THOMAS YANKEELOV

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. doi request reprint Clinically relevant modeling of tumor growth and treatment response
    Thomas E Yankeelov
    Institute of Imaging Science, Vanderbilt University, Nashville, TN 37212, USA
    Sci Transl Med 5:187ps9. 2013
  2. pmc An algorithm for longitudinal registration of PET/CT images acquired during neoadjuvant chemotherapy in breast cancer: preliminary results
    Xia Li
    Vanderbilt University Institute of Imaging Science, Vanderbilt University, 1161 21st Avenue South, AA 1105 Medical Center North, Nashville, TN 37232 2310, USA
    EJNMMI Res 2:62. 2012
  3. pmc Simultaneous PET-MRI in oncology: a solution looking for a problem?
    Thomas E Yankeelov
    Institute of Imaging Science, Vanderbilt University, Nashville, TN 37232, USA
    Magn Reson Imaging 30:1342-56. 2012
  4. pmc Incorporating the effects of transcytolemmal water exchange in a reference region model for DCE-MRI analysis: theory, simulations, and experimental results
    Thomas E Yankeelov
    Institute of Imaging Science, Vanderbilt University, 1161 21st Avenue South, Nashville, TN 37232, USA
    Magn Reson Med 59:326-35. 2008
  5. pmc Has quantitative multimodal imaging of treatment response arrived?
    Thomas E Yankeelov
    Institute of Imaging Science and Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, Tennessee, USA
    Clin Cancer Res 15:6473-5. 2009
  6. pmc Integration of quantitative DCE-MRI and ADC mapping to monitor treatment response in human breast cancer: initial results
    Thomas E Yankeelov
    Institute of Imaging Science, Vanderbilt University, Nashville, TN 37232 2310, USA
    Magn Reson Imaging 25:1-13. 2007
  7. ncbi request reprint Repeatability of a reference region model for analysis of murine DCE-MRI data at 7T
    Thomas E Yankeelov
    Institute of Imaging Science, and Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, Tennessee 37232 2310, USA
    J Magn Reson Imaging 24:1140-7. 2006
  8. pmc The role of magnetic resonance imaging biomarkers in clinical trials of treatment response in cancer
    Thomas E Yankeelov
    Institute of Imaging Science, Vanderbilt University, Nashville, TN, USA
    Semin Oncol 38:16-25. 2011
  9. ncbi request reprint Quantitative pharmacokinetic analysis of DCE-MRI data without an arterial input function: a reference region model
    Thomas E Yankeelov
    Institute of Imaging Science, Vanderbilt University, Nashville, TN 37232 2675, USA
    Magn Reson Imaging 23:519-29. 2005
  10. ncbi request reprint Correlation between estimates of tumor perfusion from microbubble contrast-enhanced sonography and dynamic contrast-enhanced magnetic resonance imaging
    Thomas E Yankeelov
    Institute of Imaging Science, Department of Radiology, Vanderbilt University, Nashville, Tennessee, USA
    J Ultrasound Med 25:487-97. 2006

Research Grants

Detail Information

Publications35

  1. doi request reprint Clinically relevant modeling of tumor growth and treatment response
    Thomas E Yankeelov
    Institute of Imaging Science, Vanderbilt University, Nashville, TN 37212, USA
    Sci Transl Med 5:187ps9. 2013
    ..In the near future, these models could be able to forecast clinical outputs, such as overall response to treatment and time to progression, which will provide opportunities for guided intervention and improved patient care...
  2. pmc An algorithm for longitudinal registration of PET/CT images acquired during neoadjuvant chemotherapy in breast cancer: preliminary results
    Xia Li
    Vanderbilt University Institute of Imaging Science, Vanderbilt University, 1161 21st Avenue South, AA 1105 Medical Center North, Nashville, TN 37232 2310, USA
    EJNMMI Res 2:62. 2012
    ..abstract:..
  3. pmc Simultaneous PET-MRI in oncology: a solution looking for a problem?
    Thomas E Yankeelov
    Institute of Imaging Science, Vanderbilt University, Nashville, TN 37232, USA
    Magn Reson Imaging 30:1342-56. 2012
    ..We consider the relative advantages and disadvantages afforded by PET-MRI and summarize current opinions and evidence as to the likely value of PET-MRI in the management of cancer...
  4. pmc Incorporating the effects of transcytolemmal water exchange in a reference region model for DCE-MRI analysis: theory, simulations, and experimental results
    Thomas E Yankeelov
    Institute of Imaging Science, Vanderbilt University, 1161 21st Avenue South, Nashville, TN 37232, USA
    Magn Reson Med 59:326-35. 2008
    ..Analysis of experimental data shows that the new approach returns K(trans) and v(e) values that are up to 90% and 73%, respectively, greater than conventional fast exchange analyses...
  5. pmc Has quantitative multimodal imaging of treatment response arrived?
    Thomas E Yankeelov
    Institute of Imaging Science and Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, Tennessee, USA
    Clin Cancer Res 15:6473-5. 2009
    ..One promising approach is to apply imaging techniques in preclinical studies designed to mimic a corresponding clinical trial in order to inform that trial...
  6. pmc Integration of quantitative DCE-MRI and ADC mapping to monitor treatment response in human breast cancer: initial results
    Thomas E Yankeelov
    Institute of Imaging Science, Vanderbilt University, Nashville, TN 37232 2310, USA
    Magn Reson Imaging 25:1-13. 2007
    ....
  7. ncbi request reprint Repeatability of a reference region model for analysis of murine DCE-MRI data at 7T
    Thomas E Yankeelov
    Institute of Imaging Science, and Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, Tennessee 37232 2310, USA
    J Magn Reson Imaging 24:1140-7. 2006
    ..To test the repeatability of a reference region (RR) model for the analysis of dynamic contrast-enhanced MRI (DCE-MRI) in a mouse model of cancer at high field...
  8. pmc The role of magnetic resonance imaging biomarkers in clinical trials of treatment response in cancer
    Thomas E Yankeelov
    Institute of Imaging Science, Vanderbilt University, Nashville, TN, USA
    Semin Oncol 38:16-25. 2011
    ..We also discuss the limitations and future research directions required for these techniques to gain greater acceptance and to have their maximum impact...
  9. ncbi request reprint Quantitative pharmacokinetic analysis of DCE-MRI data without an arterial input function: a reference region model
    Thomas E Yankeelov
    Institute of Imaging Science, Vanderbilt University, Nashville, TN 37232 2675, USA
    Magn Reson Imaging 23:519-29. 2005
    ..This allows for acquiring images with higher spatial resolution and/or SNR, and therefore, increased ability to probe tissue heterogeneity...
  10. ncbi request reprint Correlation between estimates of tumor perfusion from microbubble contrast-enhanced sonography and dynamic contrast-enhanced magnetic resonance imaging
    Thomas E Yankeelov
    Institute of Imaging Science, Department of Radiology, Vanderbilt University, Nashville, Tennessee, USA
    J Ultrasound Med 25:487-97. 2006
    ..We compared measurements of tumor perfusion from microbubble contrast-enhanced sonography (MCES) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in an animal tumor model...
  11. pmc Coregistration of ultrasonography and magnetic resonance imaging with a preliminary investigation of the spatial colocalization of vascular endothelial growth factor receptor 2 expression and tumor perfusion in a murine tumor model
    Mary E Loveless
    Institute of Imaging Science, Vanderbilt University, Nashville, Tennessee 37232 2675, USA
    Mol Imaging 8:187-98. 2009
    ..In summary, a method for accurately coregistering small animal US and MRI has been presented that allows for comparison of quantitative metrics provided by the two modalities...
  12. ncbi request reprint Measuring tumor perfusion in control and treated murine tumors: correlation of microbubble contrast-enhanced sonography to dynamic contrast-enhanced magnetic resonance imaging and fluorodeoxyglucose positron emission tomography
    Kenneth J Niermann
    Departments of Radiation Oncology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2675, USA
    J Ultrasound Med 26:749-56. 2007
    ....
  13. pmc A method for assessing the microvasculature in a murine tumor model using contrast-enhanced ultrasonography
    Mary E Loveless
    Institute of Imaging Science, Vanderbilt University, Nashville, TN 37232 2675, USA
    J Ultrasound Med 27:1699-709. 2008
    ..The purpose of this study was to develop a method for assessing tumor vascularity in a preclinical model of breast cancer using contrast-enhanced ultrasonography...
  14. pmc Validation of an algorithm for the nonrigid registration of longitudinal breast MR images using realistic phantoms
    Xia Li
    Institute of Imaging Science, Vanderbilt University, Nashville, Tennessee 37232, USA
    Med Phys 37:2541-52. 2010
    ....
  15. pmc Characterization of tissue structure at varying length scales using temporal diffusion spectroscopy
    John C Gore
    Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN 37232, USA
    NMR Biomed 23:745-56. 2010
    ....
  16. pmc Molecular imaging without radiopharmaceuticals?
    John C Gore
    Institute of Imaging Science, Vanderbilt University, Nashville, Tennessee 37232 2310, USA
    J Nucl Med 50:999-1007. 2009
    ..For ultrasound detection, gas-filled bubbles can provide a sufficient backscattered sound intensity to be detectable at concentrations and sizes not much different from agents designed for these other modalities...
  17. pmc Enhancement of histological volumes through averaging and their use for the analysis of magnetic resonance images
    Xia Li
    Department of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN 37240 1662, USA
    Magn Reson Imaging 27:401-16. 2009
    ..Finally, we validate our approach quantitatively on MR image volumes by comparing volumetric measurements obtained manually and obtained automatically with our atlases...
  18. pmc Functional colonography of Min mice using dark lumen dynamic contrast-enhanced MRI
    C Chad Quarles
    Department of Radiology and Radiological Sciences, Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, Tennessee 37232 2310, USA
    Magn Reson Med 60:718-26. 2008
    ..The functional dark-lumen colonography approach described herein provides new opportunities for the noninvasive assessment of gastrointestinal disease pathology and treatment response in mouse models...
  19. ncbi request reprint Sonographic depiction of microvessel perfusion: principles and potential
    Arthur C Fleischer
    Department of Radiology, Vanderbilt University Medical Center, 1161 21st Ave S, Nashville, TN 37232 2675, USA
    J Ultrasound Med 23:1499-506. 2004
    ..To provide an overview of the technical aspects and potential clinical applications of microvessel perfusion as depicted by microbubble-enhanced sonography...
  20. pmc Automatic nonrigid registration of whole body CT mice images
    Xia Li
    Department of Electrical Engineering, Institute of Imaging Science, Vanderbilt University, Nashville, Tennessee 37240 1662, USA
    Med Phys 35:1507-20. 2008
    ..They demonstrate that the approach they propose can successfully register image volumes even when these volumes are very different in size and shape or if they have been acquired with the subjects in different positions...
  21. pmc Integrating spatially resolved three-dimensional MALDI IMS with in vivo magnetic resonance imaging
    Tuhin K Sinha
    Department of Radiology and Radiological Sciences, Vanderbilt University, 1161 21st Avenue South, Nashville, Tennessee 37232, USA
    Nat Methods 5:57-9. 2008
    ..This approach enabled us to analyze proteomic profiles from MALDI IMS data with corresponding in vivo data provided by magnetic resonance imaging...
  22. ncbi request reprint Comparison of a reference region model with direct measurement of an AIF in the analysis of DCE-MRI data
    Thomas E Yankeelov
    Institute of Imaging Science, Vanderbilt University, Nashville, Tennessee 37232 2310, USA
    Magn Reson Med 57:353-61. 2007
    ..1% for ve. However, the RR parameter values were much less precise than the AIF method. The mean SDs for Ktrans and ve for the RR analysis were 0.024 min-1 and 0.06, respectively, vs. 0.002 min-1 and 0.03 for AIF analysis...
  23. pmc A nonrigid registration algorithm for longitudinal breast MR images and the analysis of breast tumor response
    Xia Li
    Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN 37232 2310, USA
    Magn Reson Imaging 27:1258-70. 2009
    ..The registration results demonstrate the proposed algorithm can successfully register breast MR images acquired at different time points and allow for analysis of the registered parameter maps...
  24. ncbi request reprint Simultaneous measurement of arterial input function and tumor pharmacokinetics in mice by dynamic contrast enhanced imaging: effects of transcytolemmal water exchange
    Rong Zhou
    Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Magn Reson Med 52:248-57. 2004
    ..5 or more corresponding to a CA dose of 0.05 mmole/kg...
  25. ncbi request reprint Noninvasive assessment of tumor vasculature response to radiation-mediated, vasculature-targeted therapy using quantified power Doppler sonography: implications for improvement of therapy schedules
    Dong Wook Nathan Kim
    Department of Radiation Oncology, Vanderbilt University School of Medicine, 1301 22nd Ave S, B 902, Nashville, TN 37232, USA
    J Ultrasound Med 25:1507-17. 2006
    ....
  26. pmc The integration of quantitative multi-modality imaging data into mathematical models of tumors
    Nkiruka C Atuegwu
    Institute of Imaging Science, Vanderbilt University, Nashville, TN, USA
    Phys Med Biol 55:2429-49. 2010
    ....
  27. pmc alpha2beta1 integrin expression in the tumor microenvironment enhances tumor angiogenesis in a tumor cell-specific manner
    Zhonghua Zhang
    Department of Pathology, Vanderbilt University School of Medicine, Nashville, TN 37232 2561, USA
    Blood 111:1980-8. 2008
    ..Thus integrin alpha2-null mice represent an example of genetic alterations of "the soil" determining response to the "seed."..
  28. pmc New insights into tumor microstructure using temporal diffusion spectroscopy
    Daniel C Colvin
    Institute of Imaging Science, Department of Physics and Astronomy, Vanderbilt University, Nashville, Tennessee, USA
    Cancer Res 68:5941-7. 2008
    ..These results show the benefit of OGSE methods for revealing microscopic variations in tumors in vivo and confirm that diffusion measurements depend on factors other than cellularity...
  29. pmc Implementation of a semi-automated post-processing system for parametric MRI mapping of human breast cancer
    Robert E Lee
    Vanderbilt University Institute of Imaging Science, 1161 21st Ave S AA 1105 MCN, Nashville, TN 37232 2310, USA
    J Digit Imaging 22:424-36. 2009
    ..The system shows promise for becoming both a robust research picture archival and communications system working with the standard hospital PACS and an image post-processing environment that extends to other medical image modalities...
  30. ncbi request reprint Evidence for shutter-speed variation in CR bolus-tracking studies of human pathology
    Thomas E Yankeelov
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    NMR Biomed 18:173-85. 2005
    ..Normal muscle regions in the leg allow validation of the shutter-speed model K(trans), v(e), and tau(i) magnitudes, by comparison with results of previous careful rat leg studies not possible for human subjects...
  31. ncbi request reprint Shutter-speed analysis of contrast reagent bolus-tracking data: Preliminary observations in benign and malignant breast disease
    Xin Li
    Advanced Imaging Research Center, Oregon Health and Science University, 3181 S W Sam Jackson Park Road, Portland, OR 97239, USA
    Magn Reson Med 53:724-9. 2005
    ..Furthermore, the shutter-speed model clearly reveals focal "hot spots" of elevated CR perfusion/permeation present in only the malignant tumors...
  32. ncbi request reprint Incorporating contrast agent diffusion into the analysis of DCE-MRI data
    Martin Pellerin
    Centre d imagerie moléculaire de Sherbrooke and Département de médecine nucléaire et de radiobiologie, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Magn Reson Med 58:1124-34. 2007
    ..In addition, K(trans) distributions from the DP model more closely corresponded to the observed sharp delineation between highly and poorly perfused areas observed in the mouse tumors...
  33. ncbi request reprint Variation of the relaxographic "shutter-speed" for transcytolemmal water exchange affects the CR bolus-tracking curve shape
    Thomas E Yankeelov
    Chemistry Department, Brookhaven National Laboratory, Upton, New York, USA
    Magn Reson Med 50:1151-69. 2003
    ..The BOLERO analysis shows promise for in vivo vascular phenotyping in pathophysiology. It also includes a provision for approximating the separation of the perfusion and permeability contributions to CR extravasation...

Research Grants6

  1. Evaluation of MRI Biomarkers of Breast Cancer Response
    Thomas E Yankeelov; Fiscal Year: 2010
    ..We hypothesize that the combined analysis of contrast enhanced MRI and diffusion MRI data will provide predictive, non-invasive measurements of tumor response to treatment. ..
  2. MRI Evaluation of Tumor Growth and Treatment Response
    THOMAS YANKEELOV; Fiscal Year: 2007
    ..abstract_text> ..
  3. Evaluation and Validation of Imaging Biomarkers of Tumor Response to Treatment
    Thomas E Yankeelov; Fiscal Year: 2010
    ....