Neil D Woodward

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. doi request reprint Prefrontal cortex activity during response selection predicts processing speed impairment in schizophrenia
    Neil D Woodward
    Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN, USA
    J Int Neuropsychol Soc 19:782-91. 2013
  2. ncbi request reprint Resting-state networks in schizophrenia
    H Karbasforoushan
    Psychotic Disorders and Psychiatric Neuroimaging Programs, Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Curr Top Med Chem 12:2404-14. 2012
  3. pmc Thalamocortical dysconnectivity in schizophrenia
    Neil D Woodward
    Psychotic Disorders and Psychiatric Neuroimaging Programs, Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN, USA
    Am J Psychiatry 169:1092-9. 2012
  4. pmc Functional resting-state networks are differentially affected in schizophrenia
    Neil D Woodward
    Psychotic Disorders Program, Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN, United States
    Schizophr Res 130:86-93. 2011
  5. pmc Correlation of individual differences in schizotypal personality traits with amphetamine-induced dopamine release in striatal and extrastriatal brain regions
    Neil D Woodward
    Psychiatric Neuroimaging Program, Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN, USA
    Am J Psychiatry 168:418-26. 2011
  6. pmc Cerebral morphology and dopamine D2/D3 receptor distribution in humans: a combined [18F]fallypride and voxel-based morphometry study
    Neil D Woodward
    Psychiatric Neuroimaging Program, Vanderbilt Psychiatric Hospital, Suite 3057, 1601 23rd Ave S, Nashville, TN 37212, USA
    Neuroimage 46:31-8. 2009
  7. doi request reprint Abnormal prefrontal cortical activity and connectivity during response selection in first episode psychosis, chronic schizophrenia, and unaffected siblings of individuals with schizophrenia
    Neil D Woodward
    Psychiatric Neuroimaging Program, Vanderbilt University School of Medicine, Nashville, TN 37212, United States
    Schizophr Res 109:182-90. 2009
  8. ncbi request reprint An fMRI investigation of procedural learning in unaffected siblings of individuals with schizophrenia
    Neil D Woodward
    Department of Psychology, Vanderbilt University, Nashville, TN 37203, USA
    Schizophr Res 94:306-16. 2007
  9. ncbi request reprint COMT val108/158met genotype, cognitive function, and cognitive improvement with clozapine in schizophrenia
    Neil D Woodward
    Department of Psychology, Vanderbilt University, Nashville, TN 37203, USA
    Schizophr Res 90:86-96. 2007
  10. ncbi request reprint A meta-analysis of cognitive change with haloperidol in clinical trials of atypical antipsychotics: dose effects and comparison to practice effects
    Neil D Woodward
    Department of Psychology, Vanderbilt University, 301 Wilson Hall, 111 21st Ave S, Nashville, TN 37203, USA
    Schizophr Res 89:211-24. 2007

Detail Information

Publications26

  1. doi request reprint Prefrontal cortex activity during response selection predicts processing speed impairment in schizophrenia
    Neil D Woodward
    Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN, USA
    J Int Neuropsychol Soc 19:782-91. 2013
    ..Interventions that improve response selection and normalize dorsolateral PFC function may improve processing speed in schizophrenia...
  2. ncbi request reprint Resting-state networks in schizophrenia
    H Karbasforoushan
    Psychotic Disorders and Psychiatric Neuroimaging Programs, Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Curr Top Med Chem 12:2404-14. 2012
    ..Combined, these findings provide broad support for dysconnectivity theories of schizophrenia. We conclude our review with a discussion of the limitations of the existing literature and potentially important areas of future research...
  3. pmc Thalamocortical dysconnectivity in schizophrenia
    Neil D Woodward
    Psychotic Disorders and Psychiatric Neuroimaging Programs, Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN, USA
    Am J Psychiatry 169:1092-9. 2012
    ....
  4. pmc Functional resting-state networks are differentially affected in schizophrenia
    Neil D Woodward
    Psychotic Disorders Program, Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN, United States
    Schizophr Res 130:86-93. 2011
    ..Further work is needed to determine if the alterations are related to disturbances in white matter connectivity, neurodevelopmental abnormalities, and genetic risk for schizophrenia...
  5. pmc Correlation of individual differences in schizotypal personality traits with amphetamine-induced dopamine release in striatal and extrastriatal brain regions
    Neil D Woodward
    Psychiatric Neuroimaging Program, Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN, USA
    Am J Psychiatry 168:418-26. 2011
    ..The authors sought to determine whether individual differences in normal variation in schizotypal traits are correlated with dopamine transmission in the striatum and in extrastriatal brain regions...
  6. pmc Cerebral morphology and dopamine D2/D3 receptor distribution in humans: a combined [18F]fallypride and voxel-based morphometry study
    Neil D Woodward
    Psychiatric Neuroimaging Program, Vanderbilt Psychiatric Hospital, Suite 3057, 1601 23rd Ave S, Nashville, TN 37212, USA
    Neuroimage 46:31-8. 2009
    ..Clinical studies comparing dopamine receptor availability between clinical and control groups may benefit by accounting for potential differences in cerebral morphology that exist even after spatial normalization...
  7. doi request reprint Abnormal prefrontal cortical activity and connectivity during response selection in first episode psychosis, chronic schizophrenia, and unaffected siblings of individuals with schizophrenia
    Neil D Woodward
    Psychiatric Neuroimaging Program, Vanderbilt University School of Medicine, Nashville, TN 37212, United States
    Schizophr Res 109:182-90. 2009
    ..The findings suggest that altered activity and connectivity of the right dlPFC appears to be related to genetic vulnerability for schizophrenia and may represent a potential endophenotype of the disorder...
  8. ncbi request reprint An fMRI investigation of procedural learning in unaffected siblings of individuals with schizophrenia
    Neil D Woodward
    Department of Psychology, Vanderbilt University, Nashville, TN 37203, USA
    Schizophr Res 94:306-16. 2007
    ..Identification of genes related to the function of cerebral regions such as the prefrontal cortex, parietal lobe, and basal ganglia may assist in delineating the genetic contributions to schizophrenia...
  9. ncbi request reprint COMT val108/158met genotype, cognitive function, and cognitive improvement with clozapine in schizophrenia
    Neil D Woodward
    Department of Psychology, Vanderbilt University, Nashville, TN 37203, USA
    Schizophr Res 90:86-96. 2007
    ..The results are discussed in relation to previous cross-sectional studies and prospective investigations of the associations between COMT genotype, cognition, and cognitive improvement with atypical APDs in schizophrenia...
  10. ncbi request reprint A meta-analysis of cognitive change with haloperidol in clinical trials of atypical antipsychotics: dose effects and comparison to practice effects
    Neil D Woodward
    Department of Psychology, Vanderbilt University, 301 Wilson Hall, 111 21st Ave S, Nashville, TN 37203, USA
    Schizophr Res 89:211-24. 2007
    ....
  11. pmc Dopaminergic network differences in human impulsivity
    Joshua W Buckholtz
    Department of Psychology, Vanderbilt University, Nashville, TN 37240, USA
    Science 329:532. 2010
    ..Path analysis confirmed that the impact of decreased midbrain D2/D3 autoreceptor availability on trait impulsivity is mediated in part through its effect on stimulated striatal DA release...
  12. pmc A thalamocorticostriatal dopamine network for psychostimulant-enhanced human cognitive flexibility
    Gregory R Samanez-Larkin
    Department of Psychology, Vanderbilt University, Nashville, Tennessee Institute of Imaging Science, Vanderbilt University, Nashville, Tennessee 37240, USA
    Biol Psychiatry 74:99-105. 2013
    ..Everyday life demands continuous flexibility in thought and behavior. We examined whether individual differences in dopamine function are related to variability in the effects of amphetamine on one aspect of flexibility: task switching...
  13. pmc Dopamine D2 receptor levels in striatum, thalamus, substantia nigra, limbic regions, and cortex in schizophrenic subjects
    Robert M Kessler
    Department of Radiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Biol Psychiatry 65:1024-31. 2009
    ..Studies in schizophrenic patients have reported dopaminergic abnormalities in striatum, substantia nigra, thalamus, anterior cingulate, hippocampus, and cortex that have been related to positive symptoms and cognitive impairments...
  14. pmc The interrelationship of dopamine D2-like receptor availability in striatal and extrastriatal brain regions in healthy humans: a principal component analysis of [18F]fallypride binding
    David H Zald
    Department of Psychology, Vanderbilt University, 325 Wilson Hall, 111 21st Ave South, Nashville, TN 37212, USA
    Neuroimage 51:53-62. 2010
    ..This conclusion has significant implications for neuropsychiatric models that posit global or regionally specific relationships between dopaminergic tone and behavior...
  15. pmc Dopaminergic mechanisms of individual differences in human effort-based decision-making
    Michael T Treadway
    Department of Psychology, Vanderbilt University, Nashville, Tennessee 37240, USA
    J Neurosci 32:6170-6. 2012
    ..These findings highlight the role of DA signaling in striatal, prefrontal, and insular regions as key neurochemical mechanisms underlying individual differences in cost/benefit decision-making...
  16. doi request reprint Association of Sult4A1 SNPs with psychopathology and cognition in patients with schizophrenia or schizoaffective disorder
    Herbert Y Meltzer
    Department of Psychiatry, Vanderbilt University Medical Center, Nashville, TN 37212, United States
    Schizophr Res 106:258-64. 2008
    ....
  17. pmc Mesolimbic dopamine reward system hypersensitivity in individuals with psychopathic traits
    Joshua W Buckholtz
    Department of Psychology, Vanderbilt University, Nashville, Tennessee, USA
    Nat Neurosci 13:419-21. 2010
    ..These findings suggest that neurochemical and neurophysiological hyper-reactivity of the dopaminergic reward system may comprise a neural substrate for impulsive-antisocial behavior and substance abuse in psychopathy...
  18. ncbi request reprint A meta-analysis of neuropsychological change to clozapine, olanzapine, quetiapine, and risperidone in schizophrenia
    Neil D Woodward
    Department of Psychology, Vanderbilt University, Nashville, TN 37203, USA
    Int J Neuropsychopharmacol 8:457-72. 2005
    ..Atypical antipsychotics produce a mild remediation of cognitive deficits in schizophrenia, and specific atypicals have differential effects within certain cognitive domains...
  19. doi request reprint The effect of adjunctive armodafinil on cognitive performance and psychopathology in antipsychotic-treated patients with schizophrenia/schizoaffective disorder: a randomized, double-blind, placebo-controlled trial
    William V Bobo
    Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN, USA
    Schizophr Res 130:106-13. 2011
    ..The efficacy, safety and tolerability of adjunctive armodafinil for cognitive performance, and negative and affective symptoms, were examined in 60 patients with schizophrenia or schizoaffective disorder...
  20. pmc Eye-movement behavior reveals relational memory impairment in schizophrenia
    Lisa E Williams
    Department of Psychiatry, Vanderbilt University, Nashville, Tennessee 37212, USA
    Biol Psychiatry 68:617-24. 2010
    ..Previous studies have demonstrated impaired relational memory in schizophrenia. We studied eye-movement behavior as an indirect measure of relational memory, together with forced-choice recognition as an explicit measure...
  21. pmc Reduced gray matter volume in psychotic disorder patients with a history of childhood sexual abuse
    Julia M Sheffield
    Department of Psychiatry, Vanderbilt University, 1601 23rd Ave S, Nashville, TN 37212, USA
    Schizophr Res 143:185-91. 2013
    ..These findings indicate that some of the variance of gray matter volume in psychotic disorders can be explained by a history of sexual abuse...
  22. pmc Intact associative learning in patients with schizophrenia: evidence from a Go/NoGo paradigm
    Austin A Woolard
    Department of Psychiatry, Vanderbilt University, 1601 23rd Avenue South, Nashville, TN 37212 3133, USA
    Schizophr Res 122:131-5. 2010
    ..In the present study, we investigated the effect of associative learning during a Go/NoGo task in healthy controls subjects and patients with schizophrenia...
  23. pmc Human Ecstasy use is associated with increased cortical excitability: an fMRI study
    Amy L Bauernfeind
    Psychiatric Neuroimaging Program, Vanderbilt University Medical Center, Nashville, TN 37212, USA
    Neuropsychopharmacology 36:1127-41. 2011
    ..When considered in the context of previous results, cortical hyper-excitability may be a biomarker for MDMA-induced serotonin neurotoxicity...
  24. pmc Prior MDMA (Ecstasy) use is associated with increased basal ganglia-thalamocortical circuit activation during motor task performance in humans: an fMRI study
    John Karageorgiou
    Psychiatric Neuroimaging Program, Vanderbilt University School of Medicine, Nashville, TN 37072, USA
    Neuroimage 46:817-26. 2009
    ..Further studies examining behavioral correlates and the specific neurophysiological basis of the observed findings are warranted...
  25. doi request reprint Response selection impairment in schizophrenia transcends sensory and motor modalities
    Neil D Woodward
    Psychotic Disorders and Psychiatric Neuroimaging Programs, Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN, USA
    Schizophr Res 152:446-9. 2014
    ..These results implicate dysfunction of amodal response selection brain regions in schizophrenia. Interventions that reduce the length of response selection stage processing may improve processing speed in schizophrenia. ..
  26. ncbi request reprint Procedural learning in schizophrenia investigated with functional magnetic resonance imaging
    Lenka Zedkova
    Department of Psychiatry and Bebensee Schizophrenia Research Unit, University of Alberta, Edmonton, Alberta, Canada
    Schizophr Res 88:198-207. 2006
    ..The results are thus consistent with a neurodevelopmental pathology impinging on fronto-subcortical circuitry...