Li Yang

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. pmc Transforming growth factor beta: tumor suppressor or promoter? Are host immune cells the answer?
    Li Yang
    Department of Cancer Biology, The Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tenessee 37232, USA
    Cancer Res 68:9107-11. 2008
  2. ncbi request reprint Host and direct antitumor effects and profound reduction in tumor metastasis with selective EP4 receptor antagonism
    Li Yang
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Cancer Res 66:9665-72. 2006
  3. pmc Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis
    Li Yang
    Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Cancer Cell 13:23-35. 2008
  4. doi request reprint Transforming growth factor-beta regulates mammary carcinoma cell survival and interaction with the adjacent microenvironment
    Brian Bierie
    Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232 6838, USA
    Cancer Res 68:1809-19. 2008
  5. pmc Resuscitating cancer immunosurveillance: selective stimulation of DLL1-Notch signaling in T cells rescues T-cell function and inhibits tumor growth
    Yuhui Huang
    Department of Cancer Biology, Vanderbilt University, Nashville, Tennessee, USA
    Cancer Res 71:6122-31. 2011
  6. pmc Characterization of the MDSC proteome associated with metastatic murine mammary tumors using label-free mass spectrometry and shotgun proteomics
    Angela M Boutte
    Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
    PLoS ONE 6:e22446. 2011
  7. ncbi request reprint Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis
    Li Yang
    Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Cancer Cell 6:409-21. 2004
  8. pmc Rgs2 mediates pro-angiogenic function of myeloid derived suppressor cells in the tumor microenvironment via upregulation of MCP-1
    Kimberly C Boelte
    Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
    PLoS ONE 6:e18534. 2011
  9. pmc Identification of a myeloid-derived suppressor cell cystatin-like protein that inhibits metastasis
    Angela M Boutte
    Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    FASEB J 25:2626-37. 2011
  10. pmc Distinct roles of VEGFR-1 and VEGFR-2 in the aberrant hematopoiesis associated with elevated levels of VEGF
    Yuhui Huang
    Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232 6838, USA
    Blood 110:624-31. 2007

Detail Information

Publications71

  1. pmc Transforming growth factor beta: tumor suppressor or promoter? Are host immune cells the answer?
    Li Yang
    Department of Cancer Biology, The Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tenessee 37232, USA
    Cancer Res 68:9107-11. 2008
    ..Recent advances in multiple disciplines suggest that immune cells from the tumor host may provide the answer...
  2. ncbi request reprint Host and direct antitumor effects and profound reduction in tumor metastasis with selective EP4 receptor antagonism
    Li Yang
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Cancer Res 66:9665-72. 2006
    ..Selective antagonism of the EP4 receptor may thus represent a novel therapeutic approach for the treatment of cancer and especially its propensity to metastasize...
  3. pmc Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis
    Li Yang
    Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Cancer Cell 13:23-35. 2008
    ..Together, these data indicate that Gr-1+CD11b+ cells contribute to TGFbeta-mediated metastasis through enhancing tumor cell invasion and metastasis...
  4. doi request reprint Transforming growth factor-beta regulates mammary carcinoma cell survival and interaction with the adjacent microenvironment
    Brian Bierie
    Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232 6838, USA
    Cancer Res 68:1809-19. 2008
    ....
  5. pmc Resuscitating cancer immunosurveillance: selective stimulation of DLL1-Notch signaling in T cells rescues T-cell function and inhibits tumor growth
    Yuhui Huang
    Department of Cancer Biology, Vanderbilt University, Nashville, Tennessee, USA
    Cancer Res 71:6122-31. 2011
    ..Overall, our findings uncover a novel mechanism of tumoral immune escape and suggest that a soluble multivalent form of DLL1 may offer a generalized therapeutic intervention to stimulate T-cell immunity and suppress tumor growth...
  6. pmc Characterization of the MDSC proteome associated with metastatic murine mammary tumors using label-free mass spectrometry and shotgun proteomics
    Angela M Boutte
    Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
    PLoS ONE 6:e22446. 2011
    ..Therapeutic interventions aimed at these pathways in MDSC may offer a new route to control malignancy and metastasis...
  7. ncbi request reprint Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis
    Li Yang
    Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Cancer Cell 6:409-21. 2004
    ..Our data provide evidence that Gr+CD11b+ cells of immune origin induced by tumors directly contribute to tumor growth and vascularization by producing MMP9 and differentiating into ECs...
  8. pmc Rgs2 mediates pro-angiogenic function of myeloid derived suppressor cells in the tumor microenvironment via upregulation of MCP-1
    Kimberly C Boelte
    Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
    PLoS ONE 6:e18534. 2011
    ..Myeloid derived suppressor cells (MDSCs) are dramatically elevated in cancer patients and tumor bearing mice. MDSCs modulate the tumor microenvironment through attenuating host immune response and increasing vascularization...
  9. pmc Identification of a myeloid-derived suppressor cell cystatin-like protein that inhibits metastasis
    Angela M Boutte
    Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    FASEB J 25:2626-37. 2011
    ..The finding suggests that malignant tumors promote invasion/metastasis not only through up-regulation of proteases but also down-regulation of protease inhibitors...
  10. pmc Distinct roles of VEGFR-1 and VEGFR-2 in the aberrant hematopoiesis associated with elevated levels of VEGF
    Yuhui Huang
    Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232 6838, USA
    Blood 110:624-31. 2007
    ..Our findings suggest that selective blockade of VEGFR-2 rather than of both receptors may optimally overcome the adverse hematologic consequences of elevated VEGF levels found in malignancy...
  11. pmc Gr-1+CD11b+ myeloid-derived suppressor cells: formidable partners in tumor metastasis
    Li Yang
    Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, TN, USA
    J Bone Miner Res 25:1701-6. 2010
    ..They also have a potential role in the osteolysis associated with bone metastases. They are formidable partners in tumor metastasis...
  12. pmc Cancer-associated immunodeficiency and dendritic cell abnormalities mediated by the prostaglandin EP2 receptor
    Li Yang
    Department of Medicine, The Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    J Clin Invest 111:727-35. 2003
    ..Our data demonstrate an important role for the EP2 receptor in PGE(2)-induced inhibition of DC differentiation and function and the diminished antitumor cellular immune responses in vivo...
  13. ncbi request reprint Tumor-host immune interactions and dendritic cell dysfunction
    Li Yang
    Vanderbilt University School of Medicine, Department of Cancer Biology, The Vanderbilt Ingram Cancer Center, Nashville, Tennessee 37232, USA
    Adv Cancer Res 92:13-27. 2004
    ..Finally, we will discuss altered dendritic cell function and differentiation in some detail, as it is likely to be one of the most fundamental mechanisms by which tumors escape immune responses...
  14. doi request reprint Kidney injury molecule-1
    Joseph V Bonventre
    Renal Division, Brigham and Women s Hospital, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Opin Crit Care 16:556-61. 2010
    ....
  15. ncbi request reprint Inhibition of epidermal growth factor receptor signaling elevates 15-hydroxyprostaglandin dehydrogenase in non-small-cell lung cancer
    Li Yang
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Cancer Res 67:5587-93. 2007
    ..This effect is reversible in a subset of NSCLC upon treatment with an EGFR TKI...
  16. pmc Novel assays for detection of urinary KIM-1 in mouse models of kidney injury
    Venkata S Sabbisetti
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Toxicol Sci 131:13-25. 2013
    ..Mouse KIM-1 was stable for multiple freeze-thaw cycles, for up to 5 days at room temperature and up to at least an year when stored at -80°C...
  17. ncbi request reprint Synthesis of 1,1,2-triphenylethylenes and their antiproliferative effect on human cancer cell lines
    Lifang Zheng
    National Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, Gansu, PRC
    Anticancer Drugs 18:1039-44. 2007
    ..Structure-activity relationship analysis demonstrates that the methoxyl group on the 2-phenyl ring contributes critically to the activity...
  18. ncbi request reprint Immunogene therapy of tumors with vaccine based on xenogeneic epidermal growth factor receptor
    You Lu
    Key Laboratory of Biotherapy of Human Diseases, Ministry of Education and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, The People s Republic of China
    J Immunol 170:3162-70. 2003
    ....
  19. ncbi request reprint Combination of low-dose gemcitabine and recombinant quail vascular endothelial growth factor receptor-2 as a vaccine induces synergistic antitumor activities
    Jian Mei Hou
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, People s Republic of China
    Oncology 69:81-7. 2005
    ..The observations may provide a new bio-chemotherapeutic approach for cancer...
  20. ncbi request reprint Immunotherapy of tumors with vaccine based on quail homologous vascular endothelial growth factor receptor-2
    Ji Yan Liu
    Key Laboratory of Biotherapy of Human Diseases and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Guo Xue Xiang, No 37, Chengdu, Sichuan, 610041, The People s Republic of China
    Blood 102:1815-23. 2003
    ..The observations may provide a vaccine strategy for cancer therapy through the induction of autoimmunity against the growth factor receptor associated with angiogenesis in a cross-reaction with single xenogeneic homologous protein...
  21. ncbi request reprint [Antitumor effects of recombinant quail vascular endothelial growth factor receptor 2, as a vaccine, combined with cisplatin on LL/2 tumor model in mice]
    Jian Mei Hou
    National Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, P R China
    Ai Zheng 24:391-6. 2005
    ..Antiangiogenic therapy represents a new strategy of tumor biotherapy. This study was designed to explore antitumor effect of recombinant quail vascular endothelial growth factor receptor 2 (qVEGFR) combined with cisplatin...
  22. ncbi request reprint [Inhibition of tumor growth and metastasis via local administration of recombinant human endostatin adenovirus]
    Yang Wu
    Center for Biotherapy of Cancer and Cancer Research Center, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041 P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 21:557-61. 2004
    ..The authors designed a topical antiangiogenic gene therapy with recombinant human endostatin adenovirus (Ad-hEndo) and assessed its effects on the inhibition of angiogenesis in vitro, and tumor growth and metastasis in vivo...
  23. ncbi request reprint Unusual sesquiterpene lactones from Ligularia virgaurea spp. oligocephala
    Quan Xiang Wu
    State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P R China
    Org Lett 6:2313-6. 2004
    ..1 represents a novel sesquiterpene carbon framework, and a possible biosynthetic process is proposed. 2 is a novel eremophilane-type sesquiterpene...
  24. ncbi request reprint Induction of apoptosis and tumor regression by vesicular stomatitis virus in the presence of gemcitabine in lung cancer
    Qiu Li
    Key Laboratory of Biotherapy of Human Diseases, Ministry of Education, Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, China
    Int J Cancer 112:143-9. 2004
    ..The present findings may be of importance to the further exploration of the potential application of this combined approach in the treatment of lung cancer...
  25. doi request reprint Wogonin induces the granulocytic differentiation of human NB4 promyelocytic leukemia cells and up-regulates phospholipid scramblase 1 gene expression
    Kun Zhang
    Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, Nanjing 210009, China
    Cancer Sci 99:689-95. 2008
    ..Taken together, the results reported here demonstrated that wogonin could promote the granulocytic differentiation of NB4 cells by up-regulating the expression of PLSCR1 gene...
  26. ncbi request reprint [Liver targeting of cationic liposomes modified with soybean-derived sterylglucoside in vitro]
    Jing Shi
    Department of Pharmaceutics, School of Pharmaceutical Science, Peking University, Beijing 100083, China
    Yao Xue Xue Bao 41:19-23. 2006
    ..To construct a liposomal liver targeting delivery system by adding soybean-derived sterylglucoside (SG) to the cationic liposomes...
  27. ncbi request reprint Establishment and characterization of a high metastatic potential in the peritoneum for human gastric cancer by orthotopic tumor cell implantation
    Feihu Bai
    State Key Laboratory of Cancer Biology and Institute of Digestive Diseases, Xijing Hospital, The Fourth Military Medical University, Xi an, Shaanxi Province, China
    Dig Dis Sci 52:1571-8. 2007
    ..The high-metastatic cell line appears to be useful for investigating the mechanisms of peritoneal metastasis and preventing peritoneal metastasis of human gastric cancer...
  28. ncbi request reprint Amphiregulin, a TH2 cytokine enhancing resistance to nematodes
    Dietmar M Zaiss
    David H Smith Center for Vaccine Biology and Immunology and Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14642, USA
    Science 314:1746. 2006
    ..This newly recognized link between T(H)2 cells and epithelial proliferation should help in planning therapeutic interventions for helminth infections and other diseases that involve both cell proliferation and allergy, such as asthma...
  29. ncbi request reprint [Intraoperative and postoperative intra-peritoneal administration of peptide PIII inhibits peritoneal metastasis of gastric cancer]
    Fei hu Bai
    Department of Gastrointestinal, the Affiliated Hospital of Ningxia Medical College, Yinchuan 750004, China
    Zhonghua Yi Xue Za Zhi 86:3260-3. 2006
    ..To evaluate the preventive potential of intraoperative or early postoperative local administration of peptide PIII into the abdominal cavity against peritoneal carcinomatosis...
  30. doi request reprint Preparation of mannan modified anionic PCL-PEG-PCL nanoparticles at one-step for bFGF antigen delivery to improve humoral immunity
    MaLing Gou
    State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China
    Colloids Surf B Biointerfaces 64:135-9. 2008
    ..The prepared anionic mannan modified PCEC nanoparticles (MPCEC) might have great potential application in vaccine delivery systems...
  31. ncbi request reprint T regulatory and primed uncommitted CD4 T cells express CD73, which suppresses effector CD4 T cells by converting 5'-adenosine monophosphate to adenosine
    James J Kobie
    David H Smith Center for Vaccine Biology and Immunology and Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Immunol 177:6780-6. 2006
    ..Infiltration of either Treg or Thpp cells at inflammatory sites could potentially convert 5'-AMP generated by neutrophils or dying cells into the anti-inflammatory mediator adenosine, thus dampening excessive immune reactions...
  32. ncbi request reprint [Effect of lenti-mCCL20 on the growth of mouse tumor]
    Hong Xia Li
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China
    Sichuan Da Xue Xue Bao Yi Xue Ban 37:712-6. 2006
    ..We aim at inducing a potent antitumor immune response via CCL20 expressing in situ tumor...
  33. pmc A noncoding RNA in Saccharomyces cerevisiae is an RNase P substrate
    Li Yang
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06511, USA
    RNA 13:682-90. 2007
    ..These data indicate that HRA1 RNA is a substrate for RNase P and does not appear as a direct consequence of separate regulatory effects of the enzyme on ncRNAs...
  34. doi request reprint Periplocoside A, a pregnane glycoside from Periploca sepium Bge, prevents concanavalin A-induced mice hepatitis through inhibiting NKT-derived inflammatory cytokine productions
    Jin Wan
    State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, People s Republic of China
    Int Immunopharmacol 8:1248-56. 2008
    ..These findings suggested that PSA has the therapeutic potential for treatment of human autoimmune-related hepatitis...
  35. ncbi request reprint Transcription-inhibition and antitumor activities of N-alkylated tetraazacyclododecanes
    Xiao Qin Xiong
    College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei 430072, PR China
    Chem Biodivers 4:2791-7. 2007
    ..Three compounds, 5-7, were found to exhibit significant biological activities, with IC50 values towards HeLa cells in the low-micromolar range...
  36. pmc In vivo identification of the outer membrane protein OmcA-MtrC interaction network in Shewanella oneidensis MR-1 cells using novel hydrophobic chemical cross-linkers
    Haizhen Zhang
    Department of Chemistry, Washington State University, Pullman, Washington, USA
    J Proteome Res 7:1712-20. 2008
    ....
  37. doi request reprint Cell-specific gene transfection from a gene-functionalized poly(d,l-lactic acid) substrate fabricated by the layer-by-layer assembly technique
    Kaiyong Cai
    College of Bioengineering, Chongqing University, Chongqing, PR China
    Angew Chem Int Ed Engl 47:7479-81. 2008
  38. doi request reprint Octa-substituted anionic porphyrins: topoisomerase I inhibition and tumor cell apoptosis induction
    Baoping Zhai
    College of Chemistry and Molecular Sciences, State Key Laboratory of Virology, and School of Life Science, Wuhan University, Hubei, Wuhan 430072, PR China
    Bioconjug Chem 19:1535-42. 2008
    ..The results implied that compounds 4, 6, and 8 are potential inhibitors to Topo I, which might be one of the important factors inducing apoptosis of tumor cells...
  39. pmc Prevention of estrogen-DNA adduct formation in MCF-10F cells by resveratrol
    Muhammad Zahid
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Free Radic Biol Med 45:136-45. 2008
    ..We conclude that Resv can protect breast cells from carcinogenic estrogen metabolites, suggesting that it could be used in breast cancer prevention...
  40. doi request reprint Wogonin induced differentiation and G1 phase arrest of human U-937 leukemia cells via PKCdelta phosphorylation
    Hai Wei Zhang
    Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, Nanjing 210009, China
    Eur J Pharmacol 591:7-12. 2008
    ..Taken together, wogonin induced U-937 cells to undergo granulocytic differentiation and G1 phase arrest via PKCdelta phosphorylation-induced upregulation of p21 proteins...
  41. ncbi request reprint HeLa cells apoptosis induced by 1,7-dimethyl-1,4,7,10-tetraazacyclododecane
    Li Yang
    College of Chemistry and Molecular Sciences, Wuhan University, Hubei, Wuhan 430072, PR China
    Bioorg Med Chem Lett 17:1818-22. 2007
    ..The HeLa cells apoptosis induced by DMC was examined by flow cytometric meter, and further confirmed by observing the morphological changes and DNA fragmentation. No observation of A549 cells induced apoptosis was observed by DMC...
  42. ncbi request reprint Proteasome-independent down-regulation of estrogen receptor-alpha (ERalpha) in breast cancer cells treated with 4,4'-dihydroxy-trans-stilbene
    Kannan V Balan
    Department of Pediatrics, Rainbow Babies and Children s Hospital, 11100 Euclid Avenue, Suite 3100, Case Western Reserve University, Cleveland, OH 44106, USA
    Biochem Pharmacol 72:573-81. 2006
    ..Here, we present data to show that both 4-OH and 4'-OH are critical for the ability of 4,4'-DHS to induce down-regulation of ERalpha and suggest that 4,4'-DHS provides a useful scaffold for development of novel ERalpha antagonists...
  43. ncbi request reprint [Expression of estrogen sulfotransferase (EST) gene and bridging integrator protein-1 (BIN1) gene and their significance in breast tissues]
    Wen hui Deng
    Department of Obstetrics and Gynecology, Beijing Hospital, Department of Health, Beijing 100 730, P R China
    Ai Zheng 23:1302-5. 2004
    ..EST and BIN1 may be protective in tumorigenesis. This study was to detect the gene expression of EST and BIN1 in breast cancer tissues,and further investigate the carcinogenesis mechanism of breast cancer...
  44. ncbi request reprint Mutation of a lysine residue in a homeodomain generates dominant negative thyroid transcription factor 1
    Li Yang
    Division of Pulmonary Biology, Children s Hospital Medical Center and Department of Pediatrics, The University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    Biochemistry 43:12489-97. 2004
    ..Mutation at this acetylation site shows a dominant negative effect on SP-B gene transcription. The study supports a concept that acetylation is an important mechanism for TTF-1 activity...
  45. ncbi request reprint [Progress in molecular genetics of correlating genes of breast cancer]
    Yang Wu
    Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041 P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 19:152-5. 2002
    ..Abnormality of breast cancer susceptibility gene (BRCA) is of great significance, especially in the development of breast cancer...
  46. ncbi request reprint Epigenetic modification regulates both expression of tumor-associated genes and cell cycle progressing in human colon cancer cell lines: Colo-320 and SW1116
    Jing Yuan Fang
    Shanghai Institute of Digestive Disease, Renji Hospital Shanghai Second Medical University, Shanghai 200001, China
    Cell Res 14:217-26. 2004
    ..In conclusion, regulation by epigenetic modification of the transcription of tumor-associated genes and the cell cycle progression in both human colon cancer cell lines Colo-320 and SW1116 is gene-specific...
  47. ncbi request reprint Active immunotherapy of tumors with a recombinant xenogeneic endoglin as a model antigen
    Guang hong Tan
    Key Laboratory of Biotherapy of Human Diseases, Ministry of Education, P R China
    Eur J Immunol 34:2012-21. 2004
    ..Remarkably, no marked toxicity was found in the immunized mice. These observations may provide an alternative rational strategy for active cancer immunotherapy...
  48. ncbi request reprint Synthesis of several chemokines but few cytokines by primed uncommitted precursor CD4 T cells suggests that these cells recruit other immune cells without exerting direct effector functions
    Li Yang
    David H Smith Center for Vaccine Biology and Immunology, and the Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Eur J Immunol 34:1617-26. 2004
    ..The secretion of several chemokines, but few cytokines, by primed uncommitted Thpp cells suggests that their activation during an immune response may recruit effector cells without directly polarizing effector functions...
  49. ncbi request reprint Eremophilane sesquiterpene lactones from Ligularia virgaurea ssp. oligocephala
    Quan Xiang Wu
    National Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, PR China
    Planta Med 70:479-82. 2004
    ..Their structures were elucidated by spectroscopic methods including intensive 2D NMR techniques (gCOSY, gHMQC, gHMBC and 1H-1H NOESY for 2) and HR-ESI-MS...
  50. ncbi request reprint Synergy between signal transducer and activator of transcription 3 and retinoic acid receptor-alpha in regulation of the surfactant protein B gene in the lung
    Li Yang
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Mol Endocrinol 18:1520-32. 2004
    ..Therefore, the IL-6/Stat3 signaling axis plays an important role in surfactant protein homeostasis and respiratory inflammation in the lung...
  51. ncbi request reprint Lysosomal acid lipase deficiency causes respiratory inflammation and destruction in the lung
    Xuemei Lian
    Div of Human Genetics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 286:L801-7. 2004
    ..The studies support the concept that neutral lipid metabolites play essential roles in pulmonary homeostasis, inflammatory responses, remodeling, and injury repair...
  52. ncbi request reprint [The effect of estrogen benzoate on normal human breast tissue implanted into athymic nude mice]
    Wen hui Deng
    Department of Obstectric and Gyneology, Beijing Hospital, Beijing 100730, China
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 25:70-3. 2003
    ..To investigate the proliferating effect of estradiol benzoate on normal human breast tissue...
  53. ncbi request reprint Peroxisome proliferator-activated receptor gamma and ligands inhibit surfactant protein B gene expression in the lung
    Li Yang
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 278:36841-7. 2003
    ..The studies support the concept that surfactant protein B homeostasis is influenced by neutral lipid metabolites in the lung...
  54. ncbi request reprint [Significance of detecting disseminated tumor cells in peripheral blood of gastric and colorectal cancer patients]
    Xi Wei Zhang
    Department of General Surgery, First Hospital, Nanjing Medical University, Nanjing 210029, China
    Zhonghua Zhong Liu Za Zhi 25:66-9. 2003
    ..To evaluate the clinical significance of CK20 mRNA expression in detecting disseminated tumor cells in peripheral blood of gastric and colorectal cancer patients...
  55. ncbi request reprint Inhibition of tumor growth with a vaccine based on xenogeneic homologous fibroblast growth factor receptor-1 in mice
    Qiu ming He
    Key Laboratory of Biotherapy of Human Diseases, Ministry of Education, People s Republic of China and Cancer Center, West China Hospital, Guo Xue Xiang No 37, Sichuan 610041, People s Republic of China
    J Biol Chem 278:21831-6. 2003
    ..These observations may provide a new vaccine strategy for cancer therapy through the induction of autoimmunity against FGFR-1 associated with angiogenesis in a cross-reaction...
  56. ncbi request reprint [Effects of phytoestrogen alpha-zearalanol on normal human breast]
    Wen hui Deng
    Department of Obstetrics and Gynecology, Beijing Hospital, Beijing 100730, China
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 26:566-70. 2004
    ..To study the effects of phytoestrogen alpha-zearalanol (alpha-ZAL) on normal human breast...
  57. ncbi request reprint [The mechanism of anti-tumor immune response against mouse melanoma to xenogeneic vaccination]
    Feng Luo
    Key Lab of Biotherapy of Human Diseases, Ministry of Education, PR China, West China Hospital, Sichuan University, Chengdu 610041, China
    Sichuan Da Xue Xue Bao Yi Xue Ban 35:757-60. 2004
    ..To investigate the immunological mechanism for inhibiting melanoma growth in mouse by vaccination with xenogeneic melanocytes...
  58. ncbi request reprint [Research on Rho-kinase expression in pulmonary arterioles of rat exposed to hypoxia]
    Li Yang
    Department of Respiratory, West China Hospital, Sichuan University, Chengdu 610041, China
    Sichuan Da Xue Xue Bao Yi Xue Ban 37:395-8. 2006
    ..To evaluate the expression and the role of Rho-kinase (ROCK I and ROCK II )in the development of hypoxic pulmonary hypertension of rat...
  59. ncbi request reprint [Experimental study of anti-cancer effect of Mannan-modified targeted nanoliposome on mice]
    Li Yang
    The Central Teaching Laboratory for Modern Pharmacy, West China Pharmacy School, Sichuan University, Chengdu 610041, China
    Sichuan Da Xue Xue Bao Yi Xue Ban 37:357-60. 2006
    ..To test the anti-cancer effect of mannan-modified targeted nanoliposome on mice...
  60. ncbi request reprint [Determining the primary site of metastatic adenocarcinoma in serous fluid: a cytological study]
    Fang Fang
    Department of Pathology, Beijing Hospital, China
    Zhonghua Bing Li Xue Za Zhi 34:641-5. 2005
    ..To explore cytological parameters that may identify the primary sites of metastatic adenocarcinomas in serous fluid...
  61. ncbi request reprint Medical applications of macrocyclic polyamines
    Feng Liang
    College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei, PR China, 430072
    Curr Med Chem 13:711-27. 2006
    ..The current rational design, and medical applications of macrocyclic polyamines will be reviewed in this manuscript...
  62. ncbi request reprint Combination of porphyrins and DNA-alkylation agents: synthesis and tumor cell apoptosis induction
    Hanping He
    College of Chemistry and Molecular Sciences, Wuhan University, Hubei, PR China
    Bioorg Med Chem 14:1068-77. 2006
    ....
  63. ncbi request reprint CD73 and Ly-6A/E distinguish in vivo primed but uncommitted mouse CD4 T cells from type 1 or type 2 effector cells
    Li Yang
    David H Smith Center for Vaccine Biology and Immunology, and the Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Immunol 175:6458-64. 2005
    ..CD73 and Ly-6A/E expression therefore identify a population of Thpp-like cells in C57BL/6 mice and at least some other Ly-6.2 mice...
  64. ncbi request reprint Total synthesis of phorboxazole B
    De Run Li
    Shanghai Institute of Organic Chemistry, 354 Fenglin Rd, Shanghai 200032, PR China
    Chemistry 12:1185-204. 2006
    ....
  65. ncbi request reprint [Screening and identification of phage-displayed polypeptides specifically binding to human gastric cancer with high metastatic potential to peritoneum]
    Ke dong Zhang
    Affiliated Hospital, Ningxia Medical College, Yinchuan 750004, China
    Zhonghua Zhong Liu Za Zhi 27:397-400. 2005
    ..By means of phage-display technique, to screen polypeptides that specifically bind to human gastric cancer with high metastatic potential to peritoneum...
  66. ncbi request reprint [Effects of benefiting-bone capsule on the expression of transforming growth factor-beta1 mRNA in bone tissue of the ovariectomized rats]
    Ronghua Zhang
    The Affiliated First Hospital, Jinan University, Guangzhou 510632
    Zhong Yao Cai 28:312-5. 2005
    ....
  67. ncbi request reprint [Preparation of 8-chloro-adenosine long circulation liposomes and its pharmacokinetics in rats]
    Li Yang
    Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China
    Yao Xue Xue Bao 40:382-4. 2005
    ..To prepare 8-chloro-adenosine (8-Cl-A) long circulation liposomes with high entrapped efficiency and prolonged action-time of 8-Cl-A in vivo...
  68. ncbi request reprint [Prokaryotic expression, purification and identification of recombinant Xenopus laevis and mouse vascular endothelial growth factors]
    Ting Niu
    The State Key Laboratory of Biotherapy, Sichuan University, Chengdu, China
    Sichuan Da Xue Xue Bao Yi Xue Ban 36:301-4. 2005
    ..To perform prokaryotic expression, purification and identification of Xenopus laevis and mouse vascular endothelial growth factors (VEGF)...
  69. ncbi request reprint Synergistic anti-tumor effect of recombinant human endostatin adenovirus combined with gemcitabine
    Yang Wu
    State Key Laboratory of Biotherapy for Human Diseases, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan 610041, PRC
    Anticancer Drugs 16:551-7. 2005
    ..Our data support the idea of synergistic anti-tumor properties of endostatin plus low-dose chemotherapy against human lung cancer in vivo...
  70. ncbi request reprint [Effect of ligustrazine on airway remodeling in asthmatic rats]
    Wen jian Wang
    Department of Pediatrics, Zhongda Hospital, Southeast University, Nanjing 210009, China
    Zhonghua Jie He He Hu Xi Za Zhi 27:833-6. 2004
    ..To observe the effect and mechanism of ligustrazine on the airway remodeling...
  71. ncbi request reprint Active immunogene therapy of cancer with vaccine on the basis of chicken homologous matrix metalloproteinase-2
    Jing mei Su
    Key Laboratory of Biotherapy of Human Diseases, Ministry of Education, P R China and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041 Sichuan, The People s Republic of China
    Cancer Res 63:600-7. 2003
    ....