GRANT WILKINSON

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. ncbi request reprint Genetic variability in cytochrome P450 3A5 and in vivo cytochrome P450 3A activity: some answers but still questions
    Grant R Wilkinson
    Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tenn 37232 6602, USA
    Clin Pharmacol Ther 76:99-103. 2004
  2. ncbi request reprint Drug metabolism and variability among patients in drug response
    Grant R Wilkinson
    Department of Pharmacology, Vanderbilt University, Nashville, TN 37232 6600, USA
    N Engl J Med 352:2211-21. 2005
  3. ncbi request reprint Genotype-phenotype associations for common CYP3A4 and CYP3A5 variants in the basal and induced metabolism of midazolam in European- and African-American men and women
    Michael D Floyd
    Division of Clinical Pharmacology, Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6602, USA
    Pharmacogenetics 13:595-606. 2003
  4. ncbi request reprint Multilocus genetic interactions and response to efavirenz-containing regimens: an adult AIDS clinical trials group study
    Alison A Motsinger
    Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA
    Pharmacogenet Genomics 16:837-45. 2006
  5. ncbi request reprint Coordinate induction of both cytochrome P4503A and MDR1 by St John's wort in healthy subjects
    George K Dresser
    Division of Clinical Pharmacology, Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Clin Pharmacol Ther 73:41-50. 2003
  6. ncbi request reprint Pharmacogenetics of efavirenz and central nervous system side effects: an Adult AIDS Clinical Trials Group study
    David W Haas
    Program for Human Genetics, Vanderbilt University School of Medicine, 345 24th Avenue North, Nashville, TN 37203, USA
    AIDS 18:2391-400. 2004
  7. ncbi request reprint Pharmacogenetics of long-term responses to antiretroviral regimens containing Efavirenz and/or Nelfinavir: an Adult Aids Clinical Trials Group Study
    David W Haas
    Vanderbilt University School of Medicine, Nashville, TN 37203, USA
    J Infect Dis 192:1931-42. 2005
  8. ncbi request reprint Lorazepam is an independent risk factor for transitioning to delirium in intensive care unit patients
    Pratik Pandharipande
    Department of Anesthesia Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Anesthesiology 104:21-6. 2006
  9. ncbi request reprint Pharmacogenetics of nevirapine-associated hepatotoxicity: an Adult AIDS Clinical Trials Group collaboration
    David W Haas
    Microbiology and Immunology, Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA
    Clin Infect Dis 43:783-6. 2006
  10. ncbi request reprint The erythromycin breath test reflects P-glycoprotein function independently of cytochrome P450 3A activity
    Daniel Kurnik
    Department of Medicine, Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232 6602, USA
    Clin Pharmacol Ther 80:228-34. 2006

Research Grants

Detail Information

Publications26

  1. ncbi request reprint Genetic variability in cytochrome P450 3A5 and in vivo cytochrome P450 3A activity: some answers but still questions
    Grant R Wilkinson
    Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tenn 37232 6602, USA
    Clin Pharmacol Ther 76:99-103. 2004
  2. ncbi request reprint Drug metabolism and variability among patients in drug response
    Grant R Wilkinson
    Department of Pharmacology, Vanderbilt University, Nashville, TN 37232 6600, USA
    N Engl J Med 352:2211-21. 2005
  3. ncbi request reprint Genotype-phenotype associations for common CYP3A4 and CYP3A5 variants in the basal and induced metabolism of midazolam in European- and African-American men and women
    Michael D Floyd
    Division of Clinical Pharmacology, Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6602, USA
    Pharmacogenetics 13:595-606. 2003
    ..In most healthy subjects, variability in intestinal and hepatic CYP3A activity, using midazolam as an in-vivo probe, is modest and common polymorphisms in CYP3A4 and CYP3A5 do not appear to have important functional significance...
  4. ncbi request reprint Multilocus genetic interactions and response to efavirenz-containing regimens: an adult AIDS clinical trials group study
    Alison A Motsinger
    Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA
    Pharmacogenet Genomics 16:837-45. 2006
    ..We examined whether long-term responses to efavirenz, and/or plasma efavirenz exposure, are better predicted by multilocus genetic interactions than by individual polymorphisms...
  5. ncbi request reprint Coordinate induction of both cytochrome P4503A and MDR1 by St John's wort in healthy subjects
    George K Dresser
    Division of Clinical Pharmacology, Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Clin Pharmacol Ther 73:41-50. 2003
    ..However, the relative contributions of enhanced metabolism and efflux transport to the overall induction process are unknown...
  6. ncbi request reprint Pharmacogenetics of efavirenz and central nervous system side effects: an Adult AIDS Clinical Trials Group study
    David W Haas
    Program for Human Genetics, Vanderbilt University School of Medicine, 345 24th Avenue North, Nashville, TN 37203, USA
    AIDS 18:2391-400. 2004
    ..Efavirenz is metabolized by cytochrome P4502B6 (CYP2B6). We investigated whether polymorphisms in CYP2B6, CYP3A4, CYP3A5, and MDR1 were associated with efavirenz central nervous system side effects and pharmacokinetics...
  7. ncbi request reprint Pharmacogenetics of long-term responses to antiretroviral regimens containing Efavirenz and/or Nelfinavir: an Adult Aids Clinical Trials Group Study
    David W Haas
    Vanderbilt University School of Medicine, Nashville, TN 37203, USA
    J Infect Dis 192:1931-42. 2005
    ..Nelfinavir is a substrate for P-glycoprotein, which is encoded by MDR1. The present study examined associations between genetic variants and long-term responses to treatment...
  8. ncbi request reprint Lorazepam is an independent risk factor for transitioning to delirium in intensive care unit patients
    Pratik Pandharipande
    Department of Anesthesia Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Anesthesiology 104:21-6. 2006
    ..Sedative and analgesic medications relieve anxiety and pain but may contribute to patients' transitioning into delirium...
  9. ncbi request reprint Pharmacogenetics of nevirapine-associated hepatotoxicity: an Adult AIDS Clinical Trials Group collaboration
    David W Haas
    Microbiology and Immunology, Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA
    Clin Infect Dis 43:783-6. 2006
    ..Among participants in a randomized study in South Africa (FTC-302), MDR1 3435C-->T was significantly associated with decreased risk of hepatotoxicity (risk ratio, 0.30; P=.016)...
  10. ncbi request reprint The erythromycin breath test reflects P-glycoprotein function independently of cytochrome P450 3A activity
    Daniel Kurnik
    Department of Medicine, Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232 6602, USA
    Clin Pharmacol Ther 80:228-34. 2006
    ..Thus studies were undertaken to determine the effect of tariquidar, a potent P-glycoprotein inhibitor that does not affect CYP3A activity, on the ERBT and on the CYP3A-mediated metabolism of midazolam, a non-P-glycoprotein substrate...
  11. doi request reprint Tariquidar, a selective P-glycoprotein inhibitor, does not potentiate loperamide's opioid brain effects in humans despite full inhibition of lymphocyte P-glycoprotein
    Daniel Kurnik
    Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Anesthesiology 109:1092-9. 2008
    ..The authors studied the effect of the highly selective, potent P-glycoprotein inhibitor tariquidar on loperamide's central opioid effects...
  12. pmc Associations between CYP2B6 polymorphisms and pharmacokinetics after a single dose of nevirapine or efavirenz in African americans
    David W Haas
    USA
    J Infect Dis 199:872-80. 2009
    ..We characterized associations between genetic polymorphisms and the pharmacokinetics of single doses of nevirapine and efavirenz...
  13. ncbi request reprint A multi-investigator/institutional DNA bank for AIDS-related human genetic studies: AACTG Protocol A5128
    David W Haas
    Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA
    HIV Clin Trials 4:287-300. 2003
    ..Human DNA banks must allow future analyses while addressing confidentiality, ethical, and regulatory issues...
  14. ncbi request reprint Genetic variability in CYP3A5 and its possible consequences
    Hong Guang Xie
    Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Pharmacogenomics 5:243-72. 2004
    ....
  15. ncbi request reprint MDR1 gene polymorphisms and phase 1 viral decay during HIV-1 infection: an adult AIDS Clinical Trials Group study
    David W Haas
    Division of Infectious Diseases, Vanderbilt University School of Medicine, 345 24th Avenue, North, Suite 105, Nashville, TN 37212, USA
    J Acquir Immune Defic Syndr 34:295-8. 2003
    ..It is concluded with 95% confidence that phase 1 viral decay differences between exon 26 TT and CC groups are unlikely to exceed 18%...
  16. ncbi request reprint In vivo comparisons of constitutive cytochrome P450 3A activity assessed by alprazolam, triazolam, and midazolam
    Andrew L Masica
    Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232 6602, USA
    Clin Pharmacol Ther 76:341-9. 2004
    ..Accordingly, the disposition of 3 closely related benzodiazepines with extensive and similar CYP3A-mediated metabolism characteristics but different pharmacokinetics was investigated, and correlations between the drugs were examined...
  17. ncbi request reprint Differential in vivo sensitivity to inhibition of P-glycoprotein located in lymphocytes, testes, and the blood-brain barrier
    Edna F Choo
    Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232 6602, USA
    J Pharmacol Exp Ther 317:1012-8. 2006
    ..Such resistance can be overcome by a sufficiently high dose of an inhibitor; however, whether this is safely attainable in the clinical situation remains to be determined...
  18. ncbi request reprint Pharmacogenetics of plasma efavirenz exposure after treatment discontinuation: an Adult AIDS Clinical Trials Group Study
    Heather J Ribaudo
    Statistical Data Analysis Center, Harvard School of Public Health, Harvard Medical School, Boston, MA, USA
    Clin Infect Dis 42:401-7. 2006
    ..Lower plasma efavirenz clearance is associated with a cytochrome P450 2B6 gene (CYP2B6) polymorphism (516G-->T) that is more frequent among African American individuals than among European American individuals...
  19. ncbi request reprint Different contributions of polymorphisms in VKORC1 and CYP2C9 to intra- and inter-population differences in maintenance dose of warfarin in Japanese, Caucasians and African-Americans
    Harumi Takahashi
    Department of Pharmacotherapy, Meiji Pharmaceutical University, Kiyose, Tokyo, Japan
    Pharmacogenet Genomics 16:101-10. 2006
    ....
  20. ncbi request reprint 5'-Flanking region polymorphisms of CYP2C9 and their relationship to S-warfarin metabolism in white and Japanese patients
    Harumi Takahashi
    Department of Pharmacotherapy, Meiji Pharmaceutical University, Kiyose, Tokyo, Japan
    Blood 103:3055-7. 2004
    ..In conclusion, either unidentified polymorphisms further upstream in the promoter region or environmental factor(s) account for the differences in the warfarin doses between whites and Japanese...
  21. ncbi request reprint CYP2C9 and oral anticoagulation therapy with acenocoumarol and warfarin: similarities yet differences
    Harumi Takahashi
    Department of Pharmacotherapy, Meiji Pharmaceutical University, Tokyo, Japan
    Clin Pharmacol Ther 75:376-80. 2004
  22. ncbi request reprint Population differences in S-warfarin metabolism between CYP2C9 genotype-matched Caucasian and Japanese patients
    Harumi Takahashi
    Department of Pharmacotherapy, Meiji Pharmaceutical University, Noshio 2 522 1, Kiyose, Tokyo 204 8588, Japan
    Clin Pharmacol Ther 73:253-63. 2003
    ....
  23. ncbi request reprint Single plasma concentrations of 1'-hydroxymidazolam or the ratio of 1'-hydroxymidazolam:midazolam do not predict midazolam clearance in healthy subjects
    Janyce F Rogers
    Clinical Pharmacology Research Center, Bassett Healthcare, Cooperstown, New York 13326 1394, USA
    J Clin Pharmacol 42:1079-82. 2002
    ..29, p = 0.31). Single sampling of 1'-hydroxymidazolam or 1'-hydroxymidazolam:midazolam plasma concentrations cannot be used to predict midazolam clearance in healthy adults...
  24. ncbi request reprint Clinical sedation scores as indicators of sedative and analgesic drug exposure in intensive care unit patients
    Andrew L Masica
    Baylor Institute for Health Care Research and Improvement, Baylor Health Care System, Dallas, Texas, USA
    Am J Geriatr Pharmacother 5:218-31. 2007
    ..These issues are of particular concern in elderly patients (aged > or =65 years), who account for at least half of all ICU admissions and nearly two thirds of ICU days...
  25. ncbi request reprint Cytochrome P450 2E1 and 3A activities do not differ between Mexicans and European Americans
    Russell A Poland
    Department of Psychiatry, Research Center on the Psychobiology of Ethnicity, Harbor UCLA Medical Center, Torrance, CA, USA
    Clin Pharmacol Ther 72:288-93. 2002
    ....
  26. ncbi request reprint Limited sampling strategy to predict AUC of the CYP3A phenotyping probe midazolam in adults: application to various assay techniques
    Jooran S Kim
    Clinical Pharmacology Research Center, Bassett Healthcare, Cooperstown, New York 13326 1394, USA
    J Clin Pharmacol 42:376-82. 2002
    ..A limited sampling strategy is more convenient and cost-effective than standard sampling strategies and is applicable to more than one assay technique...

Research Grants5

  1. CHEMOPREVENTIVE AGENTS AND HUMAN CYTOCHROME P450 IN VIVO
    GRANT WILKINSON; Fiscal Year: 2002
    ..Moreover, the information will be of value in the further development and evaluation of the efficacy/ toxicity of these new chemopreventive agent. ..