pine Road, La Jolla, CA, USA
    Biochem Biophys Res Commun 303:733-44. 2003
    ..This review will focus on the implementation of subtractive immunization for the production of antibodies otherwise unobtainable by standard immunization...
  10. ncbi A quantitative analysis of rate-limiting steps in the metastatic cascade using human-specific real-time polymerase chain reaction
    Andries Zijlstra
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Cancer Res 62:7083-92. 2002
    ..Thus, a very facile metastasis model system coupled with the sensitive, real-time PCR-based assay allows for the identification and quantification of rate-limiting steps in the metastatic cascade for select human tumor cell lines...

Research Grants4

  1. The molecular mechanisms of migration of which lead to tumor cell intravasation.
    Andries Zijlstra; Fiscal Year: 2007
    ..In order to metastasize, tumor cells have mobilize themselves and enter the circulation. The proposed work is focused on identifying and understanding the mechanisms by which tumor cells can be immobilized. ..
  2. Tetraspanin-mediated regulation of tumor cell migration and metastasis
    Andries Zijlstra; Fiscal Year: 2010
    ..The overall goal of proposed work is to develop mechanisms of molecular intervention which immobilizes tumor cells and prevent tumor cell metastasis in cancer patients. ..
  3. Tetraspanin-mediated regulation of tumor cell migration and metastasis
    Andries Zijlstra; Fiscal Year: 2011
    ..The overall goal of proposed work is to develop mechanisms of molecular intervention which immobilizes tumor cells and prevent tumor cell metastasis in cancer patients. ..