Lan Wu

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. pmc Activation of invariant natural killer T cells by lipid excess promotes tissue inflammation, insulin resistance, and hepatic steatosis in obese mice
    Lan Wu
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 109:E1143-52. 2012
  2. ncbi request reprint Oxidative stress is a mediator of glucose toxicity in insulin-secreting pancreatic islet cell lines
    Lan Wu
    Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, 715 PRB, Vanderbilt University Medical Center, 2220 Pierce Avenue, Nashville, TN 37232, USA
    J Biol Chem 279:12126-34. 2004
  3. ncbi request reprint Ascorbic acid recycling by cultured beta cells: effects of increased glucose metabolism
    Robert J Steffner
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 6303, USA
    Free Radic Biol Med 37:1612-21. 2004
  4. pmc Glycolipid antigen induces long-term natural killer T cell anergy in mice
    Vrajesh V Parekh
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Clin Invest 115:2572-83. 2005
  5. pmc Activated invariant NKT cells control central nervous system autoimmunity in a mechanism that involves myeloid-derived suppressor cells
    Vrajesh V Parekh
    Department of Pathology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Immunol 190:1948-60. 2013
  6. pmc Impact of bacteria on the phenotype, functions, and therapeutic activities of invariant NKT cells in mice
    Sungjune Kim
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Clin Invest 118:2301-15. 2008
  7. pmc PD-1/PD-L blockade prevents anergy induction and enhances the anti-tumor activities of glycolipid-activated invariant NKT cells
    Vrajesh V Parekh
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Immunol 182:2816-26. 2009
  8. pmc Invariant natural killer T cells as sensors and managers of inflammation
    Luc Van Kaer
    Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Trends Immunol 34:50-8. 2013
  9. pmc Glycolipid ligands of invariant natural killer T cells as vaccine adjuvants
    Sungjune Kim
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Medical Center North, Nashville, TN 37232, USA
    Expert Rev Vaccines 7:1519-32. 2008
  10. doi request reprint Invariant NK T cells: potential for immunotherapeutic targeting with glycolipid antigens
    Luc Van Kaer
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Medical Center North, Room A 5301, 1161 21st Avenue South, Nashville, TN 37232 32363, USA
    Immunotherapy 3:59-75. 2011

Collaborators

Detail Information

Publications29

  1. pmc Activation of invariant natural killer T cells by lipid excess promotes tissue inflammation, insulin resistance, and hepatic steatosis in obese mice
    Lan Wu
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 109:E1143-52. 2012
    ..These findings place iNKT cells into the complex network linking lipid excess to inflammation in obesity and suggest new therapeutic avenues for obesity-associated metabolic disorders...
  2. ncbi request reprint Oxidative stress is a mediator of glucose toxicity in insulin-secreting pancreatic islet cell lines
    Lan Wu
    Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, 715 PRB, Vanderbilt University Medical Center, 2220 Pierce Avenue, Nashville, TN 37232, USA
    J Biol Chem 279:12126-34. 2004
    ..The level of beta cell GK may also be critical in this process...
  3. ncbi request reprint Ascorbic acid recycling by cultured beta cells: effects of increased glucose metabolism
    Robert J Steffner
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 6303, USA
    Free Radic Biol Med 37:1612-21. 2004
    ..Impaired ascorbate recycling as a result of increased glucose metabolism may have implications for the role of ascorbate in insulin secretion in diabetes mellitus and may partially explain glucose toxicity in beta cells...
  4. pmc Glycolipid antigen induces long-term natural killer T cell anergy in mice
    Vrajesh V Parekh
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Clin Invest 115:2572-83. 2005
    ..Our findings have important implications for the development of NKT cell-based vaccines and immunotherapies...
  5. pmc Activated invariant NKT cells control central nervous system autoimmunity in a mechanism that involves myeloid-derived suppressor cells
    Vrajesh V Parekh
    Department of Pathology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Immunol 190:1948-60. 2013
    ....
  6. pmc Impact of bacteria on the phenotype, functions, and therapeutic activities of invariant NKT cells in mice
    Sungjune Kim
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Clin Invest 118:2301-15. 2008
    ..These findings may have important implications for the development of iNKT cell-based therapies...
  7. pmc PD-1/PD-L blockade prevents anergy induction and enhances the anti-tumor activities of glycolipid-activated invariant NKT cells
    Vrajesh V Parekh
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Immunol 182:2816-26. 2009
    ..Collectively, our findings reveal a critical role for the PD-1/PD-L costimulatory pathway in the alphaGalCer-mediated induction of iNKT cell anergy that can be targeted for the development of immunotherapies...
  8. pmc Invariant natural killer T cells as sensors and managers of inflammation
    Luc Van Kaer
    Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Trends Immunol 34:50-8. 2013
    ..These new findings should be instrumental to promote the immunomodulatory properties of iNKT cells for treatment of inflammatory diseases...
  9. pmc Glycolipid ligands of invariant natural killer T cells as vaccine adjuvants
    Sungjune Kim
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Medical Center North, Nashville, TN 37232, USA
    Expert Rev Vaccines 7:1519-32. 2008
    ..This review aims to summarize the immunomodulatory activities of iNKT cell ligands and to discuss prospects for developing iNKT cell-based vaccine adjuvants...
  10. doi request reprint Invariant NK T cells: potential for immunotherapeutic targeting with glycolipid antigens
    Luc Van Kaer
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Medical Center North, Room A 5301, 1161 21st Avenue South, Nashville, TN 37232 32363, USA
    Immunotherapy 3:59-75. 2011
    ..In this article, we review the immunodulatory activities of iNKT cells and the potential for developing iNKT cell-based prophylactic and curative therapies of human disease...
  11. pmc Impaired autophagy, defective T cell homeostasis, and a wasting syndrome in mice with a T cell-specific deletion of Vps34
    Vrajesh V Parekh
    Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Immunol 190:5086-101. 2013
    ..Collectively, our study reveals a critical role for Vps34 in autophagy and for the peripheral homeostasis and function of T lymphocytes...
  12. ncbi request reprint Quantitative and qualitative differences in the in vivo response of NKT cells to distinct alpha- and beta-anomeric glycolipids
    Vrajesh V Parekh
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Immunol 173:3693-706. 2004
    ..These findings indicate that NKT cells can fine-tune their immune responses to distinct glycolipid Ags in vivo, a property that may be exploited for the development of effective and safe NKT cell-based immunotherapies...
  13. ncbi request reprint Addition of dietary fat to cholesterol in the diets of LDL receptor knockout mice: effects on plasma insulin, lipoproteins, and atherosclerosis
    Lan Wu
    Division of Cardiology, Department of Medicine, Columbia University Medical Center, New York, NY, USA
    J Lipid Res 47:2215-22. 2006
    ..Our data suggest that when lipoprotein profiles are similar, addition of fat to a cholesterol-rich diet does not increase atherosclerotic lesion formation in Ldlr(-/-) mice...
  14. pmc Invariant natural killer T cells: bridging innate and adaptive immunity
    Luc Van Kaer
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Medical Center North, Room A 5301, 1161 21st Ave South, Nashville, TN 37232 2363, USA
    Cell Tissue Res 343:43-55. 2011
    ..Here, we review the innate-like properties and functions of iNKT cells and discuss their interactions with other cell types of the immune system...
  15. pmc Natural killer T cells in health and disease
    Lan Wu
    Department of Microbiology and Immunology, Room A 5301, Medical Center North, 1161 21st Avenue South, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2363, USA
    Front Biosci (Schol Ed) 3:236-51. 2011
    ..These properties of NKT cells are being exploited for therapeutic intervention to prevent or treat cancer, infections, and autoimmune and inflammatory diseases...
  16. ncbi request reprint Natural killer T cells and autoimmune disease
    Lan Wu
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Curr Mol Med 9:4-14. 2009
    ..Recent efforts have focused on developing NKT cell agonists with superior treatment efficacy than alpha-GalCer. Collectively, these studies have identified NKT cells as attractive targets for treatment of human autoimmune diseases...
  17. ncbi request reprint Role of NKT cells in the digestive system. II. NKT cells and diabetes
    Lan Wu
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Medical Center North, Nashville, TN 37232, USA
    Am J Physiol Gastrointest Liver Physiol 293:G919-22. 2007
    ..In addition, glycolipid agonists of NKT cells have been successful in preventing diabetes in mice, raising enthusiasm for the development of NKT cell-based therapies for T1D...
  18. pmc rVSV(M Delta 51)-M3 is an effective and safe oncolytic virus for cancer therapy
    Lan Wu
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Hum Gene Ther 19:635-47. 2008
    ....
  19. ncbi request reprint Immunogenicity comparison between codon optimized HIV-1 CRF BC_07 gp140 and gp145 vaccines
    Lianxing Liu
    State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wu Chang District, Wuhan 430071, China
    AIDS Res Hum Retroviruses 23:1396-404. 2007
    ....
  20. ncbi request reprint Angiotensin II type-1 receptor blocker valsartan enhances insulin sensitivity in skeletal muscles of diabetic mice
    Tetsuya Shiuchi
    Department of Medical Biochemistry, Ehime University School of Medicine, Shigenobu, Onsen gun, Japan
    Hypertension 43:1003-10. 2004
    ..Specific AT1 receptor blockade increases insulin sensitivity and glucose uptake in skeletal muscle of KK-Ay mice via stimulating the insulin signaling cascade and consequent enhancement of GLUT4 translocation to the plasma membrane...
  21. ncbi request reprint Fluvastatin enhances the inhibitory effects of a selective AT1 receptor blocker, valsartan, on atherosclerosis
    Zhen Li
    Department of Medical Biochemistry, Ehime University School of Medicine, Shigenobu, Onsen gun, Ehime, Japan
    Hypertension 44:758-63. 2004
    ..These results suggest that concomitant AT1 receptor and cholesterol biosynthesis blockade, particularly when given concomitantly, blunts oxidative stress and inflammation independent of blood pressure or cholesterol-related effects...
  22. ncbi request reprint Nifedipine inhibited angiotensin II-induced monocyte chemoattractant protein 1 expression: involvement of inhibitor of nuclear factor kappa B kinase and nuclear factor kappa B-inducing kinase
    Lan Wu
    Department of Molecular and Cellular Biology, Division of Medical Biochemistry and Cardiovascular Biology, Ehime University School of Medicine, Shitsukawa, Tohon, Ehime 791 0295, Japan
    J Hypertens 24:123-30. 2006
    ....
  23. ncbi request reprint Expression of EphA2 and Ephrin A-1 in carcinoma of the urinary bladder
    Shaji Abraham
    Department of Basic Medical Sciences, Purdue University, West Lafayette, IN 47909, USA
    Clin Cancer Res 12:353-60. 2006
    ..The purpose of this work was to determine the expression of EphA2 and its ligand, Ephrin A-1, and E-cadherin in carcinoma of the urinary bladder, and determine EphA2 as a new target for therapy in bladder cancer...
  24. ncbi request reprint Calcium channel blocker azelnidipine reduces glucose intolerance in diabetic mice via different mechanism than angiotensin receptor blocker olmesartan
    Masarsu Iwai
    Department of Molecular Cardiovascular Biology and Pharmacology, Ehime University Graduate School of Medicine, Shitsukawa, Tohon, Ehime 791 0295, Japan
    J Pharmacol Exp Ther 319:1081-7. 2006
    ....
  25. pmc Comparison of immunogenicity between codon optimized HIV-1 Thailand subtype B gp140 and gp145 vaccines
    Yanmin Wan
    State Key Laboratory for Infectious Diseases Prevention and Control, National Center for AIDS STD Control and Prevention NCAIDS, China CDC, 27 Nanwei Road, Xuanwu District, Beijing 100050, China
    Vaccine 25:4949-59. 2007
    ..However, it remains to be determined that how these observations are relevant to the neutralization of antibody activities...
  26. pmc Exponential enhancement of oncolytic vesicular stomatitis virus potency by vector-mediated suppression of inflammatory responses in vivo
    Jennifer Altomonte
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, New York, USA
    Mol Ther 16:146-53. 2008
    ....
  27. ncbi request reprint Contribution of the conserved A16Leu to insulin foldability
    Zhao Jun Zhang
    Institute of Molecular Biology, College of Life Sciences, Nan Kai University, Tian Jin 300071, China
    Protein J 27:192-6. 2008
    ..The results showed A16Leu had much more significant effects on the foldability of insulin than B17Leu...
  28. ncbi request reprint Immunomodulatory effects of erythromycin and its derivatives on human T-lymphocyte in vitro
    Lan Wu
    Department of Geratology, The First Affiliated Hospital, Chinese Medical University, Shenyang, People s Republic of China
    Immunopharmacol Immunotoxicol 29:587-96. 2007
    ....
  29. ncbi request reprint Angiotensin II subtype 2 receptor activation inhibits insulin-induced phosphoinositide 3-kinase and Akt and induces apoptosis in PC12W cells
    Tai Xing Cui
    Department of Medical Biochemistry, Ehime University School of Medicine, Ehime 791 0295, Japan
    Mol Endocrinol 16:2113-23. 2002
    ....