Danny Winder

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. pmc Emerging role for corticotropin releasing factor signaling in the bed nucleus of the stria terminalis at the intersection of stress and reward
    Yuval Silberman
    Neuroscience Program in Substance Abuse, Department of Molecular Physiology and Biophysics, Vanderbilt Brain Institute, Nashville, TN, USA
    Front Psychiatry 4:42. 2013
  2. pmc Genetic inhibition of CaMKII in dorsal striatal medium spiny neurons reduces functional excitatory synapses and enhances intrinsic excitability
    Jason R Klug
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
    PLoS ONE 7:e45323. 2012
  3. pmc Subcellular localization of the antidepressant-sensitive norepinephrine transporter
    Heinrich J G Matthies
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    BMC Neurosci 10:65. 2009
  4. ncbi request reprint Synaptic plasticity in drug reward circuitry
    Danny G Winder
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232 0615, USA
    Curr Mol Med 2:667-76. 2002
  5. ncbi request reprint Norepinephrine modulates glutamatergic transmission in the bed nucleus of the stria terminalis
    Regula E Egli
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232 0615, USA
    Neuropsychopharmacology 30:657-68. 2005
  6. ncbi request reprint Extracellular-signal regulated kinase 1-dependent metabotropic glutamate receptor 5-induced long-term depression in the bed nucleus of the stria terminalis is disrupted by cocaine administration
    Brad A Grueter
    Department of Molecular Physiology, Center for Molecular Neuroscience, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Neurosci 26:3210-9. 2006
  7. pmc Dopamine enhances fast excitatory synaptic transmission in the extended amygdala by a CRF-R1-dependent process
    Thomas L Kash
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0615, USA
    J Neurosci 28:13856-65. 2008
  8. pmc Operant sensation seeking engages similar neural substrates to operant drug seeking in C57 mice
    Christopher M Olsen
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232 0615, USA
    Neuropsychopharmacology 34:1685-94. 2009
  9. pmc Alpha1-adrenergic receptor-induced heterosynaptic long-term depression in the bed nucleus of the stria terminalis is disrupted in mouse models of affective disorders
    Zoe A McElligott
    Vanderbilt Brain Institute, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Neuropsychopharmacology 33:2313-23. 2008
  10. ncbi request reprint Effects of periadolescent versus adult cocaine exposure on cocaine conditioned place preference and motor sensitization in mice
    Nicole L Schramm-Sapyta
    Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Psychopharmacology (Berl) 173:41-8. 2004

Research Grants

Collaborators

Detail Information

Publications36

  1. pmc Emerging role for corticotropin releasing factor signaling in the bed nucleus of the stria terminalis at the intersection of stress and reward
    Yuval Silberman
    Neuroscience Program in Substance Abuse, Department of Molecular Physiology and Biophysics, Vanderbilt Brain Institute, Nashville, TN, USA
    Front Psychiatry 4:42. 2013
    ..This review will examine the role of CRF signaling in drug addiction and reinstatement with an emphasis on critical neurocircuitry within the BNST that may offer new insights into treatments for addiction...
  2. pmc Genetic inhibition of CaMKII in dorsal striatal medium spiny neurons reduces functional excitatory synapses and enhances intrinsic excitability
    Jason R Klug
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
    PLoS ONE 7:e45323. 2012
    ..These data suggest that CaMKII plays a critical role in setting the excitability rheostat of striatal MSNs by coordinating excitatory synaptic drive and the resulting depolarization response...
  3. pmc Subcellular localization of the antidepressant-sensitive norepinephrine transporter
    Heinrich J G Matthies
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    BMC Neurosci 10:65. 2009
    ..Limited, and somewhat contradictory, information currently describes the axonal transport and localization of NET in neurons...
  4. ncbi request reprint Synaptic plasticity in drug reward circuitry
    Danny G Winder
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232 0615, USA
    Curr Mol Med 2:667-76. 2002
    ..Thus, the present data suggest that regulation of synaptic plasticity in reward circuits is a tractable candidate mechanism underlying aspects of addiction...
  5. ncbi request reprint Norepinephrine modulates glutamatergic transmission in the bed nucleus of the stria terminalis
    Regula E Egli
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232 0615, USA
    Neuropsychopharmacology 30:657-68. 2005
    ..Further experiments demonstrate that the actions of NE on glutamatergic transmission can be correlated with beta-AR function...
  6. ncbi request reprint Extracellular-signal regulated kinase 1-dependent metabotropic glutamate receptor 5-induced long-term depression in the bed nucleus of the stria terminalis is disrupted by cocaine administration
    Brad A Grueter
    Department of Molecular Physiology, Center for Molecular Neuroscience, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Neurosci 26:3210-9. 2006
    ....
  7. pmc Dopamine enhances fast excitatory synaptic transmission in the extended amygdala by a CRF-R1-dependent process
    Thomas L Kash
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0615, USA
    J Neurosci 28:13856-65. 2008
    ....
  8. pmc Operant sensation seeking engages similar neural substrates to operant drug seeking in C57 mice
    Christopher M Olsen
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232 0615, USA
    Neuropsychopharmacology 34:1685-94. 2009
    ..OSS may have predictive validity for screening compounds for use in the treatment of drug addiction. In addition, we also discuss the potential relevance of this animal model to the field of behavioral addictions...
  9. pmc Alpha1-adrenergic receptor-induced heterosynaptic long-term depression in the bed nucleus of the stria terminalis is disrupted in mouse models of affective disorders
    Zoe A McElligott
    Vanderbilt Brain Institute, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Neuropsychopharmacology 33:2313-23. 2008
    ..Thus a loss of this plasticity at glutamatergic synapses in BNST could contribute to affective behavioral phenotypes of these mice...
  10. ncbi request reprint Effects of periadolescent versus adult cocaine exposure on cocaine conditioned place preference and motor sensitization in mice
    Nicole L Schramm-Sapyta
    Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Psychopharmacology (Berl) 173:41-8. 2004
    ..OBJECTIVES. We tested the relationship between cocaine exposure at two different ages in mice and the development of subsequent drug-seeking behavior to test for age-specific exposure effects...
  11. pmc Repeated homotypic stress elevates 2-arachidonoylglycerol levels and enhances short-term endocannabinoid signaling at inhibitory synapses in basolateral amygdala
    Sachin Patel
    Department of Psychiatry, Vanderbilt University, Nashville, TN 37212, USA
    Neuropsychopharmacology 34:2699-709. 2009
    ..We suggest stress-induced enhancement of eCB-mediated suppression of inhibitory transmission in the BLA could contribute to affective dysregulation associated with chronic stress...
  12. pmc Chronic ethanol exposure leads to divergent control of dopaminergic synapses in distinct target regions
    Julie C Healey
    Department of Molecular Physiology and Biophysics, 23rd and Pierce Avenue South, Vanderbilt University School of Medicine, Nashville TN 37232 0615, USA
    Alcohol 42:179-90. 2008
    ..These data thus suggest that distinct populations of catecholamine neurons may be differentially regulated by ethanol, and that ethanol and withdrawal interact to produce differential adaptations in these systems...
  13. ncbi request reprint A method for single-session cocaine self-administration in the mouse
    Christopher M Olsen
    Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN 37232 0615, USA
    Psychopharmacology (Berl) 187:13-21. 2006
    ..With the spectrum of genetically modified mice available, there is a need for well-designed drug self-administration studies tailored for rapid completion of studies in mice...
  14. ncbi request reprint A novel mouse brain slice preparation of the hippocampo-accumbens pathway
    Robert T Matthews
    Department of Anatomy and Physiology, Meharry Medical College, Nashville, TN 37208, USA
    J Neurosci Methods 137:49-60. 2004
    ..Additionally, LTD at hippocampo-accumbens synapses can be induced at a stimulus frequency known to support reinstatement of drug seeking behavior...
  15. ncbi request reprint LTP in the mouse nucleus accumbens is developmentally regulated
    Nicole L Schramm
    Department of Molecular Physiology and Biophysics, Center for Molecular Neuroscience, Vanderbilt University School of Medicine, Nashville, TN 37232 0615, USA
    Synapse 45:213-9. 2002
    ..These findings are discussed in the context of behavioral changes elicited in response to drugs of abuse, which differ in adolescent vs. adult rodents and humans...
  16. pmc Yohimbine impairs extinction of cocaine-conditioned place preference in an alpha2-adrenergic receptor independent process
    Adeola R Davis
    Vanderbilt Brain Institute, Vanderbilt University Medical Center, Nashville, Tennessee 37232 0615, USA
    Learn Mem 15:667-76. 2008
    ..Further, this action was extant in slices from alpha(2A)-AR knockout mice. Our data strongly suggest that extinction-modifying effects of yohimbine are unlikely to be due to actions at alpha(2A)-ARs...
  17. pmc In vivo metabotropic glutamate receptor 5 (mGluR5) antagonism prevents cocaine-induced disruption of postsynaptically maintained mGluR5-dependent long-term depression
    Brad A Grueter
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0615, USA
    J Neurosci 28:9261-70. 2008
    ..Thus, using a novel strategy of in vivo antagonist-induced rescue of ex vivo agonist effects for the same receptor, we provide evidence suggesting that mGluR5 activation is actively recruited by in vivo cocaine...
  18. pmc Distinct forms of Gq-receptor-dependent plasticity of excitatory transmission in the BNST are differentially affected by stress
    Zoe A McElligott
    Department of Psychiatry, Kennedy Center for Human Development, Vanderbilt Brain Institute, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 107:2271-6. 2010
    ..These data thus suggest that in the BNST, NE- and glutamate-activated G(q)-linked signaling pathways differentially tune glutamate synapse efficacy in response to stress...
  19. ncbi request reprint Group II and III metabotropic glutamate receptors suppress excitatory synaptic transmission in the dorsolateral bed nucleus of the stria terminalis
    Brad A Grueter
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Neuropsychopharmacology 30:1302-11. 2005
    ..In total, our data suggest a plausible site of action for some of the anxiolytic effects of group II and group III mGluR agonists...
  20. ncbi request reprint Microarray analysis reveals distinctive signaling between the bed nucleus of the stria terminalis, nucleus accumbens, and dorsal striatum
    Christopher M Olsen
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232 0615, USA
    Physiol Genomics 32:283-98. 2008
    ..Furthermore, these studies provide a framework for future mouse-mouse comparisons of transcriptional profiles after behavioral/pharmacological manipulation...
  21. pmc Modulation of glutamatergic synaptic transmission in the bed nucleus of the stria terminalis
    ZOE ANASTASIA MCELLIGOTT
    Vanderbilt Brain Institute, Vanderbilt University Medical Center, Nashville, TN, USA
    Prog Neuropsychopharmacol Biol Psychiatry 33:1329-35. 2009
    ..In this review we highlight studies examining synaptic plasticity and modulation of excitatory transmission within the BNST, emphasizing how such modulation may result in alterations in anxiety and reward related behavior...
  22. ncbi request reprint Group I mGluRs and long-term depression: potential roles in addiction?
    Brad A Grueter
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Room 724B, RRB, Nashville, TN 37232 0615, USA
    Mol Neurobiol 36:232-44. 2007
    ..In this review, we focus first on the evidence supporting a role for mGluRs in addiction and then on the properties of mGluR-dependent forms of synaptic plasticity, focusing in particular on Gq-linked receptor-induced LTD...
  23. ncbi request reprint Dorsal and ventral distribution of excitable and synaptic properties of neurons of the bed nucleus of the stria terminalis
    Regula E Egli
    Department of Molecular Physiology and Biophysics, Center for Molecular Neuroscience, and John F Kennedy Center for Research on Human Development, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0615, USA
    J Neurophysiol 90:405-14. 2003
    ..The data also suggest mechanisms by which information may flow through stress and reward circuits...
  24. ncbi request reprint Neuropeptide Y and corticotropin-releasing factor bi-directionally modulate inhibitory synaptic transmission in the bed nucleus of the stria terminalis
    Thomas L Kash
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232 0615, USA
    Neuropharmacology 51:1013-22. 2006
    ..These results suggest potential anatomical and cellular substrates for the robust behavioral interactions between NPY and CRF...
  25. ncbi request reprint Cocaine self-administration reduces excitatory responses in the mouse nucleus accumbens shell
    Nicole L Schramm-Sapyta
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232 0615, USA
    Neuropsychopharmacology 31:1444-51. 2006
    ..This reduction in glutamatergic signaling may be one mechanism by which cocaine exerts its long-term behavioral effects...
  26. ncbi request reprint Activation of NR2A-containing NMDA receptors is not obligatory for NMDA receptor-dependent long-term potentiation
    Carl Weitlauf
    Center for Molecular Neuroscience, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0615, USA
    J Neurosci 25:8386-90. 2005
    ..Furthermore, our data demonstrate that care must be exercised in the interpretation of data generated with AAM077 when the compound is applied before an agonist...
  27. ncbi request reprint NMDA and beta1-adrenergic receptors differentially signal phosphorylation of glutamate receptor type 1 in area CA1 of hippocampus
    Amanda M Vanhoose
    Department of Molecular Physiology and Biophysics, Center for Molecular Neuroscience, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0615, USA
    J Neurosci 23:5827-34. 2003
    ....
  28. ncbi request reprint High-frequency stimulation induces ethanol-sensitive long-term potentiation at glutamatergic synapses in the dorsolateral bed nucleus of the stria terminalis
    Carl Weitlauf
    Neuroscience Graduate Program, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0615, USA
    J Neurosci 24:5741-7. 2004
    ..This effect of ethanol is accompanied by a significant and reversible dose-dependent attenuation of isolated NMDAR signaling and is mimicked by incomplete NMDAR blockade...
  29. pmc Alcohol inhibits NR2B-containing NMDA receptors in the ventral bed nucleus of the stria terminalis
    Thomas L Kash
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232 0615, USA
    Neuropsychopharmacology 33:1379-90. 2008
    ..Finally, we demonstrate that ethanol inhibits NMDARs in cells in the vBNST that project to the VTA, providing a direct means by which ethanol in the vBNST can modulate the dopaminergic system...
  30. ncbi request reprint Novel blockade of protein kinase A-mediated phosphorylation of AMPA receptors
    Amanda M Vanhoose
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0615, USA
    J Neurosci 26:1138-45. 2006
    ..Thus, in addition to the typical kinase-phosphatase rivalry mediating protein phosphorylation state, we have identified a novel form of phospho-protein regulation that occurs at GluR1 and may also occur at several other PKA substrates...
  31. pmc Alcohol exposure alters NMDAR function in the bed nucleus of the stria terminalis
    Thomas L Kash
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA
    Neuropsychopharmacology 34:2420-9. 2009
    ....
  32. ncbi request reprint Regulation of cAMP levels in area CA1 of hippocampus by Gi/o-coupled receptors is stimulus dependent in mice
    Amanda M Vanhoose
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Room 724B, RRB, Nashville, TN 37232 0615, USA
    Neurosci Lett 370:80-3. 2004
    ..In addition, the effects are also Gi/o-coupled receptor-specific, suggesting additional complexity. These data indicate that Gi/o-coupled receptors may play roles in "routing" second messenger signaling in area CA1...
  33. ncbi request reprint A potassium channel blocker induces a long-lasting enhancement of corticostriatal responses
    Eric D Norman
    Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN 37232 0615, USA
    Neuropharmacology 48:311-21. 2005
    ..Collectively, these findings demonstrate a novel form of L-type calcium channel-dependent plasticity in the adult dorsal striatum that is induced in the absence of dopaminergic input...
  34. pmc Oxidation of calmodulin alters activation and regulation of CaMKII
    A J Robison
    Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN 37232 0615, USA
    Biochem Biophys Res Commun 356:97-101. 2007
    ..When taken together, these data suggest that oxidative stress may perturb neuronal and cardiac function via a decreased ability of oxidized calmodulin to bind, activate, and regulate the interactions of CaMKII...
  35. ncbi request reprint ERK activation by G-protein-coupled receptors in mouse brain is receptor identity-specific
    Amanda M Vanhoose
    Department of Molecular Physiology and Biophysics, and The Center for Molecular Neuroscience, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0615, USA
    J Biol Chem 277:9049-53. 2002
    ..These data suggest that although most G-protein-coupled receptor subtypes activate ERK in non-neuronal cells, the coupling of G(i/o) to ERK is tightly regulated in brain...
  36. ncbi request reprint Rap1 couples cAMP signaling to a distinct pool of p42/44MAPK regulating excitability, synaptic plasticity, learning, and memory
    Alexei Morozov
    Howard Hughes Medical Institute, Columbia University, College of Physicians and Surgeons, 1051 Riverside Drive, New York, NY 10032, USA
    Neuron 39:309-25. 2003
    ..These results indicate that Rap1 couples cAMP signaling to a selective membrane-associated pool of p42/44MAPK to control excitability of pyramidal cells, the early and late phases of LTP, and the storage of spatial memory...

Research Grants18

  1. Periadolescent Noradrenergic Regulation in the BNST
    Danny Winder; Fiscal Year: 2007
    ..abstract_text> ..
  2. Periadolescent Noradrenergic Regulation in the BNST
    Danny Winder; Fiscal Year: 2007
    ....
  3. Regulation of Synaptic Transmission in BNST by Alcohol
    Danny Winder; Fiscal Year: 2007
    ....
  4. Noradrenergic Regulation in the BNST
    Danny G Winder; Fiscal Year: 2010
    ..The successful completion of these proposed studies will result in important new information about neurons that may be involved in addiction, potentially creating new targets for therapeutics development. ..
  5. Periadolescent Noradrenergic Regulation in the BNST
    Danny Winder; Fiscal Year: 2004
    ....
  6. Regulation of LTP by Gi Linked Receptors
    Danny Winder; Fiscal Year: 2004
    ..In parallel, Gi-linked receptor regulation of LTP, particularly those forms that require the activation of these cascades, will also be examined. ..
  7. ETHANOL INHIBITION OF NMDA RECEPTOR MEDIATED RESPONSES
    Danny Winder; Fiscal Year: 2004
    ..It is hoped that the outcome of these experiments will provide a basis for the development of treatments that can counteract some of the damaging neural effects of EtOH...
  8. Regulation of LTP by Gi Linked Receptors
    Danny Winder; Fiscal Year: 2003
    ..In parallel, Gi-linked receptor regulation of LTP, particularly those forms that require the activation of these cascades, will also be examined. ..
  9. ETHANOL INHIBITION OF NMDA RECEPTOR MEDIATED RESPONSES
    Danny Winder; Fiscal Year: 2003
    ..It is hoped that the outcome of these experiments will provide a basis for the development of treatments that can counteract some of the damaging neural effects of EtOH...
  10. Regulation of LTP by Gi Linked Receptors
    Danny Winder; Fiscal Year: 2002
    ..In parallel, Gi-linked receptor regulation of LTP, particularly those forms that require the activation of these cascades, will also be examined. ..
  11. ETHANOL INHIBITION OF NMDA RECEPTOR MEDIATED RESPONSES
    Danny Winder; Fiscal Year: 2002
    ..It is hoped that the outcome of these experiments will provide a basis for the development of treatments that can counteract some of the damaging neural effects of EtOH...
  12. ETHANOL INHIBITION OF NMDA RECEPTOR MEDIATED RESPONSES
    Danny Winder; Fiscal Year: 2001
    ..It is hoped that the outcome of these experiments will provide a basis for the development of treatments that can counteract some of the damaging neural effects of EtOH...
  13. Regulation of LTP by Gi Linked Receptors
    Danny Winder; Fiscal Year: 2001
    ..In parallel, Gi-linked receptor regulation of LTP, particularly those forms that require the activation of these cascades, will also be examined. ..
  14. Periadolescent Noradrenergic Regulation in the BNST
    Danny Winder; Fiscal Year: 2006
    ....
  15. Periadolescent Noradrenergic Regulation in the BNST
    Danny Winder; Fiscal Year: 2005
    ....
  16. Alcohol action on extended amygdala glutamate synapses
    Danny G Winder; Fiscal Year: 2010
    ..The successful completion of these proposed studies will result in important new information about neurons that may be involved in alcoholism, potentially creating new targets for therapeutics development. ..