G Yang

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. pmc Adiposity and fat distribution in relation to inflammation and oxidative stress in a relatively lean population of Chinese women
    Sheng Hui Wu
    Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
    Dis Markers 34:279-93. 2013
  2. pmc Polycyclic aromatic hydrocarbons: determinants of urinary 1-hydroxypyrene glucuronide concentration and risk of colorectal cancer in the Shanghai Women's Health Study
    Jonathan N Hofmann
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    BMC Cancer 13:282. 2013
  3. pmc Prediagnosis soy food consumption and lung cancer survival in women
    Gong Yang
    Vanderbilt University Medical Center, Nashville, TN 37203 1738, USA
    J Clin Oncol 31:1548-53. 2013
  4. pmc Soy food intake and risk of lung cancer: evidence from the Shanghai Women's Health Study and a meta-analysis
    Gong Yang
    Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, 2525 West End Avenue, Suite 600, Nashville, TN 37203 1738, USA
    Am J Epidemiol 176:846-55. 2012
  5. pmc Patterns and correlates of physical activity: a cross-sectional study in urban Chinese women
    Adriana L Jurj
    Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37203, USA
    BMC Public Health 7:213. 2007
  6. ncbi request reprint Impacts of weight change on prehypertension in middle-aged and elderly women
    G Yang
    Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center and Vanderbilt University School of Medicine, Nashville, TN 37203, USA
    Int J Obes (Lond) 31:1818-25. 2007
  7. ncbi request reprint Genetic polymorphisms in glutathione-S-transferase genes (GSTM1, GSTT1, GSTP1) and survival after chemotherapy for invasive breast carcinoma
    Gong Yang
    Vanderbilt Center for Health Services Research, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 8300, USA
    Cancer 103:52-8. 2005
  8. ncbi request reprint Prospective cohort study of green tea consumption and colorectal cancer risk in women
    Gong Yang
    Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville TN 37232 2587, USA
    Cancer Epidemiol Biomarkers Prev 16:1219-23. 2007
  9. ncbi request reprint Modifying effects of sulfotransferase 1A1 gene polymorphism on the association of breast cancer risk with body mass index or endogenous steroid hormones
    Gong Yang
    Department of Medicine, Center for Health Services Research and Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232 8300, USA
    Breast Cancer Res Treat 94:63-70. 2005
  10. pmc Prospective cohort study of soy food intake and colorectal cancer risk in women
    Gong Yang
    Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203 1738, USA
    Am J Clin Nutr 89:577-83. 2009

Research Grants

Collaborators

Detail Information

Publications88

  1. pmc Adiposity and fat distribution in relation to inflammation and oxidative stress in a relatively lean population of Chinese women
    Sheng Hui Wu
    Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
    Dis Markers 34:279-93. 2013
    ..This study evaluated associations of various anthropometric measures of adiposity with a panel of inflammatory and oxidative stress markers in a relatively lean population of Chinese women...
  2. pmc Polycyclic aromatic hydrocarbons: determinants of urinary 1-hydroxypyrene glucuronide concentration and risk of colorectal cancer in the Shanghai Women's Health Study
    Jonathan N Hofmann
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    BMC Cancer 13:282. 2013
    ....
  3. pmc Prediagnosis soy food consumption and lung cancer survival in women
    Gong Yang
    Vanderbilt University Medical Center, Nashville, TN 37203 1738, USA
    J Clin Oncol 31:1548-53. 2013
    ..The effect size for aggressive lung cancers was larger than that observed for other types of lung cancer. Therefore, we hypothesized that soy consumption may favorably affect the overall survival of patients with lung cancer...
  4. pmc Soy food intake and risk of lung cancer: evidence from the Shanghai Women's Health Study and a meta-analysis
    Gong Yang
    Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, 2525 West End Avenue, Suite 600, Nashville, TN 37203 1738, USA
    Am J Epidemiol 176:846-55. 2012
    ..This study suggests that soy food consumption may reduce lung cancer risk in nonsmoking women, particularly for aggressive tumors, and its effect may be modified by endogenous estrogens...
  5. pmc Patterns and correlates of physical activity: a cross-sectional study in urban Chinese women
    Adriana L Jurj
    Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37203, USA
    BMC Public Health 7:213. 2007
    ..The purpose of this study was to investigate the patterns and correlates of physical activity in middle-aged and elderly women from urban Shanghai...
  6. ncbi request reprint Impacts of weight change on prehypertension in middle-aged and elderly women
    G Yang
    Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center and Vanderbilt University School of Medicine, Nashville, TN 37203, USA
    Int J Obes (Lond) 31:1818-25. 2007
    ..Data on impacts of long-term weight change on prehypertension are sparse...
  7. ncbi request reprint Genetic polymorphisms in glutathione-S-transferase genes (GSTM1, GSTT1, GSTP1) and survival after chemotherapy for invasive breast carcinoma
    Gong Yang
    Vanderbilt Center for Health Services Research, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 8300, USA
    Cancer 103:52-8. 2005
    ....
  8. ncbi request reprint Prospective cohort study of green tea consumption and colorectal cancer risk in women
    Gong Yang
    Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville TN 37232 2587, USA
    Cancer Epidemiol Biomarkers Prev 16:1219-23. 2007
    ..43; 95% confidence interval, 0.24-0.77). The inverse association with regular tea drinking was observed for both colon and rectal cancers. This study suggests that regular consumption of green tea may reduce CRC risk in women...
  9. ncbi request reprint Modifying effects of sulfotransferase 1A1 gene polymorphism on the association of breast cancer risk with body mass index or endogenous steroid hormones
    Gong Yang
    Department of Medicine, Center for Health Services Research and Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232 8300, USA
    Breast Cancer Res Treat 94:63-70. 2005
    ..No similar effect modification was found for premenopausal breast cancer, however. These data suggest that the SULT1A1 Arg213His polymorphism may modify the effect of endogenous sex hormone exposures on postmenopausal breast cancer risk...
  10. pmc Prospective cohort study of soy food intake and colorectal cancer risk in women
    Gong Yang
    Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203 1738, USA
    Am J Clin Nutr 89:577-83. 2009
    ..Data from epidemiologic studies linking usual soy food intake with colorectal cancer are limited and inconsistent...
  11. pmc Isothiocyanate exposure, glutathione S-transferase polymorphisms, and colorectal cancer risk
    Gong Yang
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Am J Clin Nutr 91:704-11. 2010
    ..Glutathione S-transferases (GSTs) are involved in the metabolism and elimination of isothiocyanates; thus, genetic variations in these enzymes may affect in vivo bioavailability and the activity of isothiocyanates...
  12. ncbi request reprint Body weight and weight change in relation to blood pressure in normotensive men
    G Yang
    Department of Medicine, Vanderbilt University School of Medicine, Center for Health Services Research, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Hum Hypertens 21:45-52. 2007
    ....
  13. pmc Green tea consumption and colorectal cancer risk: a report from the Shanghai Men's Health Study
    Gong Yang
    Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, 2525 West End Avenue, Suite 600, IMPH, Nashville, TN 37203, USA
    Carcinogenesis 32:1684-8. 2011
    ..88, 95% CI: 0.78-0.99). No significant association was found among smokers (HR = 0.94, 95% CI: 0.66-1.34). This study suggests that regular consumption of green tea may reduce colorectal cancer risk among non-smokers...
  14. pmc Lifestyle determinants of C-reactive protein in middle-aged, urban Chinese men
    R Villegas
    Vanderbilt University Medical Center, Nashville, TN 37206, USA
    Nutr Metab Cardiovasc Dis 22:223-30. 2012
    ..The aim of this study was to investigate associations between lifestyle factors and high CRP among middle-aged men living in Shanghai, China...
  15. ncbi request reprint Body mass index and the risk of cancers of the gastric cardia and distal stomach in Shanghai, China
    B T Ji
    Division of Epidemiology, Columbia University, School of Public Health, New York, New York 10032, USA
    Cancer Epidemiol Biomarkers Prev 6:481-5. 1997
    ..Our observations in China support recent findings in Western populations that obesity contributes to the risk of gastric cardia cancer, especially among men...
  16. ncbi request reprint Variation in nutrient intakes among women in Shanghai, China
    H Cai
    Department of Medicine, Center for Health Services Research and Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, TN 37232, USA
    Eur J Clin Nutr 58:1604-11. 2004
    ....
  17. ncbi request reprint Anthropometric predictors of coronary heart disease in Chinese women
    X Zhang
    Department of Medicine, Center for Health Services Research, Vanderbilt University, Nashville, TN, USA
    Int J Obes Relat Metab Disord 28:734-40. 2004
    ..To evaluate the associations of body size and fat distribution with incidence of coronary heart disease (CHD) in Chinese women...
  18. pmc Energy balance and type 2 diabetes: a report from the Shanghai Women's Health Study
    R Villegas
    Department of Medicine, Vanderbilt Epidemiology Center, 2525 West End Avenue, Suite 600, Nashville, TN 37203, USA
    Nutr Metab Cardiovasc Dis 19:190-7. 2009
    ..The aim of this study was to examine the components of energy balance and the incidence of T2D in a cohort of middle-aged women...
  19. ncbi request reprint Soyfood consumption and risk of glycosuria: a cross-sectional study within the Shanghai Women's Health Study
    G Yang
    Center for Health Service Research, Vanderbilt University Medical Center, Nashville, TN 37232 8300, USA
    Eur J Clin Nutr 58:615-20. 2004
    ..To assess the association between soyfood intake and risk of glycosuria...
  20. pmc Dietary patterns and blood pressure among middle-aged and elderly Chinese men in Shanghai
    Sang Ah Lee
    Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, 2525 West End Avenue, Suite 600, IMPH, Nashville TN 37203 1738, USA
    Br J Nutr 104:265-75. 2010
    ..Results of the present study suggest an important role for diet in the prevention of hypertension...
  21. pmc Anthropometric measures and epithelial ovarian cancer risk among Chinese women: results from the Shanghai Women's Health Study
    X Ma
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Br J Cancer 109:751-5. 2013
    ..Studies of anthropometric measures and ovarian cancer risk have predominantly included women of European descent with mixed findings...
  22. pmc Body mass index at various ages and mortality in Chinese women: impact of potential methodological biases
    X Zhang
    Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN 37203 1738, USA
    Int J Obes (Lond) 32:1130-6. 2008
    ..Inadequate control for potential methodological biases has been suggested as an explanation for the conflicting findings concerning the relationship between body mass index (BMI) and mortality...
  23. pmc Duration of breast-feeding and the incidence of type 2 diabetes mellitus in the Shanghai Women's Health Study
    R Villegas
    Vanderbilt Epidemiology Center, Institute for Medicine and Public Health, Department of Medicine, Vanderbilt University Medical Center, 2525 West End Avenue, Suite 600, Nashville, TN 37232 1738, USA
    Diabetologia 51:258-66. 2008
    ..The aim of this study was to examine the association between lifetime breast-feeding and the incidence of type 2 diabetes mellitus in a large population-based cohort study of middle-aged women...
  24. ncbi request reprint Body fat distribution and risk of diabetes among Chinese women
    A D Rosenthal
    Department of Medicine and Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, TN 37232, USA
    Int J Obes Relat Metab Disord 28:594-9. 2004
    ..To assess the relationship between measures of central and overall obesity and risk of diabetes...
  25. ncbi request reprint Dietary intake of calcium, fiber and other micronutrients in relation to colorectal cancer risk: Results from the Shanghai Women's Health Study
    Aesun Shin
    Department of Medicine, Center for Health Services Research and Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232 2587, USA
    Int J Cancer 119:2938-42. 2006
    ..Our results suggest that calcium may be protective against colorectal cancer development even at a lower consumption level compared to Western populations...
  26. pmc Legume and soy food intake and the incidence of type 2 diabetes in the Shanghai Women's Health Study
    Raquel Villegas
    Department of Medicine, Vanderbilt Epidemiology Center, Nashville, TN 37203 1738, USA
    Am J Clin Nutr 87:162-7. 2008
    ..It has been postulated that a diet high in legumes may be beneficial for the prevention of type 2 diabetes mellitus (type 2 DM). However, data linking type 2 DM risk and legume intake are limited...
  27. ncbi request reprint Prospective study of dietary carbohydrates, glycemic index, glycemic load, and incidence of type 2 diabetes mellitus in middle-aged Chinese women
    Raquel Villegas
    Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, 2525 West End Ave, Ste 600, Nashville, TN 37203 1738, USA
    Arch Intern Med 167:2310-6. 2007
    ..Much uncertainty exists about the role of dietary glycemic index and glycemic load in the development of type 2 diabetes mellitus, especially in populations that traditionally subsist on a diet high in carbohydrates...
  28. ncbi request reprint Validity and reproducibility of the food frequency questionnaire used in the Shanghai Women's Health Study
    X O Shu
    Department of Medicine, Vanderbilt Ingram Cancer Center, Vanderbilt Center for Health Services Research, Vanderbilt University, Nashville, TN 37232 8300, USA
    Eur J Clin Nutr 58:17-23. 2004
    ..These data indicate that the SWHS FFQ can reliably and accurately measure usual intake of major nutrients and food groups among women in Shanghai...
  29. pmc Prevalence of obesity and correlations with lifestyle and dietary factors in Chinese men
    Sang Ah Lee
    Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, Tennessee, USA
    Obesity (Silver Spring) 16:1440-7. 2008
    ..To estimate the age-adjusted prevalence of general and centralized obesity among Chinese men living in urban Shanghai...
  30. pmc Vegetable but not fruit consumption reduces the risk of type 2 diabetes in Chinese women
    Raquel Villegas
    Department of Medicine, Vanderbilt Epidemiology Center, Institute for Medicine and Public Health, Nashville, TN 37203 1738, USA
    J Nutr 138:574-80. 2008
    ..Fruit intake was not associated with the incidence of diabetes in this population. Our data suggest that vegetable consumption may protect against the development of T2D...
  31. pmc Dietary and lifestyle predictors of age at natural menopause and reproductive span in the Shanghai Women's Health Study
    Tsogzolmaa Dorjgochoo
    Department of Medicine, Vanderbilt Epidemiology Center, School of Medicine, Vanderbilt University and Vanderbilt Ingram Cancer Center, Nashville, TN 37203 1738, USA
    Menopause 15:924-33. 2008
    ..We evaluated the impact of dietary, lifestyle and reproductive factors on age at natural menopause and reproductive span in Chinese women...
  32. ncbi request reprint Nutrient intake among Chinese women living in Shanghai, China
    Zhi Chen
    Department of Medicine, Center for Health Services Research and Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, TN 37232 8300, USA
    Br J Nutr 96:393-9. 2006
    ....
  33. pmc Adolescent and adult soy food intake and breast cancer risk: results from the Shanghai Women's Health Study
    Sang Ah Lee
    Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203 1738, USA
    Am J Clin Nutr 89:1920-6. 2009
    ..Soy food is a rich source of isoflavones--a class of phytoestrogens that has both antiestrogenic and anticarcinogenic properties...
  34. ncbi request reprint Population-based, case-control study of blood C-peptide level and breast cancer risk
    G Yang
    Department of Medicine and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-8300, USA
    Cancer Epidemiol Biomarkers Prev 10:1207-11. 2001
    ..The results from this study were consistent with the insulin-resistance hypothesis for breast cancer and suggest that increased levels of C-peptide may contribute to the development of breast cancer...
  35. ncbi request reprint Sociodemographic, behavioral, and reproductive factors associated with weight gain in Chinese women
    W Wen
    Department of Medicine, Vanderbilt University, Nashville, TN, USA
    Int J Obes Relat Metab Disord 27:933-40. 2003
    ..To examine whether certain sociodemographic, behavioral, and reproductive factors are associated with an increased weight gain in Chinese women...
  36. ncbi request reprint Association of passive smoking by husbands with prevalence of stroke among Chinese women nonsmokers
    Xianglan Zhang
    Department of Medicine and Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, TN 37232, USA
    Am J Epidemiol 161:213-8. 2005
    ..The authors found that women nonsmokers who lived with husbands who smoked had an elevated prevalence of stroke, and prevalence increased with increasing intensity and duration of husbands' smoking...
  37. ncbi request reprint Oral contraceptive use and risk of diabetes among Chinese women
    Aron D Rosenthal
    Department of Medicine, Center for Health Services Research and the Vanderbilt Ingram Cancer Center, Vanderbilt University, 6009 Medical Center East, 1215 21st Avenue South, Nashville, TN 37232, USA
    Contraception 69:251-7. 2004
    ..However, the attributable risk for diabetes among OC users in the general population, if confirmed by further studies, appears to be small...
  38. ncbi request reprint Physical activity and the incidence of type 2 diabetes in the Shanghai women's health study
    Raquel Villegas
    Department of Medicine, Vanderbilt Epidemiology Center Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Int J Epidemiol 35:1553-62. 2006
    ..The aim of this study was to examine the effect of occupational, commuting, daily living, and LPA on the incidence of type 2 diabetes in a cohort of middle-aged women...
  39. ncbi request reprint Spousal correlations for lifestyle factors and selected diseases in Chinese couples
    Adriana L Jurj
    Department of Medicine, Center for Health Services Research and Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Ann Epidemiol 16:285-91. 2006
    ..Thus, concordance of diseases in spouses reflects mainly environmental etiologic contributors. The purpose of this study is to investigate spousal associations for selected lifestyle characteristics and common medical conditions...
  40. ncbi request reprint Prospective cohort study of soy food consumption and risk of bone fracture among postmenopausal women
    Xianglan Zhang
    Department of Medicine, Center for Health Services Research, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tenn 37232 8300, USA
    Arch Intern Med 165:1890-5. 2005
    ..Soy consumption has been shown to modulate bone turnover and increase bone mineral density in postmenopausal women. To our knowledge, no published studies have directly examined the association between soy consumption and risk of fracture...
  41. ncbi request reprint Birthweight, childhood growth and hypertension in adulthood
    Mingfang Zhao
    Center for Health Services Research, Vanderbilt University, Nashville, TN 37232 8300, USA
    Int J Epidemiol 31:1043-51. 2002
    ..Low birthweight (BW) and childhood growth have been hypothesized to be associated with an increased risk of hypertension in later life...
  42. pmc Animal origin foods and colorectal cancer risk: a report from the Shanghai Women's Health Study
    Sang Ah Lee
    Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, 2525 West End Avenue, Nashville, TN 37203 1738, USA
    Nutr Cancer 61:194-205. 2009
    ..The latter was positively associated with colon cancer (RR = 1.4 for ever vs. never, 95% CI = 1.1-1.9). A possible role of cholesterol and environmental pollution in the etiology of CRC was suggested...
  43. pmc Prevalence and determinants of metabolic syndrome according to three definitions in middle-aged Chinese men
    Raquel Villegas
    Vanderbilt Epidemiology Center, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37203 1738, USA
    Metab Syndr Relat Disord 7:37-45. 2009
    ..We estimated the prevalence and lifestyle risk factors of metabolic syndrome according to three definitions of metabolic syndrome in urban Chinese men participating in the Shanghai Men's Health Study (SMHS)...
  44. pmc A prospective study of dietary polyunsaturated fatty acids and colorectal cancer risk in Chinese women
    Harvey J Murff
    Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN 37203 1738, USA
    Cancer Epidemiol Biomarkers Prev 18:2283-91. 2009
    ..03). These results suggest that dietary PUFA and the ratio of n-6 to n-3 PUFA intake may be positively associated with colorectal cancer risk, and this association may be mediated in part through PGE(2) production...
  45. pmc Intra-person variation of urinary biomarkers of oxidative stress and inflammation
    Xiaoyan Wu
    Division of Epidemiology, Vanderbilt University Medical Center, 2525 West End Avenue, Nashville, TN 37203 1738, USA
    Cancer Epidemiol Biomarkers Prev 19:947-52. 2010
    ..However, little information is available regarding the intra-person variation of these biomarkers, hindering their application in epidemiologic studies...
  46. pmc Dietary carbohydrates, fiber, and breast cancer risk in Chinese women
    Wanqing Wen
    Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN 37203 1738, USA
    Am J Clin Nutr 89:283-9. 2009
    ..Few studies have investigated the association of dietary carbohydrate and fiber intake with breast cancer risk in women in China, where carbohydrate intake is traditionally high...
  47. pmc Resting heart rate and risk of type 2 diabetes in women
    Xianglan Zhang
    Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN, USA
    Int J Epidemiol 39:900-6. 2010
    ..Resting heart rate has been shown to predict risk of cardiovascular disease; its association with diabetes remains unclear, particularly in non-Western populations...
  48. pmc Fruit and vegetable consumption and risk of distal gastric cancer in the Shanghai Women's and Men's Health studies
    Meira Epplein
    Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, 2525 West End Avenue, Sixth Floor, Nashville, TN 37203, USA
    Am J Epidemiol 172:397-406. 2010
    ..67). No associations between dietary intakes of select antioxidant micronutrients were seen for men or women. Fruit intake is inversely associated with distal gastric cancer risk among men in Shanghai, China...
  49. pmc General and abdominal adiposity and risk of stroke in Chinese women
    Xianglan Zhang
    Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tenn 37203 1738, USA
    Stroke 40:1098-104. 2009
    ..Although both general and abdominal adiposity are well-established risk factors for coronary heart disease, their associations with stroke are less well characterized, particularly in generally lean Asian populations...
  50. doi request reprint Association between body-mass index and risk of death in more than 1 million Asians
    Wei Zheng
    Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, TN, USA
    N Engl J Med 364:719-29. 2011
    ..Most studies that have evaluated the association between the body-mass index (BMI) and the risks of death from any cause and from specific causes have been conducted in populations of European origin...
  51. pmc Dietary calcium and magnesium intakes and the risk of type 2 diabetes: the Shanghai Women's Health Study
    Raquel Villegas
    Vanderbilt Epidemiology Center, Department of Medicine, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, TN 37203 1738, USA
    Am J Clin Nutr 89:1059-67. 2009
    ..Diet plays a key role in the development of type 2 diabetes (T2D), but little is known about the contributions of specific nutrients in populations in which dietary patterns differ from Western populations...
  52. pmc Dietary polyunsaturated fatty acids and breast cancer risk in Chinese women: a prospective cohort study
    Harvey J Murff
    Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203 1738, USA
    Int J Cancer 128:1434-41. 2011
    ..The relative amounts of n-6 PUFA to marine-derived n-3 PUFAs may be more important for breast cancer risk than individual dietary amounts of these fatty acids...
  53. pmc Oxidative stress, obesity, and breast cancer risk: results from the Shanghai Women's Health Study
    Qi Dai
    Department of Medicine and Pharmacology, Vanderbilt Epidemiology Center, Institute for Medicine and Public Health, Nashville, TN 37203 1738, USA
    J Clin Oncol 27:2482-8. 2009
    ..No prospective study has investigated whether levels of 15-F(2t)-isoprostane (15-F(2t)-IsoP) and its metabolite 2,3-dinor-5,6-dihydro-15-F(2t)-IsoP (15-F(2t)-IsoPM) are related to breast cancer risk...
  54. pmc Is green tea drinking associated with a later onset of breast cancer?
    Qi Dai
    Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Vanderbilt School of Medicine, Nashville, TN 37203 1738, USA
    Ann Epidemiol 20:74-81. 2010
    ..Because of the substantial difference in levels of estrogens between premenopausal and postmenopausal women, the relationship between tea consumption and breast cancer risk may depend on menopausal status...
  55. pmc Pregnancy, childrearing, and risk of stroke in Chinese women
    Xianglan Zhang
    Vanderbilt Epidemiology Center, Institute for Medicine and Public Health, Vanderbilt University Medical Center, Sixth Floor, Suite 600, 2525 West End Avenue, Nashville, TN 37203 1738, USA
    Stroke 40:2680-4. 2009
    ..Although it has been suggested that high gravidity and parity increase the risk for coronary heart disease, their associations with stroke are unclear...
  56. pmc Dietary patterns are associated with lower incidence of type 2 diabetes in middle-aged women: the Shanghai Women's Health Study
    Raquel Villegas
    Vanderbilt Epidemiology Center, Department of Medicine, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, TN, USA
    Int J Epidemiol 39:889-99. 2010
    ..Data linking risk of type 2 diabetes (T2D) and dietary patterns in Chinese populations are scarce...
  57. ncbi request reprint Prospective study of urinary prostaglandin E2 metabolite and colorectal cancer risk
    Qiuyin Cai
    Department of Medicine, Center for Epidemiology Research, and Vanderbilt Ingram Cancer Center, Nashville, TN, USA
    J Clin Oncol 24:5010-6. 2006
    ..We evaluated the association of urinary prostaglandin E2 metabolite (PGE-M) levels and colorectal cancer risk...
  58. ncbi request reprint Influence of exercise, walking, cycling, and overall nonexercise physical activity on mortality in Chinese women
    Charles E Matthews
    Department of Medicine, Division of General Internal Medicine and Public Health, Vanderbilt Epidemiology Center, Vanderbilt University Medical School, Nashville, TN 37203 1738, USA
    Am J Epidemiol 165:1343-50. 2007
    ..62, 0.99). These findings add new evidence that overall physical activity levels are an important determinant of longevity, and that health benefit can be obtained through an active lifestyle, exercise, or combinations of both...
  59. ncbi request reprint Dietary patterns and their correlates among middle-aged and elderly Chinese men: a report from the Shanghai Men's Health Study
    Hui Cai
    Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, TN 37232 8300, USA
    Br J Nutr 98:1006-13. 2007
    ..Future studies of diet and health in this population will need to carefully take into account these potential confounders...
  60. ncbi request reprint Genetic polymorphisms in the TGF-beta 1 gene and breast cancer survival: a report from the Shanghai Breast Cancer Study
    Xiao Ou Shu
    Department of Medicine and Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee, USA
    Cancer Res 64:836-9. 2004
    ..4, 95% confidence interval, 1.0-1.9). Our study suggests that genetic polymorphisms in the TGF-beta1 gene may play a role in breast cancer progression...
  61. ncbi request reprint A prospective study of dietary patterns and mortality in Chinese women
    Hui Cai
    Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashvill, TN, USA
    Epidemiology 18:393-401. 2007
    ..Our study prospectively examines the relationship of dietary patterns with total mortality and cause-specific mortality in a population-based cohort study of Chinese women...
  62. ncbi request reprint The Shanghai Women's Health Study: rationale, study design, and baseline characteristics
    Wei Zheng
    Center for Health Services Research, Department of Medicine, Vanderbilt University, Nashville, TN 37232 8300, USA
    Am J Epidemiol 162:1123-31. 2005
    ..The resources from the cohort will be valuable in future studies of environmental exposures and biomarkers for the risk of cancer and other chronic diseases...
  63. pmc Environmental tobacco smoke and mortality in Chinese women who have never smoked: prospective cohort study
    Wanqing Wen
    Department of Medicine, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    BMJ 333:376. 2006
    ....
  64. ncbi request reprint Physical activity patterns and their correlates among Chinese men in Shanghai
    Sang Ah Lee
    Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, TN 37203 1738, USA
    Med Sci Sports Exerc 39:1700-7. 2007
    ..Physical activity (PA) is inversely related to the risk of many chronic diseases. Understanding PA patterns and their correlates thus has significant public health implications...
  65. ncbi request reprint Reproducibility and validity of the Shanghai Women's Health Study physical activity questionnaire
    Charles E Matthews
    Department of Medicine, Vanderbilt Ingram Cancer Center, Center for Health Services Research, Vanderbilt University Medical Center, Nashville, TN 37232 8300, USA
    Am J Epidemiol 158:1114-22. 2003
    ..88). These data indicate that the SWHS PAQ is a reproducible and valid measure of exercise behaviors and that it demonstrates utility in stratifying women by levels of important lifestyle activities (e.g., housework, walking, cycling)...
  66. ncbi request reprint Soy food consumption is associated with lower risk of coronary heart disease in Chinese women
    Xianglan Zhang
    Department of Medicine, Center for Health Services Research, Vanderbilt University, Nashville, TN 37232, USA
    J Nutr 133:2874-8. 2003
    ..14; 95% CI, 0.04-0.48 for the highest vs. the lowest quartile of intake; P for trend = 0.001). This study provides, for the first time, direct evidence that soy food consumption may reduce the risk of CHD in women...
  67. pmc The Shanghai Women's Asthma and Allergy Study: objectives, design, and recruitment results
    Tina V Hartert
    Division of Allergy, Pulmonary and Critical Care Medicine, School of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 8300, USA
    Am J Epidemiol 167:1387-96. 2008
    ..This paper describes the study objectives, design, population demographics, and recruitment results...
  68. ncbi request reprint Abdominal adiposity and mortality in Chinese women
    Xianglan Zhang
    Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN 37232 8300, USA
    Arch Intern Med 167:886-92. 2007
    ..Increased abdominal adiposity has been linked to an increase in mortality in populations where many are overweight or obese; it is unclear whether the same is true in relatively lean populations...
  69. ncbi request reprint Longitudinal study of soy food intake and blood pressure among middle-aged and elderly Chinese women
    Gong Yang
    Vanderbilt Center for Health Services Research, Department of Medicine, Vanderbilt School of Medicine, and Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA
    Am J Clin Nutr 81:1012-7. 2005
    ..Several small-scale clinical trials have suggested a potential beneficial effect of short-term soy consumption on blood pressure (BP). Data are scanty on long-term effects of the usual intake of soy foods on BP in general populations...
  70. ncbi request reprint Sources of variation in nutrient intakes among men in Shanghai, China
    Hui Cai
    Department of Medicine, Center for Health Services Research and Vanderbilt Ingram Cancer Center, 6009 MCE, Vanderbilt University, 1215 21st Avenue, Nashville, TN 37232 8300, USA
    Public Health Nutr 8:1293-9. 2005
    ....
  71. ncbi request reprint Validity and reproducibility of the food-frequency questionnaire used in the Shanghai men's health study
    Raquel Villegas
    Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Medical Center East, Suite 6000, 1215 21st Avenue South, Nashville, TN 37232 8300, USA
    Br J Nutr 97:993-1000. 2007
    ..8 and 49.2%, while misclassification to opposite quartiles was between 1.5 and 6.2%. These data indicate that the SMHS FFQ can reasonably categorise usual intake of nutrients and food groups among men living in urban Shanghai...
  72. pmc Urinary polyphenols and breast cancer risk: results from the Shanghai Women's Health Study
    Jianfeng Luo
    Department of Medicine, Vanderbilt Epidemiology Center, Institute for Medicine and Public Health, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203 1738, USA
    Breast Cancer Res Treat 120:693-702. 2010
    ..In conclusion, high epicatechin may be related to a reduced risk of breast cancer. Further studies are warranted to confirm our findings...
  73. pmc Relation of blood pressure components and categories and all-cause, stroke and coronary heart disease mortality in urban Chinese women: a population-based prospective study
    Tsogzolmaa Dorjgochoo
    Department of Medicine, Vanderbilt Epidemiology Center, School of Medicine, and Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee, USA
    J Hypertens 27:468-75. 2009
    ..To determine whether various levels of blood pressure (BP), particularly normal and high normal BP or prehypertension, predict cardiovascular mortality among urban Chinese women...
  74. pmc Plasma carotenoids, tocopherols, retinol and breast cancer risk: results from the Shanghai Women Health Study (SWHS)
    Tsogzolmaa Dorjgochoo
    Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA
    Breast Cancer Res Treat 117:381-9. 2009
    ..Our results do not support an overall protective effect of lipophilic antioxidants on breast cancer risk. The few inverse associations observed for subtype of carotenoids may need to be confirmed in future studies...
  75. ncbi request reprint Should preoperative, post-chemoradiotherapy endoscopy be routine for esophageal cancer patients?
    A Shaukat
    Department of Medicine, School of Medicine and Biomedical Sciences, State University of New York, NY, USA
    Dis Esophagus 17:129-35. 2004
    ..Our data suggests that after chemoradiation, esophagoscopy is unreliable for excluding residual disease. The roles of other modalities need to be explored...
  76. pmc Use of oral contraceptives, intrauterine devices and tubal sterilization and cancer risk in a large prospective study, from 1996 to 2006
    Tsogzolmaa Dorjgochoo
    Vanderbilt Epidemiology Center, Department of Medicine, School of Medicine, Vanderbilt University, Nashville, TN 37203 1738, USA
    Int J Cancer 124:2442-9. 2009
    ..Although chance findings are a likely explanation for some of the associations found in our study, these findings suggest that various contraceptive methods or reproductive patterns may play a role in the etiology of cancer...
  77. ncbi request reprint Rapid increase in colorectal cancer rates in urban Shanghai, 1972-97, in relation to dietary changes
    Wei Cheng You
    Peking University School of Oncology and Beijing Institute for Cancer Research, Beijing, China 100036
    J Cancer Epidemiol Prev 7:143-6. 2002
    ..These changes were even more pronounced for colon cancer. The reasons for the rapid increases in cancer rates are not fully understood, but may involve dietary habits that have changed substantially overthe past two decades...
  78. ncbi request reprint Ginseng intake and gastric cancer risk in the Shanghai Women's Health Study cohort
    Farin Kamangar
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Room 3034, Bethesda, MD 20892 7232, USA
    Cancer Epidemiol Biomarkers Prev 16:629-30. 2007
  79. pmc Occupation and breast cancer risk among Shanghai women in a population-based cohort study
    Bu Tian Ji
    National Cancer Institute, NIH, DHHS, Bethesda, Maryland 20852, USA
    Am J Ind Med 51:100-10. 2008
    ..A total of 74,942 female subjects were recruited in a population-based cohort study in Shanghai, China between 1997 and 2000. We examined the relationship between occupation and breast cancer risk...
  80. ncbi request reprint Family history of cancer and risk of lung cancer among nonsmoking Chinese women
    Yawei Zhang
    School of Epidemiology and Public Health, Yale University, 60 College Street, LEPH 440, New Haven, CT 06520, USA
    Cancer Epidemiol Biomarkers Prev 16:2432-5. 2007
    ..The associations were stronger when a sibling, rather than a parent, was affected. The apparent link between lung cancer risk and a family history of colorectal, stomach, and pancreas cancers may be worth further investigation...
  81. pmc Menstrual and reproductive factors and gastric cancer risk in a large prospective study of women
    Neal D Freedman
    Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Gut 56:1671-7. 2007
    ..Gastric cancer incidence rates are consistently lower in women than men in both high and low-risk regions worldwide. Sex hormones, such as progesterone and estrogen, may protect women against gastric cancer...
  82. ncbi request reprint Inhibition of breast and ovarian tumor growth through multiple signaling pathways by using retrovirus-mediated small interfering RNA against Her-2/neu gene expression
    Gong Yang
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4095, USA
    J Biol Chem 279:4339-45. 2004
    ..siRNA-mediated gene silencing of Her-2/neu and increasing the expression of thrombospondin-1 may be a useful therapeutic strategy for Her-2/neu-over-expressing breast or ovarian cancer...
  83. pmc The chemokine growth-regulated oncogene 1 (Gro-1) links RAS signaling to the senescence of stromal fibroblasts and ovarian tumorigenesis
    Gong Yang
    Department of Pathology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 103:16472-7. 2006
    ..Therefore, Gro-1 may be a therapeutic target as well as a diagnostic marker in ovarian cancer...
  84. ncbi request reprint Activation of antioxidant pathways in ras-mediated oncogenic transformation of human surface ovarian epithelial cells revealed by functional proteomics and mass spectrometry
    Travis W Young
    Department of Pharmacology and Toxicology, Sealy Center for Structural Biology, School of Medicine, The University of Texas Medical Branch, Galveston, USA
    Cancer Res 64:4577-84. 2004
    ..It is conceivable that an enhanced antioxidation capability may constitute a common mechanism for tumor cells to evade apoptosis induced by oxidative stresses at high ROS levels...
  85. ncbi request reprint Up-regulation of tumor susceptibility gene 101 protein in ovarian carcinomas revealed by proteomics analyses
    Travis W Young
    Department of Pharmacology and Toxicology, Sealy Center for Cancer Cell Biology, School of Medicine, The University of Texas Medical Branch, Galveston, Texas 77555, USA
    Mol Cell Proteomics 6:294-304. 2007
    ..These results demonstrate that TSG101 is important for CITED2- and HIF-1alpha-mediated cellular regulation in ovarian carcinomas...
  86. ncbi request reprint Population genetics for Y-STRs haplotypes of Chinese Ewenki ethnic minority group
    Bofeng Zhu
    The Key Laboratory of Public Health of Ministry for Forensic Sciences, Xi an Jiaotong University, Yan Ta West Road No 76 Xi an 710061, Shaanxi, PR China
    J Forensic Sci 50:969-71. 2005
    ..The Ewenki people have no written script but a spoken language with three dialects belonging to the Manchu-Tungusic group of the Altai language family. Raising reindeers is the key livelihood of Ewenkis...
  87. ncbi request reprint Mitochondrial manganese-superoxide dismutase expression in ovarian cancer: role in cell proliferation and response to oxidative stress
    Yumin Hu
    Department of Molecular Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 280:39485-92. 2005
    ....
  88. ncbi request reprint Activation of BTAK expression in primary ovarian surface epithelial cells of prophylactic ovaries
    Zhihong Zhang
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 4095, USA
    Mod Pathol 20:1078-84. 2007
    ..This activation may be a key early genetic event in the development of hereditary ovarian cancer...

Research Grants4

  1. Inflammatory Biomarkers and Colorectal Cancer Risk
    Gong Yang; Fiscal Year: 2007
    ..Overall, this study will contribute significantly to the understanding of the role of inflammation in the etiology of CRC and to the development of new strategies for the assessment of CRC risk. ..
  2. Inflammatory Biomarkers and Colorectal Cancer Risk
    Gong Yang; Fiscal Year: 2010
    ..Overall, this study will contribute significantly to the understanding of the role of inflammation in the etiology of CRC and to the development of new strategies for the assessment of CRC risk. ..