Ming Zhi Zhang
Affiliation: Vanderbilt University
Zhang M, Wang Y, Paueksakon P, Harris R. Epidermal growth factor receptor inhibition slows progression of diabetic nephropathy in association with a decrease in endoplasmic reticulum stress and an increase in autophagy. Diabetes. 2014;63:2063-72 pubmed publisher
Zhang M, Xu J, Yao B, Yin H, Cai Q, Shrubsole M, et al
. Inhibition of 11beta-hydroxysteroid dehydrogenase type II selectively blocks the tumor COX-2 pathway and suppresses colon carcinogenesis in mice and humans. J Clin Invest. 2009;119:876-85 pubmed publisher
..Therefore, 11betaHSD2 inhibition represents what we believe to be a novel approach for CRC chemoprevention and therapy by increasing tumor glucocorticoid activity, which in turn selectively blocks local COX-2 activity. ..
Ding Z, Jin G, Wang W, Sun Y, Chen W, Chen L, et al
. Activin A-Smad Signaling Mediates Connective Tissue Growth Factor Synthesis in Liver Progenitor Cells. Int J Mol Sci. 2016;17:408 pubmed publisher
..Collectively, these results provide evidence for the fibrotic role of LPCs in the liver and suggest that the Activin A-Smad-CTGF/CCN2 signaling in LPCs may be a therapeutic target of liver fibrosis. ..
Zhang M. Interaction of renal corticalÂ cyclooxygenase-2 andÂ angiotensin II in postnatalÂ nephrogenesis. Kidney Int. 2017;91:771-773 pubmed publisher
..A study by FrÃ¶lich etÂ al. now strongly indicates that cortical COX-2 promotes postnatal nephrogenesis and maturation through activation of Ang II-angiotensin type 1 receptor signaling. ..
Zhang M, Yao B, Cheng H, Wang S, Inagami T, Harris R. Renal cortical cyclooxygenase 2 expression is differentially regulated by angiotensin II AT(1) and AT(2) receptors. Proc Natl Acad Sci U S A. 2006;103:16045-50 pubmed
Zhang M, Yao B, Wang S, Fan X, Wu G, Yang H, et al
. Intrarenal dopamine deficiency leads to hypertension and decreased longevity in mice. J Clin Invest. 2011;121:2845-54 pubmed publisher
..Decreasing intrarenal dopamine subjects the kidney to unbuffered responses to Ang II and results in the development of hypertension and a dramatic decrease in longevity. ..
Zhang M, Yao B, Yang S, Yang H, Wang S, Fan X, et al
. Intrarenal dopamine inhibits progression of diabetic nephropathy. Diabetes. 2012;61:2575-84 pubmed
Zhang M, Yao B, Yang S, Jiang L, Wang S, Fan X, et al
. CSF-1 signaling mediates recovery from acute kidney injury. J Clin Invest. 2012;122:4519-32 pubmed publisher
..These findings demonstrated that CSF-1-mediated expansion and polarization of resident renal macrophages/dendritic cells is an important mechanism mediating renal tubule epithelial regeneration after AKI. ..
Jiang L, Yang S, Yin H, Fan X, Wang S, Yao B, et al
. Epithelial-specific deletion of 11?-HSD2 hinders Apcmin/+ mouse tumorigenesis. Mol Cancer Res. 2013;11:1040-50 pubmed publisher
..Inhibition of 11?-HSD2 may represent a novel approach for colorectal cancer chemoprevention by increasing tumor glucocorticoid activity, which in turn inhibits tumor growth by multiple pathways. ..