PAMPEE YOUNG

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. pmc Regulation of the atheroma-enriched protein, SPRR3, in vascular smooth muscle cells through cyclic strain is dependent on integrin alpha1beta1/collagen interaction
    Amy L Pyle
    Vanderbilt University Medical Center, Department of Pathology, Nashville, TN 37232, USA
    Am J Pathol 173:1577-88. 2008
  2. pmc Brown Recluse spider bite mediated hemolysis: clinical features, a possible role for complement inhibitor therapy, and reduced RBC surface glycophorin A as a potential biomarker of venom exposure
    Eric A Gehrie
    Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
    PLoS ONE 8:e76558. 2013
  3. pmc Pyrvinium, a potent small molecule Wnt inhibitor, promotes wound repair and post-MI cardiac remodeling
    Sarika Saraswati
    Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
    PLoS ONE 5:e15521. 2010
  4. pmc Biologic properties of endothelial progenitor cells and their potential for cell therapy
    Pampee P Young
    Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Prog Cardiovasc Dis 49:421-9. 2007
  5. ncbi request reprint Enrichment of genes in the aortic intima that are associated with stratified epithelium: implications of underlying biomechanical and barrier properties of the arterial intima
    Pampee P Young
    Department of Pathology, Vanderbilt University Medical Center, Nashville, Tenn, USA
    Circulation 111:2382-90. 2005
  6. pmc Massive transfusion protocols for patients with substantial hemorrhage
    Pampee P Young
    Department of Pathology, Vanderbilt University School of Medicine, 1161 21st Ave South, C2217A MCN, Nashville, TN 37232, USA
    Transfus Med Rev 25:293-303. 2011
  7. ncbi request reprint VEGF disrupts the neonatal blood-brain barrier and increases life span after non-ablative BMT in a murine model of congenital neurodegeneration caused by a lysosomal enzyme deficiency
    Pampee P Young
    Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Exp Neurol 188:104-14. 2004
  8. doi request reprint Biomechanical stress induces novel arterial intima-enriched genes: implications for vascular adaptation to stress
    Amy L Pyle
    Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Cardiovasc Pathol 19:e13-20. 2010
  9. pmc Proteomic analysis of osteogenic sarcoma: association of tumour necrosis factor with poor prognosis
    Justin M M Cates
    Department of Pathology, Vanderbilt University Medical Center, Nashville, TN, USA
    Int J Exp Pathol 91:335-49. 2010
  10. ncbi request reprint A novel model-gel-tissue assay analysis for comparing tumor elastic properties to collagen content
    Stephanie L Barnes
    Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA
    Biomech Model Mechanobiol 8:337-43. 2009

Research Grants

Collaborators

Detail Information

Publications28

  1. pmc Regulation of the atheroma-enriched protein, SPRR3, in vascular smooth muscle cells through cyclic strain is dependent on integrin alpha1beta1/collagen interaction
    Amy L Pyle
    Vanderbilt University Medical Center, Department of Pathology, Nashville, TN 37232, USA
    Am J Pathol 173:1577-88. 2008
    ..These data suggest that SPRR3 may play a role in VSMC adaptation to local biomechanical stress within the plaque microenvironment...
  2. pmc Brown Recluse spider bite mediated hemolysis: clinical features, a possible role for complement inhibitor therapy, and reduced RBC surface glycophorin A as a potential biomarker of venom exposure
    Eric A Gehrie
    Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
    PLoS ONE 8:e76558. 2013
    ..Here, we aimed to clarify the clinical details of envenomation, to determine the efficacy of the complement inhibitor eculizumab to prevent the hemolysis in vitro, and to investigate markers of exposure to Brown Recluse venom...
  3. pmc Pyrvinium, a potent small molecule Wnt inhibitor, promotes wound repair and post-MI cardiac remodeling
    Sarika Saraswati
    Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
    PLoS ONE 5:e15521. 2010
    ..These results need to be further followed-up to determine if therapeutic inhibition of canonical Wnt may avert adverse remodeling after ischemic injury and its impact on myocardial repair and regeneration...
  4. pmc Biologic properties of endothelial progenitor cells and their potential for cell therapy
    Pampee P Young
    Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Prog Cardiovasc Dis 49:421-9. 2007
    ....
  5. ncbi request reprint Enrichment of genes in the aortic intima that are associated with stratified epithelium: implications of underlying biomechanical and barrier properties of the arterial intima
    Pampee P Young
    Department of Pathology, Vanderbilt University Medical Center, Nashville, Tenn, USA
    Circulation 111:2382-90. 2005
    ....
  6. pmc Massive transfusion protocols for patients with substantial hemorrhage
    Pampee P Young
    Department of Pathology, Vanderbilt University School of Medicine, 1161 21st Ave South, C2217A MCN, Nashville, TN 37232, USA
    Transfus Med Rev 25:293-303. 2011
    ..However, the use of MTPs remains controversial. This review describes published experiences with MTPs and illustrates the potential value of several MTPs currently utilized by academic transfusion services...
  7. ncbi request reprint VEGF disrupts the neonatal blood-brain barrier and increases life span after non-ablative BMT in a murine model of congenital neurodegeneration caused by a lysosomal enzyme deficiency
    Pampee P Young
    Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Exp Neurol 188:104-14. 2004
    ..Administration of VEGF before BMT in newborn mice with a neurodegenerative LSD, globoid-cell leukodystrophy, resulted in a significant increase in life span compared to affected animals that were injected with saline before BMT...
  8. doi request reprint Biomechanical stress induces novel arterial intima-enriched genes: implications for vascular adaptation to stress
    Amy L Pyle
    Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Cardiovasc Pathol 19:e13-20. 2010
    ..We sought to test our hypothesis that these genes were regulated by biomechanical stress in vascular smooth muscle cells (VSMCs)...
  9. pmc Proteomic analysis of osteogenic sarcoma: association of tumour necrosis factor with poor prognosis
    Justin M M Cates
    Department of Pathology, Vanderbilt University Medical Center, Nashville, TN, USA
    Int J Exp Pathol 91:335-49. 2010
    ..No significant differences in adverse outcomes were observed based on macrophage migration inhibitory factor expression...
  10. ncbi request reprint A novel model-gel-tissue assay analysis for comparing tumor elastic properties to collagen content
    Stephanie L Barnes
    Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA
    Biomech Model Mechanobiol 8:337-43. 2009
    ..5 ml g(-1) is needed for successful analysis. This is an important result in that it presents guideline constraints for conducting this analysis...
  11. doi request reprint Predefined massive transfusion protocols are associated with a reduction in organ failure and postinjury complications
    Bryan A Cotton
    Department of Surgery, Vanderbilt University Medical Center, Nashville, TN 37212, USA
    J Trauma 66:41-8; discussion 48-9. 2009
    ..The purpose of this study was to determine whether MT protocols are associated with increased organ failure and complications...
  12. pmc Low levels of tumor necrosis factor alpha increase tumor growth by inducing an endothelial phenotype of monocytes recruited to the tumor site
    Bin Li
    The Department of Veterans Affairs Medical Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Cancer Res 69:338-48. 2009
    ..Our studies suggest that TNFalpha constitutes a tumor microenvironment signal that biases recruited monocytes toward a proangiogenic/provasculogenic myeloid/endothelial phenotype...
  13. ncbi request reprint The MD/PhD pathway to a career in laboratory medicine
    Samuel A Santoro
    Department of Pathology, C 3322 MCN, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Clin Lab Med 27:425-34; abstract ix. 2007
    ..The authors believe that, for many reasons, the field of laboratory medicine represents an excellent, although underrecognized, career choice for graduates of MD/PhD programs...
  14. pmc The origin and in vivo significance of murine and human culture-expanded endothelial progenitor cells
    Emerson E Sharpe
    Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Am J Pathol 168:1710-21. 2006
    ..Taken together, the data suggest that the local neovascular microenvironment may facilitate vasculogenesis by promoting endothelial differentiation and that CE-EPCs may accelerate such vasculo-genesis...
  15. doi request reprint Damage control hematology: the impact of a trauma exsanguination protocol on survival and blood product utilization
    Bryan A Cotton
    Departments of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    J Trauma 64:1177-82; discussion 1182-3. 2008
    ....
  16. ncbi request reprint VEGF and PlGF promote adult vasculogenesis by enhancing EPC recruitment and vessel formation at the site of tumor neovascularization
    Bin Li
    Department of Pathology, Vanderbilt University School of Medicine, 1161 21st Ave South, C2217 MCN, Nashville, Tennessee 37232, USA
    FASEB J 20:1495-7. 2006
    ..Our data suggest local VEGF and/or PlGF expression promote vasculogenesis; VEGF plays a role in EPC recruitment and subsequent formation of functional vessels...
  17. doi request reprint Optimizing outcomes in damage control resuscitation: identifying blood product ratios associated with improved survival
    Oliver L Gunter
    Department of General Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    J Trauma 65:527-34. 2008
    ..The purpose of this study was to evaluate whether suggested blood product ratios yield superior survival rates...
  18. pmc Adenosine receptor-mediated adhesion of endothelial progenitors to cardiac microvascular endothelial cells
    Sergey Ryzhov
    Department of Medicine, Vanderbilt University, Nashville, Tenn, USA
    Circ Res 102:356-63. 2008
    ..Our results suggest a role for adenosine in vasculogenesis and its potential use to stimulate engraftment in cell-based therapies...
  19. doi request reprint Hyperkalemia following massive transfusion in trauma
    Brigham K Au
    Department of Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    J Surg Res 157:284-9. 2009
    ..The purpose of the current study was to determine whether critically injured patients receiving massive transfusions are at an increased risk of hyperkalemia...
  20. pmc TNFalpha accelerates monocyte to endothelial transdifferentiation in tumors by the induction of integrin alpha5 expression and adhesion to fibronectin
    Bin Li
    Vanderbilt University School of Medicine, Department of Pathology, 1161 21st Avenue South, C2217A MCN, Nashville, TN 37232, USA
    Mol Cancer Res 9:702-11. 2011
    ....
  21. pmc The Wnt modulator sFRP2 enhances mesenchymal stem cell engraftment, granulation tissue formation and myocardial repair
    Maria P Alfaro
    Department of Pathology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 105:18366-71. 2008
    ..These findings implicate sFRP2 as a key molecule for the biogenesis of a superior regenerative phenotype in MSCs...
  22. ncbi request reprint Blood donor white blood cell reduction filters as a source of human peripheral blood-derived endothelial progenitor cells
    Amylynn A Teleron
    Department of Pathology and Internal Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Transfusion 45:21-5. 2005
    ..The ability to obtain large numbers of PB EPCs would greatly facilitate characterization to further our understanding of EPC biology and their application in cellular gene therapy...
  23. doi request reprint Low-dose growth hormone administration mobilizes endothelial progenitor cells in healthy adults
    Jessica K Devin
    Department of Endocrine Neoplasia and Hormonal Disorders, 1400 Holcombe Blvd Unit 435, University of Texas M D Anderson Cancer Center, Houston, TX 77030, United States
    Growth Horm IGF Res 18:253-63. 2008
    ..We hypothesized that growth hormone (GH) administration would increase the number of circulating EPCs in adults and thereby represent a mechanism to enhance vascular health...
  24. ncbi request reprint The effects of growth hormone and insulin-like growth factor-1 on the aging cardiovascular system and its progenitor cells
    Jessica K Devin
    University of Texas MD Anderson Cancer Center, Department of Endocrine Neoplasia and Hormonal Disorders, Houston, TX 77030, USA
    Curr Opin Investig Drugs 9:983-92. 2008
    ..Modulation of the GH and IGF-1 system may therefore provide a useful therapy in the prevention of age-associated changes in the cardiovascular system and in future regenerative cell-based therapies...
  25. ncbi request reprint Biodistribution and efficacy of donor T lymphocytes in a murine model of lysosomal storage disease
    Pampee P Young
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mol Ther 7:52-61. 2003
    ..These data suggest that a LSD can be more effectively treated by directing a gene therapy approach to a hematopoietic lineage other than T lymphocytes...
  26. pmc VEGF increases engraftment of bone marrow-derived endothelial progenitor cells (EPCs) into vasculature of newborn murine recipients
    Pampee P Young
    Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, Box 8007, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 99:11951-6. 2002
    ..These findings suggest that bone marrow-derived endothelial progenitor cells can contribute to neovascularization during the newborn period and are responsive to vascular endothelial growth factor...

Research Grants5

  1. Endothelial Stem Cells in Tumor Vasculature
    PAMPEE YOUNG; Fiscal Year: 2005
    ..I hope that significant contributions to the study of stem cells will result in the establishment of a successful, independent research program. ..
  2. Creating Super Stem Cells for Cardiac and Wound Repair
    PAMPEE YOUNG; Fiscal Year: 2009
    ..Moreover, we propose that modulating the activity of this pathway will recapitulate the "super stem cell" phenotype and is an excellent future target for cell based therapies for myocardial injuries and wound regeneration. ..
  3. Creating Super Stem Cells for Cardiac and Wound Repair
    Pampee P Young; Fiscal Year: 2010
    ..Moreover, we propose that modulating the activity of this pathway will recapitulate the "super stem cell" phenotype and is an excellent future target for cell based therapies for myocardial injuries and wound regeneration. ..
  4. Creating Super Stem Cells for Cardiac and Wound Repair
    PAMPEE YOUNG; Fiscal Year: 2009
    ..Moreover, we propose that modulating the activity of this pathway will recapitulate the "super stem cell" phenotype and is an excellent future target for cell based therapies for myocardial injuries and wound regeneration. ..