Alastair J J Wood

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. doi request reprint If you don't know where you are going, you can't tell if you have arrived: defining goals for drug safety announcements
    A J J Wood
    Weill Cornell Medical College and Symphony Capital, New York, New York, USA
    Clin Pharmacol Ther 93:302-3. 2013
  2. ncbi request reprint Variability in beta-adrenergic receptor response in the vasculature: Role of receptor polymorphism
    Alastair J J Wood
    Division of Clinical Pharmacology, Vanderbilt University Medical School, Nashville, TN 37232, USA
    J Allergy Clin Immunol 110:S318-21. 2002
  3. pmc Genetic variants in the alpha2C-adrenoceptor and G-protein contribute to ethnic differences in cardiovascular stress responses
    Daniel Kurnik
    Departments of Medicine and Pharmacology, Division of Clinical Pharmacology bDepartment of Biomedical Statistics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Pharmacogenet Genomics 18:743-50. 2008
  4. ncbi request reprint Variations in the alpha2A-adrenergic receptor gene and their functional effects
    Daniel Kurnik
    Department of Medicine, Division of Clinical Pharmacology, Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN 37232 6606, USA
    Clin Pharmacol Ther 79:173-85. 2006
  5. pmc Genetic variations in the α(2A)-adrenoreceptor are associated with blood pressure response to the agonist dexmedetomidine
    Daniel Kurnik
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Circ Cardiovasc Genet 4:179-87. 2011
  6. ncbi request reprint Effect of the alpha2C-adrenoreceptor deletion322-325 variant on sympathetic activity and cardiovascular measures in healthy subjects
    Daniel Kurnik
    Department of Medicine, Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6602, USA
    J Hypertens 25:763-71. 2007
  7. ncbi request reprint Ethnic and genetic determinants of cardiovascular response to the selective alpha 2-adrenoceptor agonist dexmedetomidine
    Daniel Kurnik
    Department of Medicine, Division of Clinical Pharmacology, 542 RRB, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Hypertension 51:406-11. 2008
  8. pmc Effects of variation in the human alpha2A- and alpha2C-adrenoceptor genes on cognitive tasks and pain perception
    Utkarsh Kohli
    Departments of Medicine and Pharmacology, Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Eur J Pain 14:154-9. 2010
  9. pmc Desensitization of vascular response in vivo: contribution of genetic variation in the [alpha]2B-adrenergic receptor subtype
    Mordechai Muszkat
    Department of Medicine and Pharmacology, Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232 6602, USA
    J Hypertens 28:278-84. 2010
  10. pmc Catecholamine pathway gene variation is associated with norepinephrine and epinephrine concentrations at rest and after exercise
    Laxmi V Ghimire
    Department of Medicine, Division of Clinical, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Pharmacogenet Genomics 22:254-60. 2012

Collaborators

Detail Information

Publications33

  1. doi request reprint If you don't know where you are going, you can't tell if you have arrived: defining goals for drug safety announcements
    A J J Wood
    Weill Cornell Medical College and Symphony Capital, New York, New York, USA
    Clin Pharmacol Ther 93:302-3. 2013
    ..The article by Reber et al. in this issue is important because it is one of the few studies to examine the effect of such safety alerts on physician behavior...
  2. ncbi request reprint Variability in beta-adrenergic receptor response in the vasculature: Role of receptor polymorphism
    Alastair J J Wood
    Division of Clinical Pharmacology, Vanderbilt University Medical School, Nashville, TN 37232, USA
    J Allergy Clin Immunol 110:S318-21. 2002
    ..beta(2)AR haplotypes determine the desensitization response to chronic agonist exposure in vivo and result in altered vasodilatory responses...
  3. pmc Genetic variants in the alpha2C-adrenoceptor and G-protein contribute to ethnic differences in cardiovascular stress responses
    Daniel Kurnik
    Departments of Medicine and Pharmacology, Division of Clinical Pharmacology bDepartment of Biomedical Statistics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Pharmacogenet Genomics 18:743-50. 2008
    ....
  4. ncbi request reprint Variations in the alpha2A-adrenergic receptor gene and their functional effects
    Daniel Kurnik
    Department of Medicine, Division of Clinical Pharmacology, Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN 37232 6606, USA
    Clin Pharmacol Ther 79:173-85. 2006
    ..The objectives of this study were to systematically search for variants in the ADRA2A gene, to define the gene's haplotype structure, and to examine potential functional effects of these variants...
  5. pmc Genetic variations in the α(2A)-adrenoreceptor are associated with blood pressure response to the agonist dexmedetomidine
    Daniel Kurnik
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Circ Cardiovasc Genet 4:179-87. 2011
    ..We examined whether ADRA2A variants are also associated with cardiovascular responses to the selective α(2)-AR-agonist dexmedetomidine...
  6. ncbi request reprint Effect of the alpha2C-adrenoreceptor deletion322-325 variant on sympathetic activity and cardiovascular measures in healthy subjects
    Daniel Kurnik
    Department of Medicine, Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6602, USA
    J Hypertens 25:763-71. 2007
    ..We therefore examined the hypothesis that the ADRA2C deletion variant would alter sympathetic activity and contribute to ethnic differences in blood pressure...
  7. ncbi request reprint Ethnic and genetic determinants of cardiovascular response to the selective alpha 2-adrenoceptor agonist dexmedetomidine
    Daniel Kurnik
    Department of Medicine, Division of Clinical Pharmacology, 542 RRB, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Hypertension 51:406-11. 2008
    ..Further studies to identify determinants of alpha(2)-AR-mediated responses will be of interest...
  8. pmc Effects of variation in the human alpha2A- and alpha2C-adrenoceptor genes on cognitive tasks and pain perception
    Utkarsh Kohli
    Departments of Medicine and Pharmacology, Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Eur J Pain 14:154-9. 2010
    ..We hypothesized that common genetic variants in these genes, particularly the ADRA2C 322-325 deletion variant, affect pain perception or cognitive responses...
  9. pmc Desensitization of vascular response in vivo: contribution of genetic variation in the [alpha]2B-adrenergic receptor subtype
    Mordechai Muszkat
    Department of Medicine and Pharmacology, Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232 6602, USA
    J Hypertens 28:278-84. 2010
    ..In vitro, a common 301-303 deletion in the alpha2B-AR gene, ADRA2B, results in loss of alpha2B-AR desensitization. We examined the hypothesis that ADRA2B del301-303 or other common ADRA2B variants alter vascular desensitization in vivo...
  10. pmc Catecholamine pathway gene variation is associated with norepinephrine and epinephrine concentrations at rest and after exercise
    Laxmi V Ghimire
    Department of Medicine, Division of Clinical, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Pharmacogenet Genomics 22:254-60. 2012
    ....
  11. pmc Beta-1-adrenoceptor genetic variants and ethnicity independently affect response to beta-blockade
    Daniel Kurnik
    Department of Medicine and Pharmacology, Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6602, USA
    Pharmacogenet Genomics 18:895-902. 2008
    ..The purpose of this study was to determine whether ethnic differences in response to beta-blockade can be explained by differing distributions of functional genetic variants in the beta1-AR...
  12. pmc CYP2A6 genetic variation and dexmedetomidine disposition
    Utkarsh Kohli
    Departments of Medicine and Pharmacology, Division of Clinical Pharmacology, Vanderbilt University, Nashville, TN, USA
    Eur J Clin Pharmacol 68:937-42. 2012
    ..We examined whether CYP2A6 genotypes affect dexmedetomidine disposition...
  13. ncbi request reprint Alpha 1A-adrenergic receptor polymorphism and vascular response
    Gbenga G Sofowora
    Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Clin Pharmacol Ther 75:539-45. 2004
    ..Variability in sensitivity to phenylephrine, an alpha(1A) adrenergic agonist, has a large genetic component. We examined the hypothesis that a common polymorphism of alpha(1A)-adrenergic receptor (Arg347Cys) affects in vivo response...
  14. doi request reprint Tariquidar, a selective P-glycoprotein inhibitor, does not potentiate loperamide's opioid brain effects in humans despite full inhibition of lymphocyte P-glycoprotein
    Daniel Kurnik
    Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Anesthesiology 109:1092-9. 2008
    ..The authors studied the effect of the highly selective, potent P-glycoprotein inhibitor tariquidar on loperamide's central opioid effects...
  15. ncbi request reprint Alpha2B adrenergic receptor 301-303 deletion polymorphism and vascular alpha2 adrenergic receptor response
    Mordechai Muszkat
    Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6602, USA
    Pharmacogenet Genomics 15:23-8. 2005
    ..2+/-12.9% in del/del subjects (P=0.26). These findings suggest that the del301-303 polymorphism does not contribute significantly to interindividual in vivo variability in response to alpha2-AR activation in the hand vein...
  16. ncbi request reprint Variation in the alpha2B-adrenergic receptor gene (ADRA2B) and its relationship to vascular response in vivo
    Mordechai Muszkat
    Department of Medicine, Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6602, USA
    Pharmacogenet Genomics 15:407-14. 2005
    ..We have described novel variants and haplotypes of the ADRA2B gene. These do not alter sensitivity to a selective alpha2-adrenergic receptor agonist but some may decrease maximal venoconstriction in vivo...
  17. pmc Variation in the α(2A) adrenoceptor gene and the effect of dexmedetomidine on plasma insulin and glucose
    Laxmi V Ghimire
    Department of Medicine, Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Pharmacogenet Genomics 23:479-86. 2013
    ..We examined the hypotheses that the selective α(2A)R agonist, dexmedetomidine, decreases plasma insulin levels and increases plasma glucose levels in humans and that these effects are modified by genetic α(2A)AR variants...
  18. ncbi request reprint No association of the Asp298 variant of the endothelial nitric oxide synthase gene with preeclampsia
    Ruth Landau
    Department of Anesthesiology, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    Am J Hypertens 17:391-4. 2004
    ..Polymorphisms of the endothelial nitric oxide synthase (eNOS) gene affect NO production and have been associated with hypertension and preeclampsia in a Japanese population...
  19. pmc Independent regulation of α1 and α2 adrenergic receptor-mediated vasoconstriction in vivo
    Mordechai Muszkat
    Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 372332 6602, USA
    J Hypertens 29:251-6. 2011
    ....
  20. pmc The alpha2C-adrenoceptor deletion322-325 variant and cold-induced vasoconstriction
    Eitan A Friedman
    Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Vanderbilt University School of Medicine, 542 RRB, Nashville, TN 37232 6602, USA
    Clin Auton Res 19:247-54. 2009
    ..We tested the hypothesis that individuals with the ADRA2C del322-325 variant have attenuated vasoconstriction in response to cold...
  21. ncbi request reprint The erythromycin breath test reflects P-glycoprotein function independently of cytochrome P450 3A activity
    Daniel Kurnik
    Department of Medicine, Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232 6602, USA
    Clin Pharmacol Ther 80:228-34. 2006
    ..Thus studies were undertaken to determine the effect of tariquidar, a potent P-glycoprotein inhibitor that does not affect CYP3A activity, on the ERBT and on the CYP3A-mediated metabolism of midazolam, a non-P-glycoprotein substrate...
  22. ncbi request reprint Comparative analysis of outcome measures used in examining neurodevelopmental effects of early childhood anesthesia exposure
    Caleb H Ing
    From the Department of Anesthesiology C H I, L S S and Department of Pediatrics L S S, Columbia University College of Physicians and Surgeons, New York, New York Departments of Anesthesiology and Epidemiology C J D, J E B, G L and Departments of Psychiatry and Biostatistics M M W, Columbia University College of Physicians and Surgeons and Mailman School of Public Health, New York, New York Centre for Health Services Research, School of Population Health, University of Western Australia, Perth, Australia E M Centre for Child Health Research, Telethon Institute for Child Health Research, University of Western Australia, Perth, Australia A J W Department of Anaesthesia and Pain Management, Princess Margaret Hospital for Children, Perth, Australia M K H Department of Psychiatry, New York State Psychiatric Institute, New York, New York T F School of Medicine and Pharmacology, The University of Western Australia, Perth, Australia and Department of Anaesthesia and Pain Management, Princess Margaret Hospital for Children, Perth, Australia B S v U S Department of Anaesthesia, Murdoch Childrens Research Institute and Royal Children s Hospital, Melbourne, Australia A J D and Department of Medicine, Weill Cornell College of Medicine, and Symphony Capital LLC, New York, New York A J J W
    Anesthesiology 120:1319-32. 2014
    ..The safety of anesthetic agents in children has been evaluated using a variety of neurodevelopmental outcome measures with varied results...
  23. ncbi request reprint Genetic variability in CYP3A5 and its possible consequences
    Hong Guang Xie
    Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Pharmacogenomics 5:243-72. 2004
    ....
  24. ncbi request reprint G-protein beta(3) subunit 825 C/T polymorphism is associated with weight gain during pregnancy
    Victor Dishy
    Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville Tennessee 37232 6602, USA
    Pharmacogenetics 13:241-2. 2003
    ..006) and had a significantly higher pre-pregnancy body mass index (P = 0.02). The C825T polymorphism of the G-protein beta(3) subunit gene, known to be associated with obesity, is a determinant of weight gain during pregnancy...
  25. ncbi request reprint Differential in vivo sensitivity to inhibition of P-glycoprotein located in lymphocytes, testes, and the blood-brain barrier
    Edna F Choo
    Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232 6602, USA
    J Pharmacol Exp Ther 317:1012-8. 2006
    ..Such resistance can be overcome by a sufficiently high dose of an inhibitor; however, whether this is safely attainable in the clinical situation remains to be determined...
  26. ncbi request reprint A multi-investigator/institutional DNA bank for AIDS-related human genetic studies: AACTG Protocol A5128
    David W Haas
    Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA
    HIV Clin Trials 4:287-300. 2003
    ..Human DNA banks must allow future analyses while addressing confidentiality, ethical, and regulatory issues...
  27. ncbi request reprint Effect of acute transdermal estrogen administration on basal, mental stress and cold pressor-induced sympathetic responses in postmenopausal women
    Gbemiga G Sofowora
    Division of Clinical Pharmacology, 560 MRB 1, Vanderbilt University Medical School, Nashville, TN 37232 6602, USA
    Clin Auton Res 15:193-9. 2005
    ..02) at baseline and after the Stroop test (1881.1+/-330 ng/min vs 1014.6+/-249 ng/min) (p=0.02). Acute transdermal estrogen administration did not attenuate norepinephrine spillover or sympathetically mediated hemodynamic responses...
  28. pmc Sildenafil does not improve nitric oxide-mediated endothelium-dependent vascular responses in smokers
    Victor Dishy
    Division of Clinical Pharmacology, General Clinical Research Center, Department of Biomedical Engineering, Vanderbilt University Medical Center, Nashville, TN 37232 6602, USA
    Br J Clin Pharmacol 57:209-12. 2004
    ..To examine the hypothesis that sildenafil, a phosphodiesterase type 5 inhibitor that inhibits cGMP breakdown, could enhance nitric oxide-mediated vasodilation and reverse endothelial dysfunction in chronic smokers...
  29. ncbi request reprint beta2-Adrenergic receptor genotype and preterm delivery
    Ruth Landau
    Department of Anesthesiology, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Am J Obstet Gynecol 187:1294-8. 2002
    ..Our purpose was to determine whether the functional genetic polymorphisms of the beta(2)-adrenergic receptor (beta(2)AR) that result in changes in amino acid residues 16 and 27 are associated with preterm delivery...
  30. ncbi request reprint Long-term differences in language and cognitive function after childhood exposure to anesthesia
    Caleb Ing
    Department of Anesthesiology, Columbia University College of Physicians and Surgeons, 622 W 168th St, BHN 4 440, New York, NY 10032, USA
    Pediatrics 130:e476-85. 2012
    ..We examined the association between exposure to anesthesia in children under age 3 and outcomes in language, cognitive function, motor skills, and behavior at age 10...
  31. ncbi request reprint Alpha2-adrenergic receptor-induced vascular constriction in blacks and whites
    Mordechai Muszkat
    Division of Clinical Pharmacology, 560 RRB, Vanderbilt University School of Medicine, Nashville, Tenn 37232 6602, USA
    Hypertension 43:31-5. 2004
    ..The response to dexmedetomidine provides a model that will allow further study of the regulation of alpha2-adrenergic receptor-mediated vascular responses..
  32. ncbi request reprint Beta2-adrenoceptor Thr164Ile polymorphism is associated with markedly decreased vasodilator and increased vasoconstrictor sensitivity in vivo
    Victor Dishy
    Division of Clinical Pharmacology and General Clinical Research Center Division of General Internal Medicine, Department of Medicine and the Department of Biostatistics, Vanderbilt University Medical Center, Nashville TN, USA
    Pharmacogenetics 14:517-22. 2004
    ..Altered adrenergic vascular sensitivity may contribute to the decreased survival observed in patients with congestive heart failure carrying the Ile164 allele...
  33. ncbi request reprint Disproportionate decrease in alpha- compared with beta-adrenergic sensitivity in the dorsal hand vein in pregnancy favors vasodilation
    Ruth Landau
    Department of Anesthesiology, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Circulation 106:1116-20. 2002
    ....