R G Wiley

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. ncbi request reprint Destruction of midbrain dopaminergic neurons by using immunotoxin to dopamine transporter
    R G Wiley
    Department of Neurology, Center for Molecular Neuroscience, Vanderbilt University, Nashville, Tennessee 37212 2637, USA
    Cell Mol Neurobiol 23:839-50. 2003
  2. ncbi request reprint Targeted toxins in pain
    Ronald G Wiley
    Department of Neurology, Vanderbilt University, Nashville, TN 37212, USA
    Adv Drug Deliv Rev 55:1043-54. 2003
  3. ncbi request reprint Neuronal lesioning with axonally transported toxins
    R G Wiley
    Departments of Neurology and Pharmacology, Vanderbilt University, VAMC Nashville, TN 37212 2637, USA
    J Neurosci Methods 103:73-82. 2000
  4. ncbi request reprint Targeting neurokinin-1 receptor-expressing neurons with [Sar9,Met(O2)11 substance P-saporin
    R G Wiley
    Neurology Service 127, VAMC, Nashville, TN 37212 2637, USA
    Neurosci Lett 277:1-4. 1999
  5. ncbi request reprint Expression of m1 and m4 muscarinic receptor mRNA in the striatum following a selective lesion of striatonigral neurons
    M B Harrison
    Department of Neurology, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    Brain Res 734:323-6. 1996
  6. ncbi request reprint Modeccin and volkensin but not abrin are effective suicide transport agents in rat CNS
    R G Wiley
    Department of Neurology, Vanderbilt University, Nashville, TN
    Brain Res 438:145-54. 1988
  7. ncbi request reprint Destruction of neurokinin-1 receptor expressing cells in vitro and in vivo using substance P-saporin in rats
    R G Wiley
    Neurology Service, VAMC, Nashville, TN 37212 2637, USA
    Neurosci Lett 230:97-100. 1997
  8. ncbi request reprint Lack of effect of moderate Purkinje cell loss on working memory
    C C Wrenn
    Laboratory of Experimental Neurology, Veterans Administration Medical Center, Nashville, TN 37212, USA
    Neuroscience 107:433-45. 2001
  9. ncbi request reprint Molecular heterogeneity of protein kinase C expression in human ventricle
    H G Shin
    Departments of Medicine, Pharmacology and Surgery, Vanderbilt University School of Medicine, 37232 6602, Nashville, TN, USA
    Cardiovasc Res 48:285-99. 2000
  10. doi request reprint Neuropeptide Y receptor-expressing dorsal horn neurons: role in nocifensive reflex responses to heat and formalin
    R G Wiley
    Lab of Experimental Neurology, Neurology Service 127, Veterans Affairs Tennessee Valley Healthcare System, 1310 24th Avenue, South, Nashville, TN 37212 2637, USA
    Neuroscience 161:139-47. 2009

Research Grants

Detail Information

Publications20

  1. ncbi request reprint Destruction of midbrain dopaminergic neurons by using immunotoxin to dopamine transporter
    R G Wiley
    Department of Neurology, Center for Molecular Neuroscience, Vanderbilt University, Nashville, Tennessee 37212 2637, USA
    Cell Mol Neurobiol 23:839-50. 2003
    ..Anti-DAT-saporin joins the growing list of neural lesioning agents based on targeted cytotoxins...
  2. ncbi request reprint Targeted toxins in pain
    Ronald G Wiley
    Department of Neurology, Vanderbilt University, Nashville, TN 37212, USA
    Adv Drug Deliv Rev 55:1043-54. 2003
    ..Targeting non-lethal moieties (enzymes, genes, viruses) also may prove useful for research and therapeutic purposes...
  3. ncbi request reprint Neuronal lesioning with axonally transported toxins
    R G Wiley
    Departments of Neurology and Pharmacology, Vanderbilt University, VAMC Nashville, TN 37212 2637, USA
    J Neurosci Methods 103:73-82. 2000
    ..It is likely that more immunolesioning and neuropeptide-toxin conjugates will be developed in the near future...
  4. ncbi request reprint Targeting neurokinin-1 receptor-expressing neurons with [Sar9,Met(O2)11 substance P-saporin
    R G Wiley
    Neurology Service 127, VAMC, Nashville, TN 37212 2637, USA
    Neurosci Lett 277:1-4. 1999
    ..SSP-saporin will be useful in larger species and for intraparenchymal injections...
  5. ncbi request reprint Expression of m1 and m4 muscarinic receptor mRNA in the striatum following a selective lesion of striatonigral neurons
    M B Harrison
    Department of Neurology, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    Brain Res 734:323-6. 1996
    ..A volkensin lesion of striatonigral neurons reduced striatal m4 mRNA by 63% and m1 mRNA by only 18%, suggesting that preferential expression of m4 receptors by striatonigral neurons may contribute to their differential response...
  6. ncbi request reprint Modeccin and volkensin but not abrin are effective suicide transport agents in rat CNS
    R G Wiley
    Department of Neurology, Vanderbilt University, Nashville, TN
    Brain Res 438:145-54. 1988
    ..These agents may prove extremely useful in producing anatomically selective lesions of neurons afferent to a toxin injection site...
  7. ncbi request reprint Destruction of neurokinin-1 receptor expressing cells in vitro and in vivo using substance P-saporin in rats
    R G Wiley
    Neurology Service, VAMC, Nashville, TN 37212 2637, USA
    Neurosci Lett 230:97-100. 1997
    ..Injection of SP-SAP into the striatum selectively destroyed NK-1 receptor expressing interneurons. These results show that SP-SAP will be useful for studying the function of NK-1 receptor expressing neurons...
  8. ncbi request reprint Lack of effect of moderate Purkinje cell loss on working memory
    C C Wrenn
    Laboratory of Experimental Neurology, Veterans Administration Medical Center, Nashville, TN 37212, USA
    Neuroscience 107:433-45. 2001
    ..Furthermore, the data are consistent with the idea that the working memory deficit observed in 192-sap-injected animals is likely due to lesioning of the cholinergic basal forebrain...
  9. ncbi request reprint Molecular heterogeneity of protein kinase C expression in human ventricle
    H G Shin
    Departments of Medicine, Pharmacology and Surgery, Vanderbilt University School of Medicine, 37232 6602, Nashville, TN, USA
    Cardiovasc Res 48:285-99. 2000
    ....
  10. doi request reprint Neuropeptide Y receptor-expressing dorsal horn neurons: role in nocifensive reflex responses to heat and formalin
    R G Wiley
    Lab of Experimental Neurology, Neurology Service 127, Veterans Affairs Tennessee Valley Healthcare System, 1310 24th Avenue, South, Nashville, TN 37212 2637, USA
    Neuroscience 161:139-47. 2009
    ....
  11. ncbi request reprint Anti-nociceptive effects of selectively destroying substance P receptor-expressing dorsal horn neurons using [Sar9,Met(O2)11]-substance P-saporin: behavioral and anatomical analyses
    R G Wiley
    Laboratory of Experimental Neurology, VA TVHS, Nashville, TN 37212 2637, USA
    Neuroscience 146:1333-45. 2007
    ..SSP-sap is an attractive agent for possible treatment of chronic pain...
  12. ncbi request reprint Noradrenergic lesioning with an anti-dopamine beta-hydroxylase immunotoxin
    M J Picklo
    Department of Pharmacology, Vanderbilt University, Nashville, TN 37232
    Brain Res 666:195-200. 1994
    ..75 and 15 micrograms, respectively. The anti-D beta H immunotoxin will be a useful tool in the study of the peripheral noradrenergic system in adult and neonatal animals...
  13. doi request reprint Neuropeptide Y receptor-expressing dorsal horn neurons: role in nocifensive reflex and operant responses to aversive cold after CFA inflammation
    L L Lemons
    Lab of Experimental Neurology, Neurology Service, Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN 37212 2637, USA
    Neuroscience 216:158-66. 2012
    ....
  14. doi request reprint Galanin receptor-expressing dorsal horn neurons: role in nociception
    Laurie L Lemons
    Lab of Experimental Neurology, Neurology Service, Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN 37212 2637, USA
    Neuropeptides 45:377-83. 2011
    ..These results are different than those seen with intrathecal neuropeptide Y-saporin and suggest the potential value of selectively targeting GalR1-expressing dorsal horn neurons to control pain...
  15. ncbi request reprint Targeted toxins
    R G Wiley
    Veterans Affairs Medical Center, Nashville, Tennessee, USA
    Curr Protoc Neurosci . 2001
    ..The final protocol uses neuropeptide-toxin conjugates to selectively destroy neurons expressing the receptor for the specific neuropeptide...
  16. ncbi request reprint Lesion-induced transneuronal plasticity of the cholinergic innervation in the adult rat entorhinal cortex
    S De Lacalle
    Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
    Eur J Neurosci 10:1054-62. 1998
    ....
  17. doi request reprint Spinal mu-opioid receptor-expressing dorsal horn neurons: role in nociception and morphine antinociception
    Robert H Kline
    Laboratory of Experimental Neurology, Tennessee Valley Healthcare System, Nashville, Tennessee 37212 2637, USA
    J Neurosci 28:904-13. 2008
    ..Thus, one would predict that altering the activity of MOR-expressing dorsal horn neurons would be antinociceptive and of interest in the search for new approaches to management of chronic pain...
  18. doi request reprint Substance P receptor-expressing dorsal horn neurons: lessons from the targeted cytotoxin, substance P-saporin
    Ronald G Wiley
    Laboratory of Experimental Neurology, Neurology Service, VA TVHS, 1310 24th Avenue, South Nashville, TN 37212 2637, USA
    Pain 136:7-10. 2008
  19. ncbi request reprint Immunotoxins and neuropeptide-toxin conjugates experimental applications
    Dougles A Lappi
    Advanced Targeting Systems, 11175A Flintkote Avenue, San Diego, CA 92121, USA
    Mini Rev Med Chem 4:585-95. 2004
    ..The use of targeted toxins in research is rich and varied; here we limit ourselves to describe some of those exciting results that researchers have made in the neurosciences...
  20. ncbi request reprint Assessment of pain in laboratory animals: a comment on Mogil and Crager (2004)
    Charles J Vierck
    Pain 114:520-3; author reply 523-4. 2005

Research Grants1

  1. MOR expressing neurons in pain and morphine analgesia
    RONALD WILEY; Fiscal Year: 2004
    ..Many valuable future experiments and clinical applications may be possible if dermorphin-saporin proves effective. ..