Research Topics
Species | David ZaldSummaryAffiliation: Vanderbilt University Country: USA Publications
Research Grants
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Detail Information
Publications
Dopamine transmission in the human striatum during monetary reward tasksDavid H Zald
Department of Psychology, Vanderbilt University, Nashville, Tennessee 37212, USA
J Neurosci 24:4105-12. 2004..The implications of these results are discussed in relation to conflicting models of dopaminergic functioning arising from studies using electrophysiological and microdialysis techniques in animals...- Frontal lobe activation during object alternation acquisitionDavid H Zald
Department of Psychology, Vanderbilt University, Nashville, TN 37240, USA
Neuropsychology 19:97-105. 2005..However, activation of the presupplemental motor area was more closely associated with successful task performance. The authors suggest that areas beyond the ventral prefrontal cortex are critically involved in OA acquisition... 
Midbrain dopamine receptor availability is inversely associated with novelty-seeking traits in humansDavid H Zald
Department of Psychology, Vanderbilt University Nashville, Tennessee 37240, USA
J Neurosci 28:14372-8. 2008..We speculate that the lower midbrain (auto)receptor availability seen in high novelty seekers leads to accentuated dopaminergic responses to novelty and other conditions that induce dopamine release...- Amygdala temporal dynamics: temperamental differences in the timing of amygdala response to familiar and novel facesJennifer U Blackford
Department of Psychiatry, Vanderbilt University Medical School, Nashville, Tennessee, USA
BMC Neurosci 10:145. 2009.... - The interrelationship of dopamine D2-like receptor availability in striatal and extrastriatal brain regions in healthy humans: a principal component analysis of [18F]fallypride bindingDavid H Zald
Department of Psychology, Vanderbilt University, 325 Wilson Hall, 111 21st Ave South, Nashville, TN 37212, USA
Neuroimage 51:53-62. 2010..This conclusion has significant implications for neuropsychiatric models that posit global or regionally specific relationships between dopaminergic tone and behavior... - The human amygdala and the emotional evaluation of sensory stimuliDavid H Zald
Department of Psychology, Vanderbilt University, 301 Wilson Hall, 111 21st Ave S, Nashville, TN 37240 0009, USA
Brain Res Brain Res Rev 41:88-123. 2003..The strengths and weakness of these hypotheses and conclusions are discussed with reference to the animal literature... 
Orbitofrontal cortex contributions to food selection and decision makingDavid H Zald
Vanderbilt University, Nashville, TN, USA
Ann Behav Med 38:S18-24. 2009..CONCLUSION: An understanding of these influences on positive and negative valuation is critical in designing diets and public health programs aimed at promoting healthy eating...- Orbital versus dorsolateral prefrontal cortex: anatomical insights into content versus process differentiation models of the prefrontal cortexDavid H Zald
Department of Psychology, Vanderbilt University, Nashville, TN 37203, USA
Ann N Y Acad Sci 1121:395-406. 2007..While overarching themes may help explain the operations in both the OFC and the DLPFC, the specific operations performed in the two regions are likely to be both quantitatively and qualitatively different in nature... - Neuropsychological assessment of the orbital and ventromedial prefrontal cortexDavid H Zald
Department of Psychology, Vanderbilt University, Nashville, TN 37212, USA
Neuropsychologia 48:3377-91. 2010.... - Sex differences in amphetamine-induced displacement of [(18)F]fallypride in striatal and extrastriatal regions: a PET studyPatrizia Riccardi
Vanderbilt University Medical Center, Department of Radiology, Nashville, TN 37232 2675, USA
Am J Psychiatry 163:1639-41. 2006..The authors examined gender differences in d-amphetamine-induced displacements of [(18)F]fallypride in the striatal and extrastriatal brain regions and the correlations of these displacements with cognition and sensation seeking... - Dopamine D2 receptor levels in striatum, thalamus, substantia nigra, limbic regions, and cortex in schizophrenic subjectsRobert M Kessler
Department of Radiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Biol Psychiatry 65:1024-31. 2009..Studies in schizophrenic patients have reported dopaminergic abnormalities in striatum, substantia nigra, thalamus, anterior cingulate, hippocampus, and cortex that have been related to positive symptoms and cognitive impairments... - Amphetamine-induced displacement of [18F] fallypride in striatum and extrastriatal regions in humansPatrizia Riccardi
Department of Radiology, Vanderbilt University, Nashville, TN 37232-2675, USA
Neuropsychopharmacology 31:1016-26. 2006..43 mg/kg) can be used to study D-AMPH-induced DA release in the striatal and extrastriatal regions in humans, and their relationship with cognition and sensation-seeking behavior... - Attentional rubbernecking: cognitive control and personality in emotion-induced blindnessSteven B Most
Department of Psychology, Yale University, Box 208205, New Haven, CT 06520 8205, USA
Psychon Bull Rev 12:654-61. 2005..Participants lower in harm avoidance were able to reduce emotion-induced blindness under conditions designed to facilitate the ignoring of the emotional stimuli. Those higher in harm avoidance were unable to do so... - The neural correlates of third-party punishmentJoshua W Buckholtz
Department of Psychology, Vanderbilt University, Nashville, TN 37240, USA
Neuron 60:930-40. 2008.... - An emotion-induced attentional blink elicited by aversively conditioned stimuliStephen D Smith
Department of Psychology, Vanderbilt University, Nashville, TN, USA
Emotion 6:523-7. 2006..Thus, temporary visual deficits can be induced by otherwise neutral distractors whose aversive associations have only recently been learned... - Dopaminergic network differences in human impulsivityJoshua W Buckholtz
Department of Psychology, Vanderbilt University, Nashville, TN 37240, USA
Science 329:532. 2010..Path analysis confirmed that the impact of decreased midbrain D2/D3 autoreceptor availability on trait impulsivity is mediated in part through its effect on stimulated striatal DA release... - Conceptual, methodological, and empirical ambiguities in the linkage between anger and approach: comment on Carver and Harmon-Jones (2009)Andrew J Tomarken
Department of Psychology, Vanderbilt University, Nashville, TN 37240 7817, USA
Psychol Bull 135:209-14; discussion 215-7. 2009..Neuroimaging studies reviewed generally fail to corroborate several features of their model... - Cerebral morphology and dopamine D2/D3 receptor distribution in humans: a combined [18F]fallypride and voxel-based morphometry studyNeil D Woodward
Psychiatric Neuroimaging Program, Vanderbilt Psychiatric Hospital, Suite 3057, 1601 23rd Ave S, Nashville, TN 37212, USA
Neuroimage 46:31-8. 2009..Clinical studies comparing dopamine receptor availability between clinical and control groups may benefit by accounting for potential differences in cerebral morphology that exist even after spatial normalization... - Worth the 'EEfRT'? The effort expenditure for rewards task as an objective measure of motivation and anhedoniaMichael T Treadway
Department of Psychology, Vanderbilt University, Nashville, TN, USA
PLoS ONE 4:e6598. 2009..Using the EEfRT, we test the hypothesis that effort-based decision-making is related to trait anhedonia... - Reconsidering anhedonia in depression: lessons from translational neuroscienceMichael T Treadway
Department of Psychology, Vanderbilt University, Nashville, TN 37240, USA
Neurosci Biobehav Rev 35:537-55. 2011..These proposed modifications to the theoretical definition of anhedonia have implications for research, assessment and treatment of MDD... - Mesolimbic dopamine reward system hypersensitivity in individuals with psychopathic traitsJoshua W Buckholtz
Department of Psychology, Vanderbilt University, Nashville, Tennessee, USA
Nat Neurosci 13:419-21. 2010..These findings suggest that neurochemical and neurophysiological hyper-reactivity of the dopaminergic reward system may comprise a neural substrate for impulsive-antisocial behavior and substance abuse in psychopathy... - A unique role for the human amygdala in novelty detectionJennifer Urbano Blackford
Department of Psychiatry, Vanderbilt University Medical School, Nashville, TN 37212, USA
Neuroimage 50:1188-93. 2010..These findings suggest that the amygdala is distinctly responsive to novel unusual stimuli, making a unique contribution to the novelty detection circuit... - All I saw was the cake. Hunger effects on attentional capture by visual food cuesRichard M Piech
Department of Psychology, Vanderbilt University, PMB 407817, Nashville, TN 37240, USA
Appetite 54:579-82. 2010.... - Making something out of nothing: neutral content modulates attention in generalized anxiety disorderBunmi O Olatunji
Department of Psychology, Vanderbilt University, 111 21st Avenue South, Nashville, TN 37203, USA
Depress Anxiety 28:427-34. 2011..This study examines whether exposure to different emotional content modulates attention disengagement and impairs the perception of subsequently presented nonemotional targets in GAD... - Fearful expressions gain preferential access to awareness during continuous flash suppressionEunice Yang
Psychology Department, Vanderbilt University, Nashville, TN 37203, USA
Emotion 7:882-6. 2007..When using stimuli solely representing the eyes, a similar bias for detecting fear emerged, implicating the importance of information from the eyes in the preconscious processing of fear expressions... - A meta-analysis of cognitive change with haloperidol in clinical trials of atypical antipsychotics: dose effects and comparison to practice effectsNeil D Woodward
Department of Psychology, Vanderbilt University, 301 Wilson Hall, 111 21st Ave S, Nashville, TN 37203, USA
Schizophr Res 89:211-24. 2007.... - Prefrontal contributions to delayed spatial and object alternation: a positron emission tomography studyDavid H Zald
Department of Psychology, Vanderbilt University, USA
Neuropsychology 16:182-9. 2002..Additional activations localized to several nonfrontal regions suggest caution in interpreting alternation deficits in patients as strictly reflecting frontal lobe impairment... - Neural correlates of tasting concentrated quinine and sugar solutionsDavid H Zald
Department of Psychology, Vanderbilt University, Nashville, Tennessee 37240, USA
J Neurophysiol 87:1068-75. 2002.... - Brain activity in ventromedial prefrontal cortex correlates with individual differences in negative affectDavid H Zald
Department of Psychology, Vanderbilt University, 301 Wilson Hall, 111 21st Avenue South, Nashville, TN 37203, USA
Proc Natl Acad Sci U S A 99:2450-4. 2002..Moreover, it demonstrates that variability in basal VMPFC activity across subjects is related to individual differences in subjective emotional experience... - The rodent orbitofrontal cortex gets time and directionDavid H Zald
Department of Psychology, Vanderbilt University, Nashville, Tennessee 37203, USA
Neuron 51:395-7. 2006..In this issue of Neuron, papers by Roesch et al. and Feierstein et al. demonstrate the importance of temporal and spatial features to processing in the rodent OFC... - The neural correlates of aversive auditory stimulationDavid H Zald
Department of Psychology, Vanderbilt University, Nashville, Tennessee 37240, USA
Neuroimage 16:746-53. 2002..The data further highlight a widely distributed network of cortical and subcortical areas activated during exposure to aversive sounds... - A meta-analysis of neuropsychological change to clozapine, olanzapine, quetiapine, and risperidone in schizophreniaNeil D Woodward
Department of Psychology, Vanderbilt University, Nashville, TN 37203, USA
Int J Neuropsychopharmacol 8:457-72. 2005..Atypical antipsychotics produce a mild remediation of cognitive deficits in schizophrenia, and specific atypicals have differential effects within certain cognitive domains... - Individual differences in oral thermosensationSuzanna Manrique
Department of Psychology, 301 Wilson Hall, 111 21st Avenue South, Vanderbilt University, Nashville, TN, USA
Physiol Behav 88:417-24. 2006..D. below the mean) cool threshold detection abilities for the tongue, suggesting that there may exist subjects in the population who have profoundly poor lingual temperature processing... - Posttraumatic stress disorder in a patient with no left amygdalaStephen D Smith
Department of Psychology, University of Winnipeg, Winnipeg, Manitoba, Canada
J Abnorm Psychol 117:479-84. 2008..The authors propose that the right amygdala is preferentially involved in several processes related to the expression of PTSD symptoms, such that the disorder can occur even in the absence of the left amygdala... - Striatal dopamine transmission in healthy humans during a passive monetary reward taskHélène S Hakyemez
McConnel Brain Imaging Center, Montreal Neurological Institute, McGill University, Montreal, Canada
Neuroimage 39:2058-65. 2008..These data suggest that active behavioral engagement may be necessary to observe robust statewise increases in DA release in the striatum... - Somatosensory processing in the human inferior prefrontal cortexMatthew C Hagen
Cognitive Neuroimaging Unit, Veterans Affairs Medical Center, Minneapolis, Minnesota 55417, USA
J Neurophysiol 88:1400-6. 2002..The former region (posterior IFG/anterior frontal operculum) may have a more specific role in attending to tactile stimuli... - On the scent of human olfactory orbitofrontal cortex: meta-analysis and comparison to non-human primatesJay A Gottfried
Department of Neurology and the Cognitive Neurology and Alzheimer s Disease Center, Northwestern University Feinberg School of Medicine, 320 E Superior St, Searle 11 453, Chicago, IL 60611, USA
Brain Res Brain Res Rev 50:287-304. 2005....
Research Grants
- Individual Differences in Extrastriatal DA ReleaseDavid Zald; Fiscal Year: 2007..Taken together, the study will provide unique information on how individual differences in the organization of the human DA system are associated with personality, genetics and the subjective and cognitive effects of psychostimulants. ..
- Individual Differences in Extrastriatal DA ReleaseDavid Zald; Fiscal Year: 2009..abstract_text> ..
- The Amygdala: Emotional Modulation of AttentionDavid H Zald; Fiscal Year: 2010..Thus, the study will be able to address the effects of amygdala lesions with a degree of precision that has been unattainable in previous research on the human amygdala. ..
- The Amygdala: Emotional Modulation of AttentionDavid Zald; Fiscal Year: 2009..Thus, the study will be able to address the effects of amygdala lesions with a degree of precision that has been unattainable in previous research on the human amygdala. ..