Keith Wilson

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. pmc Deletion of cationic amino acid transporter 2 exacerbates dextran sulfate sodium colitis and leads to an IL-17-predominant T cell response
    Kshipra Singh
    Division of Gastroenterology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
    Am J Physiol Gastrointest Liver Physiol 305:G225-40. 2013
  2. pmc L-arginine uptake by cationic amino acid transporter 2 is essential for colonic epithelial cell restitution
    Kshipra Singh
    Department of Medicine, Division of Gastroenterology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Am J Physiol Gastrointest Liver Physiol 302:G1061-73. 2012
  3. pmc Phylogeographic origin of Helicobacter pylori is a determinant of gastric cancer risk
    Thibaut de Sablet
    Division of Gastroenterology, Hepatology, and Nutrition, Vanderbilt University School of Medicine, MRBIV, Room 1030C, 2215 Garland Avenue, Nashville, TN 37232, USA
    Gut 60:1189-95. 2011
  4. pmc Spermine oxidase, a polyamine catabolic enzyme that links Helicobacter pylori CagA and gastric cancer risk
    Rupesh Chaturvedi
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center Nashville, TN, USA
    Gut Microbes 3:48-56. 2012

Collaborators

Detail Information

Publications4

  1. pmc Deletion of cationic amino acid transporter 2 exacerbates dextran sulfate sodium colitis and leads to an IL-17-predominant T cell response
    Kshipra Singh
    Division of Gastroenterology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
    Am J Physiol Gastrointest Liver Physiol 305:G225-40. 2013
    ..Thus CAT2 plays an important role in controlling inflammation and IL-17 activation in an injury model of colitis, and impaired L-Arg availability may contribute to UC pathogenesis...
  2. pmc L-arginine uptake by cationic amino acid transporter 2 is essential for colonic epithelial cell restitution
    Kshipra Singh
    Department of Medicine, Division of Gastroenterology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Am J Physiol Gastrointest Liver Physiol 302:G1061-73. 2012
    ..Uptake of L-Arg, and its metabolism by Arg1 to L-Orn and conversion to L-Pro by OAT is essential for colonic epithelial wound repair...
  3. pmc Phylogeographic origin of Helicobacter pylori is a determinant of gastric cancer risk
    Thibaut de Sablet
    Division of Gastroenterology, Hepatology, and Nutrition, Vanderbilt University School of Medicine, MRBIV, Room 1030C, 2215 Garland Avenue, Nashville, TN 37232, USA
    Gut 60:1189-95. 2011
    ..Our aim was to investigate the ancestral origin of H pylori strains isolated from subjects in these high- and low-risk regions and to determine whether this is a predictive determinant of precancerous lesions...
  4. pmc Spermine oxidase, a polyamine catabolic enzyme that links Helicobacter pylori CagA and gastric cancer risk
    Rupesh Chaturvedi
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center Nashville, TN, USA
    Gut Microbes 3:48-56. 2012
    ..Inhibition of polyamine synthesis or SMO could abrogate the development of this cell population that may represent precursors for neoplastic transformation...

Research Grants12

  1. HPYLORI INDUCED DNA DAMAGE AND IMMUNE DYSREGULATION
    Keith Wilson; Fiscal Year: 2001
    ..The results of these studies will provide new information that will elucidate the central pathogenetic steps of H. pylori disease and will provide potential new targets for intervention and therapy. ..
  2. iNOS, COX-2, and Arginase in Murine Barrett's Esophagus
    Keith Wilson; Fiscal Year: 2003
    ..We will study macroscopic and histologic evidence of esophagitis, BE and BAA, gene expression, apoptosis and proliferation in A. wild-type (WT) vs. COX-2-/- mice, B. W'I- vs. iNOS -/-mice, and C. WT vs. argll -/- mice. ..
  3. Immunomodulatory effects of arginine supplementation in colitis and colon cancer
    Keith Wilson; Fiscal Year: 2009
    ....
  4. Immunomodulatory effects of arginine supplementation in colitis and colon cancer
    Keith Wilson; Fiscal Year: 2009
    ....
  5. H pylori Induced DNA Damage and Immune Dysregulation
    Keith Wilson; Fiscal Year: 2009
    ..pylori pathogenesis and associated inflammation and carcinogenesis, and may provide insight into other forms of mucosal inflammation. ..
  6. Immunomodulatory effects of arginine supplementation in colitis and colon cancer
    Keith T Wilson; Fiscal Year: 2010
    ....