Fang Yan

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. pmc Berberine inhibits proliferation and down-regulates epidermal growth factor receptor through activation of Cbl in colon tumor cells
    Lihong Wang
    Cancer Center, Xiamen University Medical College, Xiamen, People s Republic of China
    PLoS ONE 8:e56666. 2013
  2. pmc Berberine induces caspase-independent cell death in colon tumor cells through activation of apoptosis-inducing factor
    Lihong Wang
    Department of Pediatrics, Vanderbilt University Medical Center and the Monroe Carell Jr Children s Hospital at Vanderbilt, Nashville, Tennessee, United States of America
    PLoS ONE 7:e36418. 2012
  3. pmc Characterization of a probiotic-derived soluble protein which reveals a mechanism of preventive and treatment effects of probiotics on intestinal inflammatory diseases
    Fang Yan
    Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Vanderbilt University School of Medicine and the Monroe Carell Jr Children s Hospital at Vanderbilt, Nashville, TN, USA
    Gut Microbes 3:25-8. 2012
  4. pmc Berberine promotes recovery of colitis and inhibits inflammatory responses in colonic macrophages and epithelial cells in DSS-treated mice
    Fang Yan
    Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, USA
    Am J Physiol Gastrointest Liver Physiol 302:G504-14. 2012
  5. pmc Soluble proteins produced by probiotic bacteria regulate intestinal epithelial cell survival and growth
    Fang Yan
    Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Gastroenterology 132:562-75. 2007
  6. pmc Colon-specific delivery of a probiotic-derived soluble protein ameliorates intestinal inflammation in mice through an EGFR-dependent mechanism
    Fang Yan
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Monroe Carell Jr Children s Hospital at Vanderbilt, Nashville, Tennessee 37232 0696, USA
    J Clin Invest 121:2242-53. 2011
  7. pmc Epidermal growth factor receptor activation protects gastric epithelial cells from Helicobacter pylori-induced apoptosis
    Fang Yan
    Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0696, USA
    Gastroenterology 136:1297-1307, e1-3. 2009
  8. pmc Transactivation of EGF receptor and ErbB2 protects intestinal epithelial cells from TNF-induced apoptosis
    Toshimitsu Yamaoka
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 105:11772-7. 2008
  9. pmc Kinase suppressor of Ras-1 protects intestinal epithelium from cytokine-mediated apoptosis during inflammation
    Fang Yan
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2576, USA
    J Clin Invest 114:1272-80. 2004
  10. pmc TNFR1 promotes tumor necrosis factor-mediated mouse colon epithelial cell survival through RAF activation of NF-kappaB
    Karen L Edelblum
    Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0696, USA
    J Biol Chem 283:29485-94. 2008

Collaborators

Detail Information

Publications35

  1. pmc Berberine inhibits proliferation and down-regulates epidermal growth factor receptor through activation of Cbl in colon tumor cells
    Lihong Wang
    Cancer Center, Xiamen University Medical College, Xiamen, People s Republic of China
    PLoS ONE 8:e56666. 2013
    ..Taken together, these data indicate that berberine enhances Cbl activity, resulting in down-regulation of EGFR expression and inhibition of proliferation in colon tumor cells...
  2. pmc Berberine induces caspase-independent cell death in colon tumor cells through activation of apoptosis-inducing factor
    Lihong Wang
    Department of Pediatrics, Vanderbilt University Medical Center and the Monroe Carell Jr Children s Hospital at Vanderbilt, Nashville, Tennessee, United States of America
    PLoS ONE 7:e36418. 2012
    ..Notably, normal colon epithelial cells are less susceptible to berberine-induced cell death, which suggests the specific inhibitory effects of berberine on colon tumor cell growth...
  3. pmc Characterization of a probiotic-derived soluble protein which reveals a mechanism of preventive and treatment effects of probiotics on intestinal inflammatory diseases
    Fang Yan
    Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Vanderbilt University School of Medicine and the Monroe Carell Jr Children s Hospital at Vanderbilt, Nashville, TN, USA
    Gut Microbes 3:25-8. 2012
    ..These results may provide insights into the clinical application of probiotics for intestinal inflammatory disorders...
  4. pmc Berberine promotes recovery of colitis and inhibits inflammatory responses in colonic macrophages and epithelial cells in DSS-treated mice
    Fang Yan
    Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, USA
    Am J Physiol Gastrointest Liver Physiol 302:G504-14. 2012
    ..Thus berberine may represent a new therapeutic approach for treating gastrointestinal inflammatory disorders...
  5. pmc Soluble proteins produced by probiotic bacteria regulate intestinal epithelial cell survival and growth
    Fang Yan
    Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Gastroenterology 132:562-75. 2007
    ..Here, we purify and characterize 2 secreted LGG proteins that regulate intestinal epithelial cell antiapoptotic and proliferation responses...
  6. pmc Colon-specific delivery of a probiotic-derived soluble protein ameliorates intestinal inflammation in mice through an EGFR-dependent mechanism
    Fang Yan
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Monroe Carell Jr Children s Hospital at Vanderbilt, Nashville, Tennessee 37232 0696, USA
    J Clin Invest 121:2242-53. 2011
    ..These data define what we believe to be a previously unrecognized mechanism of probiotic-derived soluble proteins in protecting the intestine from injury and inflammation...
  7. pmc Epidermal growth factor receptor activation protects gastric epithelial cells from Helicobacter pylori-induced apoptosis
    Fang Yan
    Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0696, USA
    Gastroenterology 136:1297-1307, e1-3. 2009
    ..Because EGFR signaling regulates cell survival, we investigated whether activation of EGFR following H pylori infection promotes gastric epithelial survival...
  8. pmc Transactivation of EGF receptor and ErbB2 protects intestinal epithelial cells from TNF-induced apoptosis
    Toshimitsu Yamaoka
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 105:11772-7. 2008
    ....
  9. pmc Kinase suppressor of Ras-1 protects intestinal epithelium from cytokine-mediated apoptosis during inflammation
    Fang Yan
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2576, USA
    J Clin Invest 114:1272-80. 2004
    ..These effects are reversed by WT, but not kinase-inactive, KSR1. We conclude that KSR1 has an essential protective role in the intestinal epithelial cell during inflammation through activation of cell survival pathways...
  10. pmc TNFR1 promotes tumor necrosis factor-mediated mouse colon epithelial cell survival through RAF activation of NF-kappaB
    Karen L Edelblum
    Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0696, USA
    J Biol Chem 283:29485-94. 2008
    ..Thus, further understanding of colon epithelial cell-specific TNFR signaling may result in the identification of new targets for inflammatory bowel disease treatment and define novel mediators of colitis-associated cancer...
  11. pmc Helicobacter pylori regulates cellular migration and apoptosis by activation of phosphatidylinositol 3-kinase signaling
    Toni A Nagy
    Division of Gastroenterology, Departments of Medicine and Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    J Infect Dis 199:641-51. 2009
    ..pylori-induced cell migration. These results indicate that PI3K-AKT signaling regulates pathophysiologic responses to H. pylori that may lower the threshold for carcinogenesis...
  12. pmc TNF transactivation of EGFR stimulates cytoprotective COX-2 expression in gastrointestinal epithelial cells
    Stuart S Hobbs
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Am J Physiol Gastrointest Liver Physiol 301:G220-9. 2011
    ..This highlights an EGFR-dependent cell signaling pathway and response that may be significant in colitis-associated carcinoma...
  13. pmc Induction of COX-2 expression by Helicobacter pylori is mediated by activation of epidermal growth factor receptor in gastric epithelial cells
    Johanna C Sierra
    Division of Gastroenterology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
    Am J Physiol Gastrointest Liver Physiol 305:G196-203. 2013
    ..Collectively, these findings indicate that aberrant activation of the EGFR-COX-2 axis may lower the threshold for carcinogenesis associated with chronic H. pylori infection...
  14. pmc ErbB2 and ErbB3 regulate recovery from dextran sulfate sodium-induced colitis by promoting mouse colon epithelial cell survival
    Yongqin Zhang
    Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Vanderbilt University School of Medicine, Nashville, TN, USA
    Lab Invest 92:437-50. 2012
    ..These results suggest that ErbB2 and ErbB3 have important cytoprotective and reparative roles in the colonic epithelium following injury, by promoting colon epithelial cell survival...
  15. ncbi request reprint Mechanisms of probiotic action: Implications for therapeutic applications in inflammatory bowel diseases
    Charles Vanderpool
    Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0696, USA
    Inflamm Bowel Dis 14:1585-96. 2008
    ....
  16. pmc Probiotics: progress toward novel therapies for intestinal diseases
    Fang Yan
    Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Monroe Carrel Jr Children s Hospital at Vanderbilt, USA
    Curr Opin Gastroenterol 26:95-101. 2010
    ..This review focuses on the most recent advances in probiotic research from genetics to biological consequences regulated by probiotics and probiotic-derived factors...
  17. pmc Spermine oxidase mediates the gastric cancer risk associated with Helicobacter pylori CagA
    Rupesh Chaturvedi
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232 0252, USA
    Gastroenterology 141:1696-708.e1-2. 2011
    ..Spermine oxidase (SMO) metabolizes the polyamine spermine into spermidine and generates H(2)O(2), which causes apoptosis and DNA damage. We determined if pathogenic effects of CagA are attributable to SMO...
  18. pmc Activation of EGFR and ERBB2 by Helicobacter pylori results in survival of gastric epithelial cells with DNA damage
    Rupesh Chaturvedi
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee
    Gastroenterology 146:1739-51.e14. 2014
    ..A subpopulation of SMOX(high) cells are resistant to apoptosis, despite their high levels of DNA damage. Because epidermal growth factor receptor (EGFR) activation can regulate apoptosis, we determined its role in SMOX-mediated effects...
  19. pmc STAT6 deficiency ameliorates severity of oxazolone colitis by decreasing expression of claudin-2 and Th2-inducing cytokines
    Michael J Rosen
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Immunol 190:1849-58. 2013
    ..These data implicate STAT6 in the pathogenesis of colitis in vivo with important roles in altering epithelial barrier function and regulating Th2-inducing cytokine production...
  20. pmc Probiotics and immune health
    Fang Yan
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Curr Opin Gastroenterol 27:496-501. 2011
    ..This review highlights the recent scientific research findings that advance our understanding of probiotic regulation of the host immune response with potential application for disease prevention and treatment...
  21. ncbi request reprint Tumor necrosis factor regulates intestinal epithelial cell migration by receptor-dependent mechanisms
    Julissa Corredor
    Department of Pediatrics, Division of Gastroenterology and Nutrition, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2576, USA
    Am J Physiol Cell Physiol 284:C953-61. 2003
    ..We therefore conclude that TNFR2 activates a novel Src-regulated pathway involving FAK tyrosine phosphorylation that enhances migration of intestinal epithelial cells...
  22. pmc Tumor necrosis factor inhibits ligand-stimulated EGF receptor activation through a TNF receptor 1-dependent mechanism
    Steven J McElroy
    Dept of Pediatrics, Div of Pediatric Gastroenterology, Hepatology, and Nutrition, 2215 Garland Ave, 1035 MRB IV, Nashville TN, 37232 0696, USA
    Am J Physiol Gastrointest Liver Physiol 295:G285-93. 2008
    ....
  23. pmc Probiotic bacterium prevents cytokine-induced apoptosis in intestinal epithelial cells
    Fang Yan
    Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 277:50959-65. 2002
    ..These observations suggest a novel mechanism of communication between probiotic microorganisms and epithelia that increases survival of intestinal cells normally found in an environment of pro-apoptotic cytokines...
  24. ncbi request reprint Probiotics as functional food in the treatment of diarrhea
    Fang Yan
    Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Curr Opin Clin Nutr Metab Care 9:717-21. 2006
    ..This review focuses on new research findings relevant to the effects of probiotics on diarrhea prevention and treatment and potential mechanisms of action for this alternative therapy for diarrhea...
  25. ncbi request reprint Regulation of apoptosis during homeostasis and disease in the intestinal epithelium
    Karen L Edelblum
    Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0696, USA
    Inflamm Bowel Dis 12:413-24. 2006
    ....
  26. pmc Probiotics ameliorate the hydrogen peroxide-induced epithelial barrier disruption by a PKC- and MAP kinase-dependent mechanism
    A Seth
    Dept of Physiology, Univ of Tennessee Health Science Center, Memphis, TN 38163, USA
    Am J Physiol Gastrointest Liver Physiol 294:G1060-9. 2008
    ..These studies demonstrate that probiotic-secretory proteins protect the intestinal epithelial tight junctions and the barrier function from hydrogen peroxide-induced insult by a PKC- and MAP kinase-dependent mechanism...
  27. ncbi request reprint [Effects of resveratrol on growth inhibition and gap-junctional intercellular communication of HepG2 cells]
    Fang Yan
    Department of Histology and Embryology, Southern Medical University, Guangzhou 510515, China
    Nan Fang Yi Ke Da Xue Xue Bao 26:963-6. 2006
    ..To investigate the effects of the resveratrol on proliferation and gap-junctional intercellular communication (GJIC) in human liver cancer cell line HepG2...
  28. doi request reprint Proteomic analysis using 2-D liquid separations of intact proteins from whole-cell lysates
    Kan Zhu
    The University of Michigan, Ann Arbor, Michigan, USA
    Curr Protoc Protein Sci . 2004
    ..Such expression maps are useful for differential proteomic comparison between different cell samples...
  29. ncbi request reprint [The change of nitric oxide to PGE2 ratio in uterine tissues of endotoxin-treated pregnant mice]
    Weiyue Zeng
    Department of Obstetrios and Gynecology, West China Second Hospital, Sichuan University, Chengdu 610041, China
    Hua Xi Yi Ke Da Xue Xue Bao 33:104-7. 2002
    ..To investigate the relationship between preterm labour and the ratio of nitric oxide to prostaglandin E2 in uterine tissues...
  30. ncbi request reprint The endoplasmic reticulum-related events in S-nitrosoglutathione-induced neurotoxicity in cerebellar granule cells
    Jie He
    Center for Molecular Biology, Institute of Biophysics, Chinese Academy of Sciences, P O Box 33, 15 Datun Road, Chaoyang District, Beijing 100101, PR China
    Brain Res 1015:25-33. 2004
    ..These effects indicate that ER is one of the NO targets in GSNO-induced neurotoxicity in cerebellar granule cells besides mitochondria...
  31. ncbi request reprint [Sustaining effect of gene-transferring hepatic stellate cell strain CFSC/HGF on hepatocytes development]
    Yun Fang Wang
    Department of Stem Cell Biology, Beijing Institute of Transfusion Medicine, Beijing 100850, China
    Zhonghua Gan Zang Bing Za Zhi 13:45-8. 2005
    ..To investigate the sustaining effects of gene-transferring hepatic stellate cell strain CFSC/HGF on the development of hepatocytes...
  32. ncbi request reprint Expression, purification and anti-tumor activity of curcin
    Meng Jun Luo
    College of Life Sciences, Sichuan University, Chengdu 610041, China
    Acta Biochim Biophys Sin (Shanghai) 38:663-8. 2006
    ....
  33. ncbi request reprint [Resveratrol induces HepG2 cell apoptosis by depolarizing mitochondrial membrane]
    Xiao Dong Ma
    Central Laboratory, Southern Medical University, Guangzhou 510515, China
    Nan Fang Yi Ke Da Xue Xue Bao 26:406-8, 413. 2006
    ..To investigate the effects of resveratrol on the proliferation, apoptosis, mitochondrial membrane potential and cell morphology of human liver cancer cell line HepG2...
  34. ncbi request reprint Substituted tetrahydroisoquinoline compound B3 inhibited P-glycoprotein-mediated multidrug resistance in-vitro and in-vivo
    Weirong Fang
    Department of Physiology, China Pharmaceutical University, Mailbox 207, Tongjiaxiang 24, Nanjing, Jiangsu 210009, P R China
    J Pharm Pharmacol 59:1649-55. 2007
    ..Co-administration of B3 with doxorubicin significantly decreased weight and volume of tumour in nude mice. In conclusion, B3 is a novel and potent MDR reversal agent with the potential to be an adjunctive agent for tumour chemotherapy...
  35. ncbi request reprint Spindlin1, a novel nuclear protein with a role in the transformation of NIH3T3 cells
    Yanhong Gao
    Laboratory of Stem Cell Biology, Beijing Institute of Transfusion Medicine, 27 Taiping Road, Beijing 100850, PR China
    Biochem Biophys Res Commun 335:343-50. 2005
    ..Furthermore, overexpressed spindlin1 cells formed colonies in soft agar in vitro and formed tumors in nude mice. Our findings provide direct evidence that spindlin1 gene may contribute to tumorigenesis...

Research Grants4

  1. Probiotics regulate intestinal epithelial cell homeostasis
    Fang Yan; Fiscal Year: 2007
    ..Genes regulated by LGG in colon cells will be identified using DNA microarray. These findings will have significant relevance to further understanding the probiotic regulation of intestinal health. ..
  2. Probiotics-derived soluble proteins regulate intestinal inflammation
    Fang Yan; Fiscal Year: 2009
    ..Therefore, the findings from this proposal will support a scientific basis for a potential therapeutic application of p40 for preventing and/or treating human gastrointestinal inflammatory disorders. ..
  3. Probiotics-derived soluble proteins regulate intestinal inflammation
    Fang Yan; Fiscal Year: 2010
    ..Therefore, the findings from this proposal will support a scientific basis for a potential therapeutic application of p40 for preventing and/or treating human gastrointestinal inflammatory disorders. ..