David Zald

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. ncbi request reprint Dopamine transmission in the human striatum during monetary reward tasks
    David H Zald
    Department of Psychology, Vanderbilt University, Nashville, Tennessee 37212, USA
    J Neurosci 24:4105-12. 2004
  2. ncbi request reprint Frontal lobe activation during object alternation acquisition
    David H Zald
    Department of Psychology, Vanderbilt University, Nashville, TN 37240, USA
    Neuropsychology 19:97-105. 2005
  3. pmc Midbrain dopamine receptor availability is inversely associated with novelty-seeking traits in humans
    David H Zald
    Department of Psychology, Vanderbilt University Nashville, Tennessee 37240, USA
    J Neurosci 28:14372-8. 2008
  4. pmc Amygdala temporal dynamics: temperamental differences in the timing of amygdala response to familiar and novel faces
    Jennifer U Blackford
    Department of Psychiatry, Vanderbilt University Medical School, Nashville, Tennessee, USA
    BMC Neurosci 10:145. 2009
  5. pmc The interrelationship of dopamine D2-like receptor availability in striatal and extrastriatal brain regions in healthy humans: a principal component analysis of [18F]fallypride binding
    David H Zald
    Department of Psychology, Vanderbilt University, 325 Wilson Hall, 111 21st Ave South, Nashville, TN 37212, USA
    Neuroimage 51:53-62. 2010
  6. ncbi request reprint The human amygdala and the emotional evaluation of sensory stimuli
    David H Zald
    Department of Psychology, Vanderbilt University, 301 Wilson Hall, 111 21st Ave S, Nashville, TN 37240 0009, USA
    Brain Res Brain Res Rev 41:88-123. 2003
  7. doi request reprint Orbitofrontal cortex contributions to food selection and decision making
    David H Zald
    Vanderbilt University, Nashville, TN, USA
    Ann Behav Med 38:S18-24. 2009
  8. ncbi request reprint Orbital versus dorsolateral prefrontal cortex: anatomical insights into content versus process differentiation models of the prefrontal cortex
    David H Zald
    Department of Psychology, Vanderbilt University, Nashville, TN 37203, USA
    Ann N Y Acad Sci 1121:395-406. 2007
  9. doi request reprint Neuropsychological assessment of the orbital and ventromedial prefrontal cortex
    David H Zald
    Department of Psychology, Vanderbilt University, Nashville, TN 37212, USA
    Neuropsychologia 48:3377-91. 2010
  10. ncbi request reprint Sex differences in amphetamine-induced displacement of [(18)F]fallypride in striatal and extrastriatal regions: a PET study
    Patrizia Riccardi
    Vanderbilt University Medical Center, Department of Radiology, Nashville, TN 37232 2675, USA
    Am J Psychiatry 163:1639-41. 2006

Research Grants

Detail Information

Publications37

  1. ncbi request reprint Dopamine transmission in the human striatum during monetary reward tasks
    David H Zald
    Department of Psychology, Vanderbilt University, Nashville, Tennessee 37212, USA
    J Neurosci 24:4105-12. 2004
    ..The implications of these results are discussed in relation to conflicting models of dopaminergic functioning arising from studies using electrophysiological and microdialysis techniques in animals...
  2. ncbi request reprint Frontal lobe activation during object alternation acquisition
    David H Zald
    Department of Psychology, Vanderbilt University, Nashville, TN 37240, USA
    Neuropsychology 19:97-105. 2005
    ..However, activation of the presupplemental motor area was more closely associated with successful task performance. The authors suggest that areas beyond the ventral prefrontal cortex are critically involved in OA acquisition...
  3. pmc Midbrain dopamine receptor availability is inversely associated with novelty-seeking traits in humans
    David H Zald
    Department of Psychology, Vanderbilt University Nashville, Tennessee 37240, USA
    J Neurosci 28:14372-8. 2008
    ..We speculate that the lower midbrain (auto)receptor availability seen in high novelty seekers leads to accentuated dopaminergic responses to novelty and other conditions that induce dopamine release...
  4. pmc Amygdala temporal dynamics: temperamental differences in the timing of amygdala response to familiar and novel faces
    Jennifer U Blackford
    Department of Psychiatry, Vanderbilt University Medical School, Nashville, Tennessee, USA
    BMC Neurosci 10:145. 2009
    ....
  5. pmc The interrelationship of dopamine D2-like receptor availability in striatal and extrastriatal brain regions in healthy humans: a principal component analysis of [18F]fallypride binding
    David H Zald
    Department of Psychology, Vanderbilt University, 325 Wilson Hall, 111 21st Ave South, Nashville, TN 37212, USA
    Neuroimage 51:53-62. 2010
    ..This conclusion has significant implications for neuropsychiatric models that posit global or regionally specific relationships between dopaminergic tone and behavior...
  6. ncbi request reprint The human amygdala and the emotional evaluation of sensory stimuli
    David H Zald
    Department of Psychology, Vanderbilt University, 301 Wilson Hall, 111 21st Ave S, Nashville, TN 37240 0009, USA
    Brain Res Brain Res Rev 41:88-123. 2003
    ..The strengths and weakness of these hypotheses and conclusions are discussed with reference to the animal literature...
  7. doi request reprint Orbitofrontal cortex contributions to food selection and decision making
    David H Zald
    Vanderbilt University, Nashville, TN, USA
    Ann Behav Med 38:S18-24. 2009
    ..The OFC also processes information about negative valuations (i.e., cost, negative health consequences), which are influenced by factors such as temporal discounting, probability and ambiguity...
  8. ncbi request reprint Orbital versus dorsolateral prefrontal cortex: anatomical insights into content versus process differentiation models of the prefrontal cortex
    David H Zald
    Department of Psychology, Vanderbilt University, Nashville, TN 37203, USA
    Ann N Y Acad Sci 1121:395-406. 2007
    ..While overarching themes may help explain the operations in both the OFC and the DLPFC, the specific operations performed in the two regions are likely to be both quantitatively and qualitatively different in nature...
  9. doi request reprint Neuropsychological assessment of the orbital and ventromedial prefrontal cortex
    David H Zald
    Department of Psychology, Vanderbilt University, Nashville, TN 37212, USA
    Neuropsychologia 48:3377-91. 2010
    ....
  10. ncbi request reprint Sex differences in amphetamine-induced displacement of [(18)F]fallypride in striatal and extrastriatal regions: a PET study
    Patrizia Riccardi
    Vanderbilt University Medical Center, Department of Radiology, Nashville, TN 37232 2675, USA
    Am J Psychiatry 163:1639-41. 2006
    ..The authors examined gender differences in d-amphetamine-induced displacements of [(18)F]fallypride in the striatal and extrastriatal brain regions and the correlations of these displacements with cognition and sensation seeking...
  11. pmc Dopamine D2 receptor levels in striatum, thalamus, substantia nigra, limbic regions, and cortex in schizophrenic subjects
    Robert M Kessler
    Department of Radiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Biol Psychiatry 65:1024-31. 2009
    ..Studies in schizophrenic patients have reported dopaminergic abnormalities in striatum, substantia nigra, thalamus, anterior cingulate, hippocampus, and cortex that have been related to positive symptoms and cognitive impairments...
  12. ncbi request reprint Amphetamine-induced displacement of [18F] fallypride in striatum and extrastriatal regions in humans
    Patrizia Riccardi
    Department of Radiology, Vanderbilt University, Nashville, TN 37232 2675, USA
    Neuropsychopharmacology 31:1016-26. 2006
    ..43 mg/kg) can be used to study D-AMPH-induced DA release in the striatal and extrastriatal regions in humans, and their relationship with cognition and sensation-seeking behavior...
  13. ncbi request reprint Attentional rubbernecking: cognitive control and personality in emotion-induced blindness
    Steven B Most
    Department of Psychology, Yale University, Box 208205, New Haven, CT 06520 8205, USA
    Psychon Bull Rev 12:654-61. 2005
    ..Participants lower in harm avoidance were able to reduce emotion-induced blindness under conditions designed to facilitate the ignoring of the emotional stimuli. Those higher in harm avoidance were unable to do so...
  14. doi request reprint The neural correlates of third-party punishment
    Joshua W Buckholtz
    Department of Psychology, Vanderbilt University, Nashville, TN 37240, USA
    Neuron 60:930-40. 2008
    ....
  15. ncbi request reprint An emotion-induced attentional blink elicited by aversively conditioned stimuli
    Stephen D Smith
    Department of Psychology, Vanderbilt University, Nashville, TN, USA
    Emotion 6:523-7. 2006
    ..Thus, temporary visual deficits can be induced by otherwise neutral distractors whose aversive associations have only recently been learned...
  16. pmc Dopaminergic network differences in human impulsivity
    Joshua W Buckholtz
    Department of Psychology, Vanderbilt University, Nashville, TN 37240, USA
    Science 329:532. 2010
    ..Path analysis confirmed that the impact of decreased midbrain D2/D3 autoreceptor availability on trait impulsivity is mediated in part through its effect on stimulated striatal DA release...
  17. doi request reprint Conceptual, methodological, and empirical ambiguities in the linkage between anger and approach: comment on Carver and Harmon-Jones (2009)
    Andrew J Tomarken
    Department of Psychology, Vanderbilt University, Nashville, TN 37240 7817, USA
    Psychol Bull 135:209-14; discussion 215-7. 2009
    ..Neuroimaging studies reviewed generally fail to corroborate several features of their model...
  18. pmc Cerebral morphology and dopamine D2/D3 receptor distribution in humans: a combined [18F]fallypride and voxel-based morphometry study
    Neil D Woodward
    Psychiatric Neuroimaging Program, Vanderbilt Psychiatric Hospital, Suite 3057, 1601 23rd Ave S, Nashville, TN 37212, USA
    Neuroimage 46:31-8. 2009
    ..Clinical studies comparing dopamine receptor availability between clinical and control groups may benefit by accounting for potential differences in cerebral morphology that exist even after spatial normalization...
  19. pmc Worth the 'EEfRT'? The effort expenditure for rewards task as an objective measure of motivation and anhedonia
    Michael T Treadway
    Department of Psychology, Vanderbilt University, Nashville, TN, USA
    PLoS ONE 4:e6598. 2009
    ..Using the EEfRT, we test the hypothesis that effort-based decision-making is related to trait anhedonia...
  20. pmc Reconsidering anhedonia in depression: lessons from translational neuroscience
    Michael T Treadway
    Department of Psychology, Vanderbilt University, Nashville, TN 37240, USA
    Neurosci Biobehav Rev 35:537-55. 2011
    ..These proposed modifications to the theoretical definition of anhedonia have implications for research, assessment and treatment of MDD...
  21. pmc Mesolimbic dopamine reward system hypersensitivity in individuals with psychopathic traits
    Joshua W Buckholtz
    Department of Psychology, Vanderbilt University, Nashville, Tennessee, USA
    Nat Neurosci 13:419-21. 2010
    ..These findings suggest that neurochemical and neurophysiological hyper-reactivity of the dopaminergic reward system may comprise a neural substrate for impulsive-antisocial behavior and substance abuse in psychopathy...
  22. pmc A unique role for the human amygdala in novelty detection
    Jennifer Urbano Blackford
    Department of Psychiatry, Vanderbilt University Medical School, Nashville, TN 37212, USA
    Neuroimage 50:1188-93. 2010
    ..These findings suggest that the amygdala is distinctly responsive to novel unusual stimuli, making a unique contribution to the novelty detection circuit...
  23. doi request reprint All I saw was the cake. Hunger effects on attentional capture by visual food cues
    Richard M Piech
    Department of Psychology, Vanderbilt University, PMB 407817, Nashville, TN 37240, USA
    Appetite 54:579-82. 2010
    ....
  24. doi request reprint Making something out of nothing: neutral content modulates attention in generalized anxiety disorder
    Bunmi O Olatunji
    Department of Psychology, Vanderbilt University, 111 21st Avenue South, Nashville, TN 37203, USA
    Depress Anxiety 28:427-34. 2011
    ..This study examines whether exposure to different emotional content modulates attention disengagement and impairs the perception of subsequently presented nonemotional targets in GAD...
  25. ncbi request reprint Fearful expressions gain preferential access to awareness during continuous flash suppression
    Eunice Yang
    Psychology Department, Vanderbilt University, Nashville, TN 37203, USA
    Emotion 7:882-6. 2007
    ..When using stimuli solely representing the eyes, a similar bias for detecting fear emerged, implicating the importance of information from the eyes in the preconscious processing of fear expressions...
  26. ncbi request reprint A meta-analysis of cognitive change with haloperidol in clinical trials of atypical antipsychotics: dose effects and comparison to practice effects
    Neil D Woodward
    Department of Psychology, Vanderbilt University, 301 Wilson Hall, 111 21st Ave S, Nashville, TN 37203, USA
    Schizophr Res 89:211-24. 2007
    ....
  27. ncbi request reprint Prefrontal contributions to delayed spatial and object alternation: a positron emission tomography study
    David H Zald
    Department of Psychology, Vanderbilt University, USA
    Neuropsychology 16:182-9. 2002
    ..Additional activations localized to several nonfrontal regions suggest caution in interpreting alternation deficits in patients as strictly reflecting frontal lobe impairment...
  28. ncbi request reprint Neural correlates of tasting concentrated quinine and sugar solutions
    David H Zald
    Department of Psychology, Vanderbilt University, Nashville, Tennessee 37240, USA
    J Neurophysiol 87:1068-75. 2002
    ....
  29. pmc Brain activity in ventromedial prefrontal cortex correlates with individual differences in negative affect
    David H Zald
    Department of Psychology, Vanderbilt University, 301 Wilson Hall, 111 21st Avenue South, Nashville, TN 37203, USA
    Proc Natl Acad Sci U S A 99:2450-4. 2002
    ..Moreover, it demonstrates that variability in basal VMPFC activity across subjects is related to individual differences in subjective emotional experience...
  30. ncbi request reprint The rodent orbitofrontal cortex gets time and direction
    David H Zald
    Department of Psychology, Vanderbilt University, Nashville, Tennessee 37203, USA
    Neuron 51:395-7. 2006
    ..In this issue of Neuron, papers by Roesch et al. and Feierstein et al. demonstrate the importance of temporal and spatial features to processing in the rodent OFC...
  31. ncbi request reprint The neural correlates of aversive auditory stimulation
    David H Zald
    Department of Psychology, Vanderbilt University, Nashville, Tennessee 37240, USA
    Neuroimage 16:746-53. 2002
    ..The data further highlight a widely distributed network of cortical and subcortical areas activated during exposure to aversive sounds...
  32. ncbi request reprint A meta-analysis of neuropsychological change to clozapine, olanzapine, quetiapine, and risperidone in schizophrenia
    Neil D Woodward
    Department of Psychology, Vanderbilt University, Nashville, TN 37203, USA
    Int J Neuropsychopharmacol 8:457-72. 2005
    ..Atypical antipsychotics produce a mild remediation of cognitive deficits in schizophrenia, and specific atypicals have differential effects within certain cognitive domains...
  33. ncbi request reprint Individual differences in oral thermosensation
    Suzanna Manrique
    Department of Psychology, 301 Wilson Hall, 111 21st Avenue South, Vanderbilt University, Nashville, TN, USA
    Physiol Behav 88:417-24. 2006
    ..D. below the mean) cool threshold detection abilities for the tongue, suggesting that there may exist subjects in the population who have profoundly poor lingual temperature processing...
  34. pmc Posttraumatic stress disorder in a patient with no left amygdala
    Stephen D Smith
    Department of Psychology, University of Winnipeg, Winnipeg, Manitoba, Canada
    J Abnorm Psychol 117:479-84. 2008
    ..The authors propose that the right amygdala is preferentially involved in several processes related to the expression of PTSD symptoms, such that the disorder can occur even in the absence of the left amygdala...
  35. ncbi request reprint Striatal dopamine transmission in healthy humans during a passive monetary reward task
    Hélène S Hakyemez
    McConnel Brain Imaging Center, Montreal Neurological Institute, McGill University, Montreal, Canada
    Neuroimage 39:2058-65. 2008
    ..These data suggest that active behavioral engagement may be necessary to observe robust statewise increases in DA release in the striatum...
  36. ncbi request reprint Somatosensory processing in the human inferior prefrontal cortex
    Matthew C Hagen
    Cognitive Neuroimaging Unit, Veterans Affairs Medical Center, Minneapolis, Minnesota 55417, USA
    J Neurophysiol 88:1400-6. 2002
    ..The former region (posterior IFG/anterior frontal operculum) may have a more specific role in attending to tactile stimuli...
  37. ncbi request reprint On the scent of human olfactory orbitofrontal cortex: meta-analysis and comparison to non-human primates
    Jay A Gottfried
    Department of Neurology and the Cognitive Neurology and Alzheimer s Disease Center, Northwestern University Feinberg School of Medicine, 320 E Superior St, Searle 11 453, Chicago, IL 60611, USA
    Brain Res Brain Res Rev 50:287-304. 2005
    ....

Research Grants9

  1. Individual Differences in Extrastriatal DA Release
    David Zald; Fiscal Year: 2007
    ..Taken together, the study will provide unique information on how individual differences in the organization of the human DA system are associated with personality, genetics and the subjective and cognitive effects of psychostimulants. ..
  2. Individual Differences in Extrastriatal DA Release
    David Zald; Fiscal Year: 2009
    ..abstract_text> ..
  3. The Amygdala: Emotional Modulation of Attention
    David H Zald; Fiscal Year: 2010
    ..Thus, the study will be able to address the effects of amygdala lesions with a degree of precision that has been unattainable in previous research on the human amygdala. ..
  4. The Amygdala: Emotional Modulation of Attention
    David Zald; Fiscal Year: 2009
    ..Thus, the study will be able to address the effects of amygdala lesions with a degree of precision that has been unattainable in previous research on the human amygdala. ..