Hong Guang Xie

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. ncbi Additional discussions regarding the altered metabolism and transport of omeprazole after long-term use of St John's wort
    Hong Guang Xie
    Clin Pharmacol Ther 78:440-1. 2005
  2. ncbi Drugs as CYP3A probes, inducers, and inhibitors
    Yi Tong Liu
    Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China
    Drug Metab Rev 39:699-721. 2007
  3. ncbi Meta-analysis of phenotype and genotype of NAT2 deficiency in Chinese populations
    H G Xie
    Pharmacogenetics Research Institute, Hunan Medical University, Changsha, China
    Pharmacogenetics 7:503-14. 1997
  4. ncbi Genetic variations of S-mephenytoin 4'-hydroxylase (CYP2C19) in the Chinese population
    H G Xie
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 6602, USA
    Life Sci 66:PL175-81. 2000
  5. ncbi Molecular basis of ethnic differences in drug disposition and response
    H G Xie
    Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6602, USA
    Annu Rev Pharmacol Toxicol 41:815-50. 2001
  6. ncbi CYP2C9 allelic variants: ethnic distribution and functional significance
    Hong Guang Xie
    Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 6602, USA
    Adv Drug Deliv Rev 54:1257-70. 2002
  7. ncbi Effect of the alpha2C-adrenoreceptor deletion322-325 variant on sympathetic activity and cardiovascular measures in healthy subjects
    Daniel Kurnik
    Department of Medicine, Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6602, USA
    J Hypertens 25:763-71. 2007
  8. pmc Desensitization of vascular response in vivo: contribution of genetic variation in the [alpha]2B-adrenergic receptor subtype
    Mordechai Muszkat
    Department of Medicine and Pharmacology, Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232 6602, USA
    J Hypertens 28:278-84. 2010
  9. ncbi Variations in the alpha2A-adrenergic receptor gene and their functional effects
    Daniel Kurnik
    Department of Medicine, Division of Clinical Pharmacology, Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN 37232 6606, USA
    Clin Pharmacol Ther 79:173-85. 2006
  10. ncbi Variation in the alpha2B-adrenergic receptor gene (ADRA2B) and its relationship to vascular response in vivo
    Mordechai Muszkat
    Department of Medicine, Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6602, USA
    Pharmacogenet Genomics 15:407-14. 2005

Collaborators

Detail Information

Publications32

  1. ncbi Additional discussions regarding the altered metabolism and transport of omeprazole after long-term use of St John's wort
    Hong Guang Xie
    Clin Pharmacol Ther 78:440-1. 2005
  2. ncbi Drugs as CYP3A probes, inducers, and inhibitors
    Yi Tong Liu
    Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China
    Drug Metab Rev 39:699-721. 2007
    ..In this review, we systematically summarized the frequently used CYP3A probe drugs, inducers and inhibitors, and evaluated their current status in drug development and research...
  3. ncbi Meta-analysis of phenotype and genotype of NAT2 deficiency in Chinese populations
    H G Xie
    Pharmacogenetics Research Institute, Hunan Medical University, Changsha, China
    Pharmacogenetics 7:503-14. 1997
    ..In conclusion, this meta-analysis determined the accurate population frequencies of phenotype and genotype of the NAT2 genetic deficiency in healthy Chinese subjects...
  4. ncbi Genetic variations of S-mephenytoin 4'-hydroxylase (CYP2C19) in the Chinese population
    H G Xie
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 6602, USA
    Life Sci 66:PL175-81. 2000
    ..The half of all genotyped EMs (50.3%, 276 of 549) were heterozygotes. The data estimate that 14% of Chinese would be homozygotes of CYP2C19 defective alleles, and that 176 million Chinese would be slow metabolizers of CYP2C19 substrates...
  5. ncbi Molecular basis of ethnic differences in drug disposition and response
    H G Xie
    Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6602, USA
    Annu Rev Pharmacol Toxicol 41:815-50. 2001
    ..A better understanding of the molecular basis underlying ethnic differences in drug metabolism, transport, and response will contribute to improved individualization of drug therapy...
  6. ncbi CYP2C9 allelic variants: ethnic distribution and functional significance
    Hong Guang Xie
    Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 6602, USA
    Adv Drug Deliv Rev 54:1257-70. 2002
    ..In addition, possible molecular mechanisms underlying ethnic variability in the metabolism of CYP2C9 substrate drugs are discussed...
  7. ncbi Effect of the alpha2C-adrenoreceptor deletion322-325 variant on sympathetic activity and cardiovascular measures in healthy subjects
    Daniel Kurnik
    Department of Medicine, Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6602, USA
    J Hypertens 25:763-71. 2007
    ..We therefore examined the hypothesis that the ADRA2C deletion variant would alter sympathetic activity and contribute to ethnic differences in blood pressure...
  8. pmc Desensitization of vascular response in vivo: contribution of genetic variation in the [alpha]2B-adrenergic receptor subtype
    Mordechai Muszkat
    Department of Medicine and Pharmacology, Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232 6602, USA
    J Hypertens 28:278-84. 2010
    ..In vitro, a common 301-303 deletion in the alpha2B-AR gene, ADRA2B, results in loss of alpha2B-AR desensitization. We examined the hypothesis that ADRA2B del301-303 or other common ADRA2B variants alter vascular desensitization in vivo...
  9. ncbi Variations in the alpha2A-adrenergic receptor gene and their functional effects
    Daniel Kurnik
    Department of Medicine, Division of Clinical Pharmacology, Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN 37232 6606, USA
    Clin Pharmacol Ther 79:173-85. 2006
    ..The objectives of this study were to systematically search for variants in the ADRA2A gene, to define the gene's haplotype structure, and to examine potential functional effects of these variants...
  10. ncbi Variation in the alpha2B-adrenergic receptor gene (ADRA2B) and its relationship to vascular response in vivo
    Mordechai Muszkat
    Department of Medicine, Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6602, USA
    Pharmacogenet Genomics 15:407-14. 2005
    ..We have described novel variants and haplotypes of the ADRA2B gene. These do not alter sensitivity to a selective alpha2-adrenergic receptor agonist but some may decrease maximal venoconstriction in vivo...
  11. ncbi Alpha2B adrenergic receptor 301-303 deletion polymorphism and vascular alpha2 adrenergic receptor response
    Mordechai Muszkat
    Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6602, USA
    Pharmacogenet Genomics 15:23-8. 2005
    ..2+/-12.9% in del/del subjects (P=0.26). These findings suggest that the del301-303 polymorphism does not contribute significantly to interindividual in vivo variability in response to alpha2-AR activation in the hand vein...
  12. pmc Beta-1-adrenoceptor genetic variants and ethnicity independently affect response to beta-blockade
    Daniel Kurnik
    Department of Medicine and Pharmacology, Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6602, USA
    Pharmacogenet Genomics 18:895-902. 2008
    ..The purpose of this study was to determine whether ethnic differences in response to beta-blockade can be explained by differing distributions of functional genetic variants in the beta1-AR...
  13. ncbi G-protein beta(3) subunit 825 C/T polymorphism is associated with weight gain during pregnancy
    Victor Dishy
    Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville Tennessee 37232 6602, USA
    Pharmacogenetics 13:241-2. 2003
    ..006) and had a significantly higher pre-pregnancy body mass index (P = 0.02). The C825T polymorphism of the G-protein beta(3) subunit gene, known to be associated with obesity, is a determinant of weight gain during pregnancy...
  14. ncbi Genetic variability in CYP3A5 and its possible consequences
    Hong Guang Xie
    Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Pharmacogenomics 5:243-72. 2004
    ....
  15. ncbi Alpha 1A-adrenergic receptor polymorphism and vascular response
    Gbenga G Sofowora
    Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Clin Pharmacol Ther 75:539-45. 2004
    ..Variability in sensitivity to phenylephrine, an alpha(1A) adrenergic agonist, has a large genetic component. We examined the hypothesis that a common polymorphism of alpha(1A)-adrenergic receptor (Arg347Cys) affects in vivo response...
  16. pmc Increased endoplasmic reticulum stress response is involved in clopidogrel-induced apoptosis of gastric epithelial cells
    Hai Lu Wu
    Division of Gastroenterology, Department of Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, China
    PLoS ONE 8:e74381. 2013
    ..However, their exact mechanisms are largely unknown...
  17. ncbi Nitric oxide production decreases after salt loading but is not related to blood pressure changes or nitric oxide-mediated vascular responses
    Victor Dishy
    Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232 6202, USA
    J Hypertens 21:153-7. 2003
    ..It is not known if this impaired nitric oxide production is the result of hypertension or is a mechanism contributing to the blood pressure response to salt...
  18. doi Increased risk for developing major adverse cardiovascular events in stented chinese patients treated with dual antiplatelet therapy after concomitant use of the proton pump inhibitor
    Jian Jun Zou
    Division of Clinical Pharmacology, General Clinical Research Center, Nanjing Medical University Nanjing First Hospital, Nanjing, China
    PLoS ONE 9:e84985. 2014
    ....
  19. ncbi Polymorphisms in beta-adrenergic receptor genes in the acquired long QT syndrome
    Hideaki Kanki
    Department of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6602, USA
    J Cardiovasc Electrophysiol 13:252-6. 2002
    ....
  20. pmc Genetic variants in the alpha2C-adrenoceptor and G-protein contribute to ethnic differences in cardiovascular stress responses
    Daniel Kurnik
    Departments of Medicine and Pharmacology, Division of Clinical Pharmacology bDepartment of Biomedical Statistics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Pharmacogenet Genomics 18:743-50. 2008
    ....
  21. ncbi Pharmacogenetics and rheumatology: Molecular mechanisms contributing to variability in drug response
    Yu Asanuma
    Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Arthritis Rheum 52:1349-59. 2005
  22. ncbi St John's wort-associated drug interactions: short-term inhibition and long-term induction?
    Hong Guang Xie
    Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232 6602, USA
    Clin Pharmacol Ther 78:19-24. 2005
  23. pmc Berberine ameliorates chronic kidney injury caused by atherosclerotic renovascular disease through the suppression of NFκB signaling pathway in rats
    Xin Wan
    Division of Nephrology, Department of Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, China
    PLoS ONE 8:e59794. 2013
    ..Accordingly, we hypothesized that BBR treatment may ameliorate ARD-induced kidney injury through its cholesterol-lowering effect and also suppression of the pathways involved in oxidative stress, inflammation and NFκB activation...
  24. doi Efffect of the ABCC3 -211C/T polymorphism on clopidogrel responsiveness in patients with percutaneous coronary intervention
    Jian Jun Zou
    Division of Clinical Pharmacology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China
    Clin Exp Pharmacol Physiol 40:504-9. 2013
    ..In conclusion, the ABCC3 -211C/T polymorphism seems not to be associated with altered antiplatelet effects and clinical outcomes in clopidogrel-treated patients. ..
  25. doi Attenuated expression of the tight junction proteins is involved in clopidogrel-induced gastric injury through p38 MAPK activation
    Hai Lu Wu
    Division of Gastroenterology, Department of Medicine, Nanjing Medical University Nanjing First Hospital, Nanjing, China
    Toxicology 304:41-8. 2013
    ..It is concluded that attenuated expression of the TJ proteins occludin and ZO-1 in human gastric epithelial cells could be involved in clopidogrel-induced gastric mucosal injury through activation of the p38 MAPK pathway...
  26. ncbi Effects of individual ginsenosides, ginkgolides and flavonoids on CYP2C19 and CYP2D6 activity in human liver microsomes
    Nu He
    Department of Pharmacology and Toxicology, Morehouse School of Medicine, Atlanta, Georgia 30310 1458, USA
    Clin Exp Pharmacol Physiol 33:813-5. 2006
    ..4. The data suggest that the tested compounds are not likely to inhibit the metabolism of the concurrent use of a given drug whose primary route of elimination is through CYP2C19 or CYP2D6...
  27. ncbi No association of the Asp298 variant of the endothelial nitric oxide synthase gene with preeclampsia
    Ruth Landau
    Department of Anesthesiology, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    Am J Hypertens 17:391-4. 2004
    ..Polymorphisms of the endothelial nitric oxide synthase (eNOS) gene affect NO production and have been associated with hypertension and preeclampsia in a Japanese population...
  28. ncbi Gene variants in noncoding regions and their possible consequences
    Guang Ji Wang
    China Pharmaceutical University, Key Laboratory of Drug Metabolism and Pharmacokinetics, 1 Shennong Road, Nanjing, Jiangsu 210038, People s Republic of China
    Pharmacogenomics 7:203-9. 2006
    ..Thus, functional profiling or clinical relevance of noncoding variations should not be underestimated or ignored. To validate these concepts, some important examples are discussed further in this short review...
  29. ncbi Induction of cyp3a in primary cultures of human hepatocytes by ginkgolides a and B
    Nu He
    Department of Pharmacology and Toxicology, Morehouse School of Medicine, Atlanta, GA 30310, USA
    Clin Exp Pharmacol Physiol 34:632-5. 2007
    ..05 for ginkgolide A; P > 0.05 for ginkgolide B). Quercetin had no apparent induction. 4. Ginkgolide A and ginkgolide B can induce CYP3A protein expression and enzyme activity in primary cultures of human hepatocytes at higher doses...
  30. ncbi Beta2-adrenoceptor Thr164Ile polymorphism is associated with markedly decreased vasodilator and increased vasoconstrictor sensitivity in vivo
    Victor Dishy
    Division of Clinical Pharmacology and General Clinical Research Center Division of General Internal Medicine, Department of Medicine and the Department of Biostatistics, Vanderbilt University Medical Center, Nashville TN, USA
    Pharmacogenetics 14:517-22. 2004
    ..Altered adrenergic vascular sensitivity may contribute to the decreased survival observed in patients with congestive heart failure carrying the Ile164 allele...
  31. ncbi Beta2-adrenoceptor genotype and function affect hemodynamic profile heterogeneity in postural tachycardia syndrome
    Giris Jacob
    J Recanati Autonomic Dysfunction Center, Department of Internal Medicine A, Rambam Medical Center and Technion IIT, Haifa, Israel
    Hypertension 47:421-7. 2006
    ..Therefore, both decreased beta2-adrenoceptor-related vasodilation and beta2-AR polymorphisms may contribute to the hemodynamic diversity of patients with POTS...
  32. ncbi beta2-Adrenergic receptor genotype and preterm delivery
    Ruth Landau
    Department of Anesthesiology, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Am J Obstet Gynecol 187:1294-8. 2002
    ..Our purpose was to determine whether the functional genetic polymorphisms of the beta(2)-adrenergic receptor (beta(2)AR) that result in changes in amino acid residues 16 and 27 are associated with preterm delivery...