Keith T Wilson
Affiliation: Vanderbilt University
Coburn L, Singh K, Asim M, Barry D, Allaman M, Al Greene N, et al
. Loss of solute carrier family 7 member 2 exacerbates inflammation-associated colon tumorigenesis. Oncogene. 2018;: pubmed publisher
..Strategies to enhance L-Arg availability by supplementing L-Arg and/or increasing L-Arg uptake could represent a therapeutic approach in IBD to reduce the substantial long-term risk of colorectal carcinoma. ..
de Sablet T, Piazuelo M, Shaffer C, Schneider B, Asim M, Chaturvedi R, et al
. Phylogeographic origin of Helicobacter pylori is a determinant of gastric cancer risk. Gut. 2011;60:1189-95 pubmed publisher
..The phylogeographic origin of H pylori strains provides an explanation for geographic differences in cancer risk deriving from this infection. ..
Singh K, Coburn L, Asim M, Barry D, Allaman M, Shi C, et al
. Ornithine Decarboxylase in Macrophages Exacerbates Colitis and Promotes Colitis-Associated Colon Carcinogenesis by Impairing M1 Immune Responses. Cancer Res. 2018;78:4303-4315 pubmed publisher
..i>Cancer Res; 78(15); 4303-15. ©2018 AACR. ..
Gobert A, Wilson K. The Immune Battle against Helicobacter pylori Infection: NO Offense. Trends Microbiol. 2016;24:366-376 pubmed publisher
..pylori-infected gastric tissues and epithelial cells, the role of NO in H. pylori-related diseases and H. pylori gene expression, and the mechanisms whereby H. pylori regulates NO synthesis by host cells. ..
Gobert A, Wilson K. Human and Helicobacter pylori Interactions Determine the Outcome of Gastric Diseases. Curr Top Microbiol Immunol. 2017;400:27-52 pubmed publisher
..pylori-related diseases has been supported by phylogenetic analysis of the human population and their H. pylori isolates in geographic areas with varying clinical and pathologic outcomes of the infection. ..
Gogoi M, Datey A, Wilson K, Chakravortty D. Dual role of arginine metabolism in establishing pathogenesis. Curr Opin Microbiol. 2016;29:43-8 pubmed publisher
..This article sheds light upon the roles of arginine metabolism during pathological conditions and its therapeutic potential. ..
Hardbower D, Asim M, Murray Stewart T, Casero R, Verriere T, Lewis N, et al
. Arginase 2 deletion leads to enhanced M1 macrophage activation and upregulated polyamine metabolism in response to Helicobacter pylori infection. Amino Acids. 2016;48:2375-88 pubmed publisher
..Overall, the finding of this study is that ARG2 contributes to the immune evasion of H. pylori by restricting M1 macrophage activation and polyamine metabolism. ..
Gobert A, Wilson K. Polyamine- and NADPH-dependent generation of ROS during Helicobacter pylori infection: A blessing in disguise. Free Radic Biol Med. 2017;105:16-27 pubmed publisher
..It is the purpose of this review to summarize the literature about the production of ROS during H. pylori infection and their role in this infectious gastric disease. ..
Hardbower D, Asim M, Luis P, Singh K, Barry D, Yang C, et al
. Ornithine decarboxylase regulates M1 macrophage activation and mucosal inflammation via histone modifications. Proc Natl Acad Sci U S A. 2017;114:E751-E760 pubmed publisher
..Thus, ODC in macrophages tempers antimicrobial, M1 macrophage responses during bacterial infections through histone modifications and altered euchromatin formation, leading to the persistence and pathogenesis of these organisms. ..