Wei Zheng

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. pmc Exome sequencing generates high quality data in non-target regions
    Yan Guo
    Center for Quantitative Sciences, Vanderbilt Ingram Cancer Center, Nashville, TN, USA
    BMC Genomics 13:194. 2012
  2. pmc Polycyclic aromatic hydrocarbons: determinants of urinary 1-hydroxypyrene glucuronide concentration and risk of colorectal cancer in the Shanghai Women's Health Study
    Jonathan N Hofmann
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    BMC Cancer 13:282. 2013
  3. pmc Common genetic determinants of breast-cancer risk in East Asian women: a collaborative study of 23 637 breast cancer cases and 25 579 controls
    Wei Zheng
    Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA
    Hum Mol Genet 22:2539-50. 2013
  4. pmc Association of leukocyte telomere length with colorectal cancer risk: nested case-control findings from the Shanghai Women's Health Study
    Yong Cui
    Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Cancer Epidemiol Biomarkers Prev 21:1807-13. 2012
  5. pmc t-DARPP regulates phosphatidylinositol-3-kinase-dependent cell growth in breast cancer
    Bhavatarini Vangamudi
    Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Mol Cancer 9:240. 2010
  6. pmc IGFBP3 mRNA expression in benign and malignant breast tumors
    Zefang Ren
    Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University, S 1121 MCN, 1161 21st Ave, S, Nashville, TN 37232 2587, USA
    Breast Cancer Res 9:R2. 2007
  7. pmc Genetic polymorphisms in the matrix metalloproteinase 12 gene (MMP12) and breast cancer risk and survival: the Shanghai Breast Cancer Study
    Aesun Shin
    Department of Medicine, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA
    Breast Cancer Res 7:R506-12. 2005
  8. pmc Genetic and clinical predictors for breast cancer risk assessment and stratification among Chinese women
    Wei Zheng
    Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, 2525 West End Avenue, Nashville, TN 37203 1738, USA
    J Natl Cancer Inst 102:972-81. 2010
  9. doi request reprint Association between body-mass index and risk of death in more than 1 million Asians
    Wei Zheng
    Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, TN, USA
    N Engl J Med 364:719-29. 2011
  10. ncbi request reprint Population-based case-control study of CYP11A gene polymorphism and breast cancer risk
    Wei Zheng
    Drpartment of Medicine and Vanderbilt Ingram Cancer Centr, Vanderbilt University, Nashville, TN, USA
    Cancer Epidemiol Biomarkers Prev 13:709-14. 2004

Research Grants

Collaborators

Detail Information

Publications139 found, 100 shown here

  1. pmc Exome sequencing generates high quality data in non-target regions
    Yan Guo
    Center for Quantitative Sciences, Vanderbilt Ingram Cancer Center, Nashville, TN, USA
    BMC Genomics 13:194. 2012
    ..A significant amount of DNA fragments from the capture process fall outside target regions, and sequence data for positions outside target regions have been mostly ignored after alignment...
  2. pmc Polycyclic aromatic hydrocarbons: determinants of urinary 1-hydroxypyrene glucuronide concentration and risk of colorectal cancer in the Shanghai Women's Health Study
    Jonathan N Hofmann
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    BMC Cancer 13:282. 2013
    ....
  3. pmc Common genetic determinants of breast-cancer risk in East Asian women: a collaborative study of 23 637 breast cancer cases and 25 579 controls
    Wei Zheng
    Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA
    Hum Mol Genet 22:2539-50. 2013
    ..Taken together, these common genetic risk variants explain ~10% of excess familial risk of breast cancer in Asian populations...
  4. pmc Association of leukocyte telomere length with colorectal cancer risk: nested case-control findings from the Shanghai Women's Health Study
    Yong Cui
    Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Cancer Epidemiol Biomarkers Prev 21:1807-13. 2012
    ..Abnormal alteration of telomere length has been linked to several cancers; however, epidemiologic evidence about the association of telomere length with colorectal cancer risk has been conflicting...
  5. pmc t-DARPP regulates phosphatidylinositol-3-kinase-dependent cell growth in breast cancer
    Bhavatarini Vangamudi
    Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Mol Cancer 9:240. 2010
    ..In this study, we evaluated expression of t-DARPP in human primary breast tumors, and investigated the role of t-DARPP in regulating growth and proliferation in breast cancer cells...
  6. pmc IGFBP3 mRNA expression in benign and malignant breast tumors
    Zefang Ren
    Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University, S 1121 MCN, 1161 21st Ave, S, Nashville, TN 37232 2587, USA
    Breast Cancer Res 9:R2. 2007
    ..Emerging evidence over the past few years suggests that IGFBP-3 may act directly on mammary epithelial cells...
  7. pmc Genetic polymorphisms in the matrix metalloproteinase 12 gene (MMP12) and breast cancer risk and survival: the Shanghai Breast Cancer Study
    Aesun Shin
    Department of Medicine, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA
    Breast Cancer Res 7:R506-12. 2005
    ....
  8. pmc Genetic and clinical predictors for breast cancer risk assessment and stratification among Chinese women
    Wei Zheng
    Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, 2525 West End Avenue, Nashville, TN 37203 1738, USA
    J Natl Cancer Inst 102:972-81. 2010
    ..No risk assessment model that incorporates both genetic and clinical predictors is currently available to predict breast cancer risk in this population...
  9. doi request reprint Association between body-mass index and risk of death in more than 1 million Asians
    Wei Zheng
    Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, TN, USA
    N Engl J Med 364:719-29. 2011
    ..Most studies that have evaluated the association between the body-mass index (BMI) and the risks of death from any cause and from specific causes have been conducted in populations of European origin...
  10. ncbi request reprint Population-based case-control study of CYP11A gene polymorphism and breast cancer risk
    Wei Zheng
    Drpartment of Medicine and Vanderbilt Ingram Cancer Centr, Vanderbilt University, Nashville, TN, USA
    Cancer Epidemiol Biomarkers Prev 13:709-14. 2004
    ..The results from this study indicate that the TAAAA repeat polymorphism near the promoter region of the CYP11A gene may be an important susceptibility factor for breast cancer risk...
  11. pmc Circulating 25-hydroxyvitamin D and risk of epithelial ovarian cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers
    Wei Zheng
    Department of Medicine, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA
    Am J Epidemiol 172:70-80. 2010
    ..01). In conclusion, this large pooled analysis did not support an overall association between circulating 25(OH)D and ovarian cancer risk, except possibly among overweight women...
  12. pmc Genome-wide association study identifies a new breast cancer susceptibility locus at 6q25.1
    Wei Zheng
    Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Nat Genet 41:324-8. 2009
    ..01). These results strongly implicate 6q25.1 as a susceptibility locus for breast cancer...
  13. ncbi request reprint The Shanghai Women's Health Study: rationale, study design, and baseline characteristics
    Wei Zheng
    Center for Health Services Research, Department of Medicine, Vanderbilt University, Nashville, TN 37232 8300, USA
    Am J Epidemiol 162:1123-31. 2005
    ..The resources from the cohort will be valuable in future studies of environmental exposures and biomarkers for the risk of cancer and other chronic diseases...
  14. pmc Well-done meat intake, heterocyclic amine exposure, and cancer risk
    Wei Zheng
    Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203 1738, USA
    Nutr Cancer 61:437-46. 2009
    ..The majority of these studies have shown that high intake of well-done meat and high exposure to meat carcinogens, particularly HCAs, may increase the risk of human cancer...
  15. pmc Evaluation of 11 breast cancer susceptibility loci in African-American women
    Wei Zheng
    Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Nashville, TN 37203 1738, USA
    Cancer Epidemiol Biomarkers Prev 18:2761-4. 2009
    ..The results from this study extend some of the recent GWAS findings to African-Americans and may guide future efforts to identify the causal variants for breast cancer...
  16. pmc Prevalence and determinants of metabolic syndrome according to three definitions in middle-aged Chinese men
    Raquel Villegas
    Vanderbilt Epidemiology Center, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37203 1738, USA
    Metab Syndr Relat Disord 7:37-45. 2009
    ..We estimated the prevalence and lifestyle risk factors of metabolic syndrome according to three definitions of metabolic syndrome in urban Chinese men participating in the Shanghai Men's Health Study (SMHS)...
  17. pmc Prevalence and determinants of hyperuricemia in middle-aged, urban Chinese men
    Raquel Villegas
    Vanderbilt Epidemiology Center, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37203 1738, USA
    Metab Syndr Relat Disord 8:263-70. 2010
    ..Hyperuricemia is associated with metabolic syndrome and has emerged as a marker for both type 2 diabetes and cardiovascular disease. We estimated the prevalence and lifestyle risk factors of hyperuricemia in middle-aged, urban Chinese men...
  18. doi request reprint Dietary iron intake and risk of endometrial cancer: a population-based case-control study in Shanghai, China
    Asha R Kallianpur
    Institute for Medicine and Public Health, Vanderbilt Epidemiology Center and Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 37203 1738, USA
    Nutr Cancer 62:40-50. 2010
    ..Animal-derived iron intake is associated with increased risk of EC after menopause and among obese women. Avoidance of animal-derived (heme) iron may reduce the risk of EC in these women...
  19. ncbi request reprint Genetic polymorphisms in the IGFBP3 gene: association with breast cancer risk and blood IGFBP-3 protein levels among Chinese women
    Zefang Ren
    Department of Medicine, Vanderbilt University, Nashville, TN, USA
    Cancer Epidemiol Biomarkers Prev 13:1290-5. 2004
    ..05). These results indicated that IGFBP3 polymorphisms may be associated with the level of blood IGFBP-3 protein and an increased risk of breast cancer...
  20. pmc Energy balance, insulin resistance biomarkers, and breast cancer risk
    Alecia Malin Fair
    Meharry Medical College, School of Medicine, Department of Surgery, 1005 Dr D B Todd Jr Boulevard, Nashville, TN 37208 3599, USA
    Cancer Detect Prev 31:214-9. 2007
    ....
  21. ncbi request reprint A population-based case-control study of the Arg399Gln polymorphism in DNA repair gene XRCC1 and risk of breast cancer
    Xiao Ou Shu
    Department of Medicine and Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 37232 8300, USA
    Cancer Epidemiol Biomarkers Prev 12:1462-7. 2003
    ..60; 95% CI, 0.18-1.97). The overall results of the study suggest that Arg399Gln polymorphism of the XRCC1 gene alone may not play a substantial role in the risk of breast cancer among Chinese women...
  22. ncbi request reprint Expression of cytochrome P450 1B1 and catechol-O-methyltransferase in breast tissue and their associations with breast cancer risk
    Wanqing Wen
    Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Cancer Epidemiol Biomarkers Prev 16:917-20. 2007
    ..These results support the hypothesis that the formation and accumulation of catechol estrogens in breast tissue through increased CYP1B1 expression and reduced COMT expression may play a significant role in breast cancer risk...
  23. ncbi request reprint Polymorphisms in the CYP19A1 (aromatase) gene and endometrial cancer risk in Chinese women
    Meng Hua Tao
    Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine and Vanderbilt Ingram Cancer Center, Nashville, Tennessee 37203 1738, USA
    Cancer Epidemiol Biomarkers Prev 16:943-9. 2007
    ..In summary, our data show that polymorphisms in the CYP19A1 gene may contribute to endometrial carcinogenesis...
  24. ncbi request reprint Cruciferous vegetables, the GSTP1 Ile105Val genetic polymorphism, and breast cancer risk
    Sang Ah Lee
    Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, USA
    Am J Clin Nutr 87:753-60. 2008
    ..Cruciferous vegetables are the primary source of isothiocyanates and other glucosinolate derivatives that are known to induce phase II detoxifying enzymes, including glutathione S-transferases (GSTs)...
  25. pmc Dietary patterns and blood pressure among middle-aged and elderly Chinese men in Shanghai
    Sang Ah Lee
    Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, 2525 West End Avenue, Suite 600, IMPH, Nashville TN 37203 1738, USA
    Br J Nutr 104:265-75. 2010
    ..Results of the present study suggest an important role for diet in the prevention of hypertension...
  26. ncbi request reprint Genetic polymorphisms in estrogen-metabolizing genes and breast cancer survival
    Ji Rong Long
    Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, 1161 21st Avenue South, S 1121 Medical Center North, Nashville, TN 37232, USA
    Pharmacogenet Genomics 17:331-8. 2007
    ..The objective of the study is to investigate associations of breast cancer survival with genetic polymorphisms in several genes involved in estrogen metabolism (CYP1A1, CYP1A2, CYP1B1, COMT, and AhR)...
  27. ncbi request reprint Two-stage case-control study of common ATM gene variants in relation to breast cancer risk
    Chuanzhong Ye
    Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN 37232 2587, USA
    Breast Cancer Res Treat 106:121-6. 2007
    ....
  28. pmc Major metabolite of F2-isoprostane in urine may be a more sensitive biomarker of oxidative stress than isoprostane itself
    Tsogzolmaa Dorjgochoo
    Divisions of Epidemiology, Vanderbilt University School of Medicine, Nashville, TN, USA
    Am J Clin Nutr 96:405-14. 2012
    ..There is limited literature on the contributors to isoprostane metabolite 2,3-dinor-5,6-dihydro-15-F(2t)-isoprostane (15-F(2t)-IsoP-M) compared with F(2)-isoprostanes (F(2)-IsoPs) as an oxidative stress biomarker...
  29. ncbi request reprint MTR and MTRR polymorphisms, dietary intake, and breast cancer risk
    Martha J Shrubsole
    Center for Health Services Research, Vanderbilt University Medical Center, Nashville, TN 37232 2587, USA
    Cancer Epidemiol Biomarkers Prev 15:586-8. 2006
  30. pmc Adolescent and adult soy food intake and breast cancer risk: results from the Shanghai Women's Health Study
    Sang Ah Lee
    Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203 1738, USA
    Am J Clin Nutr 89:1920-6. 2009
    ..Soy food is a rich source of isoflavones--a class of phytoestrogens that has both antiestrogenic and anticarcinogenic properties...
  31. pmc Weight change and its correlates among breast cancer survivors
    Xiaoli Chen
    Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, Tennessee 37203 1738, USA
    Nutr Cancer 63:538-48. 2011
    ..Weight gain is common among breast cancer survivors. Sociodemographic, clinical, and lifestyle factors are related to weight change. Appropriate intervention strategies should be developed...
  32. pmc Association of mitochondrial DNA displacement loop (CA)n dinucleotide repeat polymorphism with breast cancer risk and survival among Chinese women
    Chuanzhong Ye
    Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine and Vanderbilt Ingram Cancer Center, Nashville, TN 37232 2400, USA
    Cancer Epidemiol Biomarkers Prev 17:2117-22. 2008
    ..62; 95% confidence interval, 1.16-2.26). These results suggest that the mtDNA D-loop (CA)(n) repeat polymorphism may be associated with breast cancer survival. Additional studies with a larger sample size are warranted...
  33. ncbi request reprint Oral contraceptive use and breast cancer risk: modification by NAD(P)H:quinone oxoreductase (NQO1) genetic polymorphisms
    Jay H Fowke
    Center for Health Services Research, Vanderbilt University Medical Center, 6110 Medical Center East, Nashville, TN 37232 8300, USA
    Cancer Epidemiol Biomarkers Prev 13:1308-15. 2004
    ..43-6.25; C/T or T/T OR 0.49, 95% CI 0.29-0.81; P for interaction < 0.01). Our results require confirmation but suggest that the OC and breast cancer association depends on the ability to invoke protection from catechol estrogens...
  34. ncbi request reprint Association of breast cancer risk with a common functional polymorphism (Asp327Asn) in the sex hormone-binding globulin gene
    Yong Cui
    Vanderbilt University Center for Health Services Research, 6th Floor, Medical Center East, Nashville, TN 37232 8300, USA
    Cancer Epidemiol Biomarkers Prev 14:1096-101. 2005
    ..05). This study suggests that the Asn allele in the SHBG gene may be related to a reduced risk of breast cancer among postmenopausal women by increasing their blood SHBG levels...
  35. pmc Correlates of high serum C-reactive protein levels in a socioeconomically disadvantaged population
    Xianglan Zhang
    Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, USA
    Dis Markers 24:351-9. 2008
    ..Moreover, inflammatory response to obesity differed by race and sex, which may contribute to CVD disparities...
  36. ncbi request reprint Association of endometrial cancer risk with a functional polymorphism (Asp(327)Asn) in the sex hormone-binding globulin gene
    Nobuhiko Kataoka
    Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, Tennessee, USA
    Cancer 109:1296-302. 2007
    ....
  37. pmc Association of leukocyte telomere length with breast cancer risk: nested case-control findings from the Shanghai Women's Health Study
    Shimian Qu
    Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, TN 37203, USA
    Am J Epidemiol 177:617-24. 2013
    ..Our results support the hypothesis that telomere shortening is associated with increased risk of breast cancer and suggest a possible elevated risk associated with long telomeres...
  38. pmc Dietary carbohydrates, fiber, and breast cancer risk in Chinese women
    Wanqing Wen
    Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN 37203 1738, USA
    Am J Clin Nutr 89:283-9. 2009
    ..Few studies have investigated the association of dietary carbohydrate and fiber intake with breast cancer risk in women in China, where carbohydrate intake is traditionally high...
  39. pmc Racial differences in the association between body mass index and serum IGF1, IGF2, and IGFBP3
    Jay H Fowke
    Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, 2525 West End Avenue, Nashville, Tennessee 37203 1738, USA
    Endocr Relat Cancer 17:51-60. 2010
    ..The effects of obesity throughout life on the IGF axis and racial differences in breast cancer risk require study...
  40. pmc Patterns and correlates of physical activity: a cross-sectional study in urban Chinese women
    Adriana L Jurj
    Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37203, USA
    BMC Public Health 7:213. 2007
    ..The purpose of this study was to investigate the patterns and correlates of physical activity in middle-aged and elderly women from urban Shanghai...
  41. ncbi request reprint Dietary patterns and their correlates among middle-aged and elderly Chinese men: a report from the Shanghai Men's Health Study
    Hui Cai
    Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, TN 37232 8300, USA
    Br J Nutr 98:1006-13. 2007
    ..Future studies of diet and health in this population will need to carefully take into account these potential confounders...
  42. ncbi request reprint Population-based case-control study of VEGF gene polymorphisms and breast cancer risk among Chinese women
    Nobuhiko Kataoka
    Department of Medicine, Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, TN, USA
    Cancer Epidemiol Biomarkers Prev 15:1148-52. 2006
    ..67; 95% CI, 0.43-1.04), particularly in premenopausal women (OR, 0.47; 95% CI, 0.27-0.81). Our study suggests that the VEGF C936T polymorphism might be a susceptibility factor for breast cancer among Chinese women...
  43. ncbi request reprint Association of cyclin D1 genotype with breast cancer risk and survival
    Xiao Ou Shu
    Department of Medicine, Vanderbilt University Center for Health Services Research, 6th Floor, Medical Center East, Nashville, TN 37232 8300, USA
    Cancer Epidemiol Biomarkers Prev 14:91-7. 2005
    ..This study suggests that CCND1 A870G polymorphism may modify the postmenopausal breast cancer risk associated with hormonal exposure and predict survival after breast cancer diagnosis...
  44. pmc Calcium intake and lung cancer risk among female nonsmokers: a report from the Shanghai Women's Health Study
    Yumie Takata
    Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA
    Cancer Epidemiol Biomarkers Prev 22:50-7. 2013
    ..Calcium has been implicated in carcinogenesis and linked to the risk of several cancers in epidemiologic studies; however, few studies have investigated the association of calcium intake with lung cancer risk, particularly among nonsmokers...
  45. pmc Evaluation of genetic susceptibility loci for obesity in Chinese women
    Jiajun Shi
    Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Am J Epidemiol 172:244-54. 2010
    ..Results from this study extend some previous GWA findings to Chinese women and show the need for additional studies to identify susceptibility loci in Chinese and other Asian populations...
  46. pmc Urinary isoflavonoids and risk of coronary heart disease
    Xianglan Zhang
    Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN 37203 1738, USA
    Int J Epidemiol 41:1367-75. 2012
    ..No previous study has used biomarkers of soy intake in assessing the relationship between soy consumption and CHD. Biomarkers that reflect both intake and metabolism may be more informative than self-reports of dietary intake...
  47. pmc Lifestyle factors and their combined impact on the risk of colorectal polyps
    Zhenming Fu
    Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Am J Epidemiol 176:766-76. 2012
    ..This study provides strong evidence that lifestyle modification is important for the prevention of colorectal polyps, especially advanced and multiple adenomas, which are established precursors of colorectal cancer...
  48. pmc Melatonin pathway genes and breast cancer risk among Chinese women
    Sandra L Deming
    Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Institute for Medicine and Public Health, Vanderbilt University School of Medicine, Eighth Floor, Suite 800 2525 West End Ave, Nashville, TN 3720 1738, USA
    Breast Cancer Res Treat 132:693-9. 2012
    ....
  49. pmc Isothiocyanate exposure, glutathione S-transferase polymorphisms, and colorectal cancer risk
    Gong Yang
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Am J Clin Nutr 91:704-11. 2010
    ..Glutathione S-transferases (GSTs) are involved in the metabolism and elimination of isothiocyanates; thus, genetic variations in these enzymes may affect in vivo bioavailability and the activity of isothiocyanates...
  50. ncbi request reprint Modifying effects of sulfotransferase 1A1 gene polymorphism on the association of breast cancer risk with body mass index or endogenous steroid hormones
    Gong Yang
    Department of Medicine, Center for Health Services Research and Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232 8300, USA
    Breast Cancer Res Treat 94:63-70. 2005
    ..No similar effect modification was found for premenopausal breast cancer, however. These data suggest that the SULT1A1 Arg213His polymorphism may modify the effect of endogenous sex hormone exposures on postmenopausal breast cancer risk...
  51. pmc Association of genetic polymorphisms in CYP19A1 and blood levels of sex hormones among postmenopausal Chinese women
    Hui Cai
    Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, TN 37203 1738, USA
    Pharmacogenet Genomics 18:657-64. 2008
    ..We investigated the associations of genetic polymorphisms in CYP19A1, a critical gene involved in estrogen synthesis, with plasma levels of sex hormones among postmenopausal Chinese women...
  52. doi request reprint UGT1A1 genetic polymorphisms, endogenous estrogen exposure, soy food intake, and endometrial cancer risk
    Sandra L Deming
    Vanderbilt Epidemiology Center, Department of Medicine and Vanderbilt Ingram Cancer Center, Nashville, TN 37203 1738, USA
    Cancer Epidemiol Biomarkers Prev 17:563-70. 2008
    ....
  53. pmc Intakes of fruits, vegetables, and related vitamins and lung cancer risk: results from the Shanghai Men's Health Study (2002-2009)
    Yumie Takata
    Vanderbilt Epidemiology Center, Vanderbilt University, Nashville, Tennessee, USA
    Nutr Cancer 65:51-61. 2013
    ..44-0.88), and 0.64 (0.46-0.88). Intake of all fruits and vegetables combined was marginally associated with lower risk. Our study suggests that the consumption of carotenoid-rich vegetables is inversely associated with lung cancer risk...
  54. pmc Distinct distribution and prognostic significance of molecular subtypes of breast cancer in Chinese women: a population-based cohort study
    Yinghao Su
    Department of Medicine, Vanderbilt Epidemiology Center, Nashville, TN 37203 1738, USA
    BMC Cancer 11:292. 2011
    ..Molecular classification of breast cancer is an important prognostic factor. The distribution of molecular subtypes of breast cancer and their prognostic value has not been well documented in Asians...
  55. pmc Associations of adult height and its components with mortality: a report from cohort studies of 135,000 Chinese women and men
    Na Wang
    Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN 37203 1738, USA
    Int J Epidemiol 40:1715-26. 2011
    ..Little is known about components of adult height in relation to mortality, particularly in developing countries...
  56. pmc The relation of magnesium and calcium intakes and a genetic polymorphism in the magnesium transporter to colorectal neoplasia risk
    Qi Dai
    Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN 37203 1738, USA
    Am J Clin Nutr 86:743-51. 2007
    ..Transient receptor potential melastatin 7 (TRPM7) is a newly found gene essential to magnesium absorption and homeostasis...
  57. pmc Legume and soy food intake and the incidence of type 2 diabetes in the Shanghai Women's Health Study
    Raquel Villegas
    Department of Medicine, Vanderbilt Epidemiology Center, Nashville, TN 37203 1738, USA
    Am J Clin Nutr 87:162-7. 2008
    ..It has been postulated that a diet high in legumes may be beneficial for the prevention of type 2 diabetes mellitus (type 2 DM). However, data linking type 2 DM risk and legume intake are limited...
  58. ncbi request reprint Influence of exercise, walking, cycling, and overall nonexercise physical activity on mortality in Chinese women
    Charles E Matthews
    Department of Medicine, Division of General Internal Medicine and Public Health, Vanderbilt Epidemiology Center, Vanderbilt University Medical School, Nashville, TN 37203 1738, USA
    Am J Epidemiol 165:1343-50. 2007
    ..62, 0.99). These findings add new evidence that overall physical activity levels are an important determinant of longevity, and that health benefit can be obtained through an active lifestyle, exercise, or combinations of both...
  59. ncbi request reprint Polymorphisms of the CYP1B1 gene may be associated with the onset of natural menopause in Chinese women
    Ji Rong Long
    Department of Medicine and Vanderbilt Ingram Cancer Center, Vanderbilt University, 1161 21st Avenue South, S 1108 Medical Center North, Nashville, TN 37232 2587, United States
    Maturitas 55:238-46. 2006
    ..6 fewer menstrual cycles than those women without this allele. In conclusion, the results from this study suggested that CYP1B1 genetic polymorphisms may be associated with the natural onset of menopause...
  60. pmc Dietary and lifestyle predictors of age at natural menopause and reproductive span in the Shanghai Women's Health Study
    Tsogzolmaa Dorjgochoo
    Department of Medicine, Vanderbilt Epidemiology Center, School of Medicine, Vanderbilt University and Vanderbilt Ingram Cancer Center, Nashville, TN 37203 1738, USA
    Menopause 15:924-33. 2008
    ..We evaluated the impact of dietary, lifestyle and reproductive factors on age at natural menopause and reproductive span in Chinese women...
  61. pmc Prevalence of obesity and correlations with lifestyle and dietary factors in Chinese men
    Sang Ah Lee
    Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, Tennessee, USA
    Obesity (Silver Spring) 16:1440-7. 2008
    ..To estimate the age-adjusted prevalence of general and centralized obesity among Chinese men living in urban Shanghai...
  62. pmc Meat intake, heterocyclic amine exposure, and metabolizing enzyme polymorphisms in relation to colorectal polyp risk
    Aesun Shin
    Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, 8th Floor, 2525 West End Avenue, Nashville, TN 37203, USA
    Cancer Epidemiol Biomarkers Prev 17:320-9. 2008
    ..These results provide strong evidence for a modifying effect of metabolizing genes on the association of meat intake and HCA exposure with colorectal polyp risk...
  63. ncbi request reprint Genetic polymorphisms in the estrogen receptor alpha gene and risk of breast cancer: results from the Shanghai Breast Cancer Study
    Qiuyin Cai
    Department of Medicine and Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 37232, USA
    Cancer Epidemiol Biomarkers Prev 12:853-9. 2003
    ..No apparent synergetic effect of these two polymorphisms was identified. Results of this study indicate that genetic polymorphisms in the ER-alpha gene may play a role in the etiology of breast cancer...
  64. ncbi request reprint Urinary phytoestrogen excretion and breast cancer risk: evaluating potential effect modifiers endogenous estrogens and anthropometrics
    Qi Dai
    Department of Medicine and Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 37232 8300, USA
    Cancer Epidemiol Biomarkers Prev 12:497-502. 2003
    ..Findings from this study suggest that the potential protective association of phytoestrogens may be modified by BMI, WHR, and blood levels of SHBG, and steroid hormones...
  65. ncbi request reprint Urinary isothiocyanate excretion, brassica consumption, and gene polymorphisms among women living in Shanghai, China
    Jay H Fowke
    Vanderbilt University Medical Center, Nashville, Tennessee 37232 8300, USA
    Cancer Epidemiol Biomarkers Prev 12:1536-9. 2003
    ..In conclusion, a single urinary ITC measure, in conjunction with markers of Phase II enzyme activity, provides a complementary measure of habitual Brassica intake among Shanghai women...
  66. pmc Polymorphisms in inflammation pathway genes and endometrial cancer risk
    Ryan J Delahanty
    Division of Epidemiology, Department of Medicineand Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA
    Cancer Epidemiol Biomarkers Prev 22:216-23. 2013
    ..Experimental and epidemiologic evidence have suggested that chronic inflammation may play a critical role in endometrial carcinogenesis...
  67. ncbi request reprint A prospective study of dietary patterns and mortality in Chinese women
    Hui Cai
    Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashvill, TN, USA
    Epidemiology 18:393-401. 2007
    ..Our study prospectively examines the relationship of dietary patterns with total mortality and cause-specific mortality in a population-based cohort study of Chinese women...
  68. ncbi request reprint Validity and reproducibility of the food-frequency questionnaire used in the Shanghai men's health study
    Raquel Villegas
    Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Medical Center East, Suite 6000, 1215 21st Avenue South, Nashville, TN 37232 8300, USA
    Br J Nutr 97:993-1000. 2007
    ..8 and 49.2%, while misclassification to opposite quartiles was between 1.5 and 6.2%. These data indicate that the SMHS FFQ can reasonably categorise usual intake of nutrients and food groups among men living in urban Shanghai...
  69. pmc Circulating 25-hydroxyvitamin D levels in relation to blood pressure parameters and hypertension in the Shanghai Women's and Men's Health Studies
    Tsogzolmaa Dorjgochoo
    Division of Epidemiology, Department of Medicine and Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, 2525 West End Avenue, Suite 600, IMPH, Nashville, TN 37203, USA
    Br J Nutr 108:449-58. 2012
    ..More research is needed to investigate the potential sex differential associations...
  70. ncbi request reprint Polymorphisms in ER-alpha gene interact with estrogen receptor status in breast cancer survival
    Sonia M Boyapati
    Center for Health Services Research, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Medical Center East, Suite 6000, Nashville, TN 37232 8300, USA
    Clin Cancer Res 11:1093-8. 2005
    ..Polymorphisms in the ER-alpha gene have been reported to be associated with breast cancer risk. However, to our knowledge, no study has been published on the relation between ER-alpha gene polymorphisms and breast cancer survival...
  71. pmc The modifying effect of C-reactive protein gene polymorphisms on the association between central obesity and endometrial cancer risk
    Wanqing Wen
    Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN 37203 1738, USA
    Cancer 112:2409-16. 2008
    ..C-reactive protein (CRP) is the most recognized biologic marker of chronic systematic inflammation, and it is conceivable that the CRP gene may work together with obesity in the development of endometrial cancer...
  72. pmc HTR1B, ADIPOR1, PPARGC1A, and CYP19A1 and obesity in a cohort of Caucasians and African Americans: an evaluation of gene-environment interactions and candidate genes
    Todd L Edwards
    Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37203, USA
    Am J Epidemiol 175:11-21. 2012
    ..A SNP in CYP19A1 interacted with dietary energy intake in African Americans, and another SNP in CYP191A had an independent association with BMI in Caucasians...
  73. pmc Genetic polymorphism in the manganese superoxide dismutase gene, antioxidant intake, and breast cancer risk: results from the Shanghai Breast Cancer Study
    Qiuyin Cai
    Department of Medicine and Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee, USA
    Breast Cancer Res 6:R647-55. 2004
    ....
  74. ncbi request reprint MTHFR polymorphisms, dietary folate intake, and breast cancer risk: results from the Shanghai Breast Cancer Study
    Martha J Shrubsole
    Department of Medicine and Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 37232 8300, USA
    Cancer Epidemiol Biomarkers Prev 13:190-6. 2004
    ..Results of this study suggest that the MTHFR C677T polymorphisms may modify the association between dietary folate intake and breast cancer risk...
  75. pmc Menopausal symptoms among breast cancer patients 6 months after diagnosis: a report from the Shanghai Breast Cancer Survival Study
    Tsogzolmaa Dorjgochoo
    Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203 1738, USA
    Menopause 16:1205-12. 2009
    ..The aim of this study was to estimate the prevalence of menopausal symptoms in relation to treatment modalities in Asian women treated for breast cancer...
  76. ncbi request reprint Abdominal adiposity and mortality in Chinese women
    Xianglan Zhang
    Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN 37232 8300, USA
    Arch Intern Med 167:886-92. 2007
    ..Increased abdominal adiposity has been linked to an increase in mortality in populations where many are overweight or obese; it is unclear whether the same is true in relatively lean populations...
  77. pmc Dietary calcium and magnesium intakes and the risk of type 2 diabetes: the Shanghai Women's Health Study
    Raquel Villegas
    Vanderbilt Epidemiology Center, Department of Medicine, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, TN 37203 1738, USA
    Am J Clin Nutr 89:1059-67. 2009
    ..Diet plays a key role in the development of type 2 diabetes (T2D), but little is known about the contributions of specific nutrients in populations in which dietary patterns differ from Western populations...
  78. ncbi request reprint Genetic variation in IGF1, IGF-1R, IGFALS, and IGFBP3 in breast cancer survival among Chinese women: a report from the Shanghai Breast Cancer Study
    Sandra L Deming
    Department of Medicine and Vanderbilt Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Breast Cancer Res Treat 104:309-19. 2007
    ..9) for the N/A-A/A genotypes (rs6413441). Taken together, these data suggest that polymorphisms in the IGF-1R and IGFBP3 genes may be associated with altered survival among subgroups of breast cancer patients defined by menopausal status...
  79. pmc Haplotype analyses of CYP19A1 gene variants and breast cancer risk: results from the Shanghai Breast Cancer Study
    Qiuyin Cai
    Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, B 2104 Medical Center North, 1161 21st Avenue South, Nashville, TN 37232 2400, USA
    Cancer Epidemiol Biomarkers Prev 17:27-32. 2008
    ..Further studies are needed to explore CYP19A1 gene-environment interactions in relation to breast cancer risk...
  80. ncbi request reprint Genetic polymorphisms of the CYP19A1 gene and breast cancer survival
    Ji Rong Long
    Department of Medicine, Center for Epidemiologic Research, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2587, USA
    Cancer Epidemiol Biomarkers Prev 15:2115-22. 2006
    ..2-4.1) for overall survival and 2.1 (95% CI, 1.1-3.9) for disease-free survival, compared with those carrying the Arg (C) allele. These results suggest that polymorphisms in the CYP19A1 gene may have effects on breast cancer prognosis...
  81. ncbi request reprint Insulin-like growth factor-I gene polymorphism and breast cancer risk in Chinese women
    Wanqing Wen
    Department of Medicine and Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, TN 37232, USA
    Int J Cancer 113:307-11. 2005
    ..22, 95% CI: 1.06-1.41, p for heterogeneity test = 0.524). The findings of this study support the hypothesis that IGF-I gene polymorphisms may be a significant genetic factor for breast cancer susceptibility...
  82. pmc Prospective cohort study of soy food intake and colorectal cancer risk in women
    Gong Yang
    Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203 1738, USA
    Am J Clin Nutr 89:577-83. 2009
    ..Data from epidemiologic studies linking usual soy food intake with colorectal cancer are limited and inconsistent...
  83. ncbi request reprint Genetic polymorphisms in glutathione-S-transferase genes (GSTM1, GSTT1, GSTP1) and survival after chemotherapy for invasive breast carcinoma
    Gong Yang
    Vanderbilt Center for Health Services Research, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 8300, USA
    Cancer 103:52-8. 2005
    ....
  84. ncbi request reprint Dietary calcium intake and breast cancer risk among Chinese women in Shanghai
    Sonia M Boyapati
    Division of General Internal Medicine and Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, TN 37232, USA
    Nutr Cancer 46:38-43. 2003
    ....
  85. ncbi request reprint Prospective study of dietary carbohydrates, glycemic index, glycemic load, and incidence of type 2 diabetes mellitus in middle-aged Chinese women
    Raquel Villegas
    Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, 2525 West End Ave, Ste 600, Nashville, TN 37203 1738, USA
    Arch Intern Med 167:2310-6. 2007
    ..Much uncertainty exists about the role of dietary glycemic index and glycemic load in the development of type 2 diabetes mellitus, especially in populations that traditionally subsist on a diet high in carbohydrates...
  86. ncbi request reprint Cytochrome P450 1B1 and catechol-O-methyltransferase genetic polymorphisms and breast cancer risk in Chinese women: results from the shanghai breast cancer study and a meta-analysis
    Wanqing Wen
    Department of Medicine, Vanderbilt Ingram Cancer Center, Center for Health Service Research, Vanderbilt University School of Medicine, Nashville, TN, USA
    Cancer Epidemiol Biomarkers Prev 14:329-35. 2005
    ..The results from this study were consistent with those from most previous studies, indicating no major associations of breast cancer risk with CYP1B1 and COMT polymorphisms...
  87. ncbi request reprint Genetic polymorphisms in uridine diphospho-glucuronosyltransferase 1A1 (UGT1A1) and risk of breast cancer
    Olufemi J Adegoke
    Department of Surgery, School of Medicine, Meharry Medical College, Vanderbilt University, Nashville, TN 37208, USA
    Breast Cancer Res Treat 85:239-45. 2004
    ..No significant associations were observed with *28 allele and breast cancer risk by estrogen receptor/progesterone receptor status...
  88. ncbi request reprint Dietary intake of calcium, fiber and other micronutrients in relation to colorectal cancer risk: Results from the Shanghai Women's Health Study
    Aesun Shin
    Department of Medicine, Center for Health Services Research and Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232 2587, USA
    Int J Cancer 119:2938-42. 2006
    ..Our results suggest that calcium may be protective against colorectal cancer development even at a lower consumption level compared to Western populations...
  89. pmc IGF-I and IGF-II genetic variation and breast cancer risk in Chinese women: results from the Shanghai Breast Cancer Study
    Sandra L Deming
    Institute for Medicine and Public Health, Vanderbilt University Medical Center, 2525 West End Avenue, Nashville, TN 3720 1738, USA
    Cancer Epidemiol Biomarkers Prev 17:255-7. 2008
  90. ncbi request reprint Nutrient intake among Chinese women living in Shanghai, China
    Zhi Chen
    Department of Medicine, Center for Health Services Research and Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, TN 37232 8300, USA
    Br J Nutr 96:393-9. 2006
    ....
  91. pmc Haplotype analysis of CYP11A1 identifies promoter variants associated with breast cancer risk
    Brian L Yaspan
    Department of Cancer Biology, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, TN 37232 0275, USA
    Cancer Res 67:5673-82. 2007
    ..94 (95% CI, 1.22-7.12), test for trend, P = 5.0e-5. Among genes controlling endogenous estrogen metabolism, CYP11A1 harbors common variants that may influence expression to significantly modify risk of breast cancer...
  92. ncbi request reprint Population-based case-control study of AhR (aryl hydrocarbon receptor) and CYP1A2 polymorphisms and breast cancer risk
    Ji Rong Long
    Department of Medicine and Vanderbilt Ingram Cancer Center, Vanderbilt University, 1161 21st Avenue South, Nashville, TN 37232, USA
    Pharmacogenet Genomics 16:237-43. 2006
    ....
  93. pmc Intake of fruits, vegetables and selected micronutrients in relation to the risk of breast cancer
    Alecia S Malin
    Department of Medicine and Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, TN, USA
    Int J Cancer 105:413-8. 2003
    ..05). Our study suggests that high intake of certain vegetables and fruits may be associated with a reduced risk of breast cancer...
  94. pmc Vegetable but not fruit consumption reduces the risk of type 2 diabetes in Chinese women
    Raquel Villegas
    Department of Medicine, Vanderbilt Epidemiology Center, Institute for Medicine and Public Health, Nashville, TN 37203 1738, USA
    J Nutr 138:574-80. 2008
    ..Fruit intake was not associated with the incidence of diabetes in this population. Our data suggest that vegetable consumption may protect against the development of T2D...
  95. ncbi request reprint Genetic polymorphisms of the transforming growth factor-beta1 gene and breast cancer risk: a possible dual role at different cancer stages
    Aesun Shin
    Department of Medicine and Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 8300, USA
    Cancer Epidemiol Biomarkers Prev 14:1567-70. 2005
    ....
  96. ncbi request reprint Association of genetic polymorphisms in the VEGF gene with breast cancer survival
    Hua Lu
    Department of Medicine, Center for Health Services Research, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 8300, USA
    Cancer Res 65:5015-9. 2005
    ..1; 95% CI, -0.9 to 4.7). The C+936T polymorphism alone was not related to overall or disease-free survival. This study suggests that VEGF polymorphisms may be a significant genetic marker for breast cancer prognosis...
  97. ncbi request reprint Polymorphisms in CYP1A1 and breast carcinoma risk in a population-based case-control study of Chinese women
    Sonia M Boyapati
    Department of Medicine, Center for Health Services Research, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Cancer 103:2228-35. 2005
    ..Cytochrome P450 1A1 (CYP1A1) is involved in the 2-hydroxylation of estrogen, the hormone that plays a critical role in the etiology of breast carcinoma...
  98. pmc Mutations in the mitochondrial DNA D-loop region and breast cancer risk
    Chuanzhong Ye
    Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, B 2104, Medical Center North, 1161 21st Avenue South, Nashville, TN 37232 2400, USA
    Breast Cancer Res Treat 119:431-6. 2010
    ..3%) than in BBD patients (15.3%) (P = 0.05) and more frequently in proliferative BBD (13.0%) than in non-proliferative BBD (7.1%). Our data suggest that somatic MnlI site mutations may play a role in the pathogenesis of breast cancer...
  99. pmc Animal origin foods and colorectal cancer risk: a report from the Shanghai Women's Health Study
    Sang Ah Lee
    Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, 2525 West End Avenue, Nashville, TN 37203 1738, USA
    Nutr Cancer 61:194-205. 2009
    ..The latter was positively associated with colon cancer (RR = 1.4 for ever vs. never, 95% CI = 1.1-1.9). A possible role of cholesterol and environmental pollution in the etiology of CRC was suggested...
  100. ncbi request reprint E-cadherin promoter polymorphisms are not associated with the aggressiveness of prostate cancer in Caucasian patients
    He Cheng Li
    Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Urol Oncol 24:496-502. 2006
    ..Decreased E-cadherin expression predicts poor outcome among patients with cancer. We sought to investigate whether -160C-->A and/or -347G-->GA polymorphisms were associated with the aggressiveness of prostate cancer...
  101. ncbi request reprint Cytochrome P450 1B1 and catechol-O-methyltransferase genetic polymorphisms and endometrial cancer risk in Chinese women
    Meng Hua Tao
    Vanderbilt Epidemiology Center, Vanderbilt University, 6009 Medical Center East, 1215 21st Avenue South, Nashville, TN 37232 8300, USA
    Cancer Epidemiol Biomarkers Prev 15:2570-3. 2006

Research Grants38

  1. CANCER RISK REDUCTION AND DIET--A COHORT STUDY OF WOMEN
    Wei Zheng; Fiscal Year: 2000
    ..g., phytoestrogens) and common genetic factors (e.g., metabolizing enzymes) and their interaction with environmental factors in the etiology of various cancers. ..
  2. Tumor Markers and Recurrent Adenomas: A Follow-up Study
    Wei Zheng; Fiscal Year: 2006
    ..This study is likely to provide valuable information for identifying high-risk adenoma patients for close surveillance and chemoprevention. ..
  3. Cancer Risk Reduction and Diet: A Cohort Study of Women
    Wei Zheng; Fiscal Year: 2007
    ..The results from this study may guide new strategies in the primary prevention of common cancer in both Western and Asian women. ..
  4. Shanghai Breast Cancer Study
    Wei Zheng; Fiscal Year: 2007
    ..abstract_text> ..
  5. MOLECULAR EPIDEMIOLOGIC STUDY OF BREAST CANCER
    Wei Zheng; Fiscal Year: 2009
    ..Results from this study will be valuable in identifying high risk women for primary and secondary prevention of breast cancer. ..
  6. Genetic Factors for Breast Cancer- A genome Wide Study
    Wei Zheng; Fiscal Year: 2010
    ..This study will generate valuable results for the identification of high-risk women for the primary and secondary prevention of breast cancer. ..
  7. Shanghai Breast Cancer Study
    Wei Zheng; Fiscal Year: 2010
    ..The results from this study will be valuable in identifying high-risk women for cost- efficient breast cancer prevention and personalized treatment and follow-up care after cancer diagnosis. ..
  8. Shanghai Breast Cancer Study
    Wei Zheng; Fiscal Year: 2005
    ..They further state that it will also create a valuable resource for future studies of genetic factors and gene-environmental interaction in the etiology of breast cancer. ..
  9. The Nashville Breast Health Study
    Wei Zheng; Fiscal Year: 2009
    ..Studies investigating gene-gene and gene-environment interaction could provide valuable information in identifying high-risk individuals for designing cost-effective preventive strategies for breast cancer. ..