Research Topics
| THOMAS YANKEELOVSummaryAffiliation: Vanderbilt University Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
An algorithm for longitudinal registration of PET/CT images acquired during neoadjuvant chemotherapy in breast cancer: preliminary resultsXia Li
Vanderbilt University Institute of Imaging Science, Vanderbilt University, 1161 21st Avenue South, AA 1105 Medical Center North, Nashville, TN 37232 2310, USA
EJNMMI Res 2:62. 2012..abstract:..- Simultaneous PET-MRI in oncology: a solution looking for a problem?Thomas E Yankeelov
Institute of Imaging Science, Vanderbilt University, Nashville, TN 37232, USA
Magn Reson Imaging 30:1342-56. 2012..We consider the relative advantages and disadvantages afforded by PET-MRI and summarize current opinions and evidence as to the likely value of PET-MRI in the management of cancer... - Integration of quantitative DCE-MRI and ADC mapping to monitor treatment response in human breast cancer: initial resultsThomas E Yankeelov
Institute of Imaging Science, Vanderbilt University, Nashville, TN 37232 2310, USA
Magn Reson Imaging 25:1-13. 2007.... - Has quantitative multimodal imaging of treatment response arrived?Thomas E Yankeelov
Institute of Imaging Science and Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, Tennessee, USA
Clin Cancer Res 15:6473-5. 2009..One promising approach is to apply imaging techniques in preclinical studies designed to mimic a corresponding clinical trial in order to inform that trial... 
Repeatability of a reference region model for analysis of murine DCE-MRI data at 7TThomas E Yankeelov
Institute of Imaging Science, and Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, Tennessee 37232 2310, USA
J Magn Reson Imaging 24:1140-7. 2006..To test the repeatability of a reference region (RR) model for the analysis of dynamic contrast-enhanced MRI (DCE-MRI) in a mouse model of cancer at high field...- Correlation between estimates of tumor perfusion from microbubble contrast-enhanced sonography and dynamic contrast-enhanced magnetic resonance imagingThomas E Yankeelov
Institute of Imaging Science, Department of Radiology, Vanderbilt University, Nashville, Tennessee, USA
J Ultrasound Med 25:487-97. 2006..We compared measurements of tumor perfusion from microbubble contrast-enhanced sonography (MCES) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in an animal tumor model... - Quantitative pharmacokinetic analysis of DCE-MRI data without an arterial input function: a reference region modelThomas E Yankeelov
Institute of Imaging Science, Vanderbilt University, Nashville, TN 37232 2675, USA
Magn Reson Imaging 23:519-29. 2005..This allows for acquiring images with higher spatial resolution and/or SNR, and therefore, increased ability to probe tissue heterogeneity... - The role of magnetic resonance imaging biomarkers in clinical trials of treatment response in cancerThomas E Yankeelov
Institute of Imaging Science, Vanderbilt University, Nashville, TN, USA
Semin Oncol 38:16-25. 2011..We also discuss the limitations and future research directions required for these techniques to gain greater acceptance and to have their maximum impact... - Incorporating the effects of transcytolemmal water exchange in a reference region model for DCE-MRI analysis: theory, simulations, and experimental resultsThomas E Yankeelov
Institute of Imaging Science, Vanderbilt University, 1161 21st Avenue South, Nashville, TN 37232, USA
Magn Reson Med 59:326-35. 2008..Analysis of experimental data shows that the new approach returns K(trans) and v(e) values that are up to 90% and 73%, respectively, greater than conventional fast exchange analyses... - Coregistration of ultrasonography and magnetic resonance imaging with a preliminary investigation of the spatial colocalization of vascular endothelial growth factor receptor 2 expression and tumor perfusion in a murine tumor modelMary E Loveless
Institute of Imaging Science, Vanderbilt University, Nashville, Tennessee 37232 2675, USA
Mol Imaging 8:187-98. 2009..In summary, a method for accurately coregistering small animal US and MRI has been presented that allows for comparison of quantitative metrics provided by the two modalities... - A method for assessing the microvasculature in a murine tumor model using contrast-enhanced ultrasonographyMary E Loveless
Institute of Imaging Science, Vanderbilt University, Nashville, TN 37232 2675, USA
J Ultrasound Med 27:1699-709. 2008..The purpose of this study was to develop a method for assessing tumor vascularity in a preclinical model of breast cancer using contrast-enhanced ultrasonography... - Measuring tumor perfusion in control and treated murine tumors: correlation of microbubble contrast-enhanced sonography to dynamic contrast-enhanced magnetic resonance imaging and fluorodeoxyglucose positron emission tomographyKenneth J Niermann
Departments of Radiation Oncology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2675, USA
J Ultrasound Med 26:749-56. 2007.... - Characterization of tissue structure at varying length scales using temporal diffusion spectroscopyJohn C Gore
Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN 37232, USA
NMR Biomed 23:745-56. 2010.... - Enhancement of histological volumes through averaging and their use for the analysis of magnetic resonance imagesXia Li
Department of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN 37240 1662, USA
Magn Reson Imaging 27:401-16. 2009..Finally, we validate our approach quantitatively on MR image volumes by comparing volumetric measurements obtained manually and obtained automatically with our atlases... - Functional colonography of Min mice using dark lumen dynamic contrast-enhanced MRIC Chad Quarles
Department of Radiology and Radiological Sciences, Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, Tennessee 37232 2310, USA
Magn Reson Med 60:718-26. 2008..The functional dark-lumen colonography approach described herein provides new opportunities for the noninvasive assessment of gastrointestinal disease pathology and treatment response in mouse models... - Automatic nonrigid registration of whole body CT mice imagesXia Li
Department of Electrical Engineering, Institute of Imaging Science, Vanderbilt University, Nashville, Tennessee 37240 1662, USA
Med Phys 35:1507-20. 2008..They demonstrate that the approach they propose can successfully register image volumes even when these volumes are very different in size and shape or if they have been acquired with the subjects in different positions... - Validation of an algorithm for the nonrigid registration of longitudinal breast MR images using realistic phantomsXia Li
Institute of Imaging Science, Vanderbilt University, Nashville, Tennessee 37232, USA
Med Phys 37:2541-52. 2010.... - Sonographic depiction of microvessel perfusion: principles and potentialArthur C Fleischer
Department of Radiology, Vanderbilt University Medical Center, 1161 21st Ave S, Nashville, TN 37232 2675, USA
J Ultrasound Med 23:1499-506. 2004..To provide an overview of the technical aspects and potential clinical applications of microvessel perfusion as depicted by microbubble-enhanced sonography... - Integrating spatially resolved three-dimensional MALDI IMS with in vivo magnetic resonance imagingTuhin K Sinha
Department of Radiology and Radiological Sciences, Vanderbilt University, 1161 21st Avenue South, Nashville, Tennessee 37232, USA
Nat Methods 5:57-9. 2008..This approach enabled us to analyze proteomic profiles from MALDI IMS data with corresponding in vivo data provided by magnetic resonance imaging... - Comparison of a reference region model with direct measurement of an AIF in the analysis of DCE-MRI dataThomas E Yankeelov
Institute of Imaging Science, Vanderbilt University, Nashville, Tennessee 37232 2310, USA
Magn Reson Med 57:353-61. 2007..1% for ve. However, the RR parameter values were much less precise than the AIF method. The mean SDs for Ktrans and ve for the RR analysis were 0.024 min-1 and 0.06, respectively, vs. 0.002 min-1 and 0.03 for AIF analysis... - Molecular imaging without radiopharmaceuticals?John C Gore
Institute of Imaging Science, Vanderbilt University, Nashville, Tennessee 37232 2310, USA
J Nucl Med 50:999-1007. 2009..For ultrasound detection, gas-filled bubbles can provide a sufficient backscattered sound intensity to be detectable at concentrations and sizes not much different from agents designed for these other modalities... - A nonrigid registration algorithm for longitudinal breast MR images and the analysis of breast tumor responseXia Li
Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN 37232 2310, USA
Magn Reson Imaging 27:1258-70. 2009..The registration results demonstrate the proposed algorithm can successfully register breast MR images acquired at different time points and allow for analysis of the registered parameter maps... - Simultaneous measurement of arterial input function and tumor pharmacokinetics in mice by dynamic contrast enhanced imaging: effects of transcytolemmal water exchangeRong Zhou
Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Magn Reson Med 52:248-57. 2004..5 or more corresponding to a CA dose of 0.05 mmole/kg... - New insights into tumor microstructure using temporal diffusion spectroscopyDaniel C Colvin
Institute of Imaging Science, Department of Physics and Astronomy, Vanderbilt University, Nashville, Tennessee, USA
Cancer Res 68:5941-7. 2008..These results show the benefit of OGSE methods for revealing microscopic variations in tumors in vivo and confirm that diffusion measurements depend on factors other than cellularity... - alpha2beta1 integrin expression in the tumor microenvironment enhances tumor angiogenesis in a tumor cell-specific mannerZhonghua Zhang
Department of Pathology, Vanderbilt University School of Medicine, Nashville, TN 37232 2561, USA
Blood 111:1980-8. 2008..Thus integrin alpha2-null mice represent an example of genetic alterations of "the soil" determining response to the "seed.".. - Noninvasive assessment of tumor vasculature response to radiation-mediated, vasculature-targeted therapy using quantified power Doppler sonography: implications for improvement of therapy schedulesDong Wook Nathan Kim
Department of Radiation Oncology, Vanderbilt University School of Medicine, 1301 22nd Ave S, B 902, Nashville, TN 37232, USA
J Ultrasound Med 25:1507-17. 2006.... - The integration of quantitative multi-modality imaging data into mathematical models of tumorsNkiruka C Atuegwu
Institute of Imaging Science, Vanderbilt University, Nashville, TN, USA
Phys Med Biol 55:2429-49. 2010.... - Implementation of a semi-automated post-processing system for parametric MRI mapping of human breast cancerRobert E Lee
Vanderbilt University Institute of Imaging Science, 1161 21st Ave S AA 1105 MCN, Nashville, TN 37232 2310, USA
J Digit Imaging 22:424-36. 2009..The system shows promise for becoming both a robust research picture archival and communications system working with the standard hospital PACS and an image post-processing environment that extends to other medical image modalities... - Incorporating contrast agent diffusion into the analysis of DCE-MRI dataMartin Pellerin
Centre d imagerie moléculaire de Sherbrooke and Département de médecine nucléaire et de radiobiologie, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
Magn Reson Med 58:1124-34. 2007..In addition, K(trans) distributions from the DP model more closely corresponded to the observed sharp delineation between highly and poorly perfused areas observed in the mouse tumors... - Shutter-speed analysis of contrast reagent bolus-tracking data: Preliminary observations in benign and malignant breast diseaseXin Li
Advanced Imaging Research Center, Oregon Health and Science University, 3181 S.W. Sam Jackson Park Road, Portland, OR 97239, USA
Magn Reson Med 53:724-9. 2005..Furthermore, the shutter-speed model clearly reveals focal "hot spots" of elevated CR perfusion/permeation present in only the malignant tumors... - Evidence for shutter-speed variation in CR bolus-tracking studies of human pathologyThomas E Yankeelov
Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
NMR Biomed 18:173-85. 2005..Normal muscle regions in the leg allow validation of the shutter-speed model K(trans), v(e), and tau(i) magnitudes, by comparison with results of previous careful rat leg studies not possible for human subjects... - Variation of the relaxographic "shutter-speed" for transcytolemmal water exchange affects the CR bolus-tracking curve shapeThomas E Yankeelov
Chemistry Department, Brookhaven National Laboratory, Upton, New York, USA
Magn Reson Med 50:1151-69. 2003..The BOLERO analysis shows promise for in vivo vascular phenotyping in pathophysiology. It also includes a provision for approximating the separation of the perfusion and permeability contributions to CR extravasation...
Research Grants
- Evaluation of MRI Biomarkers of Breast Cancer ResponseThomas E Yankeelov; Fiscal Year: 2010..We hypothesize that the combined analysis of contrast enhanced MRI and diffusion MRI data will provide predictive, non-invasive measurements of tumor response to treatment. ..
- MRI Evaluation of Tumor Growth and Treatment ResponseTHOMAS YANKEELOV; Fiscal Year: 2007..abstract_text> ..
- Evaluation and Validation of Imaging Biomarkers of Tumor Response to TreatmentThomas E Yankeelov; Fiscal Year: 2010....