Research Topics
| Danny WinderSummaryAffiliation: Vanderbilt University Country: USA Publications
Research Grants
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Publications
Subcellular localization of the antidepressant-sensitive norepinephrine transporterHeinrich J G Matthies
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
BMC Neurosci 10:65. 2009..Limited, and somewhat contradictory, information currently describes the axonal transport and localization of NET in neurons...
Synaptic plasticity in drug reward circuitryDanny G Winder
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232 0615, USA
Curr Mol Med 2:667-76. 2002..Thus, the present data suggest that regulation of synaptic plasticity in reward circuits is a tractable candidate mechanism underlying aspects of addiction...- Norepinephrine modulates glutamatergic transmission in the bed nucleus of the stria terminalisRegula E Egli
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232-0615, USA
Neuropsychopharmacology 30:657-68. 2005..Further experiments demonstrate that the actions of NE on glutamatergic transmission can be correlated with beta-AR function... - Extracellular-signal regulated kinase 1-dependent metabotropic glutamate receptor 5-induced long-term depression in the bed nucleus of the stria terminalis is disrupted by cocaine administrationBrad A Grueter
Department of Molecular Physiology, Center for Molecular Neuroscience, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
J Neurosci 26:3210-9. 2006.... - Operant sensation seeking engages similar neural substrates to operant drug seeking in C57 miceChristopher M Olsen
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232 0615, USA
Neuropsychopharmacology 34:1685-94. 2009..OSS may have predictive validity for screening compounds for use in the treatment of drug addiction. In addition, we also discuss the potential relevance of this animal model to the field of behavioral addictions... - Dopamine enhances fast excitatory synaptic transmission in the extended amygdala by a CRF-R1-dependent processThomas L Kash
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0615, USA
J Neurosci 28:13856-65. 2008.... - Alpha1-adrenergic receptor-induced heterosynaptic long-term depression in the bed nucleus of the stria terminalis is disrupted in mouse models of affective disordersZoe A McElligott
Vanderbilt Brain Institute, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Neuropsychopharmacology 33:2313-23. 2008..Thus a loss of this plasticity at glutamatergic synapses in BNST could contribute to affective behavioral phenotypes of these mice... - Chronic ethanol exposure leads to divergent control of dopaminergic synapses in distinct target regionsJulie C Healey
Department of Molecular Physiology and Biophysics, 23rd and Pierce Avenue South, Vanderbilt University School of Medicine, Nashville TN 37232 0615, USA
Alcohol 42:179-90. 2008..These data thus suggest that distinct populations of catecholamine neurons may be differentially regulated by ethanol, and that ethanol and withdrawal interact to produce differential adaptations in these systems... - A method for single-session cocaine self-administration in the mouseChristopher M Olsen
Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN 37232 0615, USA
Psychopharmacology (Berl) 187:13-21. 2006..With the spectrum of genetically modified mice available, there is a need for well-designed drug self-administration studies tailored for rapid completion of studies in mice... - Effects of periadolescent versus adult cocaine exposure on cocaine conditioned place preference and motor sensitization in miceNicole L Schramm-Sapyta
Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Psychopharmacology (Berl) 173:41-8. 2004.... - Repeated homotypic stress elevates 2-arachidonoylglycerol levels and enhances short-term endocannabinoid signaling at inhibitory synapses in basolateral amygdalaSachin Patel
Department of Psychiatry, Vanderbilt University, Nashville, TN 37212, USA
Neuropsychopharmacology 34:2699-709. 2009..We suggest stress-induced enhancement of eCB-mediated suppression of inhibitory transmission in the BLA could contribute to affective dysregulation associated with chronic stress... - Yohimbine impairs extinction of cocaine-conditioned place preference in an alpha2-adrenergic receptor independent processAdeola R Davis
Vanderbilt Brain Institute, Vanderbilt University Medical Center, Nashville, Tennessee 37232 0615, USA
Learn Mem 15:667-76. 2008..Further, this action was extant in slices from alpha(2A)-AR knockout mice. Our data strongly suggest that extinction-modifying effects of yohimbine are unlikely to be due to actions at alpha(2A)-ARs... - Microarray analysis reveals distinctive signaling between the bed nucleus of the stria terminalis, nucleus accumbens, and dorsal striatumChristopher M Olsen
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232 0615, USA
Physiol Genomics 32:283-98. 2008..Furthermore, these studies provide a framework for future mouse-mouse comparisons of transcriptional profiles after behavioral/pharmacological manipulation... - Distinct forms of Gq-receptor-dependent plasticity of excitatory transmission in the BNST are differentially affected by stressZoe A McElligott
Department of Psychiatry, Kennedy Center for Human Development, Vanderbilt Brain Institute, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Proc Natl Acad Sci U S A 107:2271-6. 2010..These data thus suggest that in the BNST, NE- and glutamate-activated G(q)-linked signaling pathways differentially tune glutamate synapse efficacy in response to stress... - In vivo metabotropic glutamate receptor 5 (mGluR5) antagonism prevents cocaine-induced disruption of postsynaptically maintained mGluR5-dependent long-term depressionBrad A Grueter
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0615, USA
J Neurosci 28:9261-70. 2008..Thus, using a novel strategy of in vivo antagonist-induced rescue of ex vivo agonist effects for the same receptor, we provide evidence suggesting that mGluR5 activation is actively recruited by in vivo cocaine... - A novel mouse brain slice preparation of the hippocampo-accumbens pathwayRobert T Matthews
Department of Anatomy and Physiology, Meharry Medical College, Nashville, TN 37208, USA
J Neurosci Methods 137:49-60. 2004..Additionally, LTD at hippocampo-accumbens synapses can be induced at a stimulus frequency known to support reinstatement of drug seeking behavior... - LTP in the mouse nucleus accumbens is developmentally regulatedNicole L Schramm
Department of Molecular Physiology and Biophysics, Center for Molecular Neuroscience, Vanderbilt University School of Medicine, Nashville, TN 37232-0615, USA
Synapse 45:213-9. 2002..These findings are discussed in the context of behavioral changes elicited in response to drugs of abuse, which differ in adolescent vs. adult rodents and humans... - Group II and III metabotropic glutamate receptors suppress excitatory synaptic transmission in the dorsolateral bed nucleus of the stria terminalisBrad A Grueter
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Neuropsychopharmacology 30:1302-11. 2005..In total, our data suggest a plausible site of action for some of the anxiolytic effects of group II and group III mGluR agonists... - NMDA and beta1-adrenergic receptors differentially signal phosphorylation of glutamate receptor type 1 in area CA1 of hippocampusAmanda M Vanhoose
Department of Molecular Physiology and Biophysics, Center for Molecular Neuroscience, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0615, USA
J Neurosci 23:5827-34. 2003.... - Modulation of glutamatergic synaptic transmission in the bed nucleus of the stria terminalisZOE ANASTASIA MCELLIGOTT
Vanderbilt Brain Institute, Vanderbilt University Medical Center, Nashville, TN, USA
Prog Neuropsychopharmacol Biol Psychiatry 33:1329-35. 2009..In this review we highlight studies examining synaptic plasticity and modulation of excitatory transmission within the BNST, emphasizing how such modulation may result in alterations in anxiety and reward related behavior... - High-frequency stimulation induces ethanol-sensitive long-term potentiation at glutamatergic synapses in the dorsolateral bed nucleus of the stria terminalisCarl Weitlauf
Neuroscience Graduate Program, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0615, USA
J Neurosci 24:5741-7. 2004..This effect of ethanol is accompanied by a significant and reversible dose-dependent attenuation of isolated NMDAR signaling and is mimicked by incomplete NMDAR blockade... - Dorsal and ventral distribution of excitable and synaptic properties of neurons of the bed nucleus of the stria terminalisRegula E Egli
Department of Molecular Physiology and Biophysics, Center for Molecular Neuroscience, and John F. Kennedy Center for Research on Human Development, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0615, USA
J Neurophysiol 90:405-14. 2003..The data also suggest mechanisms by which information may flow through stress and reward circuits... - Group I mGluRs and long-term depression: potential roles in addiction?Brad A Grueter
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Room 724B, RRB, Nashville, TN 37232 0615, USA
Mol Neurobiol 36:232-44. 2007..In this review, we focus first on the evidence supporting a role for mGluRs in addiction and then on the properties of mGluR-dependent forms of synaptic plasticity, focusing in particular on Gq-linked receptor-induced LTD... - Neuropeptide Y and corticotropin-releasing factor bi-directionally modulate inhibitory synaptic transmission in the bed nucleus of the stria terminalisThomas L Kash
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232-0615, USA
Neuropharmacology 51:1013-22. 2006..These results suggest potential anatomical and cellular substrates for the robust behavioral interactions between NPY and CRF... - Activation of NR2A-containing NMDA receptors is not obligatory for NMDA receptor-dependent long-term potentiationCarl Weitlauf
Center for Molecular Neuroscience, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0615, USA
J Neurosci 25:8386-90. 2005..Furthermore, our data demonstrate that care must be exercised in the interpretation of data generated with AAM077 when the compound is applied before an agonist... - Cocaine self-administration reduces excitatory responses in the mouse nucleus accumbens shellNicole L Schramm-Sapyta
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232-0615, USA
Neuropsychopharmacology 31:1444-51. 2006..This reduction in glutamatergic signaling may be one mechanism by which cocaine exerts its long-term behavioral effects... - Alcohol exposure alters NMDAR function in the bed nucleus of the stria terminalisThomas L Kash
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA
Neuropsychopharmacology 34:2420-9. 2009.... - Alcohol inhibits NR2B-containing NMDA receptors in the ventral bed nucleus of the stria terminalisThomas L Kash
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232 0615, USA
Neuropsychopharmacology 33:1379-90. 2008..Finally, we demonstrate that ethanol inhibits NMDARs in cells in the vBNST that project to the VTA, providing a direct means by which ethanol in the vBNST can modulate the dopaminergic system... - Novel blockade of protein kinase A-mediated phosphorylation of AMPA receptorsAmanda M Vanhoose
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0615, USA
J Neurosci 26:1138-45. 2006..Thus, in addition to the typical kinase-phosphatase rivalry mediating protein phosphorylation state, we have identified a novel form of phospho-protein regulation that occurs at GluR1 and may also occur at several other PKA substrates... - Regulation of cAMP levels in area CA1 of hippocampus by Gi/o-coupled receptors is stimulus dependent in miceAmanda M Vanhoose
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Room 724B, RRB, Nashville, TN 37232-0615, USA
Neurosci Lett 370:80-3. 2004..In addition, the effects are also Gi/o-coupled receptor-specific, suggesting additional complexity. These data indicate that Gi/o-coupled receptors may play roles in "routing" second messenger signaling in area CA1... - A potassium channel blocker induces a long-lasting enhancement of corticostriatal responsesEric D Norman
Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN 37232-0615, USA
Neuropharmacology 48:311-21. 2005..Collectively, these findings demonstrate a novel form of L-type calcium channel-dependent plasticity in the adult dorsal striatum that is induced in the absence of dopaminergic input... - Oxidation of calmodulin alters activation and regulation of CaMKIIA J Robison
Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN 37232 0615, USA
Biochem Biophys Res Commun 356:97-101. 2007..When taken together, these data suggest that oxidative stress may perturb neuronal and cardiac function via a decreased ability of oxidized calmodulin to bind, activate, and regulate the interactions of CaMKII... - ERK activation by G-protein-coupled receptors in mouse brain is receptor identity-specificAmanda M Vanhoose
Department of Molecular Physiology and Biophysics, and The Center for Molecular Neuroscience, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0615, USA
J Biol Chem 277:9049-53. 2002..These data suggest that although most G-protein-coupled receptor subtypes activate ERK in non-neuronal cells, the coupling of G(i/o) to ERK is tightly regulated in brain... - Rap1 couples cAMP signaling to a distinct pool of p42/44MAPK regulating excitability, synaptic plasticity, learning, and memoryAlexei Morozov
Howard Hughes Medical Institute, Columbia University, College of Physicians and Surgeons, 1051 Riverside Drive, New York, NY 10032, USA
Neuron 39:309-25. 2003..These results indicate that Rap1 couples cAMP signaling to a selective membrane-associated pool of p42/44MAPK to control excitability of pyramidal cells, the early and late phases of LTP, and the storage of spatial memory...
Research Grants
- Noradrenergic Regulation in the BNSTDanny G Winder; Fiscal Year: 2010..The successful completion of these proposed studies will result in important new information about neurons that may be involved in addiction, potentially creating new targets for therapeutics development. ..
- Periadolescent Noradrenergic Regulation in the BNSTDanny Winder; Fiscal Year: 2007..abstract_text> ..
- Periadolescent Noradrenergic Regulation in the BNSTDanny Winder; Fiscal Year: 2007....
- Regulation of Synaptic Transmission in BNST by AlcoholDanny Winder; Fiscal Year: 2007....
- Regulation of LTP by Gi Linked ReceptorsDanny Winder; Fiscal Year: 2004..In parallel, Gi-linked receptor regulation of LTP, particularly those forms that require the activation of these cascades, will also be examined. ..
- ETHANOL INHIBITION OF NMDA RECEPTOR MEDIATED RESPONSESDanny Winder; Fiscal Year: 2004..It is hoped that the outcome of these experiments will provide a basis for the development of treatments that can counteract some of the damaging neural effects of EtOH...
- Alcohol action on extended amygdala glutamate synapsesDanny G Winder; Fiscal Year: 2010..The successful completion of these proposed studies will result in important new information about neurons that may be involved in alcoholism, potentially creating new targets for therapeutics development. ..