Keith Wilson

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. pmc Difluoromethylornithine is a novel inhibitor of Helicobacter pylori growth, CagA translocation, and interleukin-8 induction
    Daniel P Barry
    Division of Gastroenterology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
    PLoS ONE 6:e17510. 2011
  2. pmc Cationic amino acid transporter 2 enhances innate immunity during Helicobacter pylori infection
    Daniel P Barry
    Division of Gastroenterology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
    PLoS ONE 6:e29046. 2011
  3. pmc L-arginine supplementation improves responses to injury and inflammation in dextran sulfate sodium colitis
    Lori A Coburn
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
    PLoS ONE 7:e33546. 2012
  4. pmc High-throughput multi-analyte Luminex profiling implicates eotaxin-1 in ulcerative colitis
    Lori A Coburn
    Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America Veterans Affairs Tennessee Valley Healthcare System, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
    PLoS ONE 8:e82300. 2013
  5. pmc Deletion of cationic amino acid transporter 2 exacerbates dextran sulfate sodium colitis and leads to an IL-17-predominant T cell response
    Kshipra Singh
    Division of Gastroenterology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
    Am J Physiol Gastrointest Liver Physiol 305:G225-40. 2013
  6. pmc L-arginine uptake by cationic amino acid transporter 2 is essential for colonic epithelial cell restitution
    Kshipra Singh
    Department of Medicine, Division of Gastroenterology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Am J Physiol Gastrointest Liver Physiol 302:G1061-73. 2012
  7. pmc Phylogeographic origin of Helicobacter pylori is a determinant of gastric cancer risk
    Thibaut de Sablet
    Division of Gastroenterology, Hepatology, and Nutrition, Vanderbilt University School of Medicine, MRBIV, Room 1030C, 2215 Garland Avenue, Nashville, TN 37232, USA
    Gut 60:1189-95. 2011
  8. pmc Spermine oxidase, a polyamine catabolic enzyme that links Helicobacter pylori CagA and gastric cancer risk
    Rupesh Chaturvedi
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center Nashville, TN, USA
    Gut Microbes 3:48-56. 2012

Collaborators

Detail Information

Publications8

  1. pmc Difluoromethylornithine is a novel inhibitor of Helicobacter pylori growth, CagA translocation, and interleukin-8 induction
    Daniel P Barry
    Division of Gastroenterology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
    PLoS ONE 6:e17510. 2011
    ..These findings suggest that DFMO has effects on H. pylori that may contribute to its effectiveness in reducing gastritis and colonization and may be a useful addition to anti-H. pylori therapies...
  2. pmc Cationic amino acid transporter 2 enhances innate immunity during Helicobacter pylori infection
    Daniel P Barry
    Division of Gastroenterology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
    PLoS ONE 6:e29046. 2011
    ..These findings demonstrate that CAT2 is an important regulator of the immune response during H. pylori infection...
  3. pmc L-arginine supplementation improves responses to injury and inflammation in dextran sulfate sodium colitis
    Lori A Coburn
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
    PLoS ONE 7:e33546. 2012
    ..These preclinical studies indicate that L-Arg supplementation could be a potential therapy for IBD, and that one mechanism of action may be functional enhancement of iNOS activity...
  4. pmc High-throughput multi-analyte Luminex profiling implicates eotaxin-1 in ulcerative colitis
    Lori A Coburn
    Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America Veterans Affairs Tennessee Valley Healthcare System, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
    PLoS ONE 8:e82300. 2013
    ..Our data implicate eotaxin-1 as an etiologic factor and therapeutic target in UC, and indicate that Luminex-based assays may be useful to assess IBD pathogenesis and to select patients for anti-cytokine/chemokine therapies. ..
  5. pmc Deletion of cationic amino acid transporter 2 exacerbates dextran sulfate sodium colitis and leads to an IL-17-predominant T cell response
    Kshipra Singh
    Division of Gastroenterology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
    Am J Physiol Gastrointest Liver Physiol 305:G225-40. 2013
    ..Thus CAT2 plays an important role in controlling inflammation and IL-17 activation in an injury model of colitis, and impaired L-Arg availability may contribute to UC pathogenesis...
  6. pmc L-arginine uptake by cationic amino acid transporter 2 is essential for colonic epithelial cell restitution
    Kshipra Singh
    Department of Medicine, Division of Gastroenterology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Am J Physiol Gastrointest Liver Physiol 302:G1061-73. 2012
    ..Uptake of L-Arg, and its metabolism by Arg1 to L-Orn and conversion to L-Pro by OAT is essential for colonic epithelial wound repair...
  7. pmc Phylogeographic origin of Helicobacter pylori is a determinant of gastric cancer risk
    Thibaut de Sablet
    Division of Gastroenterology, Hepatology, and Nutrition, Vanderbilt University School of Medicine, MRBIV, Room 1030C, 2215 Garland Avenue, Nashville, TN 37232, USA
    Gut 60:1189-95. 2011
    ..Our aim was to investigate the ancestral origin of H pylori strains isolated from subjects in these high- and low-risk regions and to determine whether this is a predictive determinant of precancerous lesions...
  8. pmc Spermine oxidase, a polyamine catabolic enzyme that links Helicobacter pylori CagA and gastric cancer risk
    Rupesh Chaturvedi
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center Nashville, TN, USA
    Gut Microbes 3:48-56. 2012
    ..Inhibition of polyamine synthesis or SMO could abrogate the development of this cell population that may represent precursors for neoplastic transformation...

Research Grants12

  1. HPYLORI INDUCED DNA DAMAGE AND IMMUNE DYSREGULATION
    Keith Wilson; Fiscal Year: 2000
    ..The results of these studies will provide new information that will elucidate the central pathogenetic steps of H. pylori disease and will provide potential new targets for intervention and therapy. ..
  2. Immunomodulatory effects of arginine supplementation in colitis and colon cancer
    Keith Wilson; Fiscal Year: 2009
    ....
  3. Immunomodulatory effects of arginine supplementation in colitis and colon cancer
    Keith Wilson; Fiscal Year: 2009
    ....
  4. H pylori Induced DNA Damage and Immune Dysregulation
    Keith Wilson; Fiscal Year: 2007
    ..pylori pathogenesis and associated inflammation and carcinogenesis, and may provide insight into other forms of mucosal inflammation. ..
  5. H pylori Induced DNA Damage and Immune Dysregulation
    Keith Wilson; Fiscal Year: 2006
    ..pylori pathogenesis and associated inflammation and carcinogenesis, and may provide insight into other forms of mucosal inflammation. ..
  6. H pylori Induced DNA Damage and Immune Dysregulation
    Keith Wilson; Fiscal Year: 2005
    ..pylori pathogenesis and associated inflammation and carcinogenesis, and may provide insight into other forms of mucosal inflammation. ..
  7. iNOS, COX-2, and Arginase in Murine Barrett's Esophagus
    Keith Wilson; Fiscal Year: 2003
    ..We will study macroscopic and histologic evidence of esophagitis, BE and BAA, gene expression, apoptosis and proliferation in A. wild-type (WT) vs. COX-2-/- mice, B. W'I- vs. iNOS -/-mice, and C. WT vs. argll -/- mice. ..
  8. HPYLORI INDUCED DNA DAMAGE AND IMMUNE DYSREGULATION
    Keith Wilson; Fiscal Year: 2001
    ..The results of these studies will provide new information that will elucidate the central pathogenetic steps of H. pylori disease and will provide potential new targets for intervention and therapy. ..
  9. Immunomodulatory effects of arginine supplementation in colitis and colon cancer
    Keith T Wilson; Fiscal Year: 2010
    ....
  10. H pylori Induced DNA Damage and Immune Dysregulation
    Keith Wilson; Fiscal Year: 2009
    ..pylori pathogenesis and associated inflammation and carcinogenesis, and may provide insight into other forms of mucosal inflammation. ..